Matches 101 - 150 out of 319 < 1 2 3 4 5 6 7 >
Match Document Document Title
6555546 Use of 5HT3 antagonists for promoting intestinal lavage  
The present invention is concerned with the use of 5HT 3 antagonists for promoting intestinal lavage, especially in combination with an osmotic agent.
6555552 Azabicyclic amine derivatives and their use as therapeutic agents  
The present invention relates compounds of the formula (I): wherein X represents hydrogen or a C 1-4 alkyl group optionally substituted by a hydroxy group; Y represents hydrogen, C 1-6 alkyl or...
6541520 Treatment of addiction and addiction-related behavior  
The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a mammal suffering from substance addiction. The method...
6537522 Neuroprobes for mapping monoamine reuptake sites  
Iodinated neuroprobes for mapping monoamine reuptake sites in the brain, and particularly iodinated neuroprobes that can also serve as radiotracers for use in single-photon emission computed...
6531484 Pyrrolidine modulators of CCR5 chemokine receptor activity  
Pyrrolidine compounds of Formula I: (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8a , R 8b , j, k, 1, m, and n are defined herein) are described. The compounds are modulators of CCR5...
6479509 Method of promoting smoking cessation  
A method of training a smoker to cease smoking by administering tropane compounds is provided.
6468998 Pyrrolidine compounds and medicinal utilization thereof  
The present invention provides a pyrrolidine compound of the formula (I) wherein each symbol is as defined in the specification, an optically active compound thereof and a pharmaceutically...
6465491 6-phenylpyridyl-2-amine derivatives  
The present invention relates to certain 6-phenyl-pyridin-2-ylamine derivatives that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and...
6432976 8-aza-bicyclo&lsqb 3.2.1&rsqb octane NMDA/NR2B antagonists  
Novel 3-substituted 8-aza-bicyclo[3.2.1]octanes (commonly known as “tropanes”) substituted in the 8-position are effective as NMDA NR2B antagonists useful for relieving pain.
6413961 Irrigation solution and method for inhibition of pain and inflammation  
A method and solution for perioperatively inhibiting a variety of pain, inflammation, spasm and restenosis processes resulting from cardiovascular or general surgical, therapeutic and diagnostic...
6395748 Tropane-derivatives, their preparation and use  
Compounds of formula (a), (b), (c), or (d), or any mixture thereof, or a pharmaceutically-acceptable salt thereof; wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl or...
6391888 Topical anesthetics useful for treating cancer  
The invention provides methods which are useful for treating diseases (e.g., cancer) where PKCδ is implicated, and modulation (e.g, inhibition) of its activity is desired.
6376510 Neuromuscular relaxants  
Alkoxy and/or acyloxy disubstituted and polysubstituted aralkyl and aralkenyl bis-quaternary ammonium derivatives of cyclic alkanol diesters have neuromuscular relaxant properties.
6362195 Branched alkoxy-substituted 2-aminopyridines as NOS inhibitors  
The present invention relates to 6-phenyl-pyridin-2-ylamine derivatives of the formula wherein R 1 , R 2 , R 3 and R 4 are defined as in the specification, that exhibit activity as nitric...
6350758 Tropane derivatives and method for their synthesis  
A compound of formula (I) wherein R 1 -R 6 have any of the values defined in the specification are described, as well as pharmaceutical compositions comprising a compound of formula (I), and...
6323216 Basic derivatives of benz[E]isoindol-1-ones and pyrrolo[3,4-c]quinolin-1-ones with 5-HT3-antagonistic activity, their preparation and their therapeutic use  
Novel basic derivatives of benz[e]isoindol-1-ones and pyrrolo[3,4-c]quinolin-1-ones which can be represented by the general formula (I) indicated below are described: ##STR1## in which X is CH...
6306876 4-[aryl(8-azabicyclo[3.2.1]octan-3-yl)]aminobenzoic acid derivatives  
4-[aryl(8-azabicyclo[3.2.1]octan-3yl)]aminobenzoic acid derivatives are delta-opioid receptor modulators. As delta-opioid receptor agonists, such compounds are useful as analgesics. Depending on...
6294545 Bicyclic amines and their use as insecticides  
6288079 Tropane-derivatives, their preparation and use  
Compounds of formula (a), (b), (c), or (d), or any mixture thereof, or a pharmaceutically-acceptable salt thereof; ##STR1## wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl,...
6284770 Medicaments for the treatment of non-constipated female irritable bowel syndrome  
This invention relates to the use of 5-HT3 receptor antagonists in the treatment of nonconstipated female IBS patients.
6255319 5-aryl-3-(8-azabicyclo[3.2.1]oct-3-yl)-1,3,4-oxadiazol-2(3H)-one derivatives as 5-ht4 receptor ligands  
Compound of general formula (I) ##STR1## in which R 1 represents an alkyl or cycloalkylmethyl group, X 1 represents a hydrogen or halogen atom or an alkoxy group, or alternatively OR 1 and X 1 ...
6235747 6-phenyl-pyridin-2-ylamine derivatives  
The present invention relates to certain 6-phenyl-pyridin-2-ylamine derivatives that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and...
6221879 8-azabicyclo[3.2.1] octane-3-methanamine derivatives as ligands of D2 and D3 dopamine and 5HT1A and 5HT2 serotonin receptors  
Compounds of general formula (I) ##STR1## in which U represents a group of general formula (A) or (B) ##STR2## in which formulae V represents a hydrogen or halogen atom, a (C 1 -C 3 )alkyl group...
6221878 Method for treatment of depression  
The invention relates to the use of compounds which act as antagonists of 5-hydroxytryptamine (5-HT) at 5-HT 3 receptors for the treatment of depression.
6207677 Piperidine derivatives having anxiolytic effect  
Piperidine compounds having the general formula (I), ##STR1## wherein R 1 is (a) a group consisting of alkyl, alkenyl, cycloalkyl, cycloalkenyl, phenyl, cycloalkylalkyl, cycloalkenylalkyl,...
6200991 Imidazole derivatives, preparation and therapeutic application thereof  
A compound of formula (I) ##STR1## the process of preparing compounds of formula (I), their pharmaceutical compositions, and the method of treating diseases associated with M 3 muscarinic and/or...
6177442 Bicyclic amine derivatives  
The invention provides a compound of formula (I): ##STR1## wherein A represents a bidentate group of formula --CH 2 --X--CH 2 -- (wherein X is methylene, sulfur or oxygen), X'CCY or X'WC--CYZ...
6177451 Epibatidine and derivatives thereof as nicotine cholinergic receptor agonists  
The present invention provides methods of treatment utilizing pharmaceutical compositions comprising an effective nicotine agonist amount of epibatidine (1) or a synthetic...
6166032 Method for controlling tobacco use and alleviating withdrawal symptoms due to cessation of tobacco use  
A method for controlling tobacco use and alleviating withdrawal symptoms due to the cessation of tobacco use comprising administering to a human desiring to control tobacco use and/or suffering...
6140338 Chemokine receptor antagonists  
The present invention relates to a compound of the general formula: ##STR1## wherein each of R 1 and R 2 which may be the same or different, is e.g. a hydrogen atom, a halogen atom or a lower...
6117882 5-HT.sub.4 agonists and antagonists  
Compounds of formula I: ##STR1## are used as antagonists and partial agonists for the serotonin receptor 5-HT 4 and provide therapeutic methods for treatment of disorders caused by or affected by...
6114347 Pharmaceutical formulation for the prophylaxis and pretreatment of a poisoning caused by organophosphorus cholinesterase inhibitors  
A pharmaceutical formulation for the prophylaxis and preliminary treatment of a poisoning caused by organophosphorus cholinesterase inhibitors is characterized in that it consists of an active...
6107307 Inhibition of serotonin reuptake  
This invention provides 3-(bicyclic heteroaryl)-8-azabicyclo[3.2.1]oct-2-enes and 3-(bicyclic heteroaryl)-8-azabicyclo[3.2.1]octanes which are useful for the inhibition of serotonin reuptake in...
6100275 8-azabicyclo[3.2.1.]oct-2-ene derivatives, their preparation and use  
A compound having the formula, ##STR1## or any of its enantiomers or any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R is hydrogen, alkyl, alkenyl, alkynyl,...
6087379 Cyclic amine derivatives  
A cyclic amine derivative represented by the following formula: ##STR1## wherein R 1 represents a substituted or unsubstituted phenyl group, R 2 represents a substituted of unsubstituted C 1 -C...
6077848 Benzoylecgonine, ecgonine and ecgonidine derivatives  
The present invention relates to a novel class of covalently coupled benzoylecgonine, ecgonine and ecgonidine derivatives that are useful for alleviating the symptoms of immunoregulatory disorders,...
6030966 Heterocyclic compound and their use  
The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel...
H001838 Insecticidal N-(arylalkyl)-4-[Bis(substituted aryl)hydroxymethyl]azabicyclo[3.3.1.]nonanes and [3.2.1.]octanes  
Compounds for control of insects and arcarids are disclosed and exemplified which are N-(arylalkyl)-4-[bis(substituted aryl)hydroxymethyl]azabicyclo[3.3. 1 .]nonanes and [3.2.1.]octanes, including...
6013242 Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression  
Biologically active derivatives of the tropane ring system are provided which selectively bind either to the 5-HT or DA reuptake site, leading to compounds which have use for the treatment of...
6008227 Process for blocking 5-HT and dopamine uptake with biologically active tropane derivatives  
Selective blockade of DA and 5-HT uptake sites with 3-aryltropane derivatives.
5968926 Antipsychotic method  
The present invention relates to a novel method for treating a mammal suffering from or susceptible to schizophrenia and schizophreniform diseases.
5958945 Naphthamide derivatives of 3-beta-amino azabicyclo octane or nonane as neuroleptic agents  
The invention pertains to novel azabicyclo-naphthalene-carboxamide derivatives, a method for preparing same and the use thereof as a medicament. The compounds of the invention are of formula (I)....
5935953 Methods for controlling invertebrate pests using cocaine receptor binding ligands  
The invention relates to a method of controlling an invertebrate pest, comprising contacting the pest with a pest-controlling amount of an agent having substantial inhibitory activity toward a...
5900418 Method for treatment of obesity  
A method is provided for the control of obesity comprising administering to a mammal including humans suffering from obesity an acetylcholine esterase reactivator or prodrug derivative thereof...
5880121 4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof  
4,5-Dihydronaphth 1,2-c!isoxazole derivatives of the general formula: ##STR1## where A, X and n are defined herein are disclosed. Such compounds are useful as serotonin 5-HT 3 antagonists. These...
5834484 Cocaine analogs  
Cocaine analogs are disclosed. The analogs, certain 6-alkyl substituted tropane derivatives, bind to the cocaine binding site on dopamine transporter, without interfering with the dopamine...
5821249 Anhydroecogonine compounds and their use as anticholinergic agents  
Methylecgonidine (MEG; anhydroecgonine methylester), is produced when cocaine base ("crack") is heated. MEG alone and in combination with cocaine was tested for action on isolated tracheal rings...
5817621 External remedy possessing trophoprotective effect  
A dermatological composition for external use comprising a lipid ointment base, vitamin A, a salicylic acid or a derivative thereof, D-camphor, a biogenic GABAergic substance, a biogenic...
5798363 Use for tachykinin antagonists to treat emesis  
The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel...
5770738 Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions  
The new compounds of formula A--O--CO--Z (I) (wherein A and Z are defined as explained in the specification) can be prepared by conventional...
Matches 101 - 150 out of 319 < 1 2 3 4 5 6 7 >