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9040552 Selective opioid compounds  
The present invention relates to compounds of Formula I or II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which relates to mophinan compounds useful as μ, δ and/or κ...
9023390 Sustained-release product comprising a combination of a non-opioid amine and a non-steroidal anti-inflammatory drug  
Sustained-release oral pharmaceutical compositions and methods of use, wherein the compositions are in a single dosage form and include an amine-containing compound (including salts thereof), a...
9006262 Therapeutic or prophylactic agent for cachexia  
A therapeutic or prophylactic agent for cachexia includes as an effective ingredient a compound having a specified morphinan skeleton represented by a compound of the following structure: or a...
8987293 Morphinans useful as analgesics  
Compounds of Formula (I) are disclosed. The variables R1-R11 are described herein. Certain compounds of Formula (I) are partial agonists of the mu, delta, and kappa opioid receptors, and are...
8980319 Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans  
Methods for producing stabilized solid dosage form pharmaceutical compositions are provided. In particular, methods for preparing protected granules containing morphinans, and solid dosage form...
8962646 Peripherally acting opioid compounds  
The invention relates to a compound of Formula I, II, III, IV or a pharmaceutically acceptable ester or prodrug thereof:
8957085 Carboxamide bioisosteres of opiates  
A compound of formula I is disclosed. Compounds of formula I are useful as analgesics, anti-inflammatory agents, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
8946255 Substituted morphinans and the use thereof  
The application is directed to compounds of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4a, and R4b are defined as set forth in the specification....
8921386 Opioid salts and formulations exhibiting anti-abuse and anti-dose dumping properties  
A drug substance with a pharmaceutically acceptable organic acid addition salt of an opioid wherein said organic acid is selected from Structure A: wherein R1-R4 are independently selected from H,...
8916582 Morphinan compounds  
This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of...
8901148 Large substituent, non-phenolic opioids and methods of use thereof  
8-Substituted-2,6-methano-3-benzazocines of general structure are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
8829020 Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers  
The invention relates generally to anti-angiogenesis agents and related methods of using to anti-angiogenesis agents for biomedical applications including direct monotherapy and combination...
8822490 Peripheral opioid receptor antagonists and uses thereof  
The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
8785472 Use of dextromethorphan in treating addictive behavior or bipolar disorder  
The present invention provides a method for treating addictive behavior, comprising administering Dextromethorphan (DM) to a subject suffering addictive behavior. The present invention also...
8778960 Methods for treating antipsychotic-induced weight gain  
The present invention relates to the discovery of a novel opioid modulator effective in reducing pharmacologically induced weight gain associated with atypical antipsychotic use. The present...
8772310 Peripheral opioid receptor antagonists and uses thereof  
The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof; useful as a peripheral mu opioid receptor antagonist.
8748450 Morphinan compounds  
This disclosure relates to novel morphinan compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising...
8716306 Carboxamide bioisosteres of opiates  
A compound of formula I is disclosed. Compounds of formula I are useful as analgesics, anti-inflammatory agents, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
8710072 Morphinan compounds  
This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of...
8680112 Methods for treating diseases with 4-hydroxybenzomorphans  
4-Hydroxybenzomorphans containing carboxamide or thiocarboxamide at the 3-position are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
8637567 Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamic acid  
This invention provides compounds, compositions and methods for treating a cognitive disorder or memory disorder in animals that result from aging or other neurodegenerative condition. In...
8609684 Solubilization and bioavailability of acetaminophen  
A composition for increasing the bioavailability of Acetaminophen in humans and animals, comprising Acetaminophen, a first water soluble surfactant having a cloud point greater than about 37° C.,...
8604082 Method to treat premature ejaculation in humans  
The present invention belongs to the fields of pharmacology, medicine and medicinal chemistry, and provides methods and compositions for treating sexual dysfunction; more particularly, the...
8597681 Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans  
Methods for producing stabilized solid dosage form pharmaceutical compositions are provided. In particular, methods for preparing protected granules containing morphinans, and solid dosage form...
8598191 Controlled release compositions of gamma-hydroxybutyrate  
The present invention is directed to oral pulse-release pharmaceutical dosage form containing an immediate release component of gamma-hydroxybutyric acid, and one or more delayed/controlled...
8563572 Quaternary opioid carboxamides  
Compounds of formulas: are disclosed. The compounds are useful for ameliorating the side effects of therapeutic opiates.
8557837 Sinomenine derivatives, synthetic methods and uses thereof  
The invention relates to sinomenine derivatives, methods for their synthesis and their applications. The sinomenine derivatives include oxidation derivatives, and C-10 substituted sinomenine...
8557784 Glycyrrhizinates of morphinan derivatives  
The present invention provides a pharmaceutically acceptable compound, a pharmaceutical composition comprising the above-mentioned pharmaceutically acceptable compound. The pharmaceutically...
8546348 Upregulation of opioid receptors for management  
Disclosed are methods for treating pain in a subject. The method includes upregulating expression of opioid receptors in the subject's dorsal root ganglion or trigeminal neurons. Also disclosed...
8541436 Morphinan compounds  
This disclosure relates to novel morphinan compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising...
8524274 Liposomal composition comprising an active ingredient for relaxing smooth muscle, the production of this composition and the therapeutic use thereof  
The invention relates to a pharmaceutical composition made from an active ingredient included in liposomes for topical application, whereby the liposomes have an aqueous medium in the interior...
8470845 Analgesic and methods of treating pain  
An analgesic which may be applied to wide variety of pain from various causes is disclosed. The analgesic comprises as an effective ingredient a specific morphinan derivative having a nitrogen...
8461173 Rapid release mini-tablets provide analgesia in laboratory animals  
Pellets containing an analgesic uniformly dispersed in a lipid carrier such as cholesterol mixed with fatty acid esters, can be used to provide long term pain relief. 5 mg...
8440684 Polycyclic pyrrolidine-2,5-dione derivatives as -formyl peptide receptor like-1 (FPRL-1) receptor modulators  
The present invention relates to novel polycyclic pyrrolidine-2,5-dione derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as...
8420663 Peripheral opioid receptor antagonists and uses thereof  
The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
8404706 Opioid and opioid-like compounds and uses thereof  
The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations containing the same and methods of use thereof. Uses of the present invention include, but are...
8362029 Opioid-containing oral pharmaceutical compositions and methods  
The present invention provides sustained-release oral pharmaceutical compositions and methods of use. The sustained-release oral pharmaceutical compositions include an opioid (including salts...
8338446 Peripheral opioid receptor antagonists and uses thereof  
The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof, useful as a peripheral mu opioid receptor antagonist.
8329720 Opioid salts and formulations exhibiting abuse deterrent and anti-dose dumping properties  
A drug substance with a pharmaceutically acceptable organic acid addition salt of an opioid wherein said organic acid is selected from Structure A: wherein R1-R4 are independently selected from H,...
8309570 Treatment of central neuropathic pain  
Central neuropathic pain is treated with an analgesic composition that consists essentially of an N-methyl-D-aspartate (NMDA) receptor antagonist. In one embodiment, the invention includes chronic...
8252808 Process and compounds for the production of (+)opiates  
The invention generally provides processes and intermediate compounds useful for the production of (+)-opiates. Non-limiting examples of (+) opiates that may be derived from one or more compounds...
8247425 Peripheral opioid receptor antagonists and uses thereof  
The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
8227484 Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders  
Pharmaceutical compositions and methods for treating neurological disorders by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine.
8198294 Treatment of dyskinesia  
The invention relates to the use of compounds which inhibit selectively mu opioid receptor activity, or activation, for the treatment of dyskinesia (which, for example, may arise as a side effect...
8193211 Controlled release compositions of gamma-hydroxybutyrate  
The present invention is directed to oral pulse-release pharmaceutical dosage form containing an immediate release component of gamma-hydroxybutyric acid, and one or more delayed/controlled...
8188110 Morphinan compounds  
This disclosure relates to novel morphinan compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising...
8178551 Orally bioavailable prodrugs of (+)-3-hydroxymorphinan for Parkinson'S disease prevention or treatment  
The present invention is directed to a novel prodrug of (+)-3-hydroxymorphinan compound of formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing the same, and its use...
8106065 Antitussive agent  
An antitussive, which can be used for therapy or prophylaxis of coughing, is disclosed. The antitussive comprises as an effective ingredient a morphinan derivative having a nitrogen-containing...
8093261 Rapid release mini-tablets provide analgesia in laboratory animals  
Pellets containing an analgesic uniformly dispersed in a lipid carrier such as cholesterol mixed with fatty acid esters, can be used to provide long term pain relief. 5 mg...
8067213 Production of thebaine and oripavine  
There is disclosed an improved poppy straw of a stably reproducing Papaver somniferum for the extraction of thebaine and/or oripavine, the threshed straw having thebaine and oripavine constituting...

Matches 1 - 50 out of 211 1 2 3 4 5 >