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7462628 |
Preventives/remedies for urinary disturbance
Preventives/remedies for voiding disturbance containing a compound having both of an acetylcholinesterase inhibitory action and an α1 antagonistic action which exhibits an excellent effect of...
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7247642 |
Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment
The present invention relates to optically pure S-(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their...
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7186709 |
Dihydropyrancarboxamides and uses thereof
The present invention provides novel dihydropyrancarboxamide compounds of formula (I):
and collections of these compounds, and provides methods for the synthesis of these compounds; wherein R 1...
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7144913 |
Dihydropyrrolo[1,2-a]indole and tetrahydropyrido[1,2-a]-indole derivatives as prostaglandin d2 receptor antagonists
Dihydropyrroloindoles and tetrahydropyridoindoles are prostaglandin receptor antagonists useful for the treatment of prostaglandin-mediated diseases such as allergic rhinitis, nasal congestion and...
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7135480 |
Substituted 1-benzoyl-3-cyano-pyrrolo [1,2-a] quinolines and analogs as activators of caspases and inducers of apoptosis
The present invention is directed to substituted 1-benzoyl-3-cyano-pyrrolo[1,2-α]quinolines and analogs thereof, represented by the general Formula I:
wherein R 1 –R 8 , L, Q, dash line and...
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7122555 |
Pyrido [2,1-a] isoquinoline derivatives
The present invention provides compounds of formula (I)
wherein R 1 , R 2 , R 3 and R 4 are as indicated in the description, or a pharmaceutically acceptable salt thereof. The compounds are...
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7098219 |
Inhibitors of cellular efflux pumps of microbes
Compounds are described which are efflux pump inhibitors of cellular efflux pumps of microbes. Also described are methods of preparing such compounds, methods of using such efflux pump inhibitor...
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7034037 |
Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin
The present invention is directed to medical devices and pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the...
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6962925 |
Benzo(C)quinolizine derivatives and their use as 5α-reductases inhibitors
A fully and partially reduced benzo(c)quinolizine compound of formula (1):
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6930114 |
Pyrrolo (2.1a)dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors
The present invention relates to pyrrolo[2.1-a]dihydroisoquinolines which are inhibitors of phosphodiesterase 10a and can be used for combating cancer.
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6914066 |
1,2-annelated quinoline derivatives
This invention concerns compounds of formula
the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein ═X 1 —X 2 —X 3 — is a...
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6897222 |
Pyrido[2,1-a]isoquinoline derivatives
The present invention provides compounds of formula (I):
wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the specification, and pharmaceutically acceptable salts thereof. The...
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6884433 |
Sustained release formulation containing tacrolimus
Sustained release formulation containing tacrolimus or its hydrate is provided. The time (T63.2%) required for 63.2% of the maximum amount of tacrolimus or its hydrate to be dissolved is 0.7 to 15...
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6858613 |
Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease
The invention provides compounds of Formula I:
These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful...
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6849644 |
Isoquinoline derivatives useful in the treatment of CNS disorders
The invention relates to novel tetrahydroquinoline compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of...
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6841557 |
Compounds for the treatment of addictive disorders
The treatment of addictive disorders, psychoactive substance use disorders, intoxication disorders, inhalation disorders, alcohol addiction, tobacco addiction, and nicotine addiction using a...
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6828328 |
Analgesic combination of muscarinic agonists
This invention relates to the combination of muscarinic agonists with narcotic analgesics, non-steroidal anti-inflammatory drugs or other analgesic drugs and to their use as antinociception (pain...
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6815450 |
Axon regeneration with PKC inhibitors
Regenerative growth of an adult mammalian central nervous system neuron axon subject to growth inhibition by endogenous, myelin growth repulsion factors is promoted by delivering to the axon a...
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6753333 |
Chiral fluoroquinolone arginine salt forms
The invention relates to the new arginine salt forms of S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-m
ethyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, a process for their...
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6727261 |
Pyrido&lsqb 2,1-A&rsqb Isoquinoline derivatives
The present invention provides compounds of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the specification, and pharmaceutically acceptable salts thereof. The...
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6696462 |
Anticholinergics, processes for the preparation thereof, and pharmaceutical compositions
A compound of formula 1 wherein: X - is an anion with a single negative charge; A and B, which are identical or different, are each —O—, —S—, —NH—, —CH 2 —, —CH═CH—, or...
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6664267 |
Crystalline fluoroquinolone arginine salt form
The invention relates to the new arginine salt forms of RS-(±)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-m
ethyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid,...
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6664266 |
Axon regeneration with PKC inhibitiors
Regenerative growth of an adult mammalian central nervous system neuron axon subject to growth inhibition by endogenous, myelin growth repulsion factors is promoted by delivering to the axon a...
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6630482 |
CFTR channel activator compounds and pharmaceutical compositions containing same
CFTR channel activator compounds from the benzo[c]quinolizinium family or families of compounds derived therefrom, as well as pharmaceutical compositions containing said compounds, and the uses...
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6624159 |
Heterocycle carboxamides as antiviral agents
The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
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6610685 |
Fused indole derivatives
The present invention is a chemical compound of formula (I) or a pharmaceutically acceptable salt, solvate and ester thereof, wherein R 1 to R 4 and n are as defined in the specification. A...
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6608078 |
Antibacterial chiral 8-(substituted piperidino)-benzo &lsqb i,j&rsqb quinolizines, processes, compositions and methods of treatment
The present invention relates to optically pure 8-(substituted piperidino)-benzo[i,j]quinolizines, their isomers, derivatives, salts, pseudopolymorphs, polymorphs prodrugs and hydrates thereof, to...
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6602868 |
Treatments for restless legs syndrome
The invention provides methods and use of heterocyclic amines, and phenylazacycloalkane compounds, and their pharmacologically acceptable salts for the treatment of Restless Legs Syndrome (RLS).
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6576259 |
Sustained release formulations containing tacrolimus
Sustained release formulation containing tacrolimus or its hydrate is provided. The time (T63.2%) required for 63.2% of the maximum amount of tacrolimus or its hydrate to be dissolved is 0.7 to 15...
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6555550 |
Musarinic agonists and antagonists
The present invention provides novel compounds and pharmaceutical compositions thereof useful in the treatment of pain. The compounds of the present invention are azaadamantanes, azanoradamantanes...
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6555549 |
Benzo&lsqb C&rsqb quinolizine derivatives, their preparation and use as 5α-reductases inhibitors
The present invention refers to benzo[c]quinolizine derivatives of general formula (I) their pharmaceutically acceptable salts or esters, processes for their preparation and pharmaceutical...
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6552035 |
Composition for inducing smoking cessation comprising alkaloids from Radix ipecauanhae
This invention relates to a composition for inducing smoking cessation comprising as active ingredient alkaloids from Radix ipecauanhae. In smoking cessation program using the composition, the...
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6552034 |
Benzo&lsqb c&rsqb quinolizine derivatives, their preparation and use as 5α-reductases inhibitors
The present invention refers to benzo[c]quinolizine derivatives of general formula (I) their pharmaceutically acceptable salts or esters, processes for their preparation and pharmaceutical...
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6514912 |
Use of benzo&lsqb C&rsqb quinolizine derivatives as plant growth regulators
Disclosed are compositions of benzo(c)quinolizine derivatives and methods for promoting plant and seed growth. The compounds are benzo[c]quinolizine derivatives which exert an inhibiting effect on...
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6468998 |
Pyrrolidine compounds and medicinal utilization thereof
The present invention provides a pyrrolidine compound of the formula (I) wherein each symbol is as defined in the specification, an optically active compound thereof and a pharmaceutically...
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6455032 |
Composition and method for protecting skin from UV induced immunosuppression and skin damage
Compositions and a method of protecting skin from either UV-induced immunosuppression or from UV-induced skin damage using a composition containing an extract of soy or clover, and/or the...
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6448258 |
Treating fibromyalgia and chronic fatigue syndrome
The present invention provides for methods for the treatment of fibromyalgia syndrome or chronic fatigue syndrome by the administration of heterocyclic amine-type compounds or a salt of any said...
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6440458 |
Sustained release preparations
Providing an oral formulation of a macrolide compound where the dissolution of the macrolide compound is under sustained release; and a sustained-release formulation containing a composition in...
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6436954 |
Benzoquinolizidine and benzoindolizidine derivatives and therapeutic uses thereof
Benzo[b]quinolizidine and benzo[f]indolizidine derivatives are provided which are useful for the treatment of Alzheimer's disease, senile dementia or other conditions characterized by memory loss....
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6417220 |
Mitochondrial membrane stabilizer
A prophylactic and/or therapeutic method for treating a disease caused by mitochondrial functional abnormality, or a disease with mitochondrial functional abnormality, including: administering a...
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6376507 |
NK-1 receptor antagonists for the treatment of neuronal injury and stroke
The present invention relates to a method of treating or preventing a disorder selected from stroke, epilepsy, head trauma, spinal cord trauma, ischemic neuronal damage such as cerebral ischemic...
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6346537 |
Medicinal composition
To provide a pharmaceutical composition comprising a water-insoluble active substance, surfactant(s) and solid carrier(s), which is improved in dissolution and oral absorption characteristics.
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6303622 |
Benzo[c]quinolizine derivatives, their preparation and use as 5α-reductases inhibitors
The present invention refers to benzo[c]quinolizine derivatives of general formula (I) ##STR1## their pharmaceutically acceptable salts or esters, processes for their preparation and pharmaceutical...
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6242450 |
5-HT1F antagonists
This invention provides 5-HT 1f antagonists of Formula I: ##STR1## where AR 1 , AR 2 , R, and R' are as defined in the specification.
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6211189 |
Amino-spiro-quinazoline compounds
There are provided novel compounds of formula (I) ##STR1## wherein A represents an aromatic carbocyclic ring or a 5- or 6-membered heterocyclic aromatic ring containing 1 to 3 heteroatoms which may...
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6187786 |
Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
This invention concerns compounds of formula ##STR1## the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein the dotted line represents an...
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6136806 |
Remedy for rosacea
A rosacea treating agent is provided, which is effective even on intractable rosacea which cannot be cured completely by antibiotics such as minocycline, has low toxicity, causes little side...
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6114370 |
Amnesic sedation composition and method of administering same
This invention relates to a pharmaceutical amnesic sedation composition for administering to a subject comprising an effective of: (i) a benzodiazepine derivative, (ii) a phenanthrene derivative,...
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6103736 |
Fused imidazo[1,2-a]pyridines
Compounds of the formula: ##STR1## which are useful as anti-ulcer agent are provided.
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6080754 |
Pyrrolo[2,1,5-cd]indolizine derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
The present invention relates to therapeutically active compounds of formula I ##STR1## a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel...
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