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7618940 |
Fat regulation
The present invention provides methods and compounds for regulating fat metabolism and achieving fat homoeostasis in a subject. Methods and compound for regulating body weight, reducing body fat,...
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7615533 |
TPO peptide compounds for treatment of anemia
Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
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7615532 |
Insulin derivatives
The present invention relates to insulin derivatives which are naturally occurring insulins or analogues thereof which have a side chain attached either to the α-amino group of the N-terminal...
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7611864 |
Proinsulin polypeptide-oligomer conjugates
Methods for synthesizing proinsulin polypeptides are described that include a contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide bond(s)...
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7608692 |
Exendins and exendin agonists modified with albumin
Modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, and related formulations and dosages and methods of...
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7608587 |
Exendin 4 polypeptide fragment
The present invention relates to an Exendin 4 polypeptide fragment, which has hypoglycemic activity, and can be used for the treatment of type II diabetes mellitus. The polypeptide sequence...
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7608583 |
Process for the extraction and isolation of insulin from recombinant sources
The present invention relates to the extraction and isolation of insulins from recombinant sources, particularly those expressed in and secreted by yeasts. Organic solvents have been used to...
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7605124 |
Ejection liquid and ejection method
An ejection liquid that allows a solution containing at least one kind of insulins to be stably ejected by an inkjet system using a thermal energy and a method of ejecting the solution containing...
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7605123 |
Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof
Fatty acid compositions for administration of of pharmaceutical agents, such as proteins and peptides, protein and peptide conjugates, and/or cation-polypeptide conjugate complexes. In particular,...
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7601688 |
Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
The present invention provides compositions and methods for reducing hypoglycemic episodes experienced by a subject in need of treatment for diabetes mellitus, said method comprising orally...
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7601687 |
Mechanism for identifying drugs for the treatment of type II diabetes
Insulin resistance is a central feature of type II diabetes and other diseases, and may affect every tissue of the body, including the pancreatic beta cell. Insulin signaling is mediated by a...
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7595333 |
Agent for improving acidosis
An agent for improving ketosis which comprises an insulin sensitizer, which has an excellent action and low toxicity.
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7576056 |
Peptides and compounds that bind to a receptor
Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
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7569540 |
Method for enhanced parenteral nutrition
A method for improved administration of nutrient is provide. The method includes co- or separate administration of a source of nutrients, especially carbohydrates, and insulinotropic peptides and...
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7557081 |
Alpha-1-acid glycoprotein for the treatment of diabetes
Methods of using alpha-1-acid glycoprotein, or an active derivative, to modulate the blood glucose level in mammals, particularly humans, is described. A therapeutically effective amount of...
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7556798 |
Highly efficient delivery of a large therapeutic mass aerosol
A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a...
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RE40812 |
Nasal calcitonin formulation
A liquid pharmaceutical composition is disclosed comprising calcitonin or an acid addition salt thereof and citric acid or salt thereof in a concentration from about to about 50 mM, said...
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7544656 |
Long acting injectable insulin composition and methods of making and using thereof
A method of lowering blood glucose in a mammal includes injecting a therapeutically effective amount of crystallized dextran microparticles and insulin to the mammal to lower blood glucose of the...
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7538186 |
Exendins and exendin agonists modified with polyamino acids
Modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more molecular weight increasing compounds, for example, polyamino acids, polyethylene glycol polymers,...
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7524813 |
Selectively conjugated peptides and methods of making the same
Methods for the selective conjugation of peptides which comprises an enzymatic incorporation of a functional group at the C-terminal end of a peptide followed by reaction with a second compound...
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7521069 |
Methods and compositions for pulmonary delivery of insulin
Systemic delivery of insulin to a mammalian host is accomplished by inhalation of a dry powder of insulin. It has been found that dry insulin powders are rapidly absorbed through the alveolar...
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7514403 |
Process for the stabilization of proteins in an aqueous solution comprising cysteine in a concentration between 150 and 220mM
The present invention relates to a process for the storage of proteins in an aqueous solution. The addition of cysteine delays the temporal decrease in the effective concentration of the protein....
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7504376 |
Methods and compositions for increasing the anaerobic working capacity in tissues
The invention provides compositions comprising beta-alanylhistidine peptides and beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and...
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7488716 |
Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use
The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2...
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7476652 |
Acidic insulin preparations having improved stability
The invention relates to a pharmaceutical formulation comprising a polypeptide selected from the group consisting of insulin, an insulin metabolite, an insulin analog, an insulin derivative and...
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7470663 |
Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit...
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7452860 |
Zinc-free and low-zinc insulin preparations having improved stability
The invention relates to a formulation comprising a polypeptide selected from at least one of insulin, an insulin metabolite, an insulin analog, and an insulin derivative; at least one surfactant;...
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7452858 |
Treatment of gestational diabetes
Methods for treating gestational diabetes which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that...
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7449200 |
Nanoparticles for protein/peptide delivery and delivery means
The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering proteins or peptides to an animal subject. The nanoparticles are...
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7446091 |
Methods and preparations for curing clinically ill patients
This invention relates to a life saving medicament for critically ill patients and a method of treatment. The composition is a pharmaceutically effective amount of a blood glucose regulator which...
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7442720 |
Compositions and methods for treating diabetes
The subject invention provides compositions and methods for treating diabetes in patients. In a preferred embodiment, the invention provides compositions methods for treating diabetes and/or...
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7442682 |
Transepithelial delivery of peptides with incretin hormone activities
Compositions and methods are disclosed for the treatment of diabetes and related diseases using peptides with incretin hormone activity. Preferably, the peptide with incretin hormone activity is...
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7423014 |
Insulin conjugates for treating diabetes mellitus
Methods of treating diabetes mellitus in a patient in need of such treatment include administering an effective amount of an insulin polypeptide-oligomer conjugate of formula V
to the patient...
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7419952 |
Use of exendins and agonists thereof to treat diabetes
Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist,...
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7414021 |
Method and composition for restoration of age related tissue loss in the face or selected areas of the body
A treatment method for restoring of age related tissue loss in the face or selected areas of the body is disclosed which includes injecting an injectable composition containing a growth factor and...
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7407934 |
Methods for regulating postprandial blood glucose
Methods for treating conditions associated with elevated, inappropriate or undesired post-prandial blood glucose levels are disclosed which comprise administration of an effective amount of an...
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7405279 |
Chimeric proteins for diagnosis and treatment of diabetes
Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided are immunomodulatory methods for the use of such proteins for both the prevention...
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7405196 |
Method for reducing cardiovascular morbidity and mortality in prediabetic patients and patients with type 2 diabetes
This invention relates to a method of reducing cardiovascular morbidity and mortality in a prediabetic or Type 2 Diabetes patient population. The method comprises administering an effective dosage...
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7402565 |
Processes for making acylated insulin
A method is provided which allows high yields of acylated insulin. The method comprises expressing a singe-chain insulin precursor, preferably in yeast, cleaving the single-chain insulin precursor...
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7399489 |
Exendin analog formulations
Novel formulations containing exendins, exendin agonists and/or exendin analogs are provided.
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7387996 |
Formulations of insulin
Stable insulin formulations can be prepared by mixing a monomeric insulin and a soluble acylated insulin analog.
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7387798 |
Method and composition for resuscitation
The key obstacle for current resuscitation is the acutely limited time window. The major reason for the limited time window is that the brain and spinal cord are extremely vulnerable to...
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7384915 |
Chimeric insulin-gad proteins for treating patients with type 1 diabetes or at risk of developing type 1 diabetes
Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided are immunomodulatory methods for the use of such proteins for both the prevention...
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7384914 |
Night-time oral insulin therapy
A method for protection of a mammal that has impaired glucose tolerance or early stage diabetes mellitus from developing overt or insulin dependent diabetes comprises administering an orally...
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7381702 |
Methods of treating diabetes mellitus
Methods of treating diabetes mellitus in a patient in need of such treatment include administering an effective amount of an insulin drug to the patient in order to treat diabetes mellitus in the...
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7368260 |
Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
Methods for synthesizing proinsulin polypeptides are described that include a contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide bond(s)...
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7341869 |
Compositions and methods for treating diabetes
The present invention provides an isolated population of cells containing an expressible nucleic acid encoding proinsulin containing a proinsulin cleavage site and a glucose-regulated expressible...
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7338931 |
Hydrophobic biomolecular structure
The present invention relates to a new hydrophobe biomolecular structure, which is compacted due to the passing of the structure over its point of collapse, a method for the preparation of the...
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7326680 |
Uterine contraction inhibitors
A composition for inhibiting spontaneous myometrial contraction or bradykinin-induced contraction, comprising adrenomedullin. The composition of the present invention may be used to selectively...
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7317000 |
Glucose-dependent insulins
The present invention relates to insulin derivatives having a built-in glucose sensor and a polyol moiety, capable to deliver insulin from an injected depot of an insulin derivative according to...
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