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6395746 |
Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
Methods of treating or preventing ophthalmic, otic, and nasal infections and attendant inflammation are described. The methods utilize ophthalmic, otic, and nasal compositions containing a new...
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6387923 |
Imminoribitol PNP inhibitors, preparation thereof and use thereof
Compounds represented by the formula: wherein A is selected from the group consisting of W is NH 2 or H; and each X, Y and Z is individually selected from the group consisting of OH, H and...
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6380209 |
4-(4-piperidylmethylamino) substituted heteroaryl fused pyridines: GABA brain receptor ligands
Disclosed are compounds of the formula or the pharmaceutically acceptable non-toxic salts thereof wherein: R is hydrogen, alkyl, or(un)substituted alkoxy or amino; and W is (un)substituted...
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6376508 |
Treatments for spinal muscular atrophy
The invention features a method of modulating SMN exon 7 expression in a subject by administering a histone deacetylase inhibitor.
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6376548 |
Enhanced propertied pesticides
This invention relates to enhanced propertied pesticides which can be used as fungicides, herbicides, insecticides, rodenticides or biocides, compositions comprising enhanced propertied pesticides,...
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6372757 |
Phenylurea and phenylthio urea derivatives
Phenyl urea and phenyl thiourea derivatives and their use as pharmaceuticals.
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6362191 |
Aminometyl oxooxazolidinyl benzene derivatives
The invention concerns compounds of formula (I), wherein: A is a 5 membered heteroaryl ring, a bicyclic benzo system containing such a 5 membered heteroaryl ring or a bicyclic or tricyclic...
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6358971 |
Anti-viral compounds
The present invention relates to compounds of Formula (I) below, which inhibit the growth of picornaviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A...
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6358970 |
Integrin receptor antagonists
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are...
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6358976 |
Integrin receptor antagonists
This invention relates to novel fused heterocycles which are useful as antagonists of the α v β 3 and related integrin receptors, to pharmaceutical compositions containing such compounds,...
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6348474 |
Sulfonamide compounds and medicinal use thereof
A sulfonamide compound of the formula (I): R 1 —SO 2 NHCO—A—R 2 (I) wherein R 1 is alkyl, alkenyl, alkynyl and the like; A is an optionally substituted heteropolycyclic group except...
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6344462 |
Heterocyclic compounds as bradykinin antagonists
This invention relates to a compound of the formula: wherein A 1 is lower alkylene, R 1 is substituted quinolyl, etc., R 2 is hydrogen, halogen or lower alkyl, R 3 is halogen or lower alkyl,...
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6340689 |
Methods of use of quinolone compounds against atypical upper respiratory pathogenic bacteria
A method of treating an atypical upper respiratory pathogenic bacteria comprising administering a gemifloxacin compound is disclosed.
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6340690 |
Antiviral methods using &lsqb 1,8&rsqb naphthyridine derivatives
The present invention is concerned with novel [1,8] naphthyridine derivatives useful for the inhibition of the hepatitis virus, more specifically the hepatitis C virus.
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6337336 |
Azaindole derivatives for the treatment of depression
Compounds useful in the treatment of diseases affected by disorders of the serotonin-affected neurological systems, such as depression and anxiety, are provided having the following formula: ...
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6333335 |
Phenyl-protein transferase inhibitors
The present invention is directed to tetrahydro-imidazopyridinyl compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further...
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6331548 |
1-cycloalkyl-1,8-naphthyridin-4-one derivative as type IV phosphodiesterase inhibitor
A 1-cycloalkyl-1,8-naphthylidin-4-one derivative having the formula (I): ##STR1## wherein R 1 indicates a substituted or unsubstituted cycloalkyl group or a substituted or unsubstituted...
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6329387 |
Use of thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
Methods, compositions, and compounds for modulating the activity of an endothelin peptide are provided. The methods use compositions that contain compounds that include those of the formula:...
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6323229 |
N-acyl and N-aroyl aralkylamides
A compound of the formula ##STR1## wherein m, R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined, useful in treating or preventing migraine, depression and other disorders for which a 5-HT 1 ...
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6323038 |
Diagnostic reagent for complications associated with diabetes or renal failure
In view of the situation of the prior art, the present invention specifies the structure of a late-stage product of Mailard reaction in vivo having a close relation with various tissue disorders,...
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6323213 |
Possibly substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-[4.3. 0]-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolin carboxylic acids and their derivatives
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6319920 |
2-arylethyl-(piperidin-4-ylmethyl)amine derivatives
This invention relates to muscarinic receptor antagonist compounds selected from the group of compounds represented by Formula I: ##STR1## wherein the substituents are as defined in the...
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6316431 |
Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men and method to study the dyssynergia in male rodents
This invention relates to the use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ration (DATER) as well as to a method for the treatment of detrusor urethral sphincter...
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6313137 |
Imidazo pyridine derivatives which inhibit gastric acid secretion
The present invention relates to imidazo pyridine derivatives of the formula (I), in which the phenyl moiety is substituted, and in which the imidazo pyridine moiety is substituted with a...
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6310081 |
Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
This invention provides compounds of Formula I having the structure ##STR1## wherein A, Q, R3, and R4 are as defined hereinbefore in the specification, or a pharmaceutically acceptable salt...
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6310074 |
Substituted dimeric compounds
The invention relates to compound of formula (I): A--G 1 --Cy--G 2 --Cy'--G 3 --B (I) wherein: A represents a grouping NR 1 C(Q)R 2 , C(Q)NR 2 R 3 or NR 1 C(Q)NR 2 R 3 , B...
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6310063 |
Aminoalkyl substituted pyrrolo [3,2-E]pyridine and pyrollo [2,3-b]pyrimidine derivatives: modulators of CRF1 receptors
Disclosed are compounds of the formula: ##STR1## wherein Ar, Q 1 , Q 2 , R 1 , W and X are substituents as defined herein, which compounds are water-soluble CRF 1 receptor antagonists, and are...
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6303624 |
Preventives and remedies for hyperphosphatemia
This invention has for its object to provide a pharmaceutical composition for the prevention and/or treatment of hyperphosphatemia and secondary hyperparathyroidism, inclusive of their accessory...
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6297256 |
Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands
Disclosed are aryl and heteroaryl substitated pyridino compounds. These compounds are highly selective agonists, antagonists or inverse agonists for GABA A brain receptors or prodrugs of agonists,...
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6297248 |
1-aryl-1,8-naphthylidin-4-one derivative as type IV phosphodiesterase inhibitor
A 1-aryl-1,8-naphthylidin-4-one derivative having the formula (I): ##STR1## wherein R 1 indicates a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group, R...
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6294549 |
Method for eliciting an αvβ5 or dual αvβ3/αvβ5 antagonizing effect
A method for eliciting an α v β 5 or dual α v β 3 /α v β 5 antagonizing effect in a mammal which comprises administering to the mammal a therapeutically effective amount of a compound of...
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6291475 |
Bispidine antiarrhythmic compounds
There is provided a compound of formula I, ##STR1## wherein R 1 , R 2 , R 9 , R 10 , R 11 , R 12 , X, A and B have meanings given in the description, which are useful in the prophylaxis and in the...
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6288081 |
Use of 7-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-quinolone carboxylic acid and naphthyridone carboxylic acid derivatives for treating Helicobacter pylori infections and the gastroduodenal diseases associated therewith
The invention relates to the use of quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in position 7 by a 1-aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl radical, and of...
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6268156 |
Cancer treatments
The present invention is to a method of treating cancer in patients in need thereof with an effective amount of cimetidine. Cimetidine has been found to inhibit the expression of E-selectin, the...
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6265418 |
N-acylamino acid amide compounds and intermediates for preparation thereof
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6265415 |
Compounds for inhibition of gastric acid secretion
The present invention relates to imidazo pyridine derivatives of the formula (I), in which the phenyl moiety is substituted with lower alkyl in 2- and 6-position, which inhibit exogenously or...
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6265406 |
Substituted quinolin-2 (1H) -ones useful as HIV reverse transcriptase inhibitors
This invention relates generally to quinolin-2(1H)-ones and derivatives thereof of Formula (I): ##STR1## or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms...
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6262071 |
Methods of use of antimicrobial compounds against pathogenic amycoplasma bacteria
This invention relates, in part, to newly identified methods of using quinolone antibiotics, particularly a gemifloxacin compound against certain pathogenic bacteria.
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6255318 |
Antiviral compounds
The present invention relates to heterocyclic Compounds having antiviral activity. In particular, Compounds of formula (I): ##STR1## wherein B, W, X, Y, Q, R 1 , R 2 , R 3 , R 4 and n are as...
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6245778 |
1,6-naphthyridine anti-convulsants
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## where R 1 is hydrogen, C 1 -6 alkyl optionally substituted by hydroxy or C 1 -4 alkoxy, or C 1 -6 alkylphenyl; ...
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6242460 |
Zolpidem salt forms
Zolpidem salts having improved physical stability do not exhibit a melting endotherm corresponding to zolpidem free base when heated at 5° C./minute from about 25° C. to 250° C. The salts are...
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6239141 |
Trovafloxacin oral suspensions
This invention relates to suspensions for oral administration comprising novel trovafloxacin zwitterionic crystals, and processes for preparing such crystals. This invention further relates to...
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6232324 |
Use of pyrazolopyridine compound
The present invention relates to a pharmaceutical composition for the prevention and/or the treatment of dialysis-induced hypotension and/or hypotension after dialysis which comprises, as an active...
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6228867 |
Antagonists of gonadotropin releasing hormone
There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety...
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6228868 |
Oxazoline antiproliferative agents
Compounds having Formula I ##STR1## are useful for treating cancer. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of treating cancer in a mammal.
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6218410 |
Medicines comprising Rho kinase inhibitor
A Rho kinase inhibitor is provided as a novel pharmaceutical agent, particularly as a therapeutic agent of hypertension, a therapeutic agent of angina pectoris, a suppressive agent of...
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6211184 |
Integrin antagonists
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the...
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6211194 |
Solution containing nicotine
A nicotine method and solution which utilizes an acidic solution containing nicotine. The solution is for use to treat various medical conditions, such as to reduce the need of a user of smoking...
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6207686 |
Endothelin antagonists
A compound of formula (I), in which: R 1 is lower alkyl, cyclo(lower)alkyl, optionally substituted aryl, optionally substituted heterocyclic group, cyclo(lower)alkyl(lower)alkyl, or...
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6200986 |
Hemoregulatory compounds
The present invention relates to novel compounds which have hemoregulatory activities and can be used to stimulate hematopoiesis and for the treatment of viral, fungal and bacterial infectious...
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