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8835444 Cyclohexyl amide derivatives as CRF receptor antagonists  
There are described cyclohexyl amide derivatives useful as corticotropin releasing factor (CRF) receptor antagonists Formula (I).
8835455 Crystalline forms of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium salt  
The present invention relates to novel crystalline forms of sodium salt of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-ca rboxamide (e.g., NXL-104) thereof. The present invention...
8835454 Fused bicyclic diamine derivatives as HIV attachment inhibitors  
Compounds of Formula I, including pharmaceutically acceptable salts thereof: wherein A is selected from the group of: are useful as HIV attachment inhibitors.
8829199 Aminopyrazole derivative  
A compound represented by formula (I) or a pharmacologically acceptable salt thereof, which can inhibit a fibroblast growth factor receptor (FGFR) family kinase in cancer tissues. (In the formula,...
8829026 Sulfamoyl benzoic acid heterobicyclic derivatives as TRPM8 antagonists  
The present invention relates to sulfamoyl benzoic acid heterobicyclic derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their...
8828998 Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors  
Provided herein are methods, kits, and pharmaceutical compositions that include a PI3 kinase inhibitor for treating lupus, a fibrotic condition, or inflammatory myopathies and other conditions...
8822493 SNS-595 and methods of using the same  
The present invention relates to SNS-595 and methods of treating cancer using the same.
8822689 Aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof  
The present invention relates to novel aryloazol-2-yl-cyanoethylamino derivatives of formula (I): wherein R3, R4, R5, R6, R7, P, Q, V, W, X, Y, Z and a are as defined in the description,...
8822467 Biaryl oxyacetic acid compounds  
The present invention provides biaryl oxyacetic acid compounds which may be useful for treating inflammatory disorders, including disorders affecting the respiratory system and skin. The compounds...
8822460 Fused cyclopentyl antagonists of CCR2  
The present invention comprises compounds of Formula (I). wherein: R0, R1, R2, R3, R4, R5, and A are as defined in the specification. The invention also comprises a method of preventing, treating...
8822446 Pyrrolopyridine inhibitors of kinases  
The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to...
8822494 Heteroaromatic compounds and their use as dopamine D1 ligands  
The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides of the foregoing; processes for the preparation of; intermediates used in...
8816085 Methylpyrrolopyridinecarboxamides  
The compounds of Formula (I), wherein R1, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the stereoisomers of the compounds and the salts thereof are...
8815892 P2X7R antagonists and their use  
The present application is directed to novel P2X7R antagonists that are indol-3-carboxamide or azaindole-3-carboxamide compounds, pharmaceutical compositions comprising the same and their use for...
8815869 Lactam acetamides as calcium channel blockers  
The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein Ar1, n, R1, X and Y are as defined in the specification. The present application also...
8815893 Hetarylaminonaphthyridines  
Novel hetarylaminonaphthyridine derivatives of formula (I) wherein X, R1, R2, R3, R4, W1, W2, W3, W5 and W6 have the meaning according to claim 1, are inhibitors of ATP consuming proteins, and can...
8809335 Pyrazolopyrimidine kinase inhibitors  
The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of...
8802694 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetycholine receptor ligands  
The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical...
8802695 Apoptosis signal-regulating kinase 1 inhibitors  
The present invention relates to apoptosis signal-regulating kinase 1 (“ASK1”) inhibiting compounds of the formula wherein the variables are as defined herein. The invention also relates to pha...
8796257 Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors  
A compound of formula (I): wherein:M is hydrogen or a pharmaceutically acceptable salt-forming cation;Y is OR1 or NR2R3,and R1, R2, R3 and M are as defined herein. Also, methods of treating...
8796244 Imidazopyridine derivatives as inhibitors of receptor tyrosine kinases  
The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g....
8796305 Carboxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use  
The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or...
8791114 Dihydropyrazoles  
Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH...
8791113 2,4-diaryl-substituted [1,8] naphthyridines as kinase inhibitors for use against cancer  
The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by...
8778964 Hydroxy-substituted imidazo[1,2-a]-pyridinecarboxamides and their use  
The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or...
8778977 Pyridinonyl PDK1 inhibitors  
The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.
8772288 Substituted spiro[cycloalkyl-1,3′-indo]-2′(1′H)-one derivatives and their use as P38 mitogen-activated kinase inhibitors  
The present disclosure is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), processes for preparation thereof, pharmaceutical compositions...
8765782 Indole derivatives as selective androgen receptor modulators (SARMS)  
The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen...
8765748 Indazolyl, benzimidazolyl, benzotriazolyl substituted indolinone derivatives as kinase inhibitors useful in the treatment of cancer  
The present invention is directed to a compound is represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The present invention is also directed to a pharmaceutical...
8765759 Monocyclic CGRP receptor antagonists  
The present invention is directed to compounds of the formula: (wherein variables A1, A2, A3, G1, G2, G3, G4, J, Ea, Eb, Ec, R6, R7, and Y are as described herein) which are antagonists of CGRP...
8765743 Compounds  
The invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
8765954 1,8-naphthyridine compounds for the treatment of cancer  
Compounds and compositions for treating, preventing or managing cancer are disclosed. The compositions provided herein comprise SNS-595 and N-desmethyl-SNS-595. Also provided are pharmaceutical...
8765767 Positive allosteric modulators of mGluR2  
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds modulate the mGluR2 receptor and may be...
8759341 Bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives and uses thereof  
This invention relates to novel bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof...
8758830 Pyrrolopyridines as kinase inhibitors  
Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ,...
8754101 N-cyclobutyl-imidazopyridine-methylamine as TRPV1 antagonists  
A compound of formula (I) wherein X represents a H atom, or a CH2OH group,Y represents a H atom, or a CH2OH group,but X and Y are not both CH2OH groupsand Ar is selected from or a pharmaceutically...
8754102 Nitrogen containing compounds and their use  
Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed.
8754082 Antiviral drugs for treatment of Arenavirus infection  
Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the...
8754100 Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors  
A compound represented by the formula [I]: or a pharmacologically acceptable salt or ester thereof, wherein Ring A represents a five-membered aromatic heterocyclic group or the like fused with a...
8754071 Compounds and compositions as c-kit kinase inhibitors  
The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent...
8754103 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Fused heterocyclic compounds as ion channel modulators
 
The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In...
8748454 Anti-constipation composition  
An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in ratio of bi-cyclic/mono-cyclic structure of...
8748455 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Solid forms of a pharmaceutically active substance
 
The present invention provides solid forms of the compound of formula 1 and pharmaceutical uses thereof.
8741920 Process for the manufacture of pharmaceutically active compounds  
The present invention relates to a composition comprising the compound of formula (1), and the compound of formula (B),
8741921 N-(imidazolidin-2-ylidene)-heterocyclopenta[b]pyridine derivatives as modulators of alpha 2 adrenergic receptors  
The present invention relates to novel N-(imidazolidin-2-ylidene)-heterocyclo penta[b]pyridine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use...
8741895 Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-5-yl-amines as Janus kinase inhibitors  
The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related...
8741897 Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof  
Compounds of Formula (IA), (IB), (IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or...
8735398 Hepatitis C virus inhibitors  
The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus...
8735424 Bicyclic kinase inhibitors  
New compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In...
8729081 Compositions and methods for treating alcohol use disorders, pain and other diseases  
The present invention provides compounds which antagonize epsilon protein kinase C (PKCε). These compounds have a structural formula (Ia), (Ic) or (II). The present invention also provides ...