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5665719 |
Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists
Compounds of the formula ##STR1## X is --O--, --NH-- and --NR 8 --; Y is --CH 2 --, --CHR 8 -- and --C(R 8 ) 2 --; R 1 is camphor-10-yl, C 1 -5 alkoxyl, styryl, hydroxystyryl, furyl,...
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5665729 |
Cerebroprojection method
The invention relates to the use of carbocyclically and heterocyclically fused dihydropyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for...
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5663183 |
N-(3-Aminopropyl)-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide derivatives, their preparation and their therapeutic use
Compounds of the formula: ##STR1## in which R 1 represents a hydrogen or halogen atom or a methyl or C 1 -C 4 alkoxy group, R' 1 represents a hydrogen or halogen atom, R" 1 represents a...
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5656638 |
Telomerase inhibitors
Methods and compositions for treating cancer and other diseases in which inhibition of telomerase activity can ameliorate disease symptoms or prevent or treat the disease relate to compounds...
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5656637 |
Thiazole derivatives
A novel thiazole derivative represented by general formula (I), which has a selected agonistic activity for 5-HT 3 receptor, a pharmaceutical composition thereof, and a process for producing the...
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5654319 |
N-[(4-heteroaryl-1-piperidinyl)alkyl]-2,3-naphthalimides and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5639764 |
2-[(4-heteroaryl)-1-piperidinyl)alkyl]-1,3-indandiones and related compound and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a...
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5635522 |
Immunosuppressive agents
A suppression of the human immune system is accomplished by administering to the person an effective amount of a non-toxic thioheterocycle compound having the formula ##STR1## wherein R1 is a...
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5633237 |
Imidazo[1,2-a]pyridinylalkyl phosphonic acid compounds for treatment of neurotoxic injury
A class of imidazo[1,2-a]pyridinylalkyl phosphonic acid compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac...
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5629326 |
4-(heteroaryl)-1-[(2,3-dihydro-1H-indol-1-yl)alkyl]piperidines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5624927 |
N-[4-(heteroaryl)-1-piperazinyl)alkyl]-1,2,3,4-tetrahydroisoquinolines and n-[4(heteroaryl)-1-piperazinyl)alkyl]-1,2,3,4-tetrahydroisoquinolines, related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5624934 |
Protease inhibitors
The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating and/or preventing HIV infection.
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5616590 |
Plant microbicides
Compounds of the formula I ##STR1## in which a) X is CH and Y is N; or b) X is N and Y is CH; and in which Z is a C 1 group to which there are bonded 1-3 halogen atoms or 1-3 substituted or...
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5614543 |
1-(aryloxyalkyl)-3- (heteroaryl) pyrrolidines and related compounds useful as antipsychotics and analgesics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5612342 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
[(4-heteroaryl-1-piperindyl)alkoxy]-3,4-dihydro-1(2H)-naphthalenones and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5612343 |
N-[(4-heteroaryl-1-piperazinyl)alkyl]-2,3-naphthalimides and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5607945 |
N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-1,2,3,4-tetrahydroisoquinolines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5607944 |
Bicyclic heterocyclic compounds, pharmaceutical preparations containing these compounds and processes for their preparations
The invention relates to bicyclic heterocyclic compounds of general formula ##STR1## wherein A to F, Y 1 and Y 2 are defined as in claim 1, the tautomers thereof, the stereoisomers thereof...
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5607943 |
Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations
A compound of formula I ##STR1## wherein A denotes a benzo, indolo or thieno group; R 1 denotes thienyl or the group ##STR2## wherein R 7 , R 8 and R 9 independently of one another may...
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5605913 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
1-(arylthioalkyl, arylaminoalkyl or arylmethylenealkyl)-4-(heteroaryl) piperidines and related compounds useful as antipsychotics and analgesics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5602144 |
Thienopyridones
Thienopyridone derivatives of the formula I ##STR1## in which B is CH or N, ##STR2## is ##STR3## R is H, ##STR4## R 1 , R 2 and R 5 are in each case H, A or Hal, R 3 and R 4 are in each case H,...
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5597842 |
3-heteroaryl-1-pyrrolidinealkanols and derivatives thereof and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5593995 |
2-[(4-heteroaryl-1-piperazinyl)alkyl]-1,3-indandiones and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5591745 |
(4-heteroaryl)-1-[(2,3-dihydro-1H-isoindol-2-yl)alkyl] piperidines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5589495 |
2-[(3-heteroaryl-1-pyrrolidinyl)alkyl]-1,3- indandiones and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a...
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5589494 |
2-[(3-heteroaryl-1-pyrrolidinyl)alkyl]-1,3-dioxanes and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5585385 |
Heterocyclic compounds, their production and use as tachykinin reactor antagonists
A novel compound represented by the formula: ##STR1## wherein Ring A and Ring B respectively stands for an optionally substituted homo- or hetero-cyclic ring, and at least one of them stands for an...
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5580875 |
1-[(2-pyrimidinyloxy)alkyl]-3-(heteroaryl)pyrrolidines and related compounds and therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents the compounds are especially useful for treating psychoses by administering to a mammal a...
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5580886 |
Cis-2-[(4-heteroaryl-1 -piperidinyl)alkyl]hexahydro-1H-isoindole-1,3(2H)-diones and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5580879 |
N-[(4-heteroaryl-1-pyrrolidinyl)alkyl]-1H-benz[DE]isoquinoline-1;3(2H)-di ones and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5578605 |
N-[(4-heteroaryl)-1-piperidinyl)alkyl]-1,2,3,4-tetrahydroquinolines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a...
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5578624 |
Heteroarylpyrrolidines and their use as antipsychotics and analgesics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5576328 |
Method for the secondary prevention of ischemic events
The invention relates to a new method for the secondary prevention of ischemic events comprising administering to a man in need thereof a therapeutically effective amount of a compound selected...
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5574032 |
N-[(4-(he teroaryl)-1-piperazinyl)alkyl]-10,11-dihydro-5H-dibenz[BFS]azepines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a...
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5571828 |
N-[(3-heteroaryl-1-pyrrolidinyl)alkyl]-2,3-napthalimides and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5571814 |
N-[(4-heteroaryl-1-pyrrolidinyl)alkyl]phthalimides and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5561128 |
N-[(4-(hete roaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5550130 |
1-[(1,4-benzodioxanyl)alkyl]-4-(heteroaryl)piperidines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5550162 |
N-(-3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydro-naphthalene-2-carboxamide derivatives, their preparation and their therapeutic use
Compounds of the formula: ##STR1## in which R 1 represents a hydrogen or halogen atom or a methyl or C 1 -C 4 alkoxy group, R' 1 represents a hydrogen or halogen atom, R" 1 represents a...
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5543433 |
Azine-substituted phenylacetic acid derivatives and fungicides containing these
Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH 3 ,...
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5496826 |
Pharmaceutical methods of using heterocyclic derivatives of N-phenylamides
New central nervous system agents conform to formula I: ##STR1## wherein R=H or C 1 -4 alkoxy; X=CH or N; Y=NH, O or S; Z=C 1 -4 alkyl, C 3 -6 cycloalkyl, C 2 -3 alkenyl, NH 2 , C 1 -4...
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5492908 |
Diaminotrifluoromethylpyridine derivatives, process for their production and phospholipase A.sub.2 inhibitor containing them
A method of treating rheumatoid arthritis using a diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW 1 R 1 , --COCOR 2 , --CW 1 NHCOR 2 ,...
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5491151 |
Antitumor treatment method
This invention relates to an antitumor agent containing as the effective ingredient a cyanine dye, shown by the general formula: ##STR1## where X - is a physiologically-acceptable anion; Z + , a...
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5472964 |
Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists
Compounds having the formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents....
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5464844 |
[3H,7H]thiazole[3,4-a]pyridines having antiasthmatic and antiinflammatory activities on the respiratory tract
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5464855 |
Thiophene-2-carboxamidotetrazoles and pharmaceutical use thereof
Thiophene-2-carboxamidotetrazoles inhibit the Mac-1 integrin and are thus useful for treating diseases mediated by Mac-1 adhesion, including inflammatory disorders.
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5459129 |
Condensed heterocyclic compounds, their production and use
A novel compound of the formula: ##STR1## wherein a ring A stands for an optionally substituted 5-membered ring; B stands for an optionally substituted divalent cyclic or chain group; either one of...
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5447934 |
Anti-allergic thiadiazolo [4,3-a]pyridine derivatives
Compounds of the formula I ##STR1## in which X 1 and X 2 the same or different, signify hydrogen, a C 1 - to C 6 -alkyl radical or a halogen atom or, insofar as they stand in neighbouring...
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5446045 |
Antiviral guanine analogs
A series of guanine analogs having the basic structures of ##STR1## and physiological salts thereof. Also disclosed are a variety of the use of the compounds as a composition with a physiological...
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5434153 |
2-amino-4-heteroaryl-1,4-dihydropyridines and their use in medicaments
The present invention relates to new 2-amino-4-hetero-aryl-1,4-dihydropyridines of the general formula (I) ##STR1## in which R 1 to R 4 have the meaning given in the description, processes for...
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