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8173142 |
Pharmaceutical compositions of drugs and neutralized acidic polymers
Pharmaceutical compositions comprised of low-solubility and/or acid-sensitive drugs and neutralized acidic polymers are disclosed.
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8173609 |
Macrolides useful against inflammatory and allergic diseases
New macrolide general compounds of formula I with improved activity making them useful for inhibiting human phosphodiesterase 4 and treating chronic obstructive pulmonary disease (COPD).
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8148337 |
Vaginal compositions for treating pelvic tissue infections and traumas
A method of treatment for a pelvic tissue infection by vaginally administering an antibiotic and a prostaglandin to a patient is disclosed. A method of reducing surgical trauma resulting from a...
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8143227 |
Azithromycin for treatment of skin disorders
Azithromycin has increased efficacy in treating acne and other skin conditions when administered systemically at low doses, below those previously known to produce a clinical antibiotic effect.
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8124123 |
Controlled release azithromycin solid dosages forms
A solid dosage form for oral administration comprising azithromycin in an amount below that which causes gastrointestinal side effects, which dosage form is a controlled release dosage form.
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8097594 |
Macrolides and ketolides having antimicrobial activity
The present invention provides compounds having antimicrobial activity for preventing and treating diseases caused by microbial infections. Thus, the present invention relates to novel...
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8080529 |
Macrolides with anti-inflammatory activity
The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides substituted at the...
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8080528 |
Compositions and methods for treatment of cachexia
Compositions and methods for preventing and treating wasting disorders, such as cachexia and anorexia, are provided. In one aspect, the present invention provides a method for preventing and...
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8076301 |
10-substituted macrolide antibiotics
Disclosed herein are 10-desmethyl, 10 substituted-macrolides, their preparation, pharmaceutical compositions containing them, their use and methods of treatment using them. The 10-desmethyl...
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8066981 |
Compositions and methods related to toll-like receptor-3
The invention relates to compositions and methods related to Toll-like receptor (TLR) polypeptides. In some embodiments, the invention relates to managing TLR3 related diseases. In further...
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8063021 |
Ketolide anti-infective compounds
Compounds according to formula I wherein m is 0 or 1; X is and R1, R2, R3 R4, and R5 are as defined herein, are useful as anti-infective agents.
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8058039 |
Use of erythromycin as a selective antimicrobial agent in the production of alcohols
A process for the use of low concentration levels of Erythromycin to eliminate or control the growth of unwanted or undesirable bacteria (contaminating bacteria) in the fermentation production of...
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8030282 |
Motilide polymorphs
The invention provides polymorphs of a motilide having a structure represented by formula Ia
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8017588 |
Clarithromycin or salt thereof for use in the treatment or prevention of pulmonary disease induced by destruction of pulmonary alveoli
For the purpose of treatment and/or prevention of pulmonary disorders caused by the destruction of pulmonary alveoli resulting from smoking, air pollution, noxious gas, etc., there are provided,...
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8012943 |
Antibacterial agents
Described herein are novel macrolides, the preparation of novel macrolides, the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel macrolides...
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8007820 |
Wide spectrum insecticide and miticide composition
An environmentally safe, pesticidally effective composition is provided to control insect/mite pests. In an exemplary embodiment, a composition is provided that includes a pesticidally effective,...
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7956042 |
Crystalline forms of macrolide compounds endowed with antiinflammatory activity
The present invention relates to macrolide compounds endowed with antiinflammatory activity and more particularly relates to new stable crystalline forms of a macrolide derivative with...
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7928078 |
Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy
The present invention relates to novel compounds represented by the structure I and pharmaceutical preparations thereof for the treatment of inflammatory diseases in humans and animals.
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7910559 |
Decladinosyl-macrolides with anti-inflammatory activity
The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides lacking cladinose...
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7910135 |
Hydrogel wound dressing and biomaterials formed in situ and their uses
The present invention relates to a method of forming shape-retentive and shape-conforming aggregate wound dressings and biomaterials composed of gel nanoparticles and wound or bodily fluid in which...
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7887828 |
Dual action organic formulation to control two stages of insect pests
The present invention discloses systems and methods for controlling arthropod populations. The systems include a polymeric substrate, a semiochemical that is reactive upon an adult-stage arthropod,...
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7807151 |
Probiotic, lactic acid-producing bacteria and uses thereof
The present invention discloses compositions and methodologies for the utilization of probiotic organisms in therapeutic compositions. More specifically, the present invention relates to the...
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7803779 |
Drugs for the treatment and/or prophylaxis of gastroparesis symptom
The present invention provides a therapeutic and/or preventive agent against gastroparesis symptom which is appropriate for continuous medication and which comprises a compound represented by...
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7767231 |
Taste-masking pharmaceutical compositions
The present invention relates to a pharmaceutical composition for oral administration suitable for the preparation of a ready-to-use suspension comprising coated particles comprising an active...
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7758888 |
Composition exhibiting enhanced formulation stability and delivery of topical active ingredients
A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules...
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7749970 |
Topical treatment of prevention of ocular infections
The topical application of an azalide antibiotic such as azithromycin to the eye is useful in treating or preventing ocular infections. In one embodiment, the azalide antibiotic is supplied to the...
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7732415 |
Topical treatment or prevention of ocular infections
The topical application of an azalide antibiotic such as azithromycin to the eye is useful in treating or preventing ocular infections. In one embodiment, the azalide antibiotic is supplied to the...
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7718621 |
Macrolones—amino substituted quinolones
A compound of formula (I) or a pharmaceutically acceptable derivative thereof, having antimicrobial activity, processes for their preparation, compositions containing them and to their use in...
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7704960 |
Macrolide compounds endowed with antiinflammatory activity
Macrolide compounds endowed with antiinflammatory activity are described, and more particularly macrolide derivatives lacking cladinose in position 3, with antiinflammatory activity,...
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7622452 |
C-9 alkenylidine bridged macrolides
The present invention discloses compounds of formulae (I), (II) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention...
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7608596 |
10-substituted macrolide antibiotics
Disclosed herein are 10-desmethyl, 10 substituted-macrolides, their preparation, pharmaceutical compositions containing them, their use and methods of treatment using them. The 10-desmethyl...
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7601695 |
Antibacterial agents
Described herein are novel macrolides, the preparation of novel macrolides, to the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel...
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7595300 |
7-quinolyl ketolide antibacterial agents
15-fluoroketolides of the formula having improved activity and safety, compositions comprising them, and methods for their preparation and use in the treatment of bacterial infections.
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7589067 |
6, 11-bridged tricyclic macrolides
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
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7582611 |
Motilide compounds
Compounds having a structure according to formula (I) where RA, RB, RC, RD, RE, and RF are as defined herein, are useful as prokinetic agents.
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7579324 |
Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
This invention features a compound of the following formula: T-(-L-C)m, T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic therapeutic...
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7572773 |
Single dose fast dissolving azithromycin
The present disclosure related to a method of treating an infection by oral administration of a single dose of a fast dissolving form of azithromycin. The disclosure also relates to a method of...
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7569549 |
Isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A
Substantially pure isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A having the Formula I: wherein S is an organic solvent which is at least partially miscible with...
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7569550 |
14 and 15 membered ring compounds
The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their p...
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7563773 |
Anthelmintic oral homogeneous veterinary pastes
This invention provides for, inter alia, oral homogeneous veterinary pastes for the treating, controlling and preventing of endo- and ectoparasite infections in warm-blooded animals or birds, such...
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7547679 |
Ether linked macrolides useful for the treatment of microbial infections
The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their p...
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7524823 |
Macrolides
The present invention relates to new antibiotic macrolide compounds of the general formula I: with improved activity, to medicaments comprising such antibiotics, and to the use of such antibiotics...
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7521428 |
Macrolide derivatives having effect of potentiating antifungal activity
Macrolide derivatives having enhancing effect for activities of azole antifungal agents, acting at low concentration and within a short time against fungal infection and reducing the frequency of...
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7517859 |
Spirocyclic bicyclolides
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
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7507721 |
Macrolides with antiinflammatory activity
Macrolide compounds of formula (I) wherein X, R, R1, R2, R3 and R4, have the meanings as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions...
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7462600 |
Macrolides
Macrolide compounds per se, as shown below and defined herein, and their use, e.g., as antibacterial and antiprotozoal agents in animals, including humans: Also disclosed are methods of preparing...
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7446097 |
Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy
The present invention relates to novel compounds represented by the structure I and pharmaceutical preparations thereof for the treatment of inflammatory diseases in humans and animals.
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RE40546 |
1,3-Propane diol esters and ethers and methods for their use in drug delivery
The invention relates to compounds of formula: wherein R1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms,...
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7438924 |
Dry granulated formulations of azithromycin
This invention relates to a pharmaceutical formulation, in the form of a tablet, sachet or powder for suspension dosage form, which comprises dry granulated particles of a non-dihydrate form of...
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7419961 |
9a-azalides with anti-inflammatory activity
Macrolides with anti-inflammatory activity are described. Particularly described are 9a-azalides and their anti-inflammatory activity without cladinose in position 3, the pharmaceutically...
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