Patents in Class 514/297

Matches 1 - 50 out of 185

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Match	Document	Document Title
1	7622478	1-nitroacridine/tumor inhibitor compositions The invention is directed to 1-nitroacridine derivative(s)/tumor inhibitor(s) compositions as well as methods for using said compositions for inhibiting or preventing tumor growth, particularly,...
2	7511064	Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT_2Breceptor antagonist The present invention relates to derivatives of 4-(Thio- or Selenoxanthene-9-ylidene)-piperidine or acridine and pharmaceutically acceptable salts thereof, use of these compounds as a medicament...
3	7423046	3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors Compounds of formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meaning indicated in the description, are novel effective PDE4 inhibitors.
4	7388017	Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds,...
5	7354928	Small molecule inhibitors targeted at Bcl-2 The present invention relates to small molecule antagonists of Bcl-2 family proteins such as Bcl-2 and/or Bcl-X L . In particular, the present invention provides non-peptide cell permeable small...
6	7312209	Acridone inhibitors of IMPDH enzyme Compounds having the formula (I), wherein R 3 is selected from H, OH and NH 2 ; R 30 is selected from ═O and ═S; W is —C(═O)—, —S(═O)—, or —S(O) 2 —; or W may be —CH 2...
7	7312082	Crystal structure of G-quadruplex containing a potassium ion The present invention relates to a crystal structure of G-quadruplexes and its use. The invention provides a crystal of an intramolecular G-quadruplex structure having a hexagonal space group P6,...
8	7300930	Therapeutic acridone and acridine compounds The present invention pertains to acridone and acridine compounds of formula (I), wherein either: (a) K is ═O, L is —H, alpha is a single bond, beta is a double bond, gamma is a single bond...
9	7141581	Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating...
10	7094378	Method and apparatus for inactivation of biological contaminants using photosensitizers Methods and apparatuses for treating fluids to inactivate microorganisms which may be present therein, said fluid containing one or more components selected from the group consisting of protein,...
11	7084106	Application of a viral complement inhibitory protein in the treatment and diagnosis of Alzheimer's Disease The present invention provides a novel treatment for senile dementia (Alzheimer's Type), comprising administering an anti-complement protein to a patient in need of such treatment in an amount...
12	7041674	Carbamic acid esters with anticholinergic activity A compound of formula 1 wherein X − , A, R 1 , R 2 , R 3 , and R 4 may have the meanings given in the claims and in the specification, processes for preparing them, their use in...
13	7030133	Inhibitors of formation of advanced glycation endproducts (AGEs) The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is...
14	7030132	Method of improving bioavailability of orally administered drugs, a method of screening for enhancers of such bioavailability and novel pharmaceutical compositions for oral delivery of drugs A method for increasing the systemic exposure of cells selected from tumor cells and normal cells to an orally administered pharmaceutically active compound, wherein a bioenhancer comprising an...
15	6998405	Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use Compounds of the general formula I wherein rings B, C, D and E may be present or not and, when present, are combined with A as A+C, A+E, A+B+C, A+B+D, A+B+E, A+C+E, A+B+C+D or A+B+C+D+E, rings...
16	6974821	Methods for treating neuropsychiatric disorders The invention provides methods for treating neuropsychiatric disorders such as schizophrenia, Alzheimer's Disease, autism, depression, benign forgetfulness, childhood learning disorders, closed...
17	6956043	Pharmaceutical compositions comprising 33-epi-chloro-33-desoxy-ascomycin solid dispersions A pharmaceutical composition in the form of a solid dispersion comprising a macrolide, e.g. a rapamycin or an ascomycin, and a carrier medium.
18	6906081	Use of dual H3/M2 antagonists in the treatment of cognition deficit disorders This invention relates to a method of treating cognition deficit disorders comprising administering to a mammal in need of such treatment an effective amount of a dual histamine H 3 receptor...
19	6884802	6-heteroarylphenanthridines Compounds of formula 1, in which Het is an unsubstituted or R6- and/or R7-substituted pyrrolyl, furanyl, thiophenyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl,...
20	6867197	Method of targeting conjugate molecules to mitochondria The present invention relates to genetic mutations in mitochondrial cytochrome c oxidase genes that segregate with Alzheimer's disease (AD). The invention provides methods for detecting such...
21	6831086	Process for the inactivation of viruses with the aid of acridine derivatives The invention relates to the use of acridine or acridine derivatives, preferably in combination with benzalkonium chloride, for the inactivation of enveloped or nonenveloped viruses. The process...
22	6821983	5-(9-acridinylamino)-toluidine compounds This invention relates to 9-anilinoacridine compounds, and more particularly to their synthesis and their use in pharmaceutical compositions for treating diseases.
23	6803373	Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents A combination of 9,10-dihydro-5-methoxy-9-oxo-N-[4-[2-(1,2,3,4-tetrahydro-6,7 ,-dimethoxy-2-isoquinolinyl)ethyl]pheny]-4-acridinecarboxami de or a salt thereof and paclitaxel and its analogs or...
24	6743817	Substituted fused pyrroleimines and pyrazoleimines Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R 1 and R 2 are defined herein. These compounds are highly selective agonists,...
25	6683087	Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use Compounds of the general formula I and salts thereof with pharmaceutically acceptable acids or bases are disclosed as well as the use of such compounds for the manufacturing of pharmaceutical...
26	6680282	4-Quinolinol derivatives and agrohorticultural bactericides containing the same as active ingredient A new agricultural and horticultural fungicide having an excellent control effect is provided. 4-Quinolinol derivatives represented by the following formula: or agriculturally and...
27	6642222	Pyrano, piperidino, and thiopyrano compounds and methods of use The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder...
28	6630481	Viologen linked acridine based molecule and process for the preparation thereof The present invention provides a series of novel bifunctional molecules based on viologen linked acridine, bisacridine and bisacridinium salts of the general formula 1 (1a, 1b, 1c and 1d) and or...
29	6599535	Pharmaceutical compositions A pharmaceutical composition in the form of a solid dispersion comprising a macrolide, e.g. a rapamycin or an ascomycin, and a carrier medium.
30	6589961	9-alkylamino-1-nitroacridine derivatives The invention is directed to novel 9-hydroxyalkylamino-, 9-alkoxyalkylamino-1-nitroacridine derivatives. Methods of preparation, pharmaceutical compositions comprising said derivatives and their...
31	6541483	Acridone-derived compounds useful as antineoplastic and antiretroviral agents The present invention relates to several novel acridone-derived compounds of of formula (I) or (II). These compounds are potent anti-viral agents, useful in the treatment of viral diseases, such as...
32	6521635	Inhibition of MXR transport by acridine derivatives This invention provides methods that are useful for inhibiting a MXR transporter in a cell overexpressing a MXR gene but not overexpressing a Pgp gene by contacting the cell with an acridine...
33	6514988	Condensed-ring thiophene derivatives, their production and use A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or...
34	6514987	Frangible compounds for pathogen inactivation Compounds and methods for inactivating pathogens in materials are described, including compositions and methods for inactivating pathogens in biological materials such as red blood cell...
35	6486170	Phospholipase A2 inhibitors as mediators of gene expression A signaling pathway is identified that involves the activation of phospholipase A2 and protein kinase C in human cells, which in turn confers x-ray induction of the tumor necrosis factor α (TNF)...
36	6479504	Antagonism of immunostimulatory CpG-oligonucleotides by 4-aminoquinolines and other weak bases The present invention relates generally to the field of immunology. More particularly it concerns compositions and methods for inhibiting stimulation of the immune system. The compounds and methods...
37	6469047	Tyrosine derivatives The compounds of the invention are inhibitors of alpha4 containing integrin-mediated binding to ligands such as VCAM-1 and MAdCAM.
38	6420377	Covalent conjugates of topoisomerase I and topoisomerase II inhibitors The present invention provides covalent conjugates of topoisomerase I and topoisomerase II inhibitors. Such compounds have a structure according to formula I: T I —L—T II (I) wherein: T I ...
39	6413984	8-(heterocyclylmethyl)quinoline derivatives for treating urinary incontinence The invention concerns compounds of formula (I) wherein: A represents either a hydrogen atom or a hydroxyl group; B represents a pyrrolidin-2-yl (D) or 2-piperidyl (E), B capable of being...
40	6410219	Treating blood or blood products with compounds which have a mustard, azirdinium or aziridine group and a nucleic acid binding group Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for...
41	6303593	3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity The present invention is directed to pyrrolidine compounds of the formula I: ##STR1## (wherein R 1 , R 2 , R 3 , R 4c , R 4d , and R 4f are defined herein) which are useful as modulators of...
42	6281225	Inhibiting proliferation of arterial smooth muscle cells The present invention provides methods for inhibiting restenosis at a site of vascular recanalization. The methods include intravascular administration of a reactive acridine compound to the site...
43	6262081	Composition for and method of treating neurological disorders The invention relates to a method of treating neurological disorders associated with neurotransmitter deficit in a mammal comprising administering to the mammal a therapeutically effective amount...
44	6248750	9-hydroxyamino tetrahydroacridine and related compounds There are disclosed compounds having the formula ##STR1## wherein n is 1-4; X is hydrogen, loweralkyl, cycloalkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, formyl, loweralkylcarbonyl,...
45	6242459	Substituted bis-acridines and related compounds as CCR5 receptor ligands, anti-inflammatory agents and anti-viral agents This invention relates to substituted bis-acridines and related compounds which are ligands, in particular, antagonists of the CCR5 receptor. In addition, this invention relates to the treatment...
46	6221877	Substituted 4-phthalimidocarboxanilides as inhibitors of purine salvage phosphoribosyltransferases The use of certain heterocyclic derivatives for treating parasitic protozoa infections in mammals, in particular bovine trichomoniasis and giardiasis, is disclosed.
47	6214816	Heterocyclic compounds The compounds are N-substituted azaheterocyclic compounds of formula I ##STR1## wherein R 1 and R 2 independently are hydrogen, halogen, trifluoromethyl, hydroxy, C 1 -6 -alkyl or C 1 -6 -alkoxy;...
48	6194403	Tacrine derivatives for treating Alzheimer's disease A series of tacrine derivatives has be synthesized and disclosed. These tacrine derivatives were claimed to be new and be useful for the treatment of Alzheimer's disease alone or in combination...
49	6187787	Bis(9-aminoacridine) DNA intercalating agents having antitumor activity A series of bis-acridinyl DNA intercalating agents with anticancer cell activity represented by formula (I), where Z is a linear arrangement of multiple aromatic rings, containing at least three...
50	6177441	Treating red blood cell solutions with anti-viral agents Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for...

Matches 1 - 50 out of 185

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