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8178497 |
Method of treating HIV in drug resistant non plasma viral reservoirs with monomeric DAPTA
Residual HIV-1 replication reemerges after intensive therapy from location or locations in the body called the drug resistant non-plasma viral reservoir. Methods are disclosed of treating HIV by...
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8143213 |
Effect of TULA on HIV
A method of inhibiting a retrovirus production, the method includes administering a retrovirus inhibitor selected from at least one of a TULA protein, a fragment of TULA containing a UBA domain, a...
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8114840 |
Medicament containing activated antithrombin III
The invention concerns the use of antithrombin III with a modified conformation which is referred to as activated antithrombin III (IDAAT=immune defense activated antithrombin) as a medicament.
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8088729 |
Anti-viral griffithsin compounds, compositions and methods of use
A method of inhibiting a viral infection of a host comprising administering to the host an anti-viral griffithsin polypeptide comprising SEQ ID NO: 3 or a fragment thereof comprising at least eight...
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8071540 |
Virus derived antimicrobial peptides
Described herein are peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides, designated LBU, WLBU and WR, are analogs of the Lentivirus Lytic Peptide 1 (LLP1)...
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8034769 |
Oxidized proteins and oxidized protein inhibitor compositions and methods of use thereof
The invention relates to substances which inhibit the binding of oxidized proteins to CD36 or inhibit the functions of CD36 that are induced by the interaction of CD36 with oxidized proteins. The...
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8017579 |
Treatment of viral infections
The present invention relates to polypeptides, and derivatives or analogues thereof, comprising a tandem repeat of apolipoprotein B, or a truncation thereof, derived from an HSPG receptor binding...
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7998926 |
Dimerized T-cell receptor fragment, its compositions and use
Dimers of a peptide from the T-cell receptor (Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Gln Thr) (SEQ ID NO:1) are disclosed for preventing the progression to AIDS in an animal model....
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7964559 |
MVL, an antiviral protein from a cyanobacterium
The present invention relates, e.g., to an isolated polypeptide from a cyanobacterium, Microcystis viridis, which binds specifically to an oligosaccharide comprising the tetrasaccharide...
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7915040 |
Defensin-antigen fusion proteins
The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral...
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7884073 |
Modified growth hormone
Provided are modified growth hormone polypeptides, nucleic acid molecules encoding modified growth hormone polypeptides and methods of generating modified growth hormone polypeptides. Also provided...
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7863242 |
Compositions for down-regulation of CCR5 expression and methods of use thereof
The present invention relates to the downregulation of surface receptor CCR5 expression through manipulation of the cell cycle in activated lymphocytes by administering a composition that arrests...
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7834064 |
Clinical method for the immunomodulatory and vaccine adjuvant use of poly-ICLC and other dsRNAs
An improved understanding and method for the clinical adjuvant and immunomodulatory use of dsRNAs and ply-ICLC in particular, alone or in conjunction with other drugs and various vaccines designed...
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7811995 |
Therapeutic and diagnostic peptides
This invention generally relates to peptides useful for medical diagnosis and treatment of pathogenic disorders. More specifically, the invention relates to immunostimulatory peptides which can...
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7803765 |
Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom
The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic...
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7786078 |
Template-fixed δ-hairpin peptidomimetics with CXCR4 antagonizing activity
Template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12, 14 or 18 α-amino acid residues which, depending on their positions in the chain (...
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7776821 |
Method comprising nanofiltration to obtain an MBL product safe from infectious agents and the product obtainable by this method
The present nanofiltration method is applicable on solutions of plasma-derived and recombinantly produced MBL. The MBL containing solution is subjected to a pre-treatment prior to the...
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7776818 |
Methods to treat T-cell disorders using TISF
T4 Immune Stimulating Factor (TISF) selectively induces aberrant T-cells to initiate apoptosis. TISF and peptides that are related to TISF (TISF peptides) are therefore useful for the treatment of...
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7763589 |
Compositions and methods for treating intracellular diseases
The present invention provides methods of treating intracellular infections comprising the step of administering a vector construct which directs the expression of at least one immunogenic portion...
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7754687 |
Methods of inhibiting viral infection
The present invention is directed to methods of preventing and/or treating infectious disease. In a particular aspect, the invention is directed to treating viral infections by administering an...
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7740857 |
Compositions and methods for treating malaria with cupredoxin and cytochrome
The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by the...
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7741085 |
Compound WS727713
The present invention relates to a compound WS727713, useful as a modulator of melanocortin receptors, and a process for its production by culturing in a culture medium the actinomycetes strain of...
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7741274 |
Casein derived peptides and uses thereof in therapy
Biologically active peptides that are derived from or are similar to sequences identical with the N-terminus of the oS1 fraction of milk casein. These peptides are capable of stimulating and...
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7737112 |
Composition for enzyme inhibition
Compositions comprising one or more practically insoluble proteasome inhibitors and a cyclodextrin, particularly a substituted cyclodextrin, substantially increase the solubility of these...
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7723294 |
Polypeptide films and methods
Disclosed herein are polypeptide multilayer films comprising a hybrid polypeptide comprising a first polypeptide segment and a second segment, the two segments being covalently joined by one or...
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7723303 |
Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
This invention provides novel active agents (e.g. peptides, small organic molecules, amino acid pairs, etc.) peptides that ameliorate one or more symptoms of atherosclerosis and/or other...
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7704957 |
Composition for inhibiting HIV activity extracted from Paecilomyces sp. (Tochu-kaso) J300
The present invention relates to a composition for inhibiting HIV activity comprising the extract of Paecilomyces sp. (Tochu-kaso) J300. More particularly, the present invention relates to a...
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7691805 |
Antimicrobial compounds
The invention relates to compositions comprising a compound based on the general formula (I) R1-Arg-R2—NH—CH(R3)—CH2—NH—R4 (I) and a carrier, diluent or an excipient.
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7687456 |
Compounds for enzyme inhibition
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases associated with the...
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7678766 |
Process for the preparation of cyclosporin derivatives
The invention concerns a novel method for preparing an intermediate polyanion for preparing cyclosporin derivatives by treating a cyclosporin with a hexamethyldisilazane metal salt, optionally in...
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7678833 |
Method to increase the bioavailability of cysteine
A method for increasing the bioavailability of cysteine within an animal by reducing extracellular cysteine disulfide molecules to produce extracellular cysteine molecules. A membrane permeable...
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7662403 |
Pharmaceutical formulations for intranasal administration of protein comprising a chitosan or a derivative thereof
There is provided a powder formulation for nasal delivery including a protein having a molecular weight of 10 kDa or greater and chitosan or a derivative thereof or a salt of chitosan or a salt of...
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7659255 |
Methods of inhibiting glutamate receptors by administering the tripeptide KDI
The present invention relates to a method of using biologically active peptide compounds comprising the tri-peptide motif KDI derived from the neurite outgrowth-promoting domain of laminin-1 as...
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7655629 |
Peptides and their use for the treatment of HIV infections
The invention relates to peptides with biological activity against infection having the amino acid sequence Z1-LE-X1-IP-X2-X3-X4-P-X5-X6-X7-X8-X9-X10-K-X11-X12-X13-X14-
X15-Z2, wherein X1 is a...
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7655425 |
Uses of a chemokine receptor able to bind to MCP-1, MIP-1α and/or RANTES
A chemokine receptor binds to MCP-1, MIP-1α and/or RANTES. It can be used in screening for agents which act as antagonists to MCP-1, MIP-1α and/or RANTES. Such agents may be useful in treating v...
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7642235 |
Macrocyclic peptides active against the hepatitis C virus
Compounds of formula I: wherein D, R4, R3, L0, L1, L2, R2 and RC are defined herein; or a pharmaceutically acceptable salt thereof, useful as inhibitors of the HCV NS3 protease.
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7625553 |
Method of treating cancer by administering an epithelum-derived T-cell factor
Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for...
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7612040 |
Lefty polypeptides and derivatives thereof
The disclosure relates to Lefty derivatives and the uses of Lefty polypeptides as antagonists of the function of certain ligands such as Nodal, GDF-8 (Myostatin), and GDF-11. These derivatives may...
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7589058 |
Ghrelin analogs
The invention comprises peptidyl analogs that possess agonist or antagonist ghrelin activity, along with therapeutic and non-therapeutic uses thereof.
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7585507 |
Nucleic acid molecules and polypeptides for immune modulation
The invention provides gp38 polypeptides, which play a role in immunomodulation, nucleic acid molecules encoding these polypeptides, and therapeutic and diagnostic methods employing these...
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7582604 |
Template-fixed peptidomimetics with antibacterial activity
Template-fixed β-hairpin peptidomimetics of the general formula (I), wherein Z is a template-fixed chain of 12 α-amino acid residues which, depend on their positions in the chain (counted s...
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7572599 |
Metalloprotease activation of myostatin, and methods of modulating myostatin activity
It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents...
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7563761 |
PNA conjugate for the treatment of diseases associated with HIV
The invention relates to peptide nucleic acid (PNA) conjugates which can be used for treating diseases correlated with HIV, wherein the peptide nucleic acid (PNA) inhibits the gene expression of...
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7553811 |
Methods and compositions for modulating immunity
Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of a CD200 protein or a nucleic acid encoding a CD200 protein. The...
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7538084 |
Cyclosporins
The compounds of the present invention are represented by the chemical structure found in Formula I: Formula I where A is an amino acid of Formula II: or a pharmaceutically acceptable salt thereof,...
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7531517 |
Inhibitors of cancer cell, T-cell and keratinocyte proliferation
The invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein Y is —NRaRb, —NRcC═ONRaRb, —NRcC═SNRaRb, —NRcC═NRd...
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7528104 |
Peptides that bind to the erythropoietin receptor
The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat...
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7524821 |
Scaffolded maleimide clusters for multivalent peptide assembly
Disclosed are scaffolded maleimide clusters, methods of making said clusters and use of said clusters as templates for multivalent peptide assembly. Multiple maleimide functionalities were...
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7501398 |
Inhibitor of the folding of the HIV-1-protease as antiviral agent
The invention relates to the design of inhibitors of the HIV-1-PR homodimer which do not create resistance, by blocking the folding of single monomers with the help of peptides which attach to...
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7494974 |
Carboxymethylated cross-linked tetrameric hemoglobin
The present invention includes compositions containing carboxymethylated cross-linked hemoglobin where the cysteine moiety of the hemoglobin includes thiol protecting group and where the hemoglobin...
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