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8178551 |
Orally bioavailable prodrugs of (+)-3-hydroxymorphinan for Parkinson'S disease prevention or treatment
The present invention is directed to a novel prodrug of (+)-3-hydroxymorphinan compound of formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing the same, and its use...
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8106065 |
Antitussive agent
An antitussive, which can be used for therapy or prophylaxis of coughing, is disclosed. The antitussive comprises as an effective ingredient a morphinan derivative having a nitrogen-containing...
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8093261 |
Rapid release mini-tablets provide analgesia in laboratory animals
Pellets containing an analgesic uniformly dispersed in a lipid carrier such as cholesterol mixed with fatty acid esters, can be used to provide long term pain relief. 5 mg...
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8067213 |
Production of thebaine and oripavine
There is disclosed an improved poppy straw of a stably reproducing Papaver somniferum for the extraction of thebaine and/or oripavine, the threshed straw having thebaine and oripavine constituting...
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8026252 |
Large substituent, non-phenolic opioids and methods of use thereof
8-Substituted-2,6-methano-3-benzazocines of general structure are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
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7973049 |
Morphinan compounds
This disclosure relates to novel morphinan compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising...
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7943633 |
Alkaloid compounds and their use as anti-malarial drugs
Anti-malarial alkyloid compounds have the formula: wherein R1-R11 have various disclosed values or their pharmaceutically acceptable salts, and pharmaceutical compositions containing the same.
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7932264 |
Sinomenine derivatives and preparation and uses thereof
The present invention relates to the preparation and pharmacological use of sinomenine derivatives of formula I. The approach disclosed herein is the modification of D ring by-substituting for R....
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7923454 |
Opioid and opioid-like compounds and uses thereof
The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations containing the same and methods of use thereof. Uses of the present invention include, but are not...
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7867523 |
Pharmaceutical composition
A pharmaceutical composition for the treatment of colds and influenza. The pharmaceutical composition is a mixture of: acetaminophen, diphenhydramine, dextromethorphan, arabinogalactan, vitamin C,...
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7820688 |
Topical anesthetic/opioid formulations and uses thereof
Many chemical and pharmaceutical compositions are known to produce antinociceptive effects that are helpful in relieving pain and inflammation. Both opioids and local anesthetics serve an important...
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7807651 |
Methods and materials for pain management
Disclosed are methods for treating pain in a subject. The method includes upregulating expression of opioid receptors in the subject's dorsal root ganglion neurons. Also disclosed are methods of...
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7754767 |
Method for treatment of premature ejaculation in humans
The present invention belongs to the fields of pharmacology, medicine and medicinal chemistry, and provides methods and compositions for treating sexual dysfunction; more particularly, the...
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7691874 |
Neuroprotective properties of dextrorotatory morphinans
The present application discloses a pharmaceutical composition for treating Parkinson's disease and psychotropic intoxication/abusive potential, which contains a morphinan compound.
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7659282 |
Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
Pharmaceutical compositions and methods for treating neurological disorders by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine.
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7625921 |
Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including ...
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7557119 |
Large substituent, non-phenolic opioids
8-Substituted-2,6-methano-3-benzazocines of general structure are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. One embodiment is the...
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7456224 |
Method for treating autism
A method for treating autism comprising the step of administering an effective amount of a medicament characterized as a NMDA-receptor antagonist or a pharmaceutically acceptable salt thereof.
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7320984 |
Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group
The invention provides a morphinan derivative of the Formula (I): wherein R1 is methyl, cyclopropylmethyl or the like; R2 and R3 are hydroxy, methoxy, acetoxy or the like; both Y and Z are valence...
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7291628 |
Treatment of cocaine abuse using N-substituted derivatives of morphinan
The invention is based in part on the discovery that nonselective κ agonists that possess μ receptor-mediated effects in addition to their κ agonist effects can decrease cocaine se...
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7199129 |
Derivatives of morphine-like opioid compounds
The present disclosure concerns compounds of formula (I) and pharmaceutically acceptable salts, hydrates, solvates, pharmaceutically acceptable derivatives, pro-drugs, tautomers and/or isomers...
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7101890 |
Benzazepine derivatives, drugs containing these and use of the same for producing drugs
New derivatives of benzazepine, particularly of benzofuro[3a,3,2,ef][2]benzazepin of the general formula (I) and new compounds of the general formula (III) Drugs, containing compounds of formulas...
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7087619 |
Method for the treatment of urinary incontinence
Urinary incontinence is alleviated in a mammal by administering to the mammal a urinary incontinence alleviating amount of dextromethorphan, dextrorphan, their mixtures and/or pharmaceutically...
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6897241 |
Preparation of topical regional compositions for the relief of pain
A method is presented for the preparation of topically applied compositions used for the treatment of regional pain, especially sympathetically mediated pain. NMDA receptor antagonists, such as...
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6855735 |
Ketamine treatment of restless legs syndrome
The present invention is directed to a method for treating symptoms associated with Restless Legs Syndrome (RLS). The method includes administering to a warm-blooded animal in need of such...
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6806291 |
Analgesic compounds, their synthesis and pharmaceutical compositions containing them
New analgesic compounds, which are prepared by the hydrolysis of N-acylated 4-hydroxyphenylamine derivatives, their synthesis and pharmaceutical compositions containing them are disclosed. These...
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6723894 |
Production of thebaine and oripavine
There is disclosed an improved poppy straw of a stably reproducing Papaver somniferum for the extraction of thebaine and/or oripavine, the threshed straw having thebaine and oripavine constituting...
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6670370 |
Dextromethorphan tannate
The invention pertains to a composition comprising dextromethorphan tannate and to a method for preparing dextromethorphan tannate by reacting dextromethorphan at a temperature of about 80 to about...
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6627635 |
Method of preventing abuse of opioid dosage forms
The invention relates in part to a method of reducing the abuse potential of an oral dosage form of an opioid analgesic, wherein an analgesically effective amount of an orally active opioid agonist...
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6583152 |
Composition for reducing the risk or progression of cardiovascular diseases
Elevated levels of homocysteine have been implicated as an important risk factor for cardiovascular and other diseases. A composition for decreasing levels of plasma homocysteine and a method for...
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6583151 |
Remedies for drug addiction
A method for treating drug dependence comprising administering, as the active ingredient, an opioid κ receptor agonist of a compound represented by the following formula, is disclosed wherein A ...
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6579883 |
Fluorinated 3,4-dihydroquinoline derivatives used as NOS inhibitors
The invention relates to compounds of formula (I), to a method for producing them and to their use in medicaments as NOS inhibitors.
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RE38115 |
Dextromethorphan and an oxidase inhibitor for treating intractable conditions
Methods are disclosed for increasing the effectiveness of dextromethorphan in treating chronic or intractable pain, for treating tinnitus and for treating sexual dysfunction comprising...
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6552024 |
Compositions and methods for mucosal delivery
Mucosal surface-coat-forming film dosage units containing a water-soluble hydrocolloid, an effective dose of an active agent and a mucosal adhesion enhancer; wherein the active agent is...
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6541483 |
Acridone-derived compounds useful as antineoplastic and antiretroviral agents
The present invention relates to several novel acridone-derived compounds of of formula (I) or (II). These compounds are potent anti-viral agents, useful in the treatment of viral diseases, such as...
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6538005 |
Phenanthridine-N-oxides with PDE-IV inhibiting activity
The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, arm novel active bronchial therapeutics.
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6534518 |
Polysubstituted 6-phenylphenanthridines with PDE-IV inhibiting activity
Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics.
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6500838 |
Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors
NMDA receptor antagonists can be used in methods of treatment, for reducing the frequency of stereotypic behaviors in animals and for reducing the frequency of analogous compulsive behaviors in...
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6479505 |
6-arylphenanthridines with PDE-IV inhibiting activity
Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and Ar have the meanings indicated in the description, are novel active bronchial therapeutics.
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6476025 |
Phenylphennanthridines with PDE-IV inhibiting activity
Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51, R6, R13 and R20 have the meaning indicated in the description, are novel active bronchial therapeutics
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6455537 |
Methods for treating opiate intolerance
Provided are compositions comprising an opiate analgesic and an active compound containing the R isomer of N-methylnalorphine in a pharmaceutically acceptable carrier. Also provided are methods of...
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6391886 |
Oral compositions having improved consumer aesthetics
Oral compositions containing therapeutical agents wherein the undesirable consumer aesthetics associated with these agents are mitigated using coolants and sweeteners.
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6372756 |
Epimorphian compound and its use
A novel compound N-demethyl-sinomenine, a metabolite of the anti-arthritic alkaloid sinomenine, has been identified and characterized. The compound may be incorporated in a pharmaceutical...
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6362226 |
Modulation of in vivo glutamine and glycine levels in the treatment of autism
A method of treating autism in a patient. The method includes administering to the patient an effective amount of a glutamine level reducing agent, a glycine level reducing agent or combinations...
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6342246 |
Image forms and method for ameliorating male erectile dysfunction
The use of a pharmaceutical composition for oral administration comprising a carrier and active ingredient selected from a dopamine agonist, testosterone and mixtures thereof, the composition being...
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6335030 |
Transdermally administered dextromethorphan as antitussive agent
The present invention is drawn to a device for the transdermal administration of dextromethorphan, (+)-3-methoxy-17-methyl-9a,13a,14a-morphanin, and salts, prodrugs and metabolites thereof,...
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6316027 |
Fast-dissolving dosage forms for dopamine agonists
In one embodiment, this invention relates to a pharmaceutical composition for oral administration consisting essentially of a gelatin at a concentration up to 5% by weight as a carrier, a solvent,...
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6284765 |
(+) naloxone and epinephrine combination therapy
A composition formulated for dose-wise delivery to a breathing passageway of a human, the composition comprising a carrier solution containing (+)naloxone and a pharmacologically effective amount...
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6207674 |
Dextromethorphan and oxidase inhibitor for weaning patients from narcotics and anti-depressants
Patients can be helped to break free of addictive or habit-forming narcotics and anti-depressants, by treatment using two drugs. One drug is dextromethorphan (DM), which has been used for decades...
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6197830 |
Method for achieving relief from sympathetically mediated pain
A method is presented whereby sympathetically mediated pain relief is achieved through the periodic topical administration of compositions comprising tricyclic antipressants mixed with one or more...
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