Patents in Class 514/298

Matches 1 - 50 out of 63

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Match	Document	Document Title
1	7585872	Guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (PDE) 4 inhibitors The compounds of a certain formula (1), in which R1, R2, R3, R31, R4, R5, R6 and R7 have the meanings as given in the description, are novel effective PDE4 inhibitors.
2	7378427	Processes for preparing 6-alkyl-5-arylsulfonyl-dihydrophenanthridines Synthetic methods are provided for production of compounds of the formula: where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 and R 14 are as defined in the...
3	7358245	Treatment of gastroesophageal reflux disease The administration of cannabinoid receptor agonists for inhibition of transient lower esophageal sphincter relaxations, gastroesophageal reflux disease and regurgitation is disclosed.
4	7329676	2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors The compounds of formula I in which R1, R2, R3, R31, R4, R5, R6 and R7 have the meanings as indicated in the description, are novel effective PDE4 inhibitors.
5	7304073	Method of treating myocardial ischemia-reperfusion injury using NF-kB inhibitors The present invention concerns a method of treatment or prevention of myocardial ischemia-reperfusion injury by diagnosing that a person is in need of treatment or prevention of myocardial...
6	7291596	Pharmaceutical composition for thrombin peptide derivatives Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol-containing compound. The pharmaceutical...
7	7214685	Prodrugs for a selective cancer therapy The chemotherapy of malignant tumours is greatly restricted by the generally slight differentiation of the available cytostatic agents between normal and malignant tissue. In order to achieve an...
8	7087106	Materials and methods for inhibiting fouling of surfaces exposed to aquatic environments The subject invention provides materials and methods for inhibiting the biofouling of surfaces exposed to aquatic environments. In one embodiment, the subject invention provides additives for...
9	7074782	Carbamate caspase inhibitors and uses thereof This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R 1 is hydrogen, —CHN 2 , R, CH 2 OR, CH 2 SR, or —CH 2 Y; Y is an electronegative leaving group; R 2...
10	7060729	Composition and method for treating skin The present invention relates to a composition and method for treating individuals afflicted with rosacea by combining a dicarboxylic acid, at least an antimicrobial agent, and a pharmaceutically...
11	7037919	Tetrahydroquinoline derivatives Tetrahydroquinoline derivatives of general formula (I) or salts thereof, having a specific and strong binding affinity for AR and exhibiting AR agonism or antagonism; and pharmaceutical...
12	6958347	Aminophenanthridinone and aminophenanthridine as NPY-5 antagonists The present invention provides NPY-5 receptor antagonists having a Formula (I) Methods and pharmaceutical compositions useful for treating diseases, conditions and/or disorders modulated by...
13	6894061	Substituted dihydrophenanthridinesulfonamides This invention provides a compound of formulae (I) or (II) having the structure or a pharmaceutically acceptable salt thereof which are useful for the treatment of the inflammatory component...
14	6884802	6-heteroarylphenanthridines Compounds of formula 1, in which Het is an unsubstituted or R6- and/or R7-substituted pyrrolyl, furanyl, thiophenyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl,...
15	6770668	Pharmaceutically active compounds and methods of use The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof,...
16	6743817	Substituted fused pyrroleimines and pyrazoleimines Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R 1 and R 2 are defined herein. These compounds are highly selective agonists,...
17	6723733	Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
18	6706729	Thiolesters and uses thereof This invention pertains to the discovery of a novel family of thiolesters and uses thereof. Also provided for are viricidal compounds and pharmaceutical formulations comprising these novel...
19	6696407	Huntington's disease treatment comprising administering aldose reductase inhibitors to increase striatal CNTF The present invention provides methods of modulating neurotrophic factor-associated activity, especially CNTF-associated levels and activity, using aldose reductase inhibitors. These methods are...
20	6677350	Beta-fluoroethyl thiourea compounds and use The present invention relates to compounds, compositions and methods for the prevention or treatment of mycobacterium infections. The compounds are naturally occurring and synthetic biflavonoids,...
21	6670369	Use of phanquinone for the treatment of alzheimer's disease The use of phanquinone for the manufacture of a pharmaceutical composition for the prevention or the treatment of Alzheimer's disease is disclosed. Also methods of treatment or prevention of...
22	6630483	Phenanthridine-N-oxides N-oxides of the compounds of formula (I) in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy, R2 is...
23	6538005	Phenanthridine-N-oxides with PDE-IV inhibiting activity The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, arm novel active bronchial therapeutics.
24	6534518	Polysubstituted 6-phenylphenanthridines with PDE-IV inhibiting activity Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics.
25	6514988	Condensed-ring thiophene derivatives, their production and use A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or...
26	6479505	6-arylphenanthridines with PDE-IV inhibiting activity Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and Ar have the meanings indicated in the description, are novel active bronchial therapeutics.
27	6476048	Substituted phenanthridinones and methods of use thereof This invention provides a novel class of substituted 6(5H)phenanthridinone compounds. Pharmaceutical compositions, and methods of making and using the compounds, or a pharmaceutically acceptable...
28	6476025	Phenylphennanthridines with PDE-IV inhibiting activity Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51, R6, R13 and R20 have the meaning indicated in the description, are novel active bronchial therapeutics
29	6469047	Tyrosine derivatives The compounds of the invention are inhibitors of alpha4 containing integrin-mediated binding to ligands such as VCAM-1 and MAdCAM.
30	6391887	3,4-Dihydroquinoline derivatives as nitrogen monoxide synthase (NOS) inhibitors The invention relates to compounds of formula (I), as defined herein. The invention also relates to the use of the inventive compounds for treatment of a disease caused by the effects of nitrogen...
31	6268377	Method for treating androgen-related conditions The present invention provides for the combined use of 5α-reductase inhibitors together with calcium channel blockers for the treatment of benign prostatic hyperplasia (BPH), prostate cancer,...
32	6242432	Antithrombotic organic nitrates Compounds or compositions containing compounds of the formula A-(X 1 --NO 2 ) to or salts thereof, for the preparation of antithrombotic medications wherein "to" is the integer 1 or 2X 1 is an...
33	6214839	Substituted 6-alkylphenanthridines
34	6177441	Treating red blood cell solutions with anti-viral agents Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for...
35	6127378	Phenanthridines substituted in the 6 position Compounds of the formula I in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel efficacious bronchial therapeutics.
36	6121279	Substituted 6-phenylphenanthridines The invention relates to compounds of formula (I): wherein R1, R2, R3, R31, R4, R5, R51 and R6 are as defined in the specification. The compounds are phosphodiesterase inhibitors. Also disclosed...
37	6071929	Octahydro phenanthridine derivatives useful as NMDA-R receptor subtype blockers The present invention relates to the use of tetrahydroisoquinoline derivatives of the general formula: ##STR1## wherein: A is aryl R 1 is hydrogen, hydroxy, lower alkyl, lower alkoxy, R--CO--...
38	6054448	2-amino-2-(3-substituted cyclobutyl) acetic acid derivatives Compounds of the formula ##STR1## in which R 1 is Y or Y--C 1 -6 alkyl, where Y is carboxy, tetrazolyl, --SO 2 H, --SO 3 H, --OSO 3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OP(OH)OR' or...
39	6025365	Chelerythrine and radiation combined tumor therapy Combination of low doses of irradiation and chelerythrine results in increased apoptosis in tumor cells. The doses of either irradiation or chelerythrine alone are such that increased apoptosis or...
40	5939429	Cardiovascular uses of cannabinoid compounds Hemorrhagic shock and in other conditions associated with excessive vasoconstriction, such as hypertension, peripheral vascular disease, cirrhosis of the liver, or certain forms of angina pectoris...
41	5827856	Method of treating insulin resistance The present invention provides a novel method for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting...
42	5728719	Systemic control of parasites The present invention is a method for controlling ectoparasites. More particularly, the invention relates to a method of treatment in which the warm blooded animal is dosed with an ovicidally...
43	5670514	Compositions for inhibiting bone loss The present invention provides methods of inhibiting bone loss in mammals via the administration to a mammal in need of such treatment an effective amount of a compound from a series of...
44	5654298	Amine derivatives This invention concerns novel aminopyridinium compounds of the formula I wherein R 1 , R 2 , R 3 , R 5 and R 6 are selected from the following combinations: ##STR1## (a) one of R 2 and R 6 is a...
45	5631279	Perhydroisoindole derivatives, preparation thereof and pharmaceutical compositions containing same This invention relates to perhydroisoindole derivatives of 08/448,402 formula (I), wherein radicals R are phenyl radicals optionally 2-or 3-substituted by a halogen atom or a methyl radical; R 1 ...
46	5605906	Cannabinoid receptor agonists Disclosed are novel cannabinoid (CB2) receptor agonists, their compositions, and the methods of their preparation. The compounds are useful for lowering ocular intra ocular pressure, treating...
47	5580888	Styryl derivatives as anti-inflammatory agents Compounds of general formula (1) ##STR1## are described wherein Y is a halogen atom or a group --OR 1 , wherein R 1 is an optionally substituted alkyl group; X is --O--, --S-- or --N(R 6 )--,...
48	5550134	Methods for inhibiting bone loss The present invention provides methods of inhibiting bone loss in mammals via the administration to a mammal in need of such treatment an effective amount of a compound from a series of...
49	5543433	Azine-substituted phenylacetic acid derivatives and fungicides containing these Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH 3 ,...
50	5215986	5-hydroxy-2-pyrimidinylmethylene oxaza heterocycles Novel 5, 6, or 7 membered oxaza heterocycles substituted at the 4-carbon by a 5-hydroxypyrimidinylmethylene group inhibitors of 5-lipoxygenase and/or cyclooxygenase and are thus useful in treating...

Matches 1 - 50 out of 63

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