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7125890 |
Ether substituted imidazopyridines
Imidazopyridine compounds that contain an ether or thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the...
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7122557 |
Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors
The present application describes sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds and derivatives thereof of Formula I:
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7115596 |
Thiazole compounds as integrin receptor antagonists derivatives
The present invention relates to a class of compounds represented by the Formula I
or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula...
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7115627 |
Glycinamides as factor Xa inhibitors
The present application describes glycinamidic compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
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7109192 |
Substituted imidazo-pyridinones and imidazo-pyridazinones, the preparation thereof and their use as pharmaceutical compositions
The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula
wherein R 1 to R 4 are defined as in claim 1 , the tautomers, the stereoisomers,...
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7101884 |
Tyrosine kinase inhibitors
The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to...
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7098220 |
Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same
Compounds of formula (I):
wherein:
R 1 represents hydrogen, halogen, alkyl, polyhaloalkyl, cyano, nitro, hydroxycarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or...
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7098221 |
Amide substituted imidazopyridines
Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of...
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7087603 |
Pyrazole compounds useful as protein kinase inhibitors
This invention describes novel pyrazole compounds of formula IV:
wherein Z 1 or Z 2 is nitrogen, Q is —S—, —O—, —N(R 4 )—, —C(R 6′ ) 2 —, 1,2-cyclopropanediyl,...
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7081464 |
Topical compositions of cyclic amides as immunotherapeutic agents
Novel amides and imides are inhibitors of tumor necrosis factorα and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory...
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7053093 |
Bicyclic and tricyclic hetroaromatic compounds
Disclosed are compounds of the formula:
and the pharmaceutically acceptable salts thereof, wherein W, Q, X, X 1 , Y and Z are as defined herein. These compounds bind with high selectivity...
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7053103 |
Ring fused pyrazole derivatives as CRF antagonists
This invention relates to compounds which are generally CRF-1 receptor antagonists and which are represented by Formula I or Formula II:
wherein Ar is optionally substituted aryl or heteroaryl,...
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7045529 |
Imidazopyrimidinyl and imidazopyri dinyl derivatives
Provided herein are compounds of the formula (I):
as well as stereoisomers and pharmaceutically acceptable salts thereof. Such compounds are, because of their ability to antagonize CRF, useful...
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7041675 |
Heterocyclic compounds and their use as PARP inhibitors
The invention relates to compounds of the formula I
and the tautomeric forms, possible enantiomeric and diasteromeric forms thereof, and prodrugs thereof, and use thereof as PARP inhibitors.
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7041667 |
CCR5 modulators
Compounds of Formula 1
[R egion α]—[R egion β]—[R egion γ]—[R egion δ] (1)
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7037923 |
Alkyl-[4-(trifluorophenyl)-oxazol-5-yl]-triazolo-pyridines
The present invention relates to novel alkyl-[4-(trifluorophenyl)-oxazol-5-yl]-triazolo-pyridines, to intermediates and methods for their preparation, to pharmaceutical compositions containing them...
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7034038 |
Enantiomer (-) of tenatoprazole and the therapeutic use thereof
The invention relates to enantiomer (−) of tentoprazole. The inventive enantiomer (−) of tenatoprazole, or...
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7022712 |
Solubilization of weak bases
A pharmaceutical composition for administration to mammals comprising: a weak base compound having a compound pKa below about 7; an acidic buffer with a buffer pKa below 7; and optional...
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7012080 |
Imidazopyridine compounds as 5-HT4 receptor agonists
This invention provides a compound of the formula (I):
or a pharmaceutically acceptable salt thereof, wherein
R 1 represents a hydrogen atom or a halogen atom; R 2 represents a methyl group...
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6984646 |
Imidazopyridinones as p38 map kinase inhibitors
The invention relates to imidazopyridinones of the formula
wherein the groups R 1 , R 2 , R 3 , and R 4 are as defined in claim 1, to the process for their preparation, to pharmaceutical...
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6977262 |
Dihydropyrazolopyridine compounds and pharmaceutical use thereof
The present invention provides dihydropyrazolopyridine compounds represented by the formula (I):
wherein each symbol is as defined in the specification, optically active forms thereof, and...
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6974808 |
CRF receptor antagonists and methods relating thereto
CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded...
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6969712 |
Benzimidazole derivatives
This invention relates to the compounds represented by a general formula [I]:
[in which A 1 and A 2 represent optionally fluorine-substituted methine or the like; B represents halogen,...
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6969722 |
Amide substituted imidazopyridines
Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of...
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6964957 |
Fused pyrazole compounds, pharmaceutical compositions, and methods for modulating or inhibiting ERAB or HADH2 activity
Pyrazole compounds represented by the formula:
are described. The pyrazole compounds and pharmaceutical compositions containing them may be used in inhibiting ERAB or HADH2 activity and in...
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6962926 |
Antagonist of MCP-1 function, and compositions and methods of use thereof
Compounds of formula A and formula B:
and their pharmaceutically acceptable salts, compositions comprising them, methods for their use, and their use in the preparation of medicaments. The...
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6960591 |
Propane-1,3-dione derivative
Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione...
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6960595 |
5-6 to 5-7 Heterobicycles as factor Xa inhibitors
The present application describes 5-6 or 5-7 heterobicyclics of Formula I:
or pharmaceutically acceptable salt forms thereof, wherein ring P is a 5-membered heteroaromatic and ring M is a 6 or...
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6953793 |
Substituted pyrazoles
Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.
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6951863 |
Pyridoarylphenly oxazolidinone antibacterials, and related compositions and methods
Pyridoarylphenyl oxazolidinone compounds of the formula:
in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
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6951867 |
N-substituted piperidinyl-imidazopyridine compounds as 5-HT4 receptor modulators
This invention provides a compound of the formula (I):
or a pharmaceutically acceptable salt, amide or ester thereof, wherein R 1 represents a hydrogen atom or a halogen atom; R 2 represents...
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6949564 |
NPY-5 antagonists
The present invention provides NPY-5 receptor antagonists having a Formula (IA)
Methods and pharmaceutical compositions useful for treating diseases, conditions and/or disorders modulated by...
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6946473 |
Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors
Compounds of the formula
which are useful in disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's...
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6943175 |
2-NH-heteroarylimidazoles with antibacterial activity
Compounds of formula (I):
are inhibitors of bacterial methionyl tRNA synthetase and are of use in treating bacterial infections.
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6933305 |
Amide compounds and use thereof
The present invention relates to an amide compound of the formula
wherein R 1 is a hydrogen and the like, R 2 is a hydrogen and the like, X is SO 2 and the like, Y is the formula (III) and...
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6921759 |
Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV...
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6919329 |
N-Aryl-2-oxazolidinone-5-carboxamides and their derivatives
The present invention provides antibacterial agents having the formulae I, II, and III described herein.
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6919331 |
Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides...
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6916827 |
Substituted ring-fused imidazole derivative: GABAA receptors ligands
Substituted ring-fused imidazole derivatives that bind to GABA A receptors are provided. Such compounds may be used to modulate ligand binding to GABA A receptors in vivo or in vitro, and are...
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6908926 |
Substituted imidazoles, their preparation and use
Disclosed is a novel class of substituted imidazole compounds, pharmaceutical compositions containing them and uses of these compounds in the treatment and/or prevention of diseases and disorders...
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6903113 |
Urea substituted imidazopyridines
Imidazopyridine compounds that contain urea or thiourea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the...
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6903112 |
Heterocyclylindazole and -azaindazole compounds as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
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6897223 |
Pyridine fused bicyclic metalloproteinase inhibitors
The present invention relates to fused bicyclic metalloproteinase inhibitors of the formula
wherein A, B, X, Y, and R 1 are as defined in the specification, and to pharmaceutical compositions...
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6890934 |
Sulfonamide compounds and uses thereof as medicines
The present invention relates to a sulfonamide compound of the formula (I):
wherein each symbol is as defined in the specification, a salt thereof, and a pharmaceutical composition containing...
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6887885 |
Imidazo[4,5-c]pyridin-4-one analogues as GABAA receptor ligands
A compound of formula I, or a pharmaceutically acceptable salt thereof:
wherein
X 1 represents hydrogen, halogen, C 1-6 alkyl, trifluoromethyl or C 1-6 alkoxy; X 2 represents...
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6878719 |
Sulfonamido substituted imidazopyridines
Imidazopyridine compounds that contain sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the...
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6875765 |
Arylsulfonamide ethers, and methods of use thereof
The novel arylsulfonamide ether compounds, pharmaceutical compositions and uses thereof as inhibitors of interleukin-1β converting enzyme and other cysteine proteases in the ICE family are...
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6872730 |
Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
The present invention relates to novel substituted benzofurans and benzothiophenes compounds that are antagonists of alpha V (αv) integrins, for example α v β 3 and α v β 5 integrins, their...
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6867208 |
Vitronectin receptor antagonists, their preparation and their use
The present invention relates to compounds of the formula I
A—B—D—E—F—G (I)
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6867202 |
Treatment of insulin resistance
This invention is directed to methods of treating insulin resistance in a mammal which comprise administering an effective amount of a compound of formula I,
where the variables are defined in...
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