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6177454 |
Amide derivatives and medicinal compositions thereof
An amide derivative represented by the following general formula (I) or a salt thereof and a pharmaceutical composition containing the amide derivative and a pharmaceutically acceptable vehicle....
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6172076 |
Inhibitors of prenyl-protein transferase
The present invention is directed to conformationally constrained compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further...
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6162798 |
Inhibitor of atherosclerotic intimal thickening
An inhibitor of atherosclerotic intimal thickening, which contains an effective amount of a compound of the formula (I): ##STR1## wherein ring X is phenyl, substituted phenyl or 5- or 6-membered...
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6159975 |
Antagonists of gonadotropin releasing hormone
There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety...
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6156766 |
Benzamide compounds and pharmaceutical use thereof
Benzamide compounds of the formula ##STR1## wherein each symbol is defined in the specification, isomers thereof and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical...
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6150371 |
Method for preventing and for treating autoimmune disease
A method for preventing or treating autoimmune diseases (excluding type I diabetes) by administering an insulin resistance improving substance as an active ingredient.
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6127363 |
Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction
A method is provided for treating erectile dysfunction, e.g., vasculogenic erectile dysfunction such as vasculogenic impotence. The method involves the administration of a Type IV phosphodiesterase...
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6107312 |
Thiopyridines for use in the control of helicobacter bacteria
Thiopyridines of formula (I) ##STR1## in which the substituents and symbols are as defined in the specification are suitable for use in controlling Helicobacter bacteria. They are compounded into...
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6107305 |
Use of pyrazolo [3,4-b] pyridine as cyclin dependent kinase inhibitors
Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof for use as inhibitors of cyclin dependent kinases, wherein: X is O, S(O) m ; Y is alkyl, aryl, arylalkyl,...
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6100252 |
Heterocyclic compounds and their use as angiotensin antagonists
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6087374 |
Anti-viral compounds
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6075016 |
6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
Novel compounds which are effective PDE IV inhibitors are disclosed. The compounds possess improved PDE IV inhibition as compared to theophylline or rolipram, with improved selectivity with regard...
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6071931 |
AT.sub.1 -receptor antagonists for preventing and treating postischemic renal failure and for protecting ischemic kidneys
The compound (S)-N-(1-carboxy-2-methylprop-1-yl)-N-pentanoyl-N-[2'(1H-tet
razol-5-yl)bip henyl-4-yl-methyl]amine (valsartan) of formula ##STR1## or a salt thereof, in particular a pharmaceutically...
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6069151 |
Quinolines and their therapeutic use
Compounds of the formula ##STR1## have therapeutic utility, as inhibitors of phosphodiesterase IV and TNF release.
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6066649 |
Drug for cardiovascular diseases
The invention relates to a drug, which contains one or more inhibitors for the cGMP-stimulated phosphodiesterase (PDE II) together with conventional substrates and/or diluents. Preferably the drug...
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6060480 |
Preventives/remedies for muscle tissue degenerations
An agent for the prophylaxis or treatment of muscle tissue degeneration, containing, as an active ingredient, a quinoline compound of the formula (I): ##STR1## or a pharmaceutically acceptable...
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6054466 |
Inhibitors of farnesyl-protein transferase
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to...
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6051572 |
Azetidine, pyrrolidine and piperidine derivatives
A class of azetidine, pyrrolidine and piperidine derivatives, substituted by inter alia a phenylmorpholinyl, phenylpiperidinyl or benzimidazolone moiety, are selective agonists of 5-HT 1 -like...
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6040327 |
Benzimidazole, benzoxazole and benzothiazole compounds
A compound of formula (I): ##STR1## wherein: R 1 represents halogen or a different group as defined in the description, Ra and Rb, which mnay be identical or different, represent hydrogen,...
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6037349 |
Imidazopyridines
Imidazopyridine derivatives ad pharmacologically acceptable salts having antagonistic properties towards angiotensin II can be used for the treatment of hypertension, aldosteronism and cardiac...
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6020340 |
Imidazopyridines
Compounds of formula I wherein one of A and B is a nitrogen atom and the other is CH, and Ar has one of the meanings stated in the specification, are effective bronchial therapeutics and are also...
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6017923 |
Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents
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5972975 |
Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
Substituted 2-aminopyridine compounds of Formula (I) and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders....
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5965582 |
N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect
The N-benzylindole- and benzopyrazole derivatives of the general formula 1 ##STR1## possess anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effect and are suitable for the...
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5929114 |
Arylthio compounds
Arylthiol and dithiobisarylamide antibacterial and antiviral agents have the general formula ##STR1## where A is monocyclic or bicyclic aryl which can contain up to 3 heteroatoms selected from O,...
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5922720 |
Piperazinothiopyridines for the control of Helicobacter bacteria
Compounds of formula I are piperazinothiopyridines which are useful for controlling Helicobacter bacteria. They are useful as active compounds for treating diseases based on such bacteria, and are...
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5900428 |
Pharmacological use of AII-receptor antagonists
A method for the prophylaxis and treatment of MOF using certain angiotensin II type 1 receptor antagonists and a pharmaceutical preparation comprising these compounds.
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5900414 |
Methods for administering integrin receptor antagonists
The compositions and methods of the invention provide a convenient means for systemically administering an integrin receptor antagonist or a pharmaceutically effective amount thereof to a patient...
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5891904 |
Use of inhibitors of phosphodiesterase IV
The invention relates to the use of inhibitors of phosphodiesterase IV for the modulation of the motility and peristalsis of the hollow organs of the urogenital and gastrointestinal tract.
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5889020 |
Treatment of normotensive glaucoma with angiotensin II antagonists
The present invention relates to the use of angiotensin antagonist or a pharmaceutically acceptable salt thereof for the treatment of normal tension glaucoma, wherein said angiotensin antagonist...
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5866588 |
Imidazopyridine derivatives
This invention relates to imidazopyridine derivatives with the general formula II: ##STR1## These compounds are useful as dual histamine (H 1 ) and platelet activating factor (PAF) receptor...
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5866603 |
Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
This invention discloses compounds useful as steroid sulfatase inhibitors. The compounds comprise the formula (1) ##STR1## wherein (a) R is selected from the group consisting of hydrogen, a lower...
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5861389 |
Methods of treating androgen deficiency in men using selective aromatase inhibitors
Male menopause is characterized by significant decreases in serum levels of bioavailable androgens. The administration of aromatase inhibitors to men experiencing male menopause can remedy the...
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5859030 |
Substituted arylalkylthioalkylthiopyridines for use in the control of helicobacter bacteria
A compound of the formula I ##STR1## Wherein all the variables are defined in the specification. The compounds are used for controlling Helicobacter bacteria.
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5849753 |
Pyridyl imidazole derivatives and processes for the preparation thereof
Substituted pyridyl imidazole derivatives of formula (I) inhibit effectively the action of angiotensin II and have a superior anti-hypertensive activity. ##STR1##
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5824677 |
Substituted amino alcohol compounds
Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty....
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5824696 |
Medicaments
The present invention relates to the use of an angiotensin II receptor antagonist in the manufacture of a medicament for the treatment of chronic inflammatory disease states.
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5821241 |
Fibrinogen receptor antagonists
Compounds of the invention have the formula ##STR1## The compounds have fibrinogen receptor antagonist activity.
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5789415 |
Azacyclic-heterocyclic compounds as angiotension II receptor antagonists
Compounds of the formula ##STR1## wherein: Q is naphthyl, heterocyclic or heterobicyclic; R 1 and R 2 , when taken separately, are hydrogen, hydroxy, alkyl, alkylthio, alkylsulfinyl,...
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5780482 |
Condensed 4-aminopyridines with antirheumatic activity
Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof in which one of A or B represents N and the other represents N or C--R 3 ; R 1 represents hydrogen, halo, alkyl,...
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5753671 |
Imidazopyridine derivatives as dual histamine (H.sub.1) and platelet activating factor (PAF) antagonists
Described herein are compounds of formula (II) ##STR1## pharmaceutical or veterinary compositions thereof, and methods of treating diseases or conditions mediated by histamine and/or PAF in mammals.
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5753651 |
Method of modifying angiotensin receptor activity for mediation of pain
The present invention relates to a method of modifying Angiotensin II subtype 1 (AT 1 ) receptor activity for the treatment of premenstrual syndrome (PMS) and the symptoms associated therewith, and...
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5753672 |
Imidazopyridine derivatives and process for preparing the same
An imidazopyridine derivative of the formula I!: ##STR1## wherein R 1 is a lower alkyl group, R 2 is a lower alkanoyl group, and R 3 and R 4 are each lower alkyl groups, or both combine at the...
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5741794 |
Heterocyclic sulfonamide derivatives as antagonists of PAF and angiotensin II
Compounds of formula (I), wherein: A represents: a) a --VR 6 group wherein v is --C(O), --C(O)O--, --CH 2 O--, --CH 2 OC(O)--, --C(S)--, --CH 2 OC(O)NH--, --C(S)O--, --CH 2 ...
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5739147 |
Cyclohexane derivatives, process for their preparation, and the use of the compounds for the treatment of diseases
Cyclohexane derivatives, process for their preparation, and the use of the compounds for the treatment of diseases Cyclohexane derivatives of the formula I ##STR1## wherein R 2 , R 4 and R 5 have...
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5736554 |
Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
Compounds of the Formula ##STR1## wherein: K is N or N➝O; Q is CH 2 or O; T is ##STR2## or R 3 O--CH 2 ; X is a straight or branched chain alkylene, cycloalkylene or cycloalkenylene group,...
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5710159 |
Integrin receptor antagonists
This invention relates to novel heterocycle compounds including but not limited to 3- 3- 3-(imidazolin-2-yl amino)propyloxy!isoxazol-5-ylcarbonylamino!-2-(benzyloxycarb
onylamino)-pro pionic acid,...
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5705504 |
Piperidine derivatives with PAF antagonist activity
Compounds of general formula I and their salts and solvates are PAF antagonists and as such are useful in the treatment of various diseases or disorders mediated by PAF. Pharmaceutical compositions...
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5703092 |
Hydroxamic acid compounds as metalloprotease and TNF inhibitors
The present invention provides novel hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these novel compounds for the inhibition...
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5693633 |
Angiotensin II antagonists
This invention provides novel heterocyclic derivatives, their pharmaceutical formulations, and their use for antagonizing angiotensin II receptors in mammals.
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