|
Match
|
Document |
Document Title |
|
|
7388017 |
Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease
The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds,...
|
|
|
7384957 |
3,4-dihydro-1H-isoquinolin-2-yl-derivatives
The present invention relates to novel compounds of formula I wherein the variable groups are as defined in the claims or a pharmaceutically acceptable acid addition salt thereof. The compounds of...
|
|
|
7378428 |
Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient
A nitrogen-containing bicyclic compound of formula (I) or a pharmaceutically acceptable salt thereof (wherein the symbols have the same meanings as described in the specification).
The compound...
|
|
|
7354919 |
Isoxazole compositions useful as inhibitors of ERK
Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula:
where A, B, R 1 , R 2 , T and Ht are described in the...
|
|
|
7354944 |
Thiadiazole compounds and methods of use
The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and...
|
|
|
7348339 |
Imidazopyridine derivatives as kinase inhibitors
A compound of the formula
and physiologically acceptable salts and or N-oxides thereof wherein,
X 1 is N or CR 3 ; X 2 is N or CR 4 ; X 3 is N or CR 5 ; X 4 is N or CR 6 . with the proviso...
|
|
|
7345057 |
5-HT7 receptor antagonists
The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some some tetrahydroisoquinoline substituted sulfonamide compounds, to...
|
|
|
7323474 |
Pyridine derivatives inhibiting angiogenesis and/or VEGF receptor tyrosine kinase
The invention relates to pyridine derivatives of formula (I)
wherein the substituents and symbols are defined as indicated in the description, processes for the preparation thereof, their usage...
|
|
|
7320992 |
Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
|
|
|
7312218 |
Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula Ia-If:
or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic...
|
|
|
7312222 |
Heterocyclic piperidines as modulators of chemokine receptor activity
The present application describes modulators of CCR3 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
|
|
|
7309708 |
Hepatitis C virus inhibitors
Hepatitis C virus inhibitors are disclosed having the general formula:
wherein R 1 , R 2 , R 3 , R′, B, Y and X are described in the description. Compositions comprising the compounds and...
|
|
|
7304060 |
Indazolyl-substituted pyrroline compounds as kinase inhibitors
The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I):
useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods...
|
|
|
7279489 |
Compounds and methods for modulation of estrogen receptors
Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective for ER-β over...
|
|
|
7268147 |
Compounds useful for the treatment of diseases
The invention relates to compounds of formula (1)
and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives....
|
|
|
7268135 |
Biaryl sulfonamides and methods for using same
The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
|
|
|
7265129 |
Anti-infective biaryl compounds
Compounds represented by the formula (I), where R1, R2, R3, R4, R5, and Q are as defined herein, exhibit activity against infectious pathogens
|
|
|
7265130 |
NPY Y5 antagonist
The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I):
wherein R 1 is lower alkyl, cycloalkyl or the...
|
|
|
7256201 |
Selective estrogen receptor-β ligands
The invention relates to novel compounds having the general formula: (I) and arc useful as selective ER-β ligands in the treatment or prophylaxis of Alzheimer's disease, anxiety disorders,...
|
|
|
7253188 |
Aminobenzamide derivative
This invention relates to a novel compound represented by the formula (I):
or a pharmaceutically acceptable salt thereof,
wherein R 1 is —S(O)p-A, —S—(O)q-B or —O-D, wherein p...
|
|
|
7253168 |
Substituted 1-benzyl-4-substituted piperazine analogues
Compounds of Formula I are provided, in which variables are as described herein:
Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly...
|
|
|
7253165 |
Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
The compounds are of the class of benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives, useful as D 4 antagonists. Said compounds are useful for the treatment of medical...
|
|
|
7247644 |
Ester derivatives of a decahydroisoquinoline-3-carboxylic acid as analgestics
Thus, the present invention provides compounds of formula (I) The present invention further provides the use of a compound of formula (I) for the manufacture of a medicament for the treatment of a...
|
|
|
7244725 |
Acetyl 2-hydroxy-1, 3-diaminoalkanes
Disclosed are compounds of the formula:
where variables Z, X, R 15 , R 2 , R 3 , and R C are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are...
|
|
|
7244743 |
Non-peptidic BRS-3 agonists
Selectively BRS-3-agonistic compounds of formula I
wherein A 1 , A 2 , A 3 , R 1 , R 2 , R 3 , Ar 1 , Ar 2 , Ar 3 , m and n have the meanings given in the description, and also pharmaceutical...
|
|
|
7241775 |
Composition, process of making, and medical use of substituted 4-phenyltetrahydroisoquinolines
Substituted 4-phenyltetrahydroisoquinolines of formula I, process for their preparation, their use as a medicament and medicaments containing them.
The compounds of formula I can be used, among...
|
|
|
7241774 |
Substituted tetrahydroisoquinoline compounds, methods of making, and their use
The present invention relates to novel substituted tetrahydroisoquinoline compounds, pharmaceutical compositions containing the compounds, methods of making the compounds, and methods of using the...
|
|
|
7238685 |
Benzo-fused heterocycles as endothelin antagonists
The invention relates to novel benzo-fused heterocycles and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including...
|
|
|
7217722 |
Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
An objective of the present invention is to provide compounds having Rho kinase inhibitory activity. The compounds according to the present invention are those represented by formula (I) or...
|
|
|
7217706 |
Propanolamine derivatives
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]:
Wherein each symbol is as defined in the specification or salts thereof which...
|
|
|
7214689 |
Isoquinoline compounds
The invention relatests compound of formula (I):
wherein:
n is 1, 2 or 3,
A represents a group
X represents N or NR 1 , R 2 represents an alkoxy, cycloalkyloxy or...
|
|
|
7211584 |
5-HT7 receptor ligands
The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of...
|
|
|
7211585 |
5-HT7 receptor antagonists
The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes...
|
|
|
7205313 |
Excitatory amino acid receptor antagonists
The present invention provides novel compounds of Formula (I) and Formula (I(a)), or the pharmaceutically acceptable salts thereof; methods for treating neurological disorders and neurodegenerative...
|
|
|
7189758 |
Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof
A compound of Formula (I)
wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such...
|
|
|
7186720 |
Tetrahydropyridyl-alkyl-heterocycles, method for preparing the same and pharmaceutical compositions containing the same
The present invention relates to compounds of formula (I):
in which X represents N or CH; R 1 represents a hydrogen or halogen atom or a CF 3 group; R 2 and R 3 independently represent a...
|
|
|
7166614 |
Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity
The present invention is directed to compounds of the formula I: I(wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of...
|
|
|
7166607 |
Substituted indoles
The present invention relates to substituted indoles of formula (I) useful as pharmaceutical compounds for treating respiratory disorders
|
|
|
7163949 |
4-phenyl substituted tetrahydroisoquinolines and use thereof
Provided herein are compounds of the formulae IA–IF. These compounds are tetrahydroisoquinolines of the following structure:
wherein R 1 –R 8 for compounds of each of the formulae IA, IB,...
|
|
|
7160899 |
Adenosine A2A receptor antangonists combined with neurotrophic activity compounds in the treatment of Parkinson's disease
This invention relates to the use of the combined action of a compound with neurotrophic activity and an adenosine A 2A receptor antagonist for the treatment of Parkinson's disease.
|
|
|
7157463 |
Substituted piperidines/piperazines as melanocortin receptor agonists
The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction
|
|
|
7157454 |
Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same
The invention relates to compounds of formula:
These compounds show affinity for the bradykinin receptors with selectivity towards the B 1 receptors; they may be used for the preparation of...
|
|
|
7144893 |
4-aryl quinols and analogs thereof as therapeutic agents
The present invention pertains to compounds of the formula (1) which are, inter alia, antiproliferative agents, anticancer agents, antimycobacterial agents, antituberculosis agents, and/or...
|
|
|
7144895 |
Benzene acetamide compounds useful as serine protease inhibitors
Compounds having the formula (I),
and pharmaceutically-acceptable salts, hydrates, or prodrugs thereof, are useful as serine protease inhibitors, wherein X is —OH, —O(alkyl), —O(aryl),...
|
|
|
7141561 |
Substituted diaryl heterocycles, process for their preparation and their use as medicaments
This invention discloses and claims diary heterocycles of formula (I)
and their pharmaceutically acceptable salts, pharmaceutical compositions thereof, and methods of using said compounds of...
|
|
|
7138405 |
Pharmaceutical combinations
Pharmaceutical combinations suitable for treating the lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) in men are described herein. The combinations contain an...
|
|
|
7132418 |
Peptidyl heterocyclic ketones useful as tryptase inhibitors
The present invention relates to a series of peptidyl heterocyclic ketones which are inflammatory cell serine protease inhibitors and their compositions and methods for the prevention and treatment...
|
|
|
7125870 |
Isoxazoline derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme
The present application describes novel isoxazoline of formula I or II:
or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, R 1 , R 2 , R 3 , R 4 , Z, U, X, Y, Z a , and n...
|
|
|
7125871 |
Excitatory amino acid receptor modulators
Compounds of the formula (I) in which R 1 , R 2 and X 1 have the meanings given in the specification, modulate metabotropic glutamate receptor function and are useful in treating disorders of the...
|
|
|
7125863 |
Inhibitors of dipeptidyl peptidase IV
Compounds according to formula (1), wherein R 1 is H or CN, X 1 is S, O, SO 2 or CH 2 , X 2 is CO, CH 2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The...
|