Matches 601 - 650 out of 947 < 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 >
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5489583 2-substituted 3-(4-amidinophenyl)propionic acid derivatives  
2-Substituted 3-(4-amidinophenyl)propionic acid derivatives of the formula ##STR1## in which A, Ar and B have the meanings stated in the description, and the preparation thereof are described. The...
5488057 2-oxindole compounds which have useful tyrosine kinase activity  
The present invention provides novel aryl- and heteroarylethenylene derivatives which are useful as tyrosine kinase activity inhibitors.
5484804 Perhydroisoindole derivatives as antagonists of substance P  
This invention relates to novel perhydroisoindole derivatives of general formula (I), ##STR1## wherein radicals R are phenyl radicals optionally 2- or 3-substituted by a halogen atom or a methyl...
5475007 1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and the use thereof  
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease,...
5472962 Benzothiophene derivative  
A benzothiophene derivative represented by the formula ##STR1## or a salt thereof has an excellent antiestrogenic activity, and is useful as a therapeutic agent of breast cancer, endometrial...
5462934 Condensed heterocyclic ketone derivatives and their use  
A compound of the formula: ##STR1## wherein R 1 is H or an optionally substituted hydrocarbon or acyl group; ring A is an optionally further substituted benzene ring; n is an integer of 1 to 10; R...
5459149 Penta-2,4-dienamides and use as pesticides  
The present Application discloses pesticidally active compounds of formula (I): Q(CH 2 ) a (O) b Q 1 CR 2 =CR 3 CR 4 =CR 5 CXNR 1 R x or a salt or propesticide thereof, wherein Q is an...
5446043 Isoquinolyl, quinoxalinyl and quinazolinyl derivatives as inhibitors of 5-lipoxygenase  
The invention concerns a heterocyclic cycloalkane of the formula I ##STR1## wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one...
5446051 Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists  
The present invention provides novel decahydroisoquinoline derivatives which are useful as excitatory amino acid antagonists. The invention also provides for methods of using these derivatives to...
5446071 Methods for lowering serum cholesterol  
The present invention provides methods for lowering serum cholesterol comprising administering to a mammal in need of treatment a serum cholesterol lowering amount of a compound of formula I or...
5444056 Aminoalkoxyphenyl derivatives, process for their preparation and compositions containing them  
An aminoalkoxyphenyl derivative of general formula: Cy--B--Ph--O--A--Am (1) as well as a pharmaceutically acceptable salt thereof in which B represents a...
5434162 Quinolinyl/isoquinolinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension  
Compounds characterized as quinolinyl- or isoquinolinyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension and are of...
5424323 Sterilant composition  
A biocidal, aqueous composition for killing bacteria, spores, fungi, and viruses on nonabsorbent surfaces comprises at least one quaternary ammonium compound, at least one aliphatic dialdehyde...
5416094 Antiarrhythmic and cardioprotective substituted -1(2H)isoquinolines, medicament containing them, and their use for combating heart failures  
Described are guanidinocarbonyl isoquinolines of the formula I, ##STR1## wherein R(1) is hydrogen, (amino) (cyclo) (aryl)alk(en)yl (heteroaryl); R(2) is hydrogen, halogen, alkyl, or aryl; G is a...
5411960 Substituted pyrroloanthracenes and -diones  
Substituted pyrroloanthracenes are prepared by reacting either furanoanthracenes or N-unsubstituted pyrroloanthracenes with appropriately substituted alkylamines. The compounds can be employed as...
5409929 Hydroisoindolines and hydroisoquinolines as psychotropic drugs  
There are provided novel nitrogen-containing bicyclic compounds which are useful in the treatment of physiological or drug induced psychosis or dyskinesia in a mammal. These novel compounds are...
5409938 Antimalarial korupensamines and pharmaceutical compositions and medical uses thereof  
The present invention provides new antimalarial compounds called korupensamines, korupensamine derivatives, and pharmacologically acceptable salts thereof, methods for isolating such antimalarial...
5407946 Pyrrolidine compounds which are useful as thromboxane AZ-inhibitors  
Components of formula (I): ##STR1## in which: R 1 represents optionally substituted phenylsulfonyl, naphthylsulfonyl, quinolyl, or isoquinolyl, R 2 represents hydrogen, optionally substituted...
5405845 (Pyrrolidinyl)phenyl carbamate derivatives and use  
Novel (pyrrolidinyl)phenyl carbamates and related compounds, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction utilizing the carbamates and...
5401752 Tetrahydroisoquinoline derivatives, processes for producing the same and fungicides containing the same  
Tetrahydroisoquinoline derivatives useful as fungicides are disclosed of formula [I]: ##STR1## wherein R 1 represents C 1 -C 5 linear or branched alkyl, C 2 -C 5 linear or branched alkenyl, C...
5401751 Isoquinoline derivatives suitable for use in leukotriene mediated disease  
The invention concerns a heterocycle of the formula I ##STR1## wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two...
5401766 Aminoacid derivatives, a process for their preparation, agents containing these compounds, and the use thereof  
Aminoacid derivatives of the formula I ##STR1## A , n, R 1 , R 2 and R 3 have the meanings given, and salts thereof, a process for their preparation, pharmaceutical preparations based on these...
5393764 Cyclic phenolic thioethers  
The compounds of the present invention comprise substituted phenolic thioethers represented by the formula ##STR1## wherein: R 1 and R 2 are the same or different and independently represent...
5389661 Imidazole and 1,2,4-triazole derivatives with angiotensin II antagonist properties  
This invention relates to novel substituted imidazole and triazole derivatives which antagonize the binding of angiotensin II to its receptors. The compounds are useful in the treatment of...
5389638 Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors  
The present invention provides a tetrahydroisoquinoline compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof which is an antagonist for alpha-2 adrenoreceptors and/or...
5389644 1,4-dihydropyridine compounds  
The compounds are 2,4-disubstituted 3-ethoxycarbonyl 5-methoxycarbonyl 6-methyl 1,4-dihydropyridines in their dextrorotatory form, useful to potentiate the activity of cytotoxic agents and to...
5389649 Oxathiane derivatives  
Oxathiane derivatives of formula ##STR1## in which R represents alkyl and A represents optionally substituted phenyl or a heteroaromatic group containing 1 or 2 nitrogen atoms optionally...
5387591 Pyrrolidine compounds  
Compounds of formula (I): ##STR1## in which: R 1 represents: optionally substituted alkyl, optionally substituted phenyl, pyridyl, optionally substituted phenylsulfonyl, acyl, ...
5384315 Thiophene substituted cycloamines, compositions and use  
A class of compounds having the structural formula ##STR1## in which R is C 1 -C 8 alkyl, C 3 -C 6 cycloalkyl, phenyl or substituted phenyl; N, R 1 and R 2 form a monocyclic or bicyclic...
5384322 Nitrogen-containing bicyclic compounds and pharmaceutical compositions thereof  
The invention relates to the compounds of formula (I): ##STR1## in which: A represents, with the nitrogen and carbon atoms to which it is bound, a heterocycle, B represents, with the nitrogen...
5366981 N-acyl-substituted azacyclic compounds, processes for their preparaion, and their use as pharmaceuticals  
A compound, a solvate or salt thereof, of formula (I): ##STR1## in which: A is ##STR2## p is 2; ROC-- is an acyl group linked to a substituted or unsubstituted carbocyclic aromatic ring system; ...
5366994 Use of a combination of angiotensin-converting enzyme inhibitor and calcium antagonist for the treatment of proteinuria  
A combination of angiotensin-converting enzyme inhibitors and calcium antagonists for the treatment of proteinuria is disclosed. The invention relates to the prevention and therapy of proteinuria...
5362736 Isoquinoline derivatives  
Novel isoquinoline derivatives represented by formula (I): ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 , X 1 and X 2 are as defined in the specification, have an anti-arrhythmic activity and...
5356906 (N-phthalimidoalkyl) piperidines useful as treatments for psychosis  
There is described novel (N-phthalimidoalkyl) piperidine compounds which exhibit selective sigma-receptor antagonism and therefore are useful in the treatment of physiological or drug induced...
5350762 Tetrahydrocyclopent[B]indole methanamines and related compounds  
There are disclosed various compounds of the formula below, ##STR1## where the various parameters R 1 , R 2 , R 3 , R 4 , X, m and n are as defined in the specification, which show activities as a...
5344843 Cat-1 inhibitors, pharmaceutical compositions and methods of use  
The invention relates to compounds of the formula ##STR1## wherein R 1 , R 2 , R 2 ' X, Y, Z, A, B, Q and n are as described herein. Their pharmaceutically acceptable salts, and when appropriate,...
5340811 Isoquinoline-or quinoline-sulfonamide derivative and a pharmaceutical composition comprising the same  
Disclosed is a sulfonamide derivative represented by following formula (I) and a medicine for the treatment of asthma comprising the sulfonamide derivative as an active ingredient which exhibits...
5340833 Urokinase inhibitors  
Disclosed are benzothiophene and thienothiophene derivatives useful for inhibiting urokinase activity.
5330991 Tetrahydroisoquinoline compounds and fungicides containing the same  
Tetrahydroisoquinoline derivatives of the following formula [I] and acid addition salts thereof, and ##STR1## (wherein in all of these formulae, R 1 represents C 1 -C 5 straight or branched...
5328906 0-(3-amino-2-hydroxypropyl)-hydroximic acid halides and process for preparing the same  
Hydroximic acid derivatives of the formula ##STR1## These compounds are useful for treating diabetes angiopathy.
5322848 N-acyl-substituted azacyclic compounds, processes for their preparation, and their use as pharmaceuticals  
A compound, or solvate or salt thereof, of formula ##STR1## R 1 is hydrogen, halogen, or C 1 -6 alkyl; R 2 and R 3 are hydrogen or C 1 -6 alkyl; R 5 together with R 4 forms a --(CH) 2 ) 2 ...
RE34630 Substituted isoquinolines and methods of using same  
Novel substituted isoquinoline compounds are disclosed together with novel 2-phenylethylamides useful as precursors or intermediates for the production of the isoquinolines. The substituted...
5310750 Heterocyclic compounds useful as α.sub.2 -adrenoceptor antagonists  
A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, wherein: R 1 and R 2 may each represent hydrogen or alkyl providing that at least one of R 1 or R 2 represents...
5304554 4-[(alkyl or dialkyl)amino]quinolines and their method of preparation  
Novel 4-[(alkyl or dialkyl)amino]quinolines are disclosed that are prepared by condensin BACKGROUND OF THE INVENTION The United States government has rights in this invention as a result of a...
5298503 N-(isoquinolin-5-ylsulphonyl) azacycloalkanes  
Compounds of formula (I): ##STR1## wherein R 1 , R 2 , U, X, Y, Z, n, m, p and r are as defined in the description, and medicaments containing the same.
5296485 Substituted N-phenylpiperidines and drugs therefrom  
Substituted N-phenylpiperidines I ##STR1## (R 1 =H, NO 2 , CN, halogen, C 1 -C 4 -alkyl, CF 3 , OCF 3 , OH, CH 2 OH, COOH, CHO, NH--CHO, NH 2 , CO--NH 2 , 5-tetrazinyl, R 4 --O--, R 4 --O--CH...
5292755 USPA benzolyguanidines  
Benzoylguanidines of the formula I ##STR1## where R(1) or R(2) is equal to R(6)--S(O) n -- or R(7)R(8)N--O 2 S-- and the other substituent R(1) or R(2) is in each case equal to H, F, Cl, Br,...
5292746 Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock  
The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
5288761 Open chain enediyne dihydroperoxides having DNA cleaving properties  
Open chain enediyne dihydroperoxides having eight carbons between the hydroperoxide groups that cleave DNA are disclosed, as are methods of making and using the same.
5286733 Substituted 3-piperidinealkanoates and alkanones and compositions and method of use thereof  
The invention is related to compounds, being useful in treating psychosis, of the formula: ##STR1## wherein: R 1 is hydrogen, lower-alkyl, phenyl-lower-alkyl, C 3 -C 7 -monocyclic...
Matches 601 - 650 out of 947 < 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 >