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7608596 10-substituted macrolide antibiotics  
Disclosed herein are 10-desmethyl, 10 substituted-macrolides, their preparation, pharmaceutical compositions containing them, their use and methods of treatment using them. The 10-desmethyl...
7601695 Antibacterial agents  
Described herein are novel macrolides, the preparation of novel macrolides, to the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel...
7595300 7-quinolyl ketolide antibacterial agents  
15-fluoroketolides of the formula having improved activity and safety, compositions comprising them, and methods for their preparation and use in the treatment of bacterial infections.
7589067 6, 11-bridged tricyclic macrolides  
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
7582611 Motilide compounds  
Compounds having a structure according to formula (I) where R A , R B , R C , R D , R E , and R F are as defined herein, are useful as prokinetic agents.
7579324 Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof  
This invention features a compound of the following formula: T-(-L-C) m , T...
7572773 Single dose fast dissolving azithromycin  
The present disclosure related to a method of treating an infection by oral administration of a single dose of a fast dissolving form of azithromycin. The disclosure also relates to a method of...
7569550 14 and 15 membered ring compounds  
The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their...
7569549 Isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A  
Substantially pure isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A having the Formula I: wherein S is an organic solvent which is at least partially miscible...
7563773 Anthelmintic oral homogeneous veterinary pastes  
This invention provides for, inter alia, oral homogeneous veterinary pastes for the treating, controlling and preventing of endo- and ectoparasite infections in warm-blooded animals or birds, such...
7547679 Ether linked macrolides useful for the treatment of microbial infections  
The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their...
7524823 Macrolides  
The present invention relates to new antibiotic macrolide compounds of the general formula I: with improved activity, to medicaments comprising such antibiotics, and to the use of such...
7521428 Macrolide derivatives having effect of potentiating antifungal activity  
Macrolide derivatives having enhancing effect for activities of azole antifungal agents, acting at low concentration and within a short time against fungal infection and reducing the frequency of...
7517859 Spirocyclic bicyclolides  
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
7507721 Macrolides with antiinflammatory activity  
Macrolide compounds of formula (I) wherein X, R, R 1 , R 2 , R 3 and R 4 , have the meanings as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions...
7462600 Macrolides  
Macrolide compounds per se, as shown below and defined herein, and their use, e.g., as antibacterial and antiprotozoal agents in animals, including humans: Also disclosed are methods of...
7446097 Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy  
The present invention relates to novel compounds represented by the structure I and pharmaceutical preparations thereof for the treatment of inflammatory diseases in humans and animals.
7438924 Dry granulated formulations of azithromycin  
This invention relates to a pharmaceutical formulation, in the form of a tablet, sachet or powder for suspension dosage form, which comprises dry granulated particles of a non-dihydrate form of...
RE40546 1,3-Propane diol esters and ethers and methods for their use in drug delivery  
The invention relates to compounds of formula: wherein R 1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon...
7419961 9a-azalides with anti-inflammatory activity  
Macrolides with anti-inflammatory activity are described. Particularly described are 9a-azalides and their anti-inflammatory activity without cladinose in position 3, the pharmaceutically...
7414030 6-11 Bicyclic erythromycin derivatives  
The present invention discloses compounds of formulaes I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The...
7410952 Derivatives of azithromycin  
The invention relates to derivatives of azithromycin, processes for the manufacture thereof and pharmaceutical compositions thereof preferably together with azithromycin.
7407942 3,6-bridged 9,12-oxolides  
The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
7407941 N-desmethyl-N-substituted-11-deoxyerythromycin compounds  
Compounds having the structure of formula I wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein, are prokinetic agents and can be used to treat disorders of gastric motility.
7402568 Bicyclic 9a-azalide derivatives  
The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention...
7384922 6-11 bridged oxime erythromycin derivatives  
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
7384921 Polymorphic forms of 6-11 bicyclic ketolide derivatives  
The present invention includes EP-13420 polymorphic crystalline forms: Form I, Form II, Form Ia, and monohydrate and amorphous EP-13420 which posses distinct physical properties. In another...
7365056 Substituted 9a-N-(N′-(sulfonyl)phenylcarbamoyl)derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerithomycin A and 5-0-desosaminyl-9-deoxo-9-dihydro-9-a-aza-9a-homoerithronolide A  
The invention relates to substituted 9a-N-{N′-[4-(sulfonyl)phenyl]carbamoyl} derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin A and...
7358232 Method for the antibiotic coating of bodies with interconnecting microcavities as well as coated bodies and their usage  
The invention relates to a method for the antibiotic coating of bodies with interconnecting microcavities as well as bodies coated this way and their usage. The invented method is characterized in...
7351696 Compounds  
The present invention relates to compounds of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of...
7342000 Semisynthetic macrolide antibiotics of the azalide series  
The invention relates to N″-substituted 9a-N-(N′-carbamoyl-γ-aminopropyl), 9a-N-(N′-thiocarbamoyl-γ-aminopropyl), 9a-N-[N′-β-cyanoethyl)-N′-carbamoyl-γ-aminopropyl] and...
7332476 Pyridyl substituted ketolide antibiotics  
Antimicrobial macrolide and ketolide compounds are provided having formulas XII: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising...
7312201 Tetracyclic bicyclolides  
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
7297682 Diphosphate salt of a 4″—substituted-9-deoxo-9 A—AZA—homoerythromycin derivatives and its pharmaceutical composition  
This invention relates to a novel crystalline diphosphate salt of...
7291602 11,12-lactone bicyclolides  
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
7276487 9a, 11-3C-bicyclic 9a-azalide derivatives  
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
7273853 6-11 bicyclic ketolide derivatives  
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
7271155 9A, 11-2C-bicyclic 9a-azalide derivatives  
The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention...
7271154 Antibiotic conjugates  
This invention features a compound of the following formula: wherein T is a transportophore, L is a bond or linker, and C is an antibiotic therapeutic agent, the transportophore is covalently...
RE39836 Macrolide antinfective agents  
Compounds of the formula wherein R a is H; substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C); substituted or unsubstituted alkynyl (2-10C);...
7265094 9N-substituted 6-11 bicyclic erythromycin derivatives  
The present invention discloses compounds of formula I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The...
7262172 Macrolides  
The invention relates to novel semi-synthetic macrolides of formula (I) having antibacterial activity. More particularly this invention relates to derivatives of 8a-aza-8a-homoerythromycin A, to...
RE39743 2-halogenated derivatives of 5-0 desosaminyl-erythronolide a, their preparation process and their antibiotic use  
Novel compounds of the formula wherein the substituents are defined as in the application having antibiotic properties.
7241746 Method and composition for treating periodontal disease  
The present invention is directed to a pharmaceutical composition comprising a therapeutically effective amount of misoprostol and an effective amount of an antibiotic. A suitable antibiotic is...
7241741 Methods and compositions for the treatment of asthma and related disorders  
The present invention provides methods for the treatment of respiratory tract mucositis in individuals in need of such treatment, the method comprising the systemic administration to the individual...
7229972 3,6-Bicyclolides  
The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
7211568 9-Desoxoerythromycin compounds as prokinetic agents  
9-Desoxoerythromycin compounds of formula I wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein, are useful as prokinetic agents for treating disorders of gastric motility.
RE39591 6-O-substituted ketolides having antibacterial activity  
Antimicrobial compounds having the formula as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating...
7189704 6-11 bicyclic ketolide derivatives  
The present invention discloses, inter alia, a compound of the following formula, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The...
7189703 Treatment and diagnosis of alzheimer's disease  
The invention relates to a method of treating Alzheimer's disease in a mammal comprising administering to the mammal an anti-microbial agent having anti- Chlamydia pneumoniae activity. The...
Matches 1 - 50 out of 417 1 2 3 4 5 6 7 8 9 >