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8871785 Antiviral phosphonate analogs  
The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such...
8871770 Carboxamide compounds and methods for using the same  
Disclosed are carboxamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R1, R2, R3, R4, D, J, Z, T, p, q, w and x...
8871929 Fused-imidazoyl compounds useful as antimicrobial agents  
The invention relates to fused-imidazoyl compounds of Formula (I): wherein ring A, R1, R2, R3, R4, R5, R6, R7, R8, R9, m and n are as defined herein. Also disclosed are pharmaceutical compositions...
8871754 Compounds and compositions for the treatment of parasitic diseases  
The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention...
8871784 2-aryl-acetic acids, their derivatives and pharmaceutical compositions containing them  
Selected 2-arylacetic acids, their derivatives and pharmaceutical compositions that contain these compounds are useful in inhibiting chemotactic activation of neutrophils (PMN leukocytes) induced...
8865709 Aminooxazole inhibitors of cyclin dependent kinases  
Oxazole derivatives are described. The inventive compounds are useful as kinase inhibitors, and may be used in the treatment of cancer, such as prostate cancer, lung cancer, breast cancer, colon...
8865711 Phenylimidazole derivatives as PDE10A enzyme inhibitors  
This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the...
8865734 Anti-infective compounds  
The present invention relates to small molecule compounds and their use in the treatment of bacterial infections, in particular Tuberculosis.
8865735 Solid forms of a pharmaceutically active substance  
The present invention provides solid forms of the compound of formula 1 and pharmaceutical uses thereof.
8859584 TRPV1 antagonists  
Disclosed herein are compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein X1, L, Rx, Ry, Rz, A, m, n, p, q, s, and positions a and b are as defined in the specification....
8859581 Azaheterocyclic compounds as kinase inhibitors  
The invention relates to compounds of the formula (I), to the preparation and use thereof for the preparation of a medicament for the treatment of diseases, in particular tumors and/or diseases in...
8859582 Bicyclic heterocyclic compounds as protein tyrosine kinase inhibitors  
The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, q, A, B, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions...
8859583 Bicyclic heterocyclic compounds as protein tyrosine kinase inhibitors  
The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, A, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions comprising...
8853237 Naphthyridinone analogs as mGluR5 positive allosteric modulators  
In one aspect, the invention relates to naphthyridinone analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate...
8853125 Pyrazole compounds for controlling invertebrate pests  
The present invention relates to a method for controlling invertebrate pests which method comprises treating the pests, their food supply, their habitat or their breeding ground or a plant, seed,...
8846711 Heterocyclic acrylamides and their use as pharmaceuticals  
The invention relates to novel heterocyclic acrylamide compounds (I), to the preparation of the compounds and intermediates used therein, to the use of the compounds as antibacterial medicaments...
8846084 Controlled release compositions containing zolpidem  
The present invention relates to controlled release compositions of Zolpidem or pharmaceutically acceptable salts thereof adapted to release Zolpidem over a predetermined time period, according to...
8846667 Compounds for modulating integrin CD11b/CD18  
The application describes an assay for the identification of small molecule modulators of integrin CD11b/CD18 and small molecules capable of modulating activity of this receptor. Such compounds may...
8846672 Imidazopyridines as respiratory syncytial virus antiviral agents  
A compound satisfying formula I, a prodrug, N-oxide, addition salt, quaternary amine, metal complex, or a stereochemically isomeric form thereof; compositions contain these compounds as active...
8846656 Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators  
The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination...
8841319 Use of 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives in leukemia management  
The present invention relates to the use of a compound of formula (I) wherein R1 is H, C1-C6-alkyl, phenyl-C1-C4-alkyl or phenyl, R2 is a phenyl group which is substituted with 2 or 3 C1-C6-alkoxy...
8835444 Cyclohexyl amide derivatives as CRF receptor antagonists  
There are described cyclohexyl amide derivatives useful as corticotropin releasing factor (CRF) receptor antagonists Formula (I).
8835455 Crystalline forms of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium salt  
The present invention relates to novel crystalline forms of sodium salt of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-ca rboxamide (e.g., NXL-104) thereof. The present invention...
8835454 Fused bicyclic diamine derivatives as HIV attachment inhibitors  
Compounds of Formula I, including pharmaceutically acceptable salts thereof: wherein A is selected from the group of: are useful as HIV attachment inhibitors.
8829199 Aminopyrazole derivative  
A compound represented by formula (I) or a pharmacologically acceptable salt thereof, which can inhibit a fibroblast growth factor receptor (FGFR) family kinase in cancer tissues. (In the formula,...
8829026 Sulfamoyl benzoic acid heterobicyclic derivatives as TRPM8 antagonists  
The present invention relates to sulfamoyl benzoic acid heterobicyclic derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their...
8828998 Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors  
Provided herein are methods, kits, and pharmaceutical compositions that include a PI3 kinase inhibitor for treating lupus, a fibrotic condition, or inflammatory myopathies and other conditions...
8822493 SNS-595 and methods of using the same  
The present invention relates to SNS-595 and methods of treating cancer using the same.
8822689 Aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof  
The present invention relates to novel aryloazol-2-yl-cyanoethylamino derivatives of formula (I): wherein R3, R4, R5, R6, R7, P, Q, V, W, X, Y, Z and a are as defined in the description,...
8822467 Biaryl oxyacetic acid compounds  
The present invention provides biaryl oxyacetic acid compounds which may be useful for treating inflammatory disorders, including disorders affecting the respiratory system and skin. The compounds...
8822460 Fused cyclopentyl antagonists of CCR2  
The present invention comprises compounds of Formula (I). wherein: R0, R1, R2, R3, R4, R5, and A are as defined in the specification. The invention also comprises a method of preventing, treating...
8822446 Pyrrolopyridine inhibitors of kinases  
The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to...
8822494 Heteroaromatic compounds and their use as dopamine D1 ligands  
The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides of the foregoing; processes for the preparation of; intermediates used in...
8815892 P2X7R antagonists and their use  
The present application is directed to novel P2X7R antagonists that are indol-3-carboxamide or azaindole-3-carboxamide compounds, pharmaceutical compositions comprising the same and their use for...
8815869 Lactam acetamides as calcium channel blockers  
The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein Ar1, n, R1, X and Y are as defined in the specification. The present application also...
8815893 Hetarylaminonaphthyridines  
Novel hetarylaminonaphthyridine derivatives of formula (I) wherein X, R1, R2, R3, R4, W1, W2, W3, W5 and W6 have the meaning according to claim 1, are inhibitors of ATP consuming proteins, and can...
8809335 Pyrazolopyrimidine kinase inhibitors  
The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of...
8802694 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetycholine receptor ligands  
The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical...
8802695 Apoptosis signal-regulating kinase 1 inhibitors  
The present invention relates to apoptosis signal-regulating kinase 1 (“ASK1”) inhibiting compounds of the formula wherein the variables are as defined herein. The invention also relates to pha...
8796257 Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors  
A compound of formula (I): wherein:M is hydrogen or a pharmaceutically acceptable salt-forming cation;Y is OR1 or NR2R3,and R1, R2, R3 and M are as defined herein. Also, methods of treating...
8796244 Imidazopyridine derivatives as inhibitors of receptor tyrosine kinases  
The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g....
8796305 Carboxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use  
The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or...
8791114 Dihydropyrazoles  
Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH...
8791113 2,4-diaryl-substituted [1,8] naphthyridines as kinase inhibitors for use against cancer  
The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by...
8778964 Hydroxy-substituted imidazo[1,2-a]-pyridinecarboxamides and their use  
The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or...
8778977 Pyridinonyl PDK1 inhibitors  
The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.
8772288 Substituted spiro[cycloalkyl-1,3′-indo]-2′(1′H)-one derivatives and their use as P38 mitogen-activated kinase inhibitors  
The present disclosure is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), processes for preparation thereof, pharmaceutical compositions...
8765782 Indole derivatives as selective androgen receptor modulators (SARMS)  
The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen...
8765748 Indazolyl, benzimidazolyl, benzotriazolyl substituted indolinone derivatives as kinase inhibitors useful in the treatment of cancer  
The present invention is directed to a compound is represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The present invention is also directed to a pharmaceutical...
8765759 Monocyclic CGRP receptor antagonists  
The present invention is directed to compounds of the formula: (wherein variables A1, A2, A3, G1, G2, G3, G4, J, Ea, Eb, Ec, R6, R7, and Y are as described herein) which are antagonists of CGRP...