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8722702 Compounds modulating c-fms and/or c-kit activity and uses therefor  
Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or...
8722687 Imidazo [1,2-A]pyridine derivatives as FGFR kinase inhibitors for use in therapy  
The invention relates to new bicyclic heterocyclyl derivatives of formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of...
8716273 N-(amino-heteroaryl)-1H-pyrrolopyridine-2-carboxamides derivatives preparation thereof and their use in therapy  
The invention relates to compounds of the general formula (I): Wherein X, Y, Z, Z1, Z2, Z3, Z4 and n are as defined herein. The invention also relates to a method for making the same and to the use...
8716272 N-(amino-heteroaryI)-1H-pyrrolopyridine-2-carboxamides derivatives preparation thereof and their use in therapy  
The invention relates to compounds of the general formula (I): Wherein X, Y, Z, Z1, Z2, Z3, Z4 and n are as defined herein. The invention also relates to a method for making the same and to the use...
8710073 Anti-infective derivatives, method for the production thereof, pharmaceutical compositions containing same and uses of said derivatives in treatment  
The present invention relates to bi-substrate inhibitor molecules combining (i) a pyridine, pyridinium or dihydropyridine-type structure allied to active metabolites of isoniazide, or related...
8710074 Dihydronaphthyridinyl(organo)methanone analogs as positive allosteric mGluR5 modulators  
In one aspect, the invention relates to dihydronaphthyridinyl(organo)methanone analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the...
8709419 Combination therapy  
The present invention relates to a combination therapy of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl ]-2,4-difluoro-phenyl}-amide, or a pharmaceutically...
8710043 TRPM8 antagonists and their use in treatments  
Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and...
8703794 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof  
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the...
8703165 Spiro fused 1-amino-piperdine pyrrolidine dione derivatives with pesticidal activity  
Compounds of the formula (I) wherein the substituents are as defined in claim 1, are useful as pesticides.
8703797 Condensed ring pyridine compounds as subtype-selective modulators of sphingosine-1-phosphate-2 (S1P2) receptors  
The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist biological activity, wherein these...
8697692 Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase inhibitors  
The present invention relates to pyrrolo[3,2-c]pyridine-4-one 2-indolinone compounds of Formula (I) and their pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8 X, Y...
8697697 Pyrazole derivatives as ERK inhibitors  
This invention describes substituted pyrazole derivatives of Formula I and methods of making and using the compounds. These compounds have utility in the treatment of conditions or diseases in...
8691813 Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors  
The present invention relates to novel indole and benzoxazine derivatives which are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (“mGluR2”) and which are use...
8691838 Heterocycles as protein kinase inhibitors  
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds of Formula I, analogs, prodrugs and...
8691839 Aminotetraline derivatives  
The present application relates generally to amino tetraline derivative compounds and methods of use, specifically, embodiments including compounds of formula (I) described herein, pharmaceutically...
8685981 Cyclic compound having hetero atom  
Compounds exhibiting an osteogenesis-promoting action having the general formula (I) or a pharmacologically acceptable salt thereof: wherein A is selected from among a 3- to 10-membered...
8685983 Method of treating cancer with substituted amide derivatives  
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
8680096 Diphenyl-pyrazolopyridine derivatives, preparation thereof, and use thereof as nuclear receptor not modulators  
The invention relates to a formula (I), in which R is a hydrogen or halogen atom or a (C1-C6)alkyl group; X is one or more substituents selected from a hydrogen or halogen atom, a (C1-C6)alkyl,...
8680113 BMI-1 protein expression modulators  
Compounds having Formula I: wherein the variables Ar1, Ar2, R1, R2 and R3 are defined herein, pharmaceutical compositions, and methods of using such compounds or compositions for inhibiting Bmi-1...
8680089 Fused pyridine derivatives  
Fused pyridine derivatives shown as the general formula (I), and their pharmaceutically acceptable salts, stereoisomers or solvates thereof are disclosed, which belong to the technical field of...
8673934 Anti-infective agents and/or immunomodulators used for preventive therapy following an acute cerebrovascular accident  
The invention refers to agents for the preventive therapy after acute stroke, in particular having the aim to prevent infections after stroke. The agents inventively employed in pharmaceutical...
8673935 Drugs for the treatment of sarcogylcanopathies  
Inhibitors of the endoplasmic reticulum associated degradation (ERAD) pathway, particularly inhibitors of mannosidase I, are used for the preparation of a medicinal product intended to treat...
8673928 Compounds and methods for kinase modulation, and indications therefor  
and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds of...
8669268 Deuterium-enriched prasugrel  
The present application describes deuterium-enriched prasugrel, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
8669270 SNS-595 and methods of using the same  
The present invention relates to SNS-595 and methods of treating cancer using the same.
8669269 Imidazopyridine derivatives which inhibit the secretion of gastric acid  
The present invention relates to substituted imidazo[1,2-a]pyridines of formula I where R is —CH2COOH or —COOH, which inhibits exogenously or endogenously stimulated gastric acid secretion and can...
8664240 R-7-(3-aminomethyl-4-methoxyimino-3-methyl-pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid and L-aspartic acid salt, process for the preparation thereof and pharmaceutical composition comprising the same for antimicrobial  
Disclosed herein are R-7-(3-aminomethyl-4-methoxyimino-3-methyl-pyrrolidin-1-yl)- 1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine- 3-carboxylic acid and L-aspartic acid salt, process...
8658637 Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof  
Compounds of Formula (IA) wherein R1, R2, R3, A, B, C, D, E, G, X, Y, and Z are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such...
8658645 Use of quinolone antibiotics  
The present invention relates to the use of certain quinolone antibiotics for controlling bacterial disorders of the oral cavity, in particular in veterinary medicine.
8658669 Bridged bicyclic heteroaryl substituted triazoles useful as Axl inhibitors  
Bridged bicyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine...
8648092 Imidazo[1,2-a]pyridine derivatives: preparation and pharmaceutical applications  
The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds...
8648080 Acid pump antagonist for the treatment of diseases involved in abnormal gastrointestinal motility  
The present invention relates to a use of a compound having an acid pump antagonistic activity, a pharmaceutically acceptable salt thereof or a pharmaceutical composition thereof for the...
8648086 5,6-bicyclic heteroaryl-containing urea compounds as kinase inhibitors  
The present invention provides 5,6-bicyclic heteroaryl-containing urea compounds of Formula I or II and use of the same for treating conditions mediated by protein kinase such as VEGFR2, c-Met,...
8642587 Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy  
The present invention relates to heterocyclic compounds of the formula (I) or a physiologically tolerated salt thereof. The present invention also relates to pharmaceutical compositions comprising...
8637542 Kinase inhibitors and methods of use  
The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating lipid kinases such PB kinases, tryosine kinases and protein...
8637513 Heterocycle phenyl amide T-type calcium channel antagonists  
The present invention is directed to heterocycle phenyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and...
8633216 Imidazo[1,5-a]pyridine derivatives, method for preparing same and pharmaceutical compositions containing same  
The invention concerns compounds of formula I, a method for preparing said compounds, pharmaceutical compositions containing same and the therapeutic uses thereof.
8623889 Substituted 6,6-fused nitrogenous heterocyclic compounds and uses thereof  
The invention provides novel compounds having the general formula: wherein X1 is N or N+O−, and one of X2, X3 and X4 is N or N+—O− and the remainder of X2, X3 and X4 is C. R2, R3, R4, R5, R6. A, B ...
8623890 Nematocidal sulfonamides  
Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein Z is O or S; andR1, R2, R3, Q and n are as defined in the disclosure. Also disclosed are compositions containing the...
8618128 1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof  
Provided herein are compounds according to Formulas (I) or (II) and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating...
8618102 Bridged diazepan orexin receptor antagonists  
The present invention is directed to bridged diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric...
8618127 Methods and compositions for alleviating stuttering  
Methods of treating stuttering include treating people with gamma-aminobutyric acid (GABA) receptor modulators, including cyclopyrrolones. A second active agent may be used with GABA receptor...
8614226 Hetaryl-[1,8]naphthyridine derivatives  
Novel hetaryl-[1,8]naphthyridine derivatives of formula (I) wherein R1, R2, W1, W3, W5 and W6 have the meaning according to claim 1, are inhibitors of ATP consuming proteins, and can be employed,...
8609686 Substituted azabicyclic compounds and the use thereof  
The present application relates to novel substituted pyrrolopyridine, pyrazolopyridine and isoxazolopyridine derivatives, to processes for their preparation, to their use for the treatment and/or...
8609653 Azaindole compounds and methods for treating HIV  
Provided are compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a...
8604050 Bicyclic derivatives of azabicyclic carboxamides, preparation thereof and therapeutic use thereof  
The disclosure relates to compounds of formula (I): wherein X1, X2, X3, X4, Y, n, A, and W are as defined in the disclosure, or a salt thereof, or a hydrate or solvate thereof, and to processes for...
8604049 4-dimethylamino-phenyl-substituted naphthyridines, and use thereof as medicaments  
The invention relates to novel substituted naphthyridines of formula 1 as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof. In...
8598166 Polysubstituted derivatives of 6-heteroarylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof  
Compounds of formula (I): wherein R1, R2, R3, R4, Het and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.
8592448 Substituted pyrrolo[2,3-b]-pyridines and -pyrazines  
Compounds of Formula I, as shown below and defined herein: (I) pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including...