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6583155 |
Method for treating allergies using substituted pyrazoles
A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
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6576643 |
Vitronectin receptor antagonists
Compounds of the formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis: or a pharmaceutically acceptable salt thereof.
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6573283 |
Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta&lsqb a&rsqb naphthalene
Compounds of the formula: are useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety...
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6573260 |
Cycloalkyl-substituted aminomethylpyrrolidine derivatives
This invention provides a quinolone derivative which exerts strong antibacterial action upon various bacteria and has high safety, and it relates to a compound having a structure of formula (I),...
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6569868 |
2-indolinone derivatives as modulators of protein kinase activity
The present invention relates to novel imidazoly 2-indolinones and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to...
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6569869 |
Annulated azole derivatives useful as microbicidal agents
Novel fused azole derivatives of the formula in which R 1 , R 2 , A and G are as defined in the description, and also their acid addition salts and metal salt complexes, a plurality of processes...
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6559169 |
Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-benzodioxan
Compounds of the formula useful for the treatment of depression and other conditions such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, sexual dysfunction,...
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6552049 |
Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-&lsqb 1,4&rsqb -benzodioxans
Compounds of the formula useful for the treatment of depression such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction,...
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6552037 |
2-Substituted imidazo&lsqb 1,2-A&rsqb pyridine derivatives
Disclosed are compounds of the formula: and the pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X, A, B, C, D and W are defined herein, which compounds bind with high...
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6545013 |
2,7-naphthyridine derivatives
2,7-Naphthyridine containing squaric acids of formula (1) are described: wherein Ar 1 is an optionally substituted 2,7-naphthridin-1-yl group; L 2 is a covalent bond or a linker atom or group;...
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6545014 |
Method of treating glaucoma
Methods, compositions, and compounds for modulating the activity of an endothelin peptide are provided. The methods use compositions that contain compounds that include those of the formula: ...
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6541480 |
1-aryl-1,8-naphthylidin-4-one derivative as type IV phosphodiesterase inhibitor
A 1-aryl-1,8-naphthylidin-4-one derivative having the formula (I): wherein R 1 indicates a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group, R 2 , R 3...
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6531482 |
Method and compositions for maintaining glomerular filtration rate while inhibiting extracellular matrix accumulation
This invention provides a method of and compositions for increasing or maintaining glomerular filtration rate while preserving renal structure in a patient comprising administering an angiotensin...
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6525065 |
Pharmaceutical compositions and methods for effecting dopamine release
Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release...
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6521638 |
2,3-dihydro-1H-isoindole derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents)
Compounds of formula (I) wherein R 1 , R 2 , A, q are as defined herein, and salts thereof, have affinity for dopamine receptors, in particular the D3 receptor, and thus have potential in the...
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6518270 |
Heterocyclic compounds for inhibition of gastric acid secretion, processes for their preparation and pharmaceutical compositions thereof
The present invention relates to heterocyclic compounds of the formula (I), in which the phenyl moiety is substituted with lower alkyl in 2- and 6-position, which inhibit exogenously or...
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6518281 |
Immunotherapeutic agents
Novel amides and imides are inhibitors of tumor necrosis factorα and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory...
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6514997 |
Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the picornaviral 3C protease. Also...
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6509347 |
Crystalline forms of an integrin receptor antagonist
The present invention relates to novel crystalline forms of the integrin αvβ3 antagonist...
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6506747 |
Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents
1-(4-aminophenyl)pyrazoles optionally substituted on the 3- and 5-positions of the pyrazole ring and on the amino group at the 4-position of the phenyl ring are disclosed and described, which...
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6498166 |
Pyrazolopyridines
The invention provides the compounds of formula (I) wherein: R 0 and R 1 are independently selected from H, halogen, C 1-6 alkyl, C 1-6 alkoxy, or C 1-6 alkoxy substituted by one or more...
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6495560 |
Vitronectin receptor antagonist
A compound of the formula (I) is disclosed which is a vitronectin receptor antagonist and is useful in the treatment of osteoporosis: or a pharmaceutically acceptable salt thereof.
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6492391 |
Crystal modification d of 8-cyano-1-cyclopropyl-7-(1s, 6s- 2,8-diazabicyclo-&lsqb 4.3.0&rsqb nonan-8-yl)-6-fluoro-1,4- dihydro-4-oxo-3-quinolinecarboxylic acid
The present invention relates to a defined crystal modification of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-
8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, to...
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6492382 |
Dried or frozen pharmaceutical preparation containing a class III antiarrhythmic compound
The present invention relates to dried preparations containing a class III antiarrhythmic compound in the form of a crystalline or amorphous salt or any combination thereof, where the counterion is...
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6489337 |
Method for treating histamine H3 receptor-mediated disorders with 2- or 3-aryl substituted imidazo&lsqb 1,2-a&rsqb pyridines
The invention features methods of using pharmaceutically-active 2- or 3-aryl substituted imidazopyridines for the treatment of histamine H 3 receptor-mediated disorders.
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6486171 |
Piperidine compounds
A compound selected from those of formula (I): wherein: W represents optionally substituted naphthyl, or a group of formula Y (wherein) as defined in the description, n represents an integer...
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6479506 |
Triazolo-pyridine derivatives as ligands for GABA receptors
Substituted or 6,7-ring fused 1,2,3-triazolo[4,5-b]pyridine derivatives are selective ligands for GABA A receptors useful in the treatment of disorders of the central nervous system.
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6476046 |
Diazabicyclo&lsqb 4.3.0&rsqb nonanes, and methods of use thereof
One aspect of the present invention relates to diazabicyclo[4.3.0]nonanes. A second aspect of the present invention relates to the use of the diazabicyclo[4.3.0]nonanes as ligands for various...
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6476045 |
Azaindole derivatives and their use as therapeutic agents
The present invention relates to compounds of the formula (I): wherein: Het represents a heterocyclic residue selected from: where the dotted line in (b) represents an optional double bond; A...
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6472403 |
αV integrin receptor antagonists
The present invention relates to novel imidazolidinone derivatives thereof, their synthesis, and their use as αv integrin receptor antagonists. More particularly, the compounds of the present...
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6469023 |
Heterocyclic spiro-derivative
The present invention provides an antibacterial compound useful as medicines, animal drugs, fisheries drugs or antibacterial preservatives and to an antibacterial agent or preparation which...
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6465507 |
3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to...
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6465481 |
Bispidine compounds useful in the treatment of cardiac arrythmias
There is provided compounds of formula I, wherein R 1 , R 2 , R 3 , R 4 , R 5a , R 5b , R 6 , R 9 , X, A and B have meanings given in the description, which are useful in the prophylaxis and in...
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6465482 |
Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise Wherein: R 1 , R 2 and R 3 are each, independently, hydrogen, halogen, CF...
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6455540 |
Methods of use of quinolone compounds against anaerobic pathogenic bacteria
This invention relates, in part, to newly identified methods of using quinolone antibiotics, particularly a gemifloxacin compound against pathogenic bacteria, especially anaerobic pathogens.
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6455539 |
Squaric acid derivates
Squaric acid derivatives of formula (1) are described: wherein R 1 is a group Ar 1 Ar 2 Alk- in which Ar 1 is an optionally substituted aromatic or heteroaromatic group; Ar 2 is an optionally...
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6451803 |
N-acyl and n-aroyl aralkyl amides useful in treating seritonergic disorders
This invention relates to the use of a compound of the formula wherein m, R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined in the disclosure, for treating or preventing migraine, depression and...
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6448261 |
Arylamino fused pyridines
Corticotropin releasing factor (CRF) antagonists of formula I; and their use in treating anxiety, depression, and other psychiatric and neurological disorders.
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6440956 |
Bicyclic polyaminoacid metal complexes, their process of preparation and their application in medical imaging
Metal chelates of the amides of formula in which R has the formula Use in medical imaging.
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6436955 |
Crystal modification A of 8-cyano-1-cyclopropyl-7-(is,6s-2,8-diazabicyclo&lsqb 4.3.0&rsqb nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
The present invention relates to a defined crystal modification of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0] nonan-8-yl)-6-fluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acid of the...
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6436965 |
PDE IV inhibiting amides, compositions and methods of treatment
Compounds represented by formula I: as well as pharmaceutically acceptable salts and hydrates thereof are disclosed as useful for treating or preventing diseases and conditions mediated by...
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6432995 |
Aromatic heterocyclic compounds and their use as anti-inflammatory agents
Novel aromatic heterocyclic compounds inhibit cytokines production involved in immunoregulation and inflammation such as interleukin-1 and tumor necrosis factor production. The compounds are...
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6426353 |
α v integrin receptor antagonists
The present invention relates to novel compounds formed by metabolic conversion of compounds of structural formula (1), pharmaceutical compositions containing such compounds, and their use as...
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6420365 |
Imidazopyridines and related derivatives as selective modulators of bradykinin B2 receptors
Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein A, B, C, D, Y, R 1 , R 3 , R 4 , R 5 , and R 6 are variables defined herein, which...
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6420381 |
Naphthyridine derivatives
A compound of the formula (I): wherein Ring A is substituted or unsubstituted pyridine ring, Y is substituted or unsubstituted alkyl, etc., R 1 is hydrogen, or substituted or unsubstituted...
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6417181 |
Naphthyl-substituted and anilide-substituted sulfonamides
The present invention relates to new naphthyl- and anilide-substituted sulphonamides of the general formula (I) in which the substituents A, D, E, G, R 1 , R 2 , R 3 , R 4 and X have the...
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6413958 |
4-hydroxy-1,8-naphthyridine-3-carboxamides as antiviral agents
Certain novel 4-hydroxy-1,8-naphthyridine-3-carboxyamides. The compounds are effective in the treatment or prevention of viral infections, particularly viral infections caused by herpes simplex...
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RE37729 |
4-Heteroaryl-1-piperidinealkylamines and derivatives thereof and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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6399593 |
Cyclic regimens using cyclic urea and cyclic amide derivatives
This invention concerns cyclic combination therapies using progestational agents and indoline derivatives which are progesterone receptor antagonists of the general structure: wherein: A, B and...
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6395747 |
Remedies for multiple sclerosis
A medicine for treatment of multiple sclerosis comprising, as an effective component, ibudilast represented by the chemical formula (1) below. Ibudilast is effective to experimental autoimmune...
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