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7612045 |
Compounds, compositions and methods for controlling biofilms and bacterial infections
The present invention provides compounds and compositions useful for controlling bacterial biofilms as well as for controlling and/or preventing bacterial infections. The compounds of the invention...
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7393837 |
Inhibition of PEX in the treatment of metabolic bone diseases
The present invention relates to a method of treating metabolic bone diseases in a patient, which comprises the modulation of PEX activity to modulate the bone micro-environmental concentrations of...
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7326691 |
Compositions comprising amphotericin B, methods, and systems
A composition includes particles including at least about 95 wt % of amphotericin B, wherein the particles have a mass median diameter ranging from about 1.1 μm to about 1.9 μm. Another...
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7241741 |
Methods and compositions for the treatment of asthma and related disorders
The present invention provides methods for the treatment of respiratory tract mucositis in individuals in need of such treatment, the method comprising the systemic administration to the individual...
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7220726 |
Antifungal pimaricin compositions and therapeutic methods employing same
An antifungal composition suitable for parenteral administration to a mammal includes an amount of pimaricin or an antifungal derivative thereof that is effective to inhibit the growth of a fungal...
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7193706 |
Computer interfaced scanning fluorescence lifetime microscope applied to directed evolution
This invention provides a method for screening large numbers of individual cells or colonies of cells using scanning microscopy coupled with fluorescence lifetime measurement and analysis, using...
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7163703 |
Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
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7153838 |
Pharmacologically acceptable solvent vehicles
An antifungal composition suitable for parenteral administration to a mammal includes an amount of pimaricin or an antifungal derivative thereof that is effective to inhibit the growth of a fungal...
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7115576 |
Water-soluble antibiotic comprising an amino sugar, in the form of a polysaccharide conjugate
The invention relates to novel pharmaceutical forms for antibiotics containing amino sugar, amphotericin B, daunorubicin and doxorubicin, in which the known side effects are reduced and which can...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7053061 |
Amphotercin B structured emulsion
Parenteral compositions of oil-coated-Amphotericin B in structured-emulsion form, having LD50 of at least 400 mg/kg in mice and process for making the same have been described. The process...
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7045507 |
Substituted tetracycline compounds as synergistic antifungal agents
Methods and compositions for treating for the synergistic treatment of fungal associated disorders are discussed.
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7011826 |
Control of acidosis
The present invention relates to a vaccine for the prevention of lactic acidosis in a vertebrate, said vaccine comprising at least one isolated microorganism, or fragment or fragments thereof,...
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RE38984 |
Antifungal combination therapy
There is described antifungal combination therapy comprising the use of known antifungal agents such as the azoles or polyenes in combination with a pneumocandin derivative antifungal agent. More...
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6919317 |
Pharmaceutical composition comprising squalene epoxidase inhibitor and macrolide immunomodulator
Synergistic combinations of a squalene epoxidase inhibitor such as terbinafine and a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro, 33-desoxyascomycin are provided,...
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6914051 |
Penetrating antibiotic gel for soft tissue diseases
A penetrating antibiotic gel for treating pain, inflammation and other pathological conditions affecting musculoskeletal tissues and other soft tissues of the body. The composition includes an...
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6884784 |
Diagnosis and management of infection caused by chlamydia
The present invention provides a unique approach for the diagnosis and management of infections by Chlamydia species, particularly C. pneumoniae . The invention is based, in part, upon the...
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6846837 |
Topical administration of basic antifungal compositions to treat fungal infections of the nails
Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a...
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6844004 |
Topical formulations of natamycin/pimaricin
The present invention relates to formulations of Pimaricin (also called Natamycin), that are useful for the treatment and suppression of topical infections such as those caused by various pathogens...
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6821526 |
Compositions and devices using a spinosyn compound for control of insects
The subject invention pertains to compositions and devices for controlling insects and, in particular, houseflies. Insecticidal compositions of the present invention comprise spinosad and,...
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6770306 |
Drugs for reducing vaginal acidity and treatment of vaginitis, and the use thereof
The present invention relates to a pharmaceutical composition for reducing vaginal acidity, treating abnormal enhancement of vaginal acidity, and high acidity vaginitis associated with abnormal...
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6770290 |
Amphotericin B liposome preparation
A novel composition and method for solubilizing amphiphilic drugs in a small amount of organic solvent for use in improved liposomes is disclosed. A phosphatidylglycerol is acidified in a small...
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6710033 |
Methods and treatment of multiple sclerosis
The invention features methods and reagents for the diagnosis, monitoring, and treatment of multiple sclerosis. The invention is based in part on the discovery that Chlamydia is present in patients...
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6667302 |
Heterocyclic topoisomerase poisons
The invention provides compounds of formula I: wherein R 1 to R 5 have any of the values defined in the specification, as well as pharmaceutically acceptable salts of the compounds,...
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6664241 |
Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
The present invention provides two new classes of polyene macrolide amide derivatives useful for treating or preventing fungal infections. The new polyene macrolide amide derivatives exhibit...
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6660761 |
Method of treatment for fungal infections with a synergistic formulation of antifungal agents
The present invention relates to a method of treatment of fungal infections consisting essentially of a synergistic combination of plant compounds that are useful for enhancing the activity of...
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6649595 |
Regulation of biological events using novel compounds
Materials and methods are disclosed for regulation of biological events such as target gene transcription and growth, proliferation or differentiation of engineered cells.
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6593371 |
Treatment for wart and related disorders
A novel treatment for wart and related disorders such as papillomas derived from extracts of pepper, ginger, and related plant species containing vanillyl (FIG. 3 ), and piperidine (FIG. 7 ) ring...
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6586407 |
Injectable pharmaceutical formulations for partricin derivatives
New injectable pharmaceutical formulations are described, containing a partricin derivative in the form of a free base as the active ingredient, or a pharmaceutically acceptable water-soluble salt...
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6576617 |
Direct action anti-mycotic
A composition comprising a perishable material susceptible to spoilage from mold, fungus, or yeast growth and a natamycin material dispersed in or on the perishable material to provide the material...
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6562796 |
Derivatives of polyene macrolides and preparation and use thereof
The present invention provides a new class of polyene macrolide derivatives useful for treating or preventing fungal infections. The new polyene macrolide derivatives exhibit surprisingly superior...
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6555566 |
Methods and materials for treating and preventing inflammation of mucosal tissue
The invention involves methods and materials for treating and preventing non-invasive fungus-induced mucositis. Specifically, the invention involves administrating an antifungal agent such that it...
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6541455 |
Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents
Methods and kits for removing, treating or preventing head lice infestations in patients in need of such treatment are disclosed and include topically applying to the lice-infested area an...
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6518252 |
Method of treating aquatic animals with an antimicrobial agent and chelating agent
The present invention relates to novel method of reducing microbial infections, especially bacterial infections, of animals, especially of aquatic animals such as fish maintained in tanks or...
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6509319 |
EDTA and other chelators with or without antifungal antimicrobial agents for the prevention and treatment of fungal infections
A pharmaceutical composition comprising at least one antifungal agent and at least one chelator, and a method for administering the pharmaceutical composition to a patient having a fungal...
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6468964 |
Control of acidic gut syndrome
According to the present invention there is provided a method for the treatment or prophylaxis of acidic gut syndrome resulting from the accumulation of acid and production of endotoxin in the...
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6455518 |
Pharmaceutical compositions for the treatment of transplant rejection, autoimmune or inflammatory conditions comprising cyclosporin a and 40-O-(2-hydroxyethyl)-rapamycin
A synergistic combination of an IL-2 transcription inhibitor (e.g., cyclosporin A or FK506) and 40-O-(2-hydroxyethyl)-rapamycin is provided, which is useful in the treatment and prevention of...
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6448233 |
Topical application of a combination of benzoyl peroxide and a second active ingredient
Disclosed herein is a dispensing system for benzoyl chloride and an antimicrobial agent which antimicrobial agent is a macrolide or an aminoglycoside antibiotic. The dispensing system comprises a...
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6432935 |
Pharmaceutical compositions, mainly vaginal suppository, containing many different active ingredients
Compositions comprising an antibiotic, sulphonamide, at least one an antiquagul agent, e.g., clotrimazol (bis-phenyl-(2-chlorophenyl)-1-imidazolyl-methane), natamycin, or nystatin,and...
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6399607 |
Aminomethylene amide analogs of pyrazinamide with intracellular antimycobacterial activity against pyrazinamide-resistant mycobacteria combined with a rifamycin
Methods for treating diseases involving pyrazinamide-resistant mycobacteria comprise administering to a mammal in need of treatment a therapeutically effective amount of a combination of rifamycin...
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6395711 |
Macrolides with antitumor activity
The compound referred to herein as IB-962 12, having structure (I) can be obtained by cultivating the strain of Micromonospora sp. ES25-008, available under the accession number CECT-3333, and can...
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6369036 |
Antifungal composition
The present invention provides a method of preparing an improved antifungal composition containing an antifungal compound of the polyene type such as natamycin wherein the antifungal compound is...
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6362160 |
Immunophilin-binding agents prevent glutamate neurotoxicity associated with vascular stroke and neurodegenerative diseases
Immunophilin-binding agents inhibit the phosphatase calcineurin, leading to the increased phosphorylation of certain brain proteins, including nitric oxide synthase. The increased levels of...
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6342482 |
Formulations for controlling human lice
Safer pediculicidal formulations comprising a spinosyn, or a physiologically acceptable derivative or salt thereof, and a physiologically acceptable carrier, and methods of controlling lice...
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6306613 |
Modulators of leaderless protein export and methods for identifying and using the same
Methods of modulating the export of a leaderless protein from a cell by contacting the cell with a compound that alters the binding of the leaderless protein and a transport molecule are provided....
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6284736 |
Amphotericin derivatives
A compound of formula (I), or a pharmaceutically acceptable salt thereof: ##STR1## wherein R 1 is a carboxylic acid group, a derivative thereof, a ketone residue, an aldehyde function or...
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6281197 |
Cardiac glycosides and their aglycone derivatives treat complications of diabetes
This invention provides methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a cardiac glycoside or aglycone derivative. Leaderless proteins include...
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6281196 |
Isolation and structural elucidation of the human cancer cell growth inhibitory compound denominated agelagalastatin
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6248718 |
Lesion-directed dry dosage forms of antibacterial agents for the treatment of acute mucosal infections of the oral cavity
The invention provides a medicament for topically treating acute bacterial infections in the oral mucosa, and methods of use. The medicament comprises a dry dosage (such as a troche or powder) of...
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6235722 |
Pharmacological preparation
A topical preparation comprising nystatin and hydrocortisone to satisfactory treat fungus infections of the skin in the ear canal.
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