Matches 151 - 200 out of 352 < 1 2 3 4 5 6 7 8 >
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6162798 Inhibitor of atherosclerotic intimal thickening  
An inhibitor of atherosclerotic intimal thickening, which contains an effective amount of a compound of the formula (I): ##STR1## wherein ring X is phenyl, substituted phenyl or 5- or 6-membered...
6159975 Antagonists of gonadotropin releasing hormone  
There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety...
6156766 Benzamide compounds and pharmaceutical use thereof  
Benzamide compounds of the formula ##STR1## wherein each symbol is defined in the specification, isomers thereof and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical...
6136819 Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations  
Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group; B denotes the group --O--, --S-- or --CHR 5 --, wherein R 5 is hydrogen, (C 1 - 6 )alkyl, phenyl or...
6071543 Pyridine-thiols reverse mucocutaneous aging  
This invention provides compositions and methods for preventing and reversing the signs and symptoms of intrinsic and photo aging. The compositions include one or more pyridine-thiols and tautomers...
6069144 N-heterocyclic compounds, intermediate products used to prepare them, agents containing them and their use in antifungal applications  
6069151 Quinolines and their therapeutic use  
Compounds of the formula ##STR1## have therapeutic utility, as inhibitors of phosphodiesterase IV and TNF release.
6063789 Aminoisoquinolines and aminotheinopyridine derivatives and their use as anti-inflammatory agents  
Compounds of formula I ##STR1## wherein R, R 1 , R 2 , and R 3 and A are as defined herein, together with pharmaceutically acceptable salts, enantiomers or tautomers are useful as pharmaceuticals,...
6051572 Azetidine, pyrrolidine and piperidine derivatives  
A class of azetidine, pyrrolidine and piperidine derivatives, substituted by inter alia a phenylmorpholinyl, phenylpiperidinyl or benzimidazolone moiety, are selective agonists of 5-HT 1 -like...
6048863 Condensed-ring thiophene derivatives and thienopyrimidine derivatives, their production and use  
Thienopyrimidine derivatives of formula: ##STR1## The present thienopyrimidine derivatives are useful for treating mammals suffering from disorders related to gonadotropin realeasing hormone (GnRH).
6046191 Combination  
The invention relates to the co-administration of an inhibitor of induced nitric oxide synthase and an inhibitor of cyclooxygenase-2 for the treatment of inflammation and inflammatory disorders.
6037348 Inhibition of viral replication  
The present invention provides a method of inhibiting influenza and flaviviral replication based on a mechanism of action in which HA-mediated fusion or E protein mediated fusion is inhibited by a...
6034093 Substituted sulfonic acid N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds  
The compounds of formula I exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain...
6015789 Combined use of GnRH agonist and antagonist  
The present invention relates to a pharmaceutical luteinizing hormone releasing hormone agonist in combination with a luteinizing hormone releasing hormone antagonist. By using a luteinizing...
6015817 Inhibitors of farnesyl-protein transferase  
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to...
6001850 Thienopyridine derivatives, their production and use  
The present thienopyridine derivatives and composition having gonadotropin-releasing hormone antagonistic activity are useful as prophylactic or therapeutic agents for the prevention or treatment...
6001849 Furopyridine, thienopyridine pyrrolopyridine useful in controlling chemical synaptic transmission  
Novel heterocyclic ether compounds having the formula: ##STR1## wherein A, m, R, X, Y 1 , Y 2 and Y 3 are specifically defined, which are useful in selectively controlling chemical synaptic...
5998433 Condensed compounds, their production and use  
This invention provides new condensed furan compounds which exhibit excellent 2,3-oxidosqualene cyclase inhibition and high-density lipoprotein-cholesterol elevating activities. This invention also...
5994321 Antiviral guanine analogs  
A series of guanine analogs and physiological salts thereof, which are useful as virus inhibitors and as antiviral agents in the treatment of viral disease, having the basic structures of: ##STR1##...
5989578 Associations of active principles containing clopidogrel and an antithrombotic agent  
The invention relates to a pharmaceutical composition containing an association of active principles, wherein the active principles are clopidogrel and aspirin, each constituent being present in a...
5977132 Prolactin production inhibitory agent  
The prolactin production inhibition agent of the present invention containing a condensed cyclic compound, which is characterized by containing a condensed bicyclic structure of an optionally...
5972975 Substituted 2-aminopyridines as inhibitors of nitric oxide synthase  
Substituted 2-aminopyridine compounds of Formula (I) and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders....
5962469 Cyclic nitrones  
The present invention is directed to novel cyclic nitrones and their use in the prevention of oxidation tissue damage by free radicals, their use in the treatment of a number of disease states in...
5952324 Bicyclic oxazine and thiazine oxazolidinone antibacterials  
Phenyloxazolidinone compound of formula (I)or a pharmaceutically acceptable salt thereof characterized by a bicyclic thiazine or oxazine substituent. The compounds are useful antimicrobial agents,...
5945432 Thrombolytic agents and thienopyridine derivatives in acute stroke  
Methods and products are provided for treating thromboembolic stroke. A method involves the administration of a thienopyridine derivative in combination with a thrombolytic agent to a patient...
5939432 Thiophenes useful for modulating the adenosine receptor  
The present invention relates to compounds of formulas (IA), (IB), and (IC): ##STR1## the preparation thereof, pharmaceutical formulations thereof, and their use in medicine as allosteric adenosine...
5932587 Heterocyclic-fused pyridines  
The heterocyclic-fused pyridines are prepared by reaction of the corresponding heterocyclic-fused pyridine aldehydes with appropriately substituted Grignard or Wittig reagents. The...
5929114 Arylthio compounds  
Arylthiol and dithiobisarylamide antibacterial and antiviral agents have the general formula ##STR1## where A is monocyclic or bicyclic aryl which can contain up to 3 heteroatoms selected from O,...
5908842 Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase  
Substituted 2-acylaminopyridine compounds and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders.
5889009 Method of inhibiting cell adhesion  
A composition comprises a 1,7-disubstituted-4-oxo-3 -quinolinecarboxylic acid or 1,7-disubstituted-4-oxo-3 -naphthyridinecarboxylic acid derivative which is useful as a prophylactic and/or...
5874451 Propanolamine derivatives, processes for their preparation, pharmaceuticals comprising these compounds, and their use  
The invention relates to substituted propanolamine derivatives and their acid addition salts. Propanolamine derivatives of formula I, ##STR1## in which R 1 to R 8 have the meanings indicated in...
5872128 Stabilized composition of ticlopidine hydrochloride  
A novel pharmaceutical composition including thieno-pyridine derivatives, primarily ticlopidine hydrochloride, having no other organic or inorganic acid stabilizing agents or metal stearates. The...
5856335 Substituted aminothienopyridines, pharmaceutical composition and use  
This application relates to compounds of the formula ##STR1## wherein R 1 , R 2 , R 3 , m and n are as defined in the specification which are useful as modulators of neurotransmitter function such...
5854263 1- (1,4-benzodioxanyl)alkyl!-3-(heteroaryl) pyrrolidines and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
5837710 HIV protease inhibitors  
HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These...
5827857 Pyrido-fused thienyl- and furanyl-oxazolidinones  
The present invention relates to new pyrido-fused thienyl- and furanyl-oxazolidinones, processes for their preparation and their use as medicaments, in particular as antibacterial medicaments.
5824677 Substituted amino alcohol compounds  
Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty....
5811427 Heterocyclic N-acetonylbenzamides  
Certain N-acetonylbenzamides and their use as fungicides are disclosed. The N-acetonylbenzamides disclosed contain a heterocyclic ring fused to an aromatic ring. These compounds are particularly...
5776963 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
5756515 Dioxo-thiopyrano-pyridine-carboxylic acid derivatives and their use as medicaments  
Dioxo-thiopyrano-pyridine-carboxylic acid derivatives are prepared by reacting appropriate aldehydes with aminocrotonic acid esters and tetrahydrothiopyran-3-one-1,1-dioxide and oxidizing the...
5753670 Carboxylic acid compound having condensed ring, salt thereof and pharmaceutical use thereof  
A novel carboxylic acid compound having a condensed ring; which is represented by the formula (I) ##STR1## wherein each symbol is as defined in the specification, a pharmacologically acceptable...
5750539 Heteroaryl diol acids as leukotriene antagonists  
Compounds of Formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are...
5750538 Method of treating hypercholesterolemia and related disorders  
The present invention relates to a novel method for treating a mammal suffering from hypercholesterolemia and related disorders.
5747486 Thienopyridine or thienopyrimidine derivatives and their use  
This invention provides an anti-inflammatory agent, particularly an agent for treating arthritis, and a bone resorption inhibiting agent, containing a thienopyridine or thienopyrimidine derivative...
5744479 Thienopyridine compounds which have useful pharmaceutical activity  
The present thienopyrimidine derivatives and compositions having gonadotropin-releasing hormone antagonistic activity are useful as propylactics or therapeutic agents for the prevention or...
5714495 Pyridine compounds as melatonergic agents  
The invention relates to a compound selected from those of formula (I): ##STR1## in which: R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined in the description and medicinal product containing the...
5700802 Furopyridine derivatives  
A class of substituted furo 2,3-b!pyridine derivatives are ligands for dopamine receptor subtypes within the body, in particular the D 4 subtype, and are therefore useful in the treatment and/or...
5686462 Anti-inflammatory method  
The invention relates to the use of carbocyclically and heterocyclically fused dihydropyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for...
5674878 Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparations  
Compound of general formula I ##STR1## wherein A is a benzo or thieno group; R 1 is (C 4 -6)cycloalkyl, (C 4 -6)cycloalkyl-(C 1 -5)alkyl or ##STR2## R 2 , m, R 3 , R 4 , R and u are defined as...
5668162 Isothiazolones lower plasma levels of lipoprotein(a)  
Plasma levels of Lp(a) are lowered by administering an isothiazolone having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected...
Matches 151 - 200 out of 352 < 1 2 3 4 5 6 7 8 >