|
Match
|
Document |
Document Title |
|
|
6518252 |
Method of treating aquatic animals with an antimicrobial agent and chelating agent
The present invention relates to novel method of reducing microbial infections, especially bacterial infections, of animals, especially of aquatic animals such as fish maintained in tanks or...
|
|
|
6482801 |
9a, 11b-dehydro derivatives of 9-oxime-3-keto-6-O- methylerythromycin
The invention relates to compounds of the formula and to pharmaceutically acceptable salts thereof, wherein R 1 and R 2 are as defined herein. The invention also relates to pharmaceutical...
|
|
|
6468979 |
Erythromycin derivatives with antibiotic activity
Erythromycin derivatives with antibiotic activity and pharmaceutically acceptable salts thereof. A process for preparing such erythromycin derivatives and pharmaceutical compositions containing...
|
|
|
6465437 |
Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
This invention relates to a novel crystalline diphosphate salt of...
|
|
|
6461607 |
Probiotic, lactic acid-producing bacteria and uses thereof
The present invention discloses compositions and methodologies for the utilization of probiotic organisms in therapeutic compositions. More specifically, the present invention relates to the...
|
|
|
6462024 |
Use of inhibitors of the sodium-hydrogen exchanger for the production of a medicament for decreasing undesired effects of substrates of the heart
Inhibitors of the sodium-hydrogen exchanger are used for the production of a medicament for decreasing the undesired effects in human and in veterinary medicine which originate from substances...
|
|
|
6455505 |
Derivatives . . . use as medicaments
A subject of the invention is, as new chemical products, the compounds of formula (I) in which X represents a hydrogen atom or a halogen atom and Z represents a hydrogen atom or the remainder of...
|
|
|
6448233 |
Topical application of a combination of benzoyl peroxide and a second active ingredient
Disclosed herein is a dispensing system for benzoyl chloride and an antimicrobial agent which antimicrobial agent is a macrolide or an aminoglycoside antibiotic. The dispensing system comprises a...
|
|
|
6440942 |
14-membered macrolides derived from leucomycins
There is described a novel class of ring contracted 14-membered macrolides, and pharmaceutically acceptable salts, esters and prodrugs thereof, having antibacterial activity, compositions...
|
|
|
6436906 |
9-amino-14-membered macrolides derived from leucomycins
Novel 9-amino-14-membered macrolides and pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically...
|
|
|
6432935 |
Pharmaceutical compositions, mainly vaginal suppository, containing many different active ingredients
Compositions comprising an antibiotic, sulphonamide, at least one an antiquagul agent, e.g., clotrimazol (bis-phenyl-(2-chlorophenyl)-1-imidazolyl-methane), natamycin, or nystatin,and...
|
|
|
6399612 |
Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
Heteroaryl butyric acid compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix...
|
|
|
6387885 |
3′,3′-N-bis-desmethyl-3′-N-cycloalkyl erythromycin derivatives as LHRH antagonists
Disclosed are 3′,3′-N-bis-desmethyl-3′-N-cycloalkyl-6-O-methyl-11-de
oxy-11,12-cyclic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone...
|
|
|
6379882 |
Method for selecting compounds for treating ischemia-related cellular damage
A method of screening for and treating subjects with a therapeutically effective amount of a compound that is effective in reducing cellular damage related to an ischemic condition, such as stroke...
|
|
|
6369035 |
3,6-hemiketals from the class of 9A-azalides
The invention relates to novel compounds from the class of macrolide antibiotics. Particularly, the invention relates to novel 3,6-heiketals from the class of 9a-azalides, to their pharmaceutically...
|
|
|
6365574 |
Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
A novel, non-hygroscopic form of azithromycin is disclosed, as well as a method for preparing it by the gradual crystallization of azithromycin from ethanol by the addition of a minimal amount of...
|
|
|
6355620 |
C-2 modified erythromycin derivatives
A compound having the formula selected from the group consisting of a compound of formula I a compound of formula II a compound of formula III as well as and pharmaceutically acceptable salts,...
|
|
|
6339063 |
9a-azalides as veterinary antimicrobial agents
9a-Azalides, and pharmaceutical compositions containing them, are useful in the treatment and prevention of bacterial respiratory and enteric infections in livestock animals, particularly in cattle...
|
|
|
6329345 |
13-membered azalides and their use as antibiotic agents
The invention relates to a method of preparing compounds of the formula 1 ##STR1## and to pharmaceutically acceptable salts thereof. The compounds of formula 1 are antibacterial agents that may be...
|
|
|
6319904 |
Formulation comprising antibacterial substance and antiulcer substance
The present invention includes a formulation which comprises an antibacterial substance and an antiulcer substance, wherein at least either of them is formulated into a gastrointestinal...
|
|
|
6306613 |
Modulators of leaderless protein export and methods for identifying and using the same
Methods of modulating the export of a leaderless protein from a cell by contacting the cell with a compound that alters the binding of the leaderless protein and a transport molecule are provided....
|
|
|
6300316 |
C-4 substituted macrolide antibiotics
This invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts thereof. The compounds of formula 1 are potent antibacterial and antiprotozoal agents that may...
|
|
|
6281197 |
Cardiac glycosides and their aglycone derivatives treat complications of diabetes
This invention provides methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a cardiac glycoside or aglycone derivative. Leaderless proteins include...
|
|
|
6281199 |
Method of treatment of heart disease caused by Chlamydia pneumoniae
A method of combatting atherosclerosis by administering an effective amount of a macrolide antibiotic, for example an azalide such as azithromycin, optionally together with one or more...
|
|
|
6277829 |
Process for preparing of aqueous formulation for opthalmic use
The present invention describes a process for the preparation of aqueous formulations containing azithromycin for ophthalmic use, as well any formulations obtained by this process and their topical...
|
|
|
6277836 |
Methods and compositions for treating inflammatory bowel disease
The present invention provides a method and composition of medications use to treat inflammatory bowel disease. The invention further provides combinations of anti-atypical mycobacterial agents...
|
|
|
6258785 |
Crystalline 9-E-(O-methyl)oxime of 11, 12-dideoxy-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyrano syloxy)-6-O-methyl-12,11-(iminocarbonyl-(2-(3-(4-(3-pyridinyl)1H-imadazol-1 -yl)propyl)hydrazono))-3-oxoerythromycin
The invention relates to crystalline 9-E-(O-methyl)oxime of 11,12-dideoxy-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ri
bohexopyr...
|
|
|
6248718 |
Lesion-directed dry dosage forms of antibacterial agents for the treatment of acute mucosal infections of the oral cavity
The invention provides a medicament for topically treating acute bacterial infections in the oral mucosa, and methods of use. The medicament comprises a dry dosage (such as a troche or powder) of...
|
|
|
6248719 |
Tricyclic 3-keto derivatives of 6-O-methylerthromycin
The present invention relates to compounds of the formula 1 ##STR1## and to pharmaceutically acceptable salts thereof, wherein R 1 -R 7 are as defined herein. The compounds of formula 1 are...
|
|
|
6239112 |
Water miscible macrolide solutions
Water miscible pharmaceutical compositions containing up about 40% of a marcrolide such as an azalide antibiotic are prepared by reaction of the macrolide with acid in a non-aqueous water miscible...
|
|
|
6218368 |
Antibiotic treatment of age-related macular degeneration
A method is provided for the treatment of age-related macular degeneration by administering various antibiotics, such as tetracycline and its derivatives, rifamycin and its derivatives, macrolides,...
|
|
|
6194387 |
6-O-aklyl erythromycin B oxime
A process of preparing a 6-O-alkyl derivative of 9-oxime erythromycin B is provided. Intermediates used in the preparation of a 6-O-alkyl 9-oxime erythromycin B are also provided. Pharmaceutical...
|
|
|
6191118 |
Erythromycin A derivatives
An erythromycin A derivative represented by Formula ##STR1## wherein R 1 is a group represented by the formula: ##STR2## a group represented by the formula: ##STR3## (c) pyridylacetyl, (d)...
|
|
|
6187768 |
Kit for flushing medical devices and method of preparation
A kit and for flushing a medical device a method of preparing the kit is disclosed. The kit includes a container containing a mixed solution a unit dose of a pharmacologically effective amount of...
|
|
|
6174865 |
Method of treating hypertriglyceridemia with an erythromycin compound
This invention relates to a method for treating humans having hypertriglyceridemia. Specifically, this invention provides for administration of an erythromycin compound that reduces triglyceride...
|
|
|
6172069 |
Method for preventing or reducing photosensitivity and or photoxicity reaction to medications
The present invention provides a method for preventing or reducing a photosensitivity and/or phototoxicity reaction which may be caused by a once-per-day dose of a medication which causes a...
|
|
|
6165985 |
11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them
Ring-contracted N-demethyl-N-isopropyl-erythromycin-A derivatives having a modified side chain and gastrointestinally effective motilin-agonistic properties and the preparation thereof are described.
|
|
|
6162792 |
Use of spiramycin for treating gastrointestinal disorders caused by H. pylori
Gastrointestinal disorders involving Helicobacter pylorid are treated by administering spiramycin or spiramycin/metronidazole combinations. In addition, administration of anti-ulcer agents may be...
|
|
|
6159945 |
9-amino-3-keto erythromycin derivatives
The invention relates to compounds of the formula I ##STR1## and to pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 and X are as defined herein. The invention also relates...
|
|
|
6124269 |
2-Halo-6-O-substituted ketolide derivatives
Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula ##STR1## compositions comprising a...
|
|
|
6107283 |
Cardiac glycosides inhibit proliferation of cells bearing FGF receptors
This invention provides methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a cardiac glycoside or aglycone derivative. Leaderless proteins include...
|
|
|
6100240 |
Macrolide derivatives
The invention relates to compounds of the formula I ##STR1## and to pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , Q, X, Y and Z are as defined herein. The invention also...
|
|
|
6100239 |
13-membered ring macrolide compound, medicine containing the same, and process for producing the same
The present invention discloses the compound represented by the formula (I) ##STR1## wherein R 1 and R 2 are hydrogen atoms, R 3 represents a hydrogen atom, a hydroxyl group or an amino group,...
|
|
|
6083706 |
Inhibitors of leaderless protein export
Methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a compound that inhibits the binding of the leaderless protein and a transport molecule are...
|
|
|
6075011 |
6-O-substituted erythromycin compounds and method for making same
Antimicrobial compounds having the formula ##STR1## as well as the pharmaceutically acceptable salts, esters and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of...
|
|
|
6071885 |
Treatment of FGF-mediated conditions by administration of a cardiac glycoside or aglycone derivative thereof
This invention provides methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a cardiac glycoside or aglycone derivative. Leaderless proteins include...
|
|
|
6071886 |
β,β-distributed derivatives of 9-deoxo-9a-N-ethenyl-9a-aza-9a-homoerythromycin A
The present invention relates to β,β-disubstituted derivatives of 9-deoxo-9a-N-ethenyl-9a-aza-9a-homoerythromycin A, new semisynthetic antibiotics of macrolide class of the general formula (I)...
|
|
|
6054435 |
6-O-substituted macrolides having antibacterial activity
The instant invention provides novel macrolide compounds and compositions useful in treating bacterial infections. Also provided are processes for preparing same.
|
|
|
6054434 |
8a-azalides as veterinary antimicrobal agents
8a-Azalides are useful in the treatment and prevention of bacterial respiratory and enteric infections in livestock animals, particularly in cattle and swine.
|
|
|
6046171 |
6,11-bridged erythromycin derivatives
Novel 6,11-bridged erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula ##STR1## compositions comprising a therapeutically...
|