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7414046 |
Gyrase inhibitors and uses thereof
The present invention relates to compounds of the formula I:
or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity....
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7410966 |
Use of and some novel imidazopyridines
The use of compounds of formula (I) wherein R 1 , R 3 , R 10 , m and Ar are as defined in the Specification and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the...
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7407969 |
Respiratory syncytial virus replication inhibitors
The present invention concerns compounds of formula (I), prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof wherein -a 1 =a 2 -a 3 =a...
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7407968 |
Compounds
Compounds of formula (I) wherein R F1 , R F2 , Z, R 1 , R 2 , Ar, X and Y are as defined in the specification as well as salts and pharmaceutical compositions including the compounds were prepared....
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7402593 |
Monohydrated sodium salt of S-tenatoprazole and the use thereof in therapy
The present invention relates to S-tenatoprazole monohydrated sodium salt, represented by the following formula
and the use thereof in therapy for the treatment of digestive diseases.
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7390811 |
Respiratory syncytial virus replication inhibitors
This invention concerns the use of compounds of formula (I) wherein -a 1 =a 2 -a 3 =a 4 - is a radical of formula —CH═CH—CH═CH—, —N═CH—CH═CH—, —CH═N—CH═CH—,...
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7381732 |
Pyrazolobenzamides and derivatives as factor Xa inhibitors
The present application describes pyrazolobenzamides and derivatives thereof of Formula I:
P 4 -P-M-M 4 I
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7375113 |
Nitrogenous fused-ring derivatives, medicinal compositions containing the derivatives, and use thereof as drugs
The present invention provides nitrogen-containing fused-ring derivatives represented by the following general formula, or pharmaceutically acceptable salts thereof, or prodrugs thereof, which...
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7371761 |
Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
The present application describes lactam-containing compounds and derivatives thereof of Formula I:
P 4 -P-M-M 4 I
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RE40245 |
Gyrase inhibitors and uses thereof
The present invention relates to compounds of the formula I:
or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase...
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7354929 |
Cannabinoid receptor ligands and uses thereof
Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein
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7348339 |
Imidazopyridine derivatives as kinase inhibitors
A compound of the formula
and physiologically acceptable salts and or N-oxides thereof wherein,
X 1 is N or CR 3 ; X 2 is N or CR 4 ; X 3 is N or CR 5 ; X 4 is N or CR 6 . with the proviso...
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7348333 |
Cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists
There are described cycloalkyl derivatives of the formula (I)
R 1 —Y-A-B-D-E-F-G (I)
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7348326 |
Heteroaryl fused aminoalkyl imidazole derivatives: selective modulators of GABAa receptors
Disclosed are compounds of the formula:
or the pharmaceutically acceptable non-toxic salts thereof wherein the A, B, C, D, X, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , are variables defined...
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7348324 |
Cyclic amine compounds as CCR5 antagonists
A compound of formula (I) (wherein R 1 is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R 2 is a hydrocarbon group...
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7338964 |
2-substituted-1-deaza purine derivatives with adenosine receptor modulating activity
The present invention relates to 2-substituted-1-deaza purine derivatives as adenosine receptor modulating agents, to methods for the preparation of these compounds and to novel intermediates...
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7332506 |
Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression
A compound represented by the formula I:
wherein A represents the following heterocycles:
and R 1-9 are as defined herein, a composition containing this compound and methods for treating...
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7332505 |
Nitrosated and nitrosylated proton pump inhibitors, compositions and methods of use
The present invention describes novel nitrosated and/or nitrosylated proton pump inhibitor compounds, and novel compositions comprising at least one proton pump inhibitor compound that is...
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7329677 |
Imidazo(4,5-b)pyridine-derivatives as inducible no-synthase inhibitors
The compounds of formula (I)
in which R1, R2, R3, R4 and R11 have the meanings as given in the description are novel effective iNOS inhibitors.
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7323494 |
Compounds and methods
Disclosed is a compound of having the formula:
pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables...
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7317021 |
Aminopyridine-derivatives as inductible no-synthase inhibitors
The compounds of Formula (I)
in which R1, R2, R3 and R4 have the meanings as given in the description are novel effective iNOS inhibitors.
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7312214 |
1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors
The present application describes 1,1-disubstituted cycloalkyl compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
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7300945 |
Benzimidazole and pyridylimidazole derivatives
This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I
The invention is particularly related to such...
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7300944 |
Pyrazolo[3,4-b]pyridin-6-ones as GSK-3 inhibitors
The present invention provides compounds of formula (I)
the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs, wherein...
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7300943 |
GSK-3 inhibitors
The invention provides compounds of formula (I)
the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs, wherein R 1 , R...
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7285551 |
Fused-ring compounds and use thereof as drugs
The present invention provides a fused ring compound of the following formula [I]
wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a...
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7279488 |
Imidazopyridine-derivatives as inducible no-synthase inhibitors
The compounds of Formula (I)
in which R1, R2, R3, R4, R5 and A have the meanings as given in the description are novel effective iNOS inhibitors.
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7268146 |
Ring fused pyrazole derivatives as CRF antagonists
This invention relates to compounds which are generally CRF-1 receptor antagonists and which are represented by Formula I or Formula II:
wherein Ar is optionally substituted aryl or heteroaryl,...
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7268145 |
Thiobenzimidazole derivatives
The present invention is a thiobenzimidazole derivative represented by the following formula (1)
or a medically acceptable salt thereof wherein said thiobenzimidazole derivative and a medically...
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7268133 |
Cannabinoid receptor ligands and uses thereof
Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein
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7265129 |
Anti-infective biaryl compounds
Compounds represented by the formula (I), where R1, R2, R3, R4, R5, and Q are as defined herein, exhibit activity against infectious pathogens
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7265128 |
3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and...
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7259171 |
Di and trifluoro-triazolo-pyridines anti-inflammatory compounds
The present invention relates to novel triazolo-pyridines of the formula I
wherein R 1 is fluoro; s is an integer from two to three; R 2 is (C 3 -C 6 )cycloalkyl optionally substituted by one...
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7259159 |
Guanidino derivatives as inhibitors of cell adhesion
The present invention relates to acylguanidino derivatives of formula (I), in which R 1 , R 2 , R 3 , A, B, X, Y and n have the meanings indicated in claim 1 , their physiologically tolerable...
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7253154 |
Substituted thiazolopyrimidines as xanthine oxidase inhibitors
The invention relates to compounds of the following formula (I) or their salts:
in which R 1 represents OR 4 or others, in which R 4 is an alkyl group having 1-8 carbon atoms which may have...
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7244748 |
Pyridines for treating injured mammalian nerve tissue
The invention provides novel pyridines, pharmaceutical compositions comprising such pyridines, and the use of such compositions in treating injured mammalian nerve tissue, including but not limited...
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7238699 |
Imidazolyl derivatives as corticotropin releasing factor inhibitors
The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF...
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7232833 |
4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
The invention relates to 4-substituted quinoline compounds of general formula:
which are active as antimicrobials, in which:
X 1 , X 2 , X 3 , X 4 and X 5 is C—R′ 1 , to C—R′ 5 ...
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7226930 |
Phosphodiesterase 4 inhibitors
Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with...
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7226929 |
Pyrrolidin-2-one derivatives as inhibitors of factor xa
The invention relates to compounds of formula (Ic)
processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the...
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7220758 |
Ether substituted imidazopyridines
Imidazopyridine compounds that contain an ether or thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the...
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7220757 |
Compositions and methods for topical administration of 2-NH-heteroarylimidazoles
Compounds of formula (I):
are inhibitors of bacterial methionyl tRNA synthetase and are of use in treating bacterial infections.
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7217721 |
Tropane derivatives useful in therapy
The present invention provides compounds of formula (I)
wherein X, Y, R 1 , R 2 and R 3 are as defined hereinabove.
The compounds of the present invention are modulators, especially...
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7205314 |
Compounds for the treatment of dementia related diseases
The present invention relates to new compounds of formula (I) wherein Y, P, R 1 , R 2 , R 3 , n, m are defined as in claim 1 , a process for their preparation and new intermediates used therein,...
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7196093 |
Reversible inhibitors of SAH hydrolase and uses thereof
1. The present invention provides compositions and methods for reversibly inhibiting S-adenosyl-L-homocysteine (SAH) hydrolase. The compounds of the present invention can be used as an...
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7192968 |
Ethylenediamine derivatives
The invention relates a compound represented by the formula (1):
Q 1 -Q 2 -C(═O)—N(R 1 )-Q 3 -N(R 2 )-T 1 -Q 4 ( 1...
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7189733 |
Compositions and methods for inhibiting TGF-β
This invention provides compounds that are useful for treating patients having a TGF-β-mediated disease, particularly an ALK5-mediated disease. The compounds are represented by formula I:
...
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7186716 |
3-Pyrrol-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors
Compounds of Formula I are useful as mediators of protein kinases and have activity as cell proliferation inhibitors:
where X, R 1 –R 7 and R 9 are as defined herein.
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7179811 |
Respiratory syncytial virus replication inhibitors
This invention concerns compounds of formula (I)
prodrugs, addition salts, or stereochemically isomeric forms thereof for use as, inter alia, respiratory syncytial virus replication inhibitors;...
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7166611 |
Pharmaceutical compositions having appetite suppressant activity
A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for...
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