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8969347 Compounds and methods for treating inflammatory and fibrotic disorders  
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound,...
8969375 CDK9 kinase inhibitors  
Disclosed are compound of Formula (Ia), wherein R1A, R1, R2, R10, J, L, T, X, Y, and Z are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used...
8969570 Beta-lactamase inhibitors  
Aryl substituted diazabicyclooctanes (DBO) compounds that inhibit β-lactamases of class A, class C or class D and potentiate β-lactam antibiotics are disclosed. In particular, this disclosure p...
8969345 Dibenzooxepin derivative  
A dibenzoxepin derivative represented by the following general formula (I) wherein Y is a hydrogen atom and the like, RA is a hydrogen atom and the like, X is the formula (b3) wherein RB is a...
8969334 Nitrogen containing compounds and their use  
Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed.
8962844 1,3,4-oxadiazole and 1,3,4-thiadiazole β-lactamase inhibitors  
β-Lactamase inhibitor compounds (BLIs) are disclosed, including compounds that have activity against class A, class C or class D β-lactamases. Methods of manufacturing the BLIs, and uses of the c...
8962843 1,3,4-oxadiazole and 1,3,4-thiadiazole beta-lactamase inhibitors  
β-Lactamase inhibitor compounds (BLIs) are disclosed, including compounds that have activity against class A, class C or class D β-lactamases. Methods of manufacturing the BLIs, and uses of the c...
8962650 Therapeutic agent for tumor  
A therapeutic agent for tumor for combined use of a compound or pharmaceutically acceptable salt thereof represented by Formula (I) and a compound represented by Formula (II): wherein R1 is C1-6...
8957102 Heterocyclic compound as protein kinase inhibitor  
Provided are novel heterocyclic compounds useful as anti-cancer drugs by suppressing protein kinase activities of growth factor receptors such as c-Met, pharmaceutical compositions containing the...
8957062 Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment  
Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The...
8957088 4-dimethylamino-phenyl-substituted naphthyridines, and use thereof as medicaments  
The invention relates to new substituted naphthyridines of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein R1...
8957066 Histone deacetylase inhibitors  
This invention relates to generally inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3) using compounds of formula (I), wherein the substituents are as defined herein.
8957087 Heterocyclic substituted acardite derivate and application thereof  
This present invention discloses a heterocyclic substituted acardite derivate and application thereof, namely compounds in the general formula (1) or the general formula (2) or pharmaceutically...
8952163 Substituted hydroxamic acids and uses thereof  
This invention provides compounds of formula (I): wherein R1a, R1b, R1c, R1d, R2a, R2b, X1, X2, and G have values as described in the specification, useful as inhibitors of HDAC6. The invention...
8952034 Fused heterocyclic compounds as ion channel modulators  
The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In...
8952004 CXCR3 receptor antagonists  
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 to R3, A, B, X, and n are as defined herein. The invention also relates to...
8946215 Hydroxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use  
The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or...
8946426 Substituted bicyclic heterocyclic compounds as gamma secretase modulators  
The present invention is concerned with substituted bicyclic heterocyclic compounds of Formula (I) wherein Het1, Het2, A1, A2, A3 and A4 have the meaning defined in the claims. The compounds...
8940756 Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases  
The invention relates to dihydronaphthyridines and related compounds; compositions comprising an effective amount of a dihydronaphthyridine or a related compound; and methods for treating or...
8940897 1,3,4-oxadiazole and 1,3,4-thiadiazole β-lactamase inhibitors  
β-Lactamase inhibitor compounds (BLIs) are disclosed, including compounds that have activity against class A, class C or class D β-lactamases. Methods of manufacturing the BLIs, and uses of the c...
8940742 Heterocyclic compounds and uses thereof  
Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and...
8933233 1,3,4-oxadiazole and 1,3,4-thiadiazole β-lactamase inhibitors  
β-Lactamase inhibitor compounds (BLIs) are disclosed, including compounds that have activity against class A, class C or class D β-lactamases. Methods of manufacturing the BLIs, and uses of the c...
8933232 1,3,4-oxadiazole and 1,3,4-thiadiazole beta-lactamase inhibitors  
β-Lactamase inhibitor compounds (BLIs) are disclosed, including compounds that have activity against class A, class C or class D β-lactamases. Methods of manufacturing the BLIs, and uses of the c...
8933094 Ethynyl compounds useful for treatment of CNS disorder  
The present invention relates to ethynyl compounds of formula wherein X, Y, Z, and R4 are as defined herein or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or...
8927724 Isoxazole beta-lactamase inhibitors  
β-Lactamase inhibitor compounds (BLIs) are disclosed, including compounds that have activity against class A, class C or class D β-lactamases. Methods of manufacturing the BLIs, and uses of the c...
8927534 Compounds for the inhibition of integrins and use thereof  
The present invention is related to a compound of formula (I), wherein A is a nonaromatic heterocyclic ring, Ar is either absent or phenylene; Ψ is a radical of formula (II), R2 is a hydrophobic ...
8927721 Naphthyridine derivative  
The present invention provides, for example, the following compound: wherein ring Z is pyridine or a carbocycle, each of which is substituted or unsubstituted,ring A is a carbocycle or a...
8927545 Inhibiting Eph B-3 kinase  
EphB3 kinase inhibitor compounds, including certain pyrazolo[1,5-a]pyridine and imidazo[1,2-a]pyridine compounds, inhibit EphB3 kinase. The EphB3 kinase inhibitor compounds can have greater potency...
8927718 Fused heterocyclic ring derivative and use thereof  
The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof. Specially, the present invention relates to a compound represented by the...
8921389 Naphthyridine derivatives as inhibitors of hypoxia inducible factor (HIF) hydroxylase  
The present disclosure relates to novel compounds, methods, and compositions capable of inhibiting HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia...
8921559 4-substituted-cyclohexylamino-4-piperidinyl-acetamide antagonists of CCR2  
The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, X, Y, and Z are as defined in the specification. The invention also comprises a method of preventing, treating or...
8916709 1,2,4-oxadiazole and 1,2,4-thiadiazole β-lactamase inhibitors  
β-Lactamase inhibitor compounds (BLIs) are disclosed, including compounds that have activity against class A, class C or class D β-lactamases. Methods of manufacturing the BLIs, and uses of the c...
8916583 Therapeutic compositions for intranasal administration of zolpidem  
The invention provides sprayable aqueous compositions containing zolpidem or single stereoisomer, mixtures of stereoisomers, pharmaceutically acceptable salts or prodrugs thereof, a solubilizing...
8916571 Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase  
The invention relates to the treatment of cancer using an inhibitor of 5′-methylthioadenosine phosphorylase (MTAP). The invention particularly relates to the treatment of prostate cancer and head a...
8912216 Hetaryl-[1,8]naphthyridine derivatives  
Novel hetaryl-[1,8]naphthyridine derivatives of formula (I) wherein R1, R2, W1, W3, W5 and W6 have the meaning according to claim 1, are inhibitors of ATP consuming proteins, and can be employed,...
8912181 Bicyclic compound or salt thereof  
A novel bicyclic compound having an HSP90 inhibitory effect and a carcinostatic effect. A pharmaceutical agent based on the HSP90 inhibitory effect and useful in the prevention and/or treatment of...
8906392 Nanocluster compositions and methods  
Compositions, methods of making, and methods of using nanoclusters in which the nanoclusters comprise a plurality of nanoparticles having a core of nanoparticles arranged such that the surfaces of...
8906912 Anxiolytic compounds  
The present invention relates to chemical compounds of general formula (I) which may possess useful therapeutic activity in a range of central nervous system disorders, and in particular, anxiety...
8906923 Antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones  
The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further...
8906911 Chemokine receptor antagonists  
Disclosed herein are chemokine receptor antagonists of formula (I) wherein R1, R2, and R3 are as defined in the specification. Compositions comprising such compounds; and methods for treating...
8906936 Pharmaceutical combination comprising co-administration of taxane and N-(1-cyclohexyl-2-{2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide or pharmaceutically acceptable salt(s) thereof  
The invention provides a pharmaceutical combination comprising: a) compounds that inhibit the binding of the Smac protein to IAPs; andb) a taxane, and a method for treating or preventing a...
8907089 Fused heterocyclic ring derivative and use thereof  
The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof. Specially, the present invention relates to a compound represented by the...
8901144 Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives  
The invention relates to fluorinated compounds and their use as integrin receptor antagonists. Novel fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives and...
8901119 Peptide deformylase inhibitors  
The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods...
8901301 Pyrrolo[2,3-]pyridine kinase inhibitors  
Propane-1-sulfonic acid {2,4-difluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3 -b]pyridine-3-carbonyl]-phenyl}-amide, propane-1-sulfonic acid...
8901149 Imidazo[1,2-a]pyridine derivatives: preparation and pharmaceutical applications  
The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds...
8901150 1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof  
Provided herein are compounds according to Formula I and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancers such...
8901118 Compounds and methods for kinase modulation, and indications therefor  
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described, wherein the compounds have formula I: In certain aspects...
8895744 Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl  
The present invention relates to compounds of formula (I) wherein R1, R2 and R3 are as defined in the description, to their pharmaceutical compositions and use thereof for the treatment of cancer...
8895745 Bicyclic heterocyclic compounds as FGFR inhibitors  
The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g....