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7608643 |
Compounds for inhibiting KSP kinesin activity
The present invention relates to compounds of Formula I or pharmaceutically acceptable salts or solvates thereof:
The present invention provides compositions comprising these compounds that are...
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7592453 |
Fused quinoline derivative and use thereof
The present invention aims at provision of a quinoline derivative having a neurokinin 2 (NK2) receptor antagonistic action and relates to a compound represented by the formula (I)
wherein R 1 ...
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7589205 |
3-thia-10-aza-phenanthrene derivatives
The compounds of formula I
in which A, R1, R2 and R3 have the meanings as given in the description, are novel effective PDE4 inhibitors.
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7589083 |
Compounds and compositions to control abnormal cell growth
A class of compounds commonly containing a trialkylammonium group have been synthesized and characterized as anticancer compounds. A representative of this class,...
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7585871 |
Phenanthridine carbonyl phenols
The present invention relates generally to phenanthridine carbonyl compositions such as substituted phenanthridine carbonyl phenols of Formula 1:
wherein R 1 to R 15 are as defined in the...
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7566710 |
Dual molecules containing a peroxide derivative, synthesis and therapeutic applications thereof
The invention relates to dual molecules formed from coupling products complying with the formula
wherein A represents a residue of molecule with anti-malarial activity, Y 1 and Y 2 ,...
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7547731 |
Formamide derivatives for the treatment of diseases
The invention relates to compounds of formula (1)
and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives....
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7544696 |
Spermicidal and/or antifungal composition and methods of using the same
Hexahydroindenopyridine compounds are provided which act as spermicides and/or fungicides, spermicidal and/or fungicidal compositions containing the same, and methods for killing motile sperm...
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7541365 |
Chemokine receptor antagonists and methods of use therefor
Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an...
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7528144 |
Molecules and methods for fluorescence microscopy
The present invention provides molecules and methods for fluorescent microscopy and visualization of biomolecules, such as cholesterol. In a preferred embodiment, the present invention provides a...
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7456193 |
Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
The present invention relates to pyridoindolone derivatives substituted in the 3-position by a heterocyclic group of general formula (I):
in which:
R 1 represents a hydrogen atom or a...
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7408063 |
1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors
This invention comprises the novel compounds of formula (I)
wherein r, s, A, X, Y 1 , Y 2 , R 1 , R 2 , R 3 , and R 4 have defined meanings, having farnesyl transferase inhibiting activity;...
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7405223 |
Treating allergic and inflammatory conditions
A method of treating and/or preventing allergic and inflammatory conditions of the skin or upper and lower airway passages, e.g. seasonal allergic rhinitis, perennial allergic rhinitis, or chronic...
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7399768 |
Quinoline derivatives
The present invention relates to novel benzo [g] quinoline derivatives, their preparation, their use as pharmaceuticals for use in the treatment of glaucoma and myopia.
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7390817 |
Combinations of a vanilloid antagonist and an NSAID for the treatment of pain
A method of treating conditions associated with pain and alleviating the symptoms associated therewith which comprises administering to a mammal, including man, a vanilloid VR-1 antagonist or a...
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7384942 |
Pyrazine based inhibitors of glycogen synthase kinase 3
New bicyclic based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The...
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7351711 |
Tricyclic indanyls as integrin inhibitors
The present invention is directed to substituted indanyl compounds of Formula (I):
Useful for treating integrin-mediated disorders such as, but not limited to unstable angina, thromboemboic...
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7307083 |
Tetrahydro-acridine and dithiolane derivatives
Compounds identified by the general formula (I) are used for the treatment of Alzheimer's disease
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7300941 |
Non-imidazole compounds
Disclosed are novel compounds of the formula
Also disclosed are pharmaceutical compositions comprising the compounds of Formula I. Also disclosed are methods of treating various diseases or...
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7300930 |
Therapeutic acridone and acridine compounds
The present invention pertains to acridone and acridine compounds of formula (I), wherein either: (a) K is ═O, L is —H, alpha is a single bond, beta is a double bond, gamma is a single bond...
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7291629 |
Neurotrophin antagonist compositions
A pharmaceutical composition comprising a compound of Formula I
wherein R 1 is selected from, inter alia, alkyl, aryl-loweralkyl, heterocycle-loweralkyl, loweralkyl-carbonate; optionally...
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7271174 |
Metabolites of tricyclic amides useful for inhibition of G-protein function and methods of treatment of proliferative diseases
The present invention relates to metabolites of tricyclic amides, and structurally related compounds, represented by the structural formula (I):
and pharmaceutically acceptable isomers,...
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7223771 |
Tricyclic imidazopyridines
The invention provides compounds of the formula (I), in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid.
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7214684 |
Methods for the treatment of allergic rhinitis
Methods are disclosed utilizing DCL, a metabolic derivative of loratadine, for the treatment of allergic rhinitis, and other disorders, while avoiding the concomitant liability of adverse...
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7214683 |
Compositions of descarboethoxyloratadine
Methods are disclosed utilizing DCL, a metabolic derivative of loratadine, for the treatment of allergic rhinitis, and other disorders, while avoiding the concomitant liability of adverse...
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7211582 |
Methods for treating urticaria using descarboethoxyloratadine
Methods are disclosed utilizing DCL, a metabolic derivative of loratadine, for the treatment of allergic rhinitis, and other disorders, while avoiding the concomitant liability of adverse...
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7192967 |
Cyclic imide-substituted pyridylalkane, alkene, alkine carboxamides useful as cytostatic and immunosuppressive agents
The invention relates to new pyridylalkane, alkene, and alkine carboxamides substituted with an imide with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid...
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7166612 |
Methods for reducing platelet activation platelet aggregaton or thrombosis
The invention provides methods and compositions for reducing platelet activation, platelet aggregation and thrombosis. The invention further provides compositions and methods for treating or...
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7157079 |
Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
In one embodiment, this invention provides methods of treating mammalian cancer or hyperproliferative cells, said method comprising contacting said cells with a tumor suppressor protein or tumor...
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7122534 |
Aryl fused azapolycyclic compounds
The present invention relates to compounds of formula (I)
and their pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 and Z are as defined herein, intermediates in the synthesis of...
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7115620 |
1,3-disubstituted-2-thioxo-imidazolidine-4,5-diones as potassium channel openers
Compounds of Formula I are provided:
wherein:
R is lower alkyl or branched lower alkyl; and Ar is phenyl, phenyl substituted with one or more of halogen, lower alkyl, lower alkoxy, lower...
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7101572 |
Taste masked aqueous liquid pharmaceutical composition
A substantially taste masked liquid pharmaceutical composition containing a pharmaceutically effective amount of an unpleasant tasting drug dissolved or dispersed in an aqueous excipient base, said...
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7087106 |
Materials and methods for inhibiting fouling of surfaces exposed to aquatic environments
The subject invention provides materials and methods for inhibiting the biofouling of surfaces exposed to aquatic environments. In one embodiment, the subject invention provides additives for...
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7081464 |
Topical compositions of cyclic amides as immunotherapeutic agents
Novel amides and imides are inhibitors of tumor necrosis factorα and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory...
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7037919 |
Tetrahydroquinoline derivatives
Tetrahydroquinoline derivatives of general formula (I) or salts thereof, having a specific and strong binding affinity for AR and exhibiting AR agonism or antagonism; and pharmaceutical...
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7034037 |
Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin
The present invention is directed to medical devices and pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the...
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6998405 |
Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use
Compounds of the general formula I
wherein rings B, C, D and E may be present or not and, when present, are combined with A as A+C, A+E, A+B+C, A+B+D, A+B+E, A+C+E, A+B+C+D or A+B+C+D+E, rings...
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6962924 |
Salt and polymorphs of desloratadine hemifumarate
This invention provides a process of preparation of novel polymorphic hemifumarate salts of 8-chloro-6,11-dihyfro-11-(4-piperidylidene)-5H-benzo[5,6]-cy
clohepta[1,2-b]pyridine, hereinafter called...
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6960586 |
Imidazole derivatives, process for their preparation and their use
The present invention provides a compound having a steroid C 17,20 -lyase inhibitory activity, which is useful as a prophylactic or therapeutic agent of prostatism and tumor such as breast cancer...
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6958328 |
Arylindenopyridines and related therapeutic and prophylactic methods
This invention provides novel arylindenopyridines of the formula:
, and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by reducing PDE activity in...
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6953791 |
Dipeptide derivatives
This invention is directed to compounds of the formula
and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone...
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6939550 |
Stabilized antihistamine syrup
An antihistaminic syrup is stabilized against degradation of the active ingredient, by the addition of and about 0.05 to about 5 mg/mL of an aminopolycarboxylic acid such as a salt of...
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6930104 |
Heterocyclic derivatives
The object of the present invention is to provide soluble β-amyloid precursor protein secretory stimulators, which are effective in treating neurodegenerative diseases as well as cerebrovascular...
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6894059 |
Compounds and methods for treatment of asthma, allergy and inflammatory disorders
The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting...
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6887883 |
Use of natural chrysanthone compounds having antiangiogenic activity
A series of compounds of natural origin are described, as useful agents for the treatment of diseases characterised by abnormal angiogenesis. These compounds are: chrysanthone A having formula (I);...
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6878388 |
Vanadium compounds for treating proliferative cell disorders
Vanadium compounds useful to prevent and/or inhibit adhesion, migration, and invasion of proliferative cells into surrounding tissue.
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6852741 |
Compositions and methods for treatment of neurological disorders
The present invention concerns methods for treating or preventing neurological disorders characterized by dysfunction of nicotinic acetylcholine receptors by co-administration of metanicotine and...
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6844344 |
Benzofuran derivatives
The present invention provides compounds of formula (I) which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of...
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6841557 |
Compounds for the treatment of addictive disorders
The treatment of addictive disorders, psychoactive substance use disorders, intoxication disorders, inhalation disorders, alcohol addiction, tobacco addiction, and nicotine addiction using a...
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6835733 |
Tropane linked benzofuran derivatives
The present invention provides compounds of formula (I) which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of...
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