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7608596 |
10-substituted macrolide antibiotics
Disclosed herein are 10-desmethyl, 10 substituted-macrolides, their preparation, pharmaceutical compositions containing them, their use and methods of treatment using them. The 10-desmethyl...
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7601695 |
Antibacterial agents
Described herein are novel macrolides, the preparation of novel macrolides, to the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel...
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7595300 |
7-quinolyl ketolide antibacterial agents
15-fluoroketolides of the formula
having improved activity and safety, compositions comprising them, and methods for their preparation and use in the treatment of bacterial infections.
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7589067 |
6, 11-bridged tricyclic macrolides
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which exhibit antibacterial properties. The present invention further...
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7582611 |
Motilide compounds
Compounds having a structure according to formula (I)
where R A , R B , R C , R D , R E , and R F are as defined herein, are useful as prokinetic agents.
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7579324 |
Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
This invention features a compound of the following formula:
T-(-L-C) m ,
T...
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7572773 |
Single dose fast dissolving azithromycin
The present disclosure related to a method of treating an infection by oral administration of a single dose of a fast dissolving form of azithromycin. The disclosure also relates to a method of...
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7569550 |
14 and 15 membered ring compounds
The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I)
and pharmaceutically acceptable derivatives thereof, to processes for their...
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7569549 |
Isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A
Substantially pure isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A having the Formula I:
wherein S is an organic solvent which is at least partially miscible...
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7563773 |
Anthelmintic oral homogeneous veterinary pastes
This invention provides for, inter alia, oral homogeneous veterinary pastes for the treating, controlling and preventing of endo- and ectoparasite infections in warm-blooded animals or birds, such...
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7547679 |
Ether linked macrolides useful for the treatment of microbial infections
The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I)
and pharmaceutically acceptable derivatives thereof, to processes for their...
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7524823 |
Macrolides
The present invention relates to new antibiotic macrolide compounds of the general formula I:
with improved activity, to medicaments comprising such antibiotics, and to the use of such...
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7521428 |
Macrolide derivatives having effect of potentiating antifungal activity
Macrolide derivatives having enhancing effect for activities of azole antifungal agents, acting at low concentration and within a short time against fungal infection and reducing the frequency of...
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7517859 |
Spirocyclic bicyclolides
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which exhibit antibacterial properties. The present invention further...
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7507721 |
Macrolides with antiinflammatory activity
Macrolide compounds of formula (I) wherein X, R, R 1 , R 2 , R 3 and R 4 , have the meanings as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions...
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7462600 |
Macrolides
Macrolide compounds per se, as shown below and defined herein, and their use, e.g., as antibacterial and antiprotozoal agents in animals, including humans:
Also disclosed are methods of...
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7446097 |
Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy
The present invention relates to novel compounds represented by the structure I and pharmaceutical preparations thereof for the treatment of inflammatory diseases in humans and animals.
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7438924 |
Dry granulated formulations of azithromycin
This invention relates to a pharmaceutical formulation, in the form of a tablet, sachet or powder for suspension dosage form, which comprises dry granulated particles of a non-dihydrate form of...
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RE40546 |
1,3-Propane diol esters and ethers and methods for their use in drug delivery
The invention relates to compounds of formula:
wherein R 1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon...
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7419961 |
9a-azalides with anti-inflammatory activity
Macrolides with anti-inflammatory activity are described. Particularly described are 9a-azalides and their anti-inflammatory activity without cladinose in position 3, the pharmaceutically...
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7414030 |
6-11 Bicyclic erythromycin derivatives
The present invention discloses compounds of formulaes I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof:
which exhibit antibacterial properties. The...
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7410952 |
Derivatives of azithromycin
The invention relates to derivatives of azithromycin, processes for the manufacture thereof and pharmaceutical compositions thereof preferably together with azithromycin.
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7407942 |
3,6-bridged 9,12-oxolides
The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which exhibit antibacterial properties. The present invention further...
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7407941 |
N-desmethyl-N-substituted-11-deoxyerythromycin compounds
Compounds having the structure of formula I
wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein, are prokinetic agents and can be used to treat disorders of gastric motility.
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7402568 |
Bicyclic 9a-azalide derivatives
The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which exhibit antibacterial properties. The present invention...
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7384922 |
6-11 bridged oxime erythromycin derivatives
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which exhibit antibacterial properties. The present invention further...
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7384921 |
Polymorphic forms of 6-11 bicyclic ketolide derivatives
The present invention includes EP-13420 polymorphic crystalline forms: Form I, Form II, Form Ia, and monohydrate and amorphous EP-13420 which posses distinct physical properties. In another...
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7365056 |
Substituted 9a-N-(N′-(sulfonyl)phenylcarbamoyl)derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerithomycin A and 5-0-desosaminyl-9-deoxo-9-dihydro-9-a-aza-9a-homoerithronolide A
The invention relates to substituted 9a-N-{N′-[4-(sulfonyl)phenyl]carbamoyl} derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin A and...
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7358232 |
Method for the antibiotic coating of bodies with interconnecting microcavities as well as coated bodies and their usage
The invention relates to a method for the antibiotic coating of bodies with interconnecting microcavities as well as bodies coated this way and their usage. The invented method is characterized in...
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7351696 |
Compounds
The present invention relates to compounds of formula (I)
and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of...
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7342000 |
Semisynthetic macrolide antibiotics of the azalide series
The invention relates to N″-substituted 9a-N-(N′-carbamoyl-γ-aminopropyl), 9a-N-(N′-thiocarbamoyl-γ-aminopropyl), 9a-N-[N′-β-cyanoethyl)-N′-carbamoyl-γ-aminopropyl] and...
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7332476 |
Pyridyl substituted ketolide antibiotics
Antimicrobial macrolide and ketolide compounds are provided having formulas XII:
as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising...
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7312201 |
Tetracyclic bicyclolides
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which exhibit antibacterial properties. The present invention further...
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7297682 |
Diphosphate salt of a 4″—substituted-9-deoxo-9 A—AZA—homoerythromycin derivatives and its pharmaceutical composition
This invention relates to a novel crystalline diphosphate salt of...
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7291602 |
11,12-lactone bicyclolides
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which exhibit antibacterial properties. The present invention further...
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7276487 |
9a, 11-3C-bicyclic 9a-azalide derivatives
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which exhibit antibacterial properties. The present invention further...
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7273853 |
6-11 bicyclic ketolide derivatives
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which exhibit antibacterial properties. The present invention further...
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7271155 |
9A, 11-2C-bicyclic 9a-azalide derivatives
The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which exhibit antibacterial properties. The present invention...
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7271154 |
Antibiotic conjugates
This invention features a compound of the following formula:
wherein T is a transportophore, L is a bond or linker, and C is an antibiotic therapeutic agent, the transportophore is covalently...
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RE39836 |
Macrolide antinfective agents
Compounds of the formula
wherein
R a is H; substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C); substituted or unsubstituted alkynyl (2-10C);...
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7265094 |
9N-substituted 6-11 bicyclic erythromycin derivatives
The present invention discloses compounds of formula I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof:
which exhibit antibacterial properties. The...
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7262172 |
Macrolides
The invention relates to novel semi-synthetic macrolides of formula (I) having antibacterial activity. More particularly this invention relates to derivatives of 8a-aza-8a-homoerythromycin A, to...
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RE39743 |
2-halogenated derivatives of 5-0 desosaminyl-erythronolide a, their preparation process and their antibiotic use
Novel compounds of the formula
wherein the substituents are defined as in the application having antibiotic properties.
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7241746 |
Method and composition for treating periodontal disease
The present invention is directed to a pharmaceutical composition comprising a therapeutically effective amount of misoprostol and an effective amount of an antibiotic. A suitable antibiotic is...
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7241741 |
Methods and compositions for the treatment of asthma and related disorders
The present invention provides methods for the treatment of respiratory tract mucositis in individuals in need of such treatment, the method comprising the systemic administration to the individual...
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7229972 |
3,6-Bicyclolides
The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which exhibit antibacterial properties. The present invention further...
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7211568 |
9-Desoxoerythromycin compounds as prokinetic agents
9-Desoxoerythromycin compounds of formula I
wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein, are useful as prokinetic agents for treating disorders of gastric motility.
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RE39591 |
6-O-substituted ketolides having antibacterial activity
Antimicrobial compounds having the formula
as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating...
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7189704 |
6-11 bicyclic ketolide derivatives
The present invention discloses, inter alia, a compound of the following formula, or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which exhibit antibacterial properties. The...
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7189703 |
Treatment and diagnosis of alzheimer's disease
The invention relates to a method of treating Alzheimer's disease in a mammal comprising administering to the mammal an anti-microbial agent having anti- Chlamydia pneumoniae activity. The...
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