Patents in Class 514/286

Matches 1 - 48 out of 48

Match	Document	Document Title
1	7629337	Chemokine receptor binding heterocyclic compounds Heterocyclic compounds that bind chemokine receptors and inhibit the binding of their natural ligands are disclosed. The invention compounds are protective against infection by HIV and exert...
2	7625921	Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including...
3	7605264	Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes,...
4	7476678	Rapamycin derivatives and the uses thereof in the treatment of neurological disorders Pharmaceutical composition containing compounds of the following structure, wherein R 1 -R 9 , R 15 , and n are defined herein, are provided. These compositions are useful in treating...
5	7456177	Heteroaryl fused azapolycyclic compounds The present invention provides a compound having the structure of formula I: wherein R 1 is hydrogen, (C 1 –C 6 ) alkyl, unconjugated (C 3 –C 6 ) alkenyl, benzyl, YC(═O)(C 1 –C 6 )...
6	7326728	Modulators of glucocorticoid receptor, AP-1, and/or NF-κβ activity and use thereof Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes,...
7	7205300	Aryl fused azapolycyclic compounds This invention is directed to compounds of the formula (I): and their pharmaceutically acceptable salts, wherein R 1 , R 2 , and R 3 are as defined herein; intermediates for the synthesis of...
8	7144882	Aryl fused azapolycyclic compounds This invention is directed to compounds of the formula (I): and their pharmaceutically acceptable salts, wherein R 1 , R 2 , and R 3 are as defined herein; intermediates for the synthesis of...
9	6908927	Pyridopyranoazepine derivatives, their preparation and their therapeutic application The invention relates to pyridopyranoazepine derivatives, to pharmaceutical compositions containing them, to process for preparing them, and to the method of use thereof in the treatment or...
10	6849619	Substituted pyridoindoles as serotonin agonists and antagonists The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R 1 , R 5 , R 6 , R 7 , R 8 , R 9...
11	6784186	Therapeutic compounds This invention relates to novel structural analogues and derivatives of compounds with general analgesic or related pharmacological activity. In particular the invention relates to derivatives of...
12	6759065	Extraction method, pharmaceutical composition and a cosmetic composition A compound is extracted from vegetable material, wherein the vegetable material is reduced and treated with a solvent. According to the invention, the vegetable material is frozen using a liquid...
13	6541484	Pyrazolo-pyridine derivatives as ligands for GABA receptors A class of substituted and/or ring-fused pyrazolo[3,4-b]pyridine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent on the pyrazole nitrogen atom...
14	6380193	Fused tricyclic compounds, methods and compositions for inhibiting PARP activity A compound of formula I: or a pharmaceutically acceptable salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof.
15	6369052	Combination of huperzine and nicotinic compounds as a neuroprotective agent The present invention provides compositions and methods for treating, preventing, or reversing neuronal dysfunction including cognitive decline, such as cognitive decline associated with aging and...
16	6346536	Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same Poly(ADP-ribose) polymerase (“PARP”) inhibitors and methods for treating neurodegenerative diseases, neural tissue damage related to cerebral ischemia and reperfusion injury, and cardiovascular...
17	6087371	Heterocyclyl-ergoline derivatives as 5-HT.sub.1A receptor ligands Ergoline derivative having formula (I) wherein R 1 is hydrogen atom or C 1 -4 alkyl group; R 2 is hydrogen, chlorine, or bromine atom, methyl or C 1 -4 alkylthio group; n is 0, 1 or 2; the...
18	5935975	Agonist-antagonist combination to reduce the use of nicotine and other drugs A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine or an agonist of...
19	5604246	2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones This invention is directed to 2-aminoalkyl-5-aminoalkylamino substituted isoquino[8,7,6-cd]indazole-6-(2H)-ones and to 2-aminoalkyl-5-aminoalkylamino...
20	5587451	Process for preparing polyazamacrocycles A process for preparing polyazamacrocyclic compounds using a nucleophilic imidazoline with (A) an ethylene oxide or an ethylene carbonate, in an aprotic solvent, followed by intramolecular...
21	5385893	Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents Tri- and tetra-cyclopolyazamacrocyclophosphonic acid compounds and their derivatives are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be...
22	5252612	Microbial immunosoppressant agent Described is a new immunosuppressant, L-683,756, a bisdemethylated, ring rearranged derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, Actinoplanacete sp....
23	5250537	5,6,7,8,9,10-hexahydro-7 ,10-iminocyclohept[b]indole,-6,7,8,9,10-hexahydro-7,11-imino-5H-cyclooct[ b]indole and substituted derivatives 5,6,7,8,9,10-Hexahydro-7,10-iminocyclohept[b]indole, 6,7,8,9,10,11-hexahydro-7,11-imino-5H-cyclooct[b]indole and substituted derivatives are effective in the treatment of psychoses with limited...
24	5196415	5-aminocarbonyl-5H-dibenzo[a.d]cyclohepten-5,10-imines for treatment of epilepsy and cocaine addiction This invention is in the field of clinical neurology and relates specifically to compounds, compositions and methods for treatment of patients with generalized epilepsy or partial (symptomatic)...
25	5177082	Huperzines and analogs The invention relates to compounds of the formulas ##STR1## wherein R 1 , R 2 and R 3 independently are hydrogen or lower alkyl, and the dotted ( . . . ) line is an optional double bond, and...
26	5164399	Rapamycin pyrazoles A compound of the structure ##STR1## wherein Z is ##STR2## and R 1 is hydrogen, alkyl, or arylalkyl, provided that when R 2 is present, R 1 is absent; R 2 is hydrogen, alkyl, or arylalkyl,...
27	5141934	Tetracyclic amines having pharmaceutical activity The present invention relates to novel tetracyclic amines and derivatives thereof useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include...
28	5100647	Method and formulations for the therapy of cystic fibrosis, Bartter's syndrome and secretory diarrheas, and for diuretic treatment Methods for the therapy of cystic fibrosis, Bartter's syndrome, and secretory diarrheas, and for diuretic treatment, by administering to a patient...
29	5098909	5-HT.sub.3 receptor antagonists for treatment of cough and bronchoconstriction A method of treatment of cough and/or bronchoconstriction in mammals, including humans, which method comprises the administration to the mammal in need of such treatment, an effective amount of a...
30	4985430	9-acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient There are disclosed a 9-acylamino-tetrahydroacridine derivative represented by the following formula (I): ##STR1## wherein R ##STR2## are as defined in the specification, its optical antipode or...
31	4879299	Treatment of heart conditions with spartein compounds Compounds of Formula (I) S--(CH2)n--Atm (I) in which S is a 17-spartein nucleus, n is 0 or 1, and A is 2-furyl, 2-thienyl or 2-(N-loweralkyl)pyrryl when n=0, or 3-furyl or 3-thienyl...
32	4803208	Opiate agonists and antagonists Dihydromorphinone compound of the general formula HDMN--R wherein ##STR1## where * indicates binding carbon R1 is an optionally substituted alkyl, alkylene, cycloalkyl, or cycloalkylene R2...
33	4762828	1,2,4-triazolo[4,3-d]-4-azatricyclo-[4.3.1.1.sup.3,8 ]undecane and 3-substituted derivatives, and intermediates thereof 1,2,4-Triazolo[4,3-d]-4-azatricyclo[4.3.1.1 3 ,8 ]-undecane and 3-derivatives and intermediates thereof are described. The compounds are useful and antiinflammatory and antihypoxia agents.
34	4755520	Spartein compounds, their preparation and use Compounds of Formula (I) S--(CH 2 ) n --A (I) in which S is a 17-spartein nucleus n is 0 or 1 and A is 2-furyl, 2-thienyl or 2-(N-alkyl)pyrryl when...
35	4599341	Substituted and bridged pyridines useful as calcium channel blockers Novel substituted and bridged pyridine compounds useful as calcium channel blockers, pharmaceutical compositions thereof, and methods of treatment are disclosed.
36	4587253	Bridged pyridine compounds useful as calcium channel blockers and analgesics Novel substituted and bridged pyridine compounds useful as calcium channel blockers and analgesics, pharmaceutical compositions thereof, and methods of treatment are disclosed.
37	4479957	Use of vindesine in treating acute lymphatic leukemia and _other susceptible neoplasms This invention relates to a method of treating neoplasms which comprises administering to a mammal suffering from a vindesinesusceptible neoplasm selected from the group consisting of acute...
38	4451468	Acidiferous 17-normal-pentyl sparteine tartaric and fumaric acid salts pharmaceutical compositions thereof Acidiferous salts of 17-β-n-pentyl sparteine are crystallized out of a solution of 17-β-n-pentyl sparteine and a dicarboxylic acid selected from the group consisting of tartaric acid, fumaric...
39	4415577	Bis-sparteine derivatives and method of using same in therapy Disclosed are a novel dimeric sparteine derivative, the 17S,17'S-bissparteine, and its physiologically compatible acid addition salts. Said compounds are produced by dimerization of 17-hydroxy...
40	4252810	9,10-Dihydro-4H-benzo[4,5]cyclohepta [1,2-b]thiophen-4,9-imines 9,10-Dihydro-4H-benzo[4,5]cyclohepta [1,2-b]thiophen-4,9-imines, derivatives and pharmaceutically acceptable salts thereof are useful as antianxiety agents, as muscle relaxants and in the treatment...
41	4248874	Benzopyrano compounds as antiglaucoma agents A method of reducing intra-ocular pressure in mammalian patients comprising administering to a glaucoma patient a therapeutically effective amount of a compound of the formula ##STR1## wherein, in...
42	4247557	Benzopyranopyridines as antiglaucoma agents A method of reducing intra-ocular pressure in mammalian patients comprising administering to a glaucoma patient a therapeutically effective amount of a compound of the formula ##STR1## wherein, in...
43	4232026	Diazaditwistanes, and pharmaceutical compositions for treating pain in warm blooded animals containing them Certain 2- and/or 9- phenylalkyl-5,11-dimethyl-5,11-diazaditwistane compounds bind to opiate receptor sites and have central nervous system activities exemplified by analgesia.
44	4229455	Imino-bridged benzocycloheptapyridines Benzocycloheptapyridines with an imine bridge in the cycloheptane ring, derivatives and pharmaceutically acceptable salts thereof are useful as antianxiety agents, as muscle relaxants and in the...
45	4217351	Benzopyrano quinuclidines useful as antiglaucoma agents A method of reducing intra-ocular pressure in mammalian patients comprising administering to a glaucoma patient a therapeutically effective amount of a compound of the formula ##STR1## wherein, in...
46	4201783	Antidepressant substituted hexahydro benzopyrano [3,2-c] pyridines Substituted hexahydro benzopyrano [3,2-c] pyridines, useful as antidepressants, have the formula ##STR1## where R is hydrogen or a saturated or unsaturated, linear or branched, lower alkyl, or an...
47	4052508	Heterocyclic dihydroanthracen imines Heterocyclic dihydroanthracen imines are disclosed to be useful as minor tranquilizers, anticonvulsants, muscle relaxants and to be useful in the treatment of extrapyramidal disorders such as...
48	4020163	Use of heterocyclic esters of 5H-[1]benzopyrano [3,4-b]pyridines as analgesics Heterocyclic esters of 1,4-ethano-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-b]pyridi nes and 1,4-ethano-1,2,3,4,13,14-hexahydro-5H-[1]benzopyrano[3,4-b]p yridines. The esters have the formulas...

Matches 1 - 48 out of 48