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7618980 |
Pyrrolo(oxo)quinolines as 5HT ligands
The present application provides pyrrolo(oxo)isoquinolines as modulators of serotonin receptors, pharmaceutical compositions containing such modulators and methods for treating various diseases,...
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7612083 |
Urea substituted imidazoquinoline ethers
Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and urea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the...
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7608643 |
Compounds for inhibiting KSP kinesin activity
The present invention relates to compounds of Formula I or pharmaceutically acceptable salts or solvates thereof:
The present invention provides compositions comprising these compounds that are...
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7608625 |
Method for treating bruxism and bruxism-related diseases
The present invention provides a preventive or therapeutic agent for bruxism or bruxism-related diseases that contains as an active ingredient at least one selected from the group consisting of...
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7601840 |
Carboline derivatives useful in the inhibition of angiogenesis
In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the...
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7601734 |
Cyclic amine compound
An object of the present invention is to provide a cyclic amine compound which has a potent inhibitory effect on the binding of α2C-adrenoceptor and is useful in preventing and treating disorders...
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7592454 |
Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists
The present application provides novel compounds according to Formula (I):
including all stereoisomers, solvates, prodrug esters and pharmaceutically acceptable salt forms thereof, wherein R 1...
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7572805 |
Pyrrolo(oxo)isoquinolines as 5HT ligands
The present application describes compounds according to Formula I, pharmaceutical compositions, comprising at least one compound according to Formula I and optionally at least one additional...
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7501436 |
5-HT3 receptor antagonists and methods of use
The subject invention provides useful and novel 5-HT3 antagonists. The subject invention also provides methods for synthesizing the compounds of invention. The invention also provides methods for...
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7470704 |
Benzonaphthyridines
The compounds of formula I
in which R1, R2, R3, R4, R5, R6 and n have the meanings as indicated in the description, are novel effective PDE3/4 inhibitors.
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7465438 |
Solubilizing agents/solvents for organic UV filters
The invention relates to the use of compounds of the general formula (I)
wherein
R, R′=H, C 1-5 -hydrocarbon radical, —O—C 1-5 -oxyhydrocarbon radical and are identical or different, R 1...
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7449476 |
Tetrahydrocarboline antiviral agents
The invention encompasses a series of tetrahydrocarboline compounds of Formula I which inhibit HIV entry by attaching to the exterior viral envelop protein gp120 and interrupting the viral entry...
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7439253 |
Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
The invention relates to novel heterocyclic compounds of general formula (I), and their salts with a base or an acid:
The invention also relates to a method for preparing these compounds, and to...
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7419985 |
4-Phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
Compounds are provided that, by way of their selective neurotransmitter binding useful for the treatment of various neurological and psychological disorders, e.g., ADHD. Such compounds are 4-phenyl...
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7408064 |
Carbazole derivatives and their use as NPY5 receptor antagonists
The use of a compound of formula (I) in the manufacture of a medicament for the treatment, in a warm-blooded animal, of disorders mediated by the neuropeptide Y5 receptor:
wherein:
R 1 ,...
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7390818 |
Pyridoindolone derivatives substituted in the 3-position by a phenyl, their preparation and their application in therapeutics
The present invention relates to pyridoindolone derivatives substituted in the 3-position by a phenyl of general formula (I):
to processes for preparing the same and to their use in therapeutics.
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7348336 |
Substituted β-carbolines
The subject matter of the present invention is directed to novel substituted β-carbolines, and specifically compounds of the formula I,
which are suitable for the production of pharmaceuticals...
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7323473 |
Condensed indoline derivatives and their use as 5-HT, in particular 5-HT2C, receptor ligands
A chemical compound of formula (I) wherein R 1 and R 2 are independently selected from hydrogen and alkyl; R 3 is alkyl; R 4 and R 5 are selected from hydrogen and alkyl; R 6 and R 7 are...
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7320986 |
Fused tri and tetra-cyclic pyrazole kinase inhibitors
Compounds having the formula (I)
are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment...
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7317020 |
Isolation and structure of Cribrostatin 6
Cribrostatin 6, a dark blue cancer cell growth inhibiting constituent of the Republic of Maldives marine sponge Cribrochalina sp. has been isolated, and its structure (shown below) elucidated,...
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7288549 |
Heterocyclic compounds, method for preparing same and use thereof as medicines, in particular as antibacterial agents
The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid:
The invention also relates to a process for the preparation of these...
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7276514 |
Pyrroloquinoline quinone drugs for treatment of cardiac injury and methods of use thereof
The invention includes composition comprising substantially purified pyrroloquinoline quinone, that are useful in methods for the treatment and prevention of cardiac injury caused by hypoxia or...
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7273885 |
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life...
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7253180 |
Pre-organized tricyclic integrase inhibitor compounds
Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
A 1 and A 2 are moieties forming a five, six,...
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7247641 |
Compounds, derivatives, compositions, preparation and uses
This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
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7235557 |
Compounds and their uses
This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
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7232831 |
Tetrahydro-β-carboline compounds and use thereof
Tetrahydro-β-carboline compounds represented by the following formulae:
wherein x, y and z are each independently an integer of 0 to 4 and R is selected from the group consisting of H, alkyl,...
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7176213 |
Imidazoquinoline derivatives and their use as adenosine A3 ligands
The present invention relates to adenosine A 3 receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the...
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7160895 |
Use of pyridoindolone derivatives for the preparation of medicinal products
The invention relates to a novel use of compounds of formula:
for the preparation of medicinal products that are useful as anticancer agents.
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7160894 |
Tricyclic compound
A novel compound represented by the formula (1):
[R 1 represents hydrogen atom, chlorine atom, or hydroxyl group; X 1 . . . X 2 represents—CH(R 2 )—CH(R 3 )—, —CH(R 2 )—CH(R 3...
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7132428 |
Pyrazoloisoquinoline derivative as kinase inhibitors for the treatment of various disorders
Compounds of the formula I
are suitable for producing pharmaceuticals for the prophylaxis and therapy of diseases whose course involves an increased activity of NIK.
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7125886 |
5-HT3 receptor antagonists and methods of use
The subject invention provides useful and novel 5-HT3 antagonists. The subject invention also provides methods for synthesizing the compounds of invention. The invention also provides methods for...
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7122554 |
Carboline derivatives
Compounds of the general structural formula
and use of the compounds and salts and solvates thereof, as therapeutic agents.
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7115621 |
Chemical compounds
Compounds of general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents as inhibitors of phosphodiesterase 5 cardiovascular disorders
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7105531 |
Tricyclic protein kinase inhibitors
This invention provides compounds of formula 1, having the structure
which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.
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7098219 |
Inhibitors of cellular efflux pumps of microbes
Compounds are described which are efflux pump inhibitors of cellular efflux pumps of microbes. Also described are methods of preparing such compounds, methods of using such efflux pump inhibitor...
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7087620 |
Liquid pharmaceutical formulations containing 3,7-diazabicyclo[3,3,1]nonane compounds and methods of treatment relating to anti-arrhythmic events
The present invention relates to the use of 3,7-diazabicyclo[3,3,1]nonane compounds, preferably of 9,9-alkylene-3,7-diazabicyclo[3,3,1]nonane compounds, and most preferably to the use of tedisamil,...
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7084154 |
2-(aminomethyl) arylamide analgesics
A chemical genus of 2-(aminomethyl)arylamides, which are useful as analgesics, is disclosed. The genus is represented by the formula I:
A representative example is:
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7084152 |
4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof
Compounds are provided that, by way of their selective neurotransmitter binding useful for the treatment of various neurological and psychological disorders, e.g., ADHD. Such compounds are 4-phenyl...
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7071206 |
Agents for treating neurodegenerative disorders
Compounds and methods of using these compounds to treat neurodegenerative diseases, especially Alzheimer's disease, are provided. The compounds that are provided for the treatment of...
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7037919 |
Tetrahydroquinoline derivatives
Tetrahydroquinoline derivatives of general formula (I) or salts thereof, having a specific and strong binding affinity for AR and exhibiting AR agonism or antagonism; and pharmaceutical...
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7030129 |
Method of reducing and treating UVB-induced immunosuppression
Methods of preventing and/or treating UV-induced immunosuppression by administration of immune response modifier compounds are disclosed herein. Suitable immune response modifier compounds include...
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7026331 |
Substituted beta-carbolines
The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I,
which are suitable for the production of...
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6998409 |
Substituted 2-pyridine cyclohexane-1,4-diamine compounds
Substituted 2-pyridine cyclohexane-1,4-diamine compounds, a method for their production, pharmaceutical compositions containing them, and the use of such substituted 2-pyridine...
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6989388 |
Thieno[2,3-c]iosquinolines for use as inhibitors of PARP
The present invention relates to compounds for the inhibition of poly(ADP-ribose) polymerase (PARP). In some embodiments, the compounds have the Formula:
wherein the constituent variables are...
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6987115 |
Antibacterial compounds
Compounds of the formula (I) are disclosed and are useful in the treatment bacterial infections:
wherein:
R 1 is Ar or Het; R 2 is C 1-6 alkyl, (R″) 2 N—(CH 2 ) m — or Ar—C 0-6...
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6984646 |
Imidazopyridinones as p38 map kinase inhibitors
The invention relates to imidazopyridinones of the formula
wherein the groups R 1 , R 2 , R 3 , and R 4 are as defined in claim 1, to the process for their preparation, to pharmaceutical...
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6969721 |
Tricyclic-2-pyridone compounds useful as HIV reverse transcriptase inhibitors
The present invention relates to tricyclic 2-pyridone compounds of formula (I):
or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are...
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6967215 |
Tetrahydrocarbazoles, a process for the preparation of those compounds, and the use thereof
Tetrahydrocarbazoles of formula
where Q is —SO 2 —; —O—; or —(CO)—; X is —(CH)—; or —N—; m is from 1 to 3; t is 0 or 1 and the remaining substituents are as defined herein,...
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6967205 |
Compounds with antibacterial and antiparasitic properties
There are provided novel compounds which have both antibacterial and antiparasitic properties, thereby reducing the need for using several compounds in combined antibacterial and antiparasitic...
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