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7612088 |
Heterocyclic compounds and their use as aldosterone synthase inhibitors
The application relates to novel heterocyclic compounds of the general formula (I) in which R, R 1 , R 2 , W, X, Y, Z and n have the meanings defined in the description, to a process for their...
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7612087 |
Heterocyclic compounds as inhibitors of beta-lactamases
This invention discloses and claims methods for inhibiting bacterial β-lactamases and treating bacterial infections by inhibiting bacterial β-lactamases in man or an animal comprising...
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7612086 |
JNK inhibitors
The present invention provides novel compounds of formula (I) and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in...
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7608627 |
6-azaindole compound
A compound represented by the formula
wherein R 1 , R 2 , R 3 and R 6 are the same or different and each is a hydrogen atom or a substituent; one of R 4 and R 5 is a hydrogen atom and the...
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7605169 |
Antibacterial agents
Napthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed.
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7605168 |
PDE4B inhibitors
Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and structural information for...
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7601839 |
Pyrrolo-pyridine kinase modulators
The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
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7601736 |
Pyridine derivatives, a process for their preparation and a pharmaceutical composition containing the same
The invention relates to novel pyridine derivatives having an inhibitory effect on production of cytokines, which are involved in inflammatory responses, thus suggesting its usefulness as...
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7598383 |
Heterocyclic inhibitors of MEK and methods of use thereof
Disclosed are compounds of the Formula I
and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X and Y are as defined in the specifications....
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7598266 |
Fused heterocyclic derivatives as PPAR modulators
The present invention is directed to compounds represented by the following structural formula, Formula I:
wherein:
(a) X is selected from the group consisting of a single bond, O, S,...
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7598264 |
HIV integrase inhibitors
Hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein a, R 1?, R 2?, R 3?, R 4? and R 5? are...
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7598257 |
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the...
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7598236 |
Diazabicyclic central nervous system active agents
Compounds of formula I
pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
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7592351 |
Substituted imidazo[1,2-a]pyridine compounds and pharmaceutical preparations containing substituted imidazo[1,2-a]pyridine compounds
Substituted imidazo[1,2-a]pyridine compounds, a process for the production thereof, pharmaceutical preparations containing such compounds and methods of using such substituted...
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7589102 |
Heterocyclic aromatic compounds useful as growth hormone secretagogues
Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I
...
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7585876 |
Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
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7585875 |
Substituted pyrazolo[1,5-a]pyridine compounds and their methods of use
The present invention is directed to substituted pyrazolo[1,5-a]pyridines and related methods for their synthesis and use.
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7585874 |
Aryl-isoxazol-4-yl-imidazo[1,2-a]pyridine derivatives
The present invention is concerned with aryl-isoxazol-4-yl-imidazo[1,2-a]pyridine derivatives of formula I:
wherein
R 1 to R 5 are as defined in the specification and pharmaceutically...
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7585873 |
1-(aminoalkyl)-3-sulfonylazaindoles as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
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7582651 |
Pyrrolopyridine derivative and use thereof
A novel pyrrolopyridine derivative which is a compound represented by the formula
wherein Ring A represents an optionally substituted pyridine ring; X represents an electron-attracting group; Y...
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7582637 |
Pyrrolo-pyridine kinase modulators
The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
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7579470 |
Fused heterocyclic compounds
Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
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7576095 |
Therapeutic agents
The present invention relates to 4,5-dihydropyrrolo[3,2-c]pyridin-4-one compounds of formula IA and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and...
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7572806 |
PPAR active compounds
Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
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7566781 |
Imidazopyridine compound
The present invention provides an imidazopyridine compound represented by formula (I),
wherein R 1 and R 2 each independently represent a C 1-6 alkyl group et al; R 3 and R 4 each...
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7566726 |
3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity
(wherein n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 15 , R 16 , R 17 , R 18 , Y and Z are defined herein) which are modulators of chemokine receptor activity and are useful...
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7566725 |
Imidazo[1,2-A] pyridine anxiolytics
Imidazo[1,2-a]pyridines of the formulae I and II:
are disclosed. The compounds are useful to treat anxiety and insomnia. Pharmaceutical compositions and methods are also disclosed. A...
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7566710 |
Dual molecules containing a peroxide derivative, synthesis and therapeutic applications thereof
The invention relates to dual molecules formed from coupling products complying with the formula
wherein A represents a residue of molecule with anti-malarial activity, Y 1 and Y 2 ,...
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7563797 |
Substituted imidazo(1,2-A)pyrimidines and imidazo(1,2-A) pyridines as cannabinoid receptor ligands
The present invention relates to compounds of formula I, II, III or IV:
wherein R 1 -R 4 , R 7 -R 10 , R 13 -R 17 and R 20 -R 24 are as described herein. The compounds are active as...
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7563788 |
Substituted Imidazo[1,2-a]pyridines as Antibacterial Agents
Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable...
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7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
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7557122 |
Pyrrolopyridine compounds, method of making them and uses thereof
Pyrrolopyridine compounds corresponding to formula (I):
as defined in the claims, pharmaceutically acceptable salts thereof, the process for preparing such compounds, pharmaceutical...
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7557121 |
Tetrahydronaphthyridine derivatives
The present invention relates to tetrahydronaphthyridine derivatives of the general formula (I):
or of the general formula (I′)
in which A and R 1 are as defined within, and to processes...
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7557114 |
Heterocyclic-substituted phenyl methanones
The present invention relates to compounds of formula I
wherein R 1 and R 2 are defined in the specification and to pharmaceutically acceptable acid addition salts thereof. Compounds of the...
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7553847 |
Use of pagoclone for the treatment of social anxiety disorder
The present invention provides methods for treating social anxiety disorder, comprising administering 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxo-hexyl)-
1-isoindolinone or...
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7550480 |
Compounds
Novel substituted 1,5,7-trisubstituted-1,8-napthyridin-2(1H)-one compounds; 1,5,7 trisubstituted-1,6-napthyridine-2-(1H)-one compounds and 1,5,7-trisubstituted quinoline-2(1H)-one compounds,...
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7547709 |
Chain-breaking antioxidants
Compounds, preferably 5-pyrimidinol and 3-pyridinol derivatives, that act as effective chain breaking antioxidants of both the lipid and water-soluble variety (analogous to the natural Vitamins E...
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7544698 |
Indoles and benzoimidazoles as modulators of the histamine H4 receptor
Benzoimidazole and indole compounds are described, which are useful as H 4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease...
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7541464 |
7-azaindoles, pharmaceutical compositions and their therapeutic applications
The present invention relates generally to compounds and compositions for the treatment of metabolic diseases and specifically, the present invention relates to compounds that therapeutically...
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7541366 |
Pyrrolo[3,2-c]pyridine derivatives and processes for the preparation thereof
The present invention provides novel pyrrolo[3,2-c]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same....
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7538123 |
Indole derivative having piperidine ring
The present invention relates to a compound represented by the following formula, a pharmacologically acceptable salt thereof, or a use thereof as a pharmaceutical:
wherein R 1 and R 2 are...
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7538120 |
Method of treating inflammatory diseases
Disclosed are methods of treating inflammatory diseases and disorders, such as arthritis and inflammatory bowel disease, in mammals.
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7534800 |
7-azaindoles as inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders
The present invention relates to novel 3,5-substituted 7-azaindole compounds of formula (I), their use in the inhibition of c-Jun N-terminal kinases, their use in medecine and particularly in the...
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7531552 |
Indole, azaindole and related heterocyclic pyrrolidine derivatives
This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine...
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7528147 |
Pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors
Novel compounds of formula (I):
or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions...
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7528146 |
Substituted 1H-pyrrolo[2,3-b]pyridines and preparation thereof
The invention relates to novel substituted 1H-pyrrolo[2,3-b]pyridines of the general formula (I)
to processes for their preparation and to intermediates therefor.
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7524859 |
(2-carboxamido)(3-amino)thiophene compounds
A method of treatment of hyperproliferative disorders comprises a step of administering an effective amount of a compound represented by
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7524858 |
Substituted pyrroline kinase inhibitors
The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
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7521557 |
Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
Compounds are provided having the formula (I)
wherein R, X, Y, Z, A and n are as defined herein, which are inhibitors of dipeptidyl peptidase IV and thus are useful in treating diabetes and...
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7514451 |
7-(4-Substituted-3-cyclopropylaminomethyl-1 pyrrolidinyl) quinolonecarboxylic acid derivative
To provide novel quinolonecarboxylic acid compounds serving as safe, strong antibacterial agents that are effective against drug-resistant bacteria that are less susceptible to conventional...
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