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7388016 Dibenzonaphthyridine derivatives and methods of use thereof  
The present invention relates to Dibenzonaphthyridine Derivatives, compositions comprising an effective amount of a Dibenzonaphthyridine Derivative and methods for treating or preventing a...
7354927 6H-[1]benzopyrano[4,3-b]quinolines and their use as estrogenic agents  
This invention provides 6H-[1]benzopyrano[4,3-b]quinoline compounds having the formula I: The invention further provides compositions including the compounds, methods for the use of the...
7307080 Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage  
The disclosure relates to compounds, pharmaceutical compositions and methods for inhibiting PARP by use of the disclosed compositions. The compounds of the disclosure have the following structures...
7268143 Isoquinoline derivatives and methods of use thereof  
The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described.
7253179 Fused heterocyclic compounds  
Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds...
7220754 Mono-ester and asymmetrically substatuted di-ester pro-drugs of dopamide D1 receptor agonists  
Mono-ester and asymmetrically substituted diesters of dihydrexidine, dinapsoline and A-86929 and substituted derivatives thereof are described. The novel ester/diester derivatives exhibit improved...
7208492 Topoisomerase-targeting agents  
The invention provides compounds of formula I or formula II: wherein: the bond represented by --- is a single bond or a double bond, and R 1 –R 5 , X, and Y have any of the meanings defined...
7199130 Substituted 5,6,6a, 11b-tetrahydro-7-oxa-5-aza-benzo[c]fluorene-6-carboxylic acid compounds as NMDA-antagonists  
Substituted 5,6,6a,11b-tetrahydro-7-oxa-5-aza-benzo[c]fluorene-6-carboxy lic acid compounds, and processes for the production thereof, pharmaceutical compositions containing these compounds and the...
7163946 5-substituted 7,9-difluoro-5H-chromeno[3,4-f]quinoline compounds as selective progesterone receptor modulator compounds  
The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by progesterone receptor. Also provided are methods of making such...
7135478 Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them  
A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.
7125885 Fused heterocyclic compounds  
The present invention provides compounds having the formula: wherein R 1 , R 2 , R, R′ and the subscript p are described herein. The compounds are useful in the treatment and/or prevention of...
7084151 5-(1',1'-cycloalkyl/alkenyl)methylidene 1,2-dihydro-5H-chromeno[3,4-ƒ]quinolines as selective progesterone receptor modulator compounds  
The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such...
7071205 5-cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds  
The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such...
7060711 Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist  
The present invention relates to derivatives of 4-(Thio- or Selenoxanthene-9-ylidene)-piperidine or acridine and pharmaceutically acceptable salts thereof, use of these compounds as a medicament...
7026329 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists  
This invention relates to a method for selectively enhancing the analgesic potency of a bimodally-acting opioid agonist such as morphine and simultaneously attenuating anti-analgesia, hyperalgesia,...
6992089 Nitro and amino substituted topoisomerase agents  
The invention provides compounds of formula I: wherein R 1 -R 9 , W, and X have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also...
6989388 Thieno[2,3-c]iosquinolines for use as inhibitors of PARP  
The present invention relates to compounds for the inhibition of poly(ADP-ribose) polymerase (PARP). In some embodiments, the compounds have the Formula: wherein the constituent variables are...
6989387 Nitro and amino substituted topoisomerase agents  
The invention provides compounds of formula I: wherein R 1 –R 9 , W, and X have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention...
6984641 Carboline derivatives as PDE5 inhibitors  
Selective inhibitors of cGMP-specific PDE, and use of the compounds and salts and solvates thereof as therapeutic agents, are disclosed.
6967215 Tetrahydrocarbazoles, a process for the preparation of those compounds, and the use thereof  
Tetrahydrocarbazoles of formula where Q is —SO 2 —; —O—; or —(CO)—; X is —(CH)—; or —N—; m is from 1 to 3; t is 0 or 1 and the remaining substituents are as defined herein,...
6960585 Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same  
Compounds of formula (I), or pharmaceutically-acceptable salts thereof, are useful in treating inflammatory and immune diseases and disorders, wherein X, Y 1 , Y 2 , and R 2- 4 are as...
6946472 Polycyclic compounds exhibiting anti-tumor activities  
This invention is concerned with novel polycyclic compounds of formula [I], wherein ring A, ring B, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X, Y, R 1′ , R 2′ , R 3′ , R 4′ , R 5′ , R 6...
6921768 Cytostatic cerium compounds  
The invention relates to cerium compounds having general formulas (I) R n i+ Y i n− and (II) R b + Y b + and their application as medicaments in the prophylaxis and/or treatment of cancer...
6916823 Method of treatment of dopamine-related dysfunction  
The present invention relates to the treatment of dopamine-related dysfunction using full D 1 dopamine receptor agonists in an intermittent dosing protocol with a short, but essential,...
6893668 Process for isolation of anticancer agent camptothecin from Nothapodytes foetida  
The present invention relates to an improved and economical process for the isolation of anticancer agent Camptothecin from the twigs and stem of Nothapodytes foetida using hot extraction 20(S)...
6872743 sPLA2 inhibitors  
A novel class of tetracyclic compounds represented by the formula I wherein R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, and n are as defined is disclosed together with the use of such compounds...
6858624 Aryl fused azapolycyclic compounds  
This invention is directed to compounds of the formula (I): and their pharmaceutically acceptable salts, wherein R 1 , R 2 , and R 3 are as defined herein; intermediates for the synthesis of...
6858620 Condensed pyridoindole derivatives  
Compounds of general structural formula (I), and use of the compounds or salts or solvates thereof as therapeutic agents, are disclosed
6858619 Fused heterocyclic compounds  
Compounds useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor are provided that have the formula: wherein A and B are CR′; V...
6844353 Fungicidal properties of sampangine and its analogs to agriculturally important fungal plant pathogens  
It has been found that sampangine and related analogs such as benzo[4,5]sampangine, 4-bromosampangine and 4-methoxysampangine may be used as effective fungicidal agents for plants. Fungicidal plant...
6838456 Condensed pyridoindole derivatives  
Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents.
6828319 Substituted indeno&lsqb 1,2-c&rsqb isoquinoline derivatives and methods of use thereof  
The invention provides novel classes of substituted Indeno[1,2-c]isoquinoline Compounds. Pharmaceutical compositions and methods of making and using the compounds, are also described.
6825209 Compounds having unique CB1 receptor binding selectivity and methods for their production and use  
Compounds are provided that are amide analogs of SR141716A having unique CB1 receptor selectivity and providing WIN sparing binding characteristics, pharmaceutical compositions containing the...
6809104 Fused heterocyclic compounds  
Compounds having the formula: wherein L is a bond or (C 1 -C 4 )alkylene, R″ is hydrogen or (C 1 -C 8 )alkyl, and R 1 , R 2 , R 4 , R, R′, and the subscript n are as described herein, are...
6706704 Method of inducing opioid analgesia and anesthesia without respiratory suppression  
The invention is directed to a pharmaceutical composition and a corresponding method for inhibiting respiratory depression in a mammalian subject during treatment with opiates. The composition...
6699899 Substituted acylhydroxamic acids and method of reducing TNFα levels  
Imido and amido substituted acylhydroxamic acids which reduce the levels of TNFα and inhibit phosphodiesterase in a mammal. A typical embodiment is...
6696459 Steroid receptor modulator compounds and methods  
Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds,...
6680326 Polycyclic compounds  
Novel polycyclic compounds of the formula [I], wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , ring A, ring B, X, Y and Z are as defined herein and the pharmaceutically acceptable salts...
6630481 Viologen linked acridine based molecule and process for the preparation thereof  
The present invention provides a series of novel bifunctional molecules based on viologen linked acridine, bisacridine and bisacridinium salts of the general formula 1 (1a, 1b, 1c and 1d) and or...
6608076 Camptothecin derivatives and polymeric conjugates thereof  
Polymeric conjugates of camptothecin derivatives having increased circulating half-lives are disclosed. In preferred aspects, the E ring lactone of the camptothecin derivative is opened and...
6562328 Fatty quat based on ante-iso compounds  
The invention discloses quaternary ante-iso acids useful as additives in personal care products. Various quaternary derivatives of ante-sio acids are described, and examples of their use in...
6548515 Dihydrofuro&lsqb 3,4-b&rsqb quinolin-1-one compounds  
The invention relates to compound of formula (I): wherein: represents a single or double bond, R 0 represents hydrogen or hydroxy or alkoxy, R 1 and R 2 , which are identical or different,...
6534516 Androgen receptor modulator compounds and methods  
Non-steroidal compounds that are high affinity, high selectivity modulators for androgen receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds,...
6514983 Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage  
This invention relates to compounds, pharmaceutical compositions, and methods of using compounds of the formula: or a pharmaceutically acceptable salt, hydrate, prodrug, or mixtures thereof,...
6506766 Glucocortiocoid-selective antinflammatory agents  
Compounds having Formula I are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor and treating immune, autoimmune and inflammatory...
6486167 Heterocyclic cytotoxic agents  
The present invention provides compounds of formula I: wherein the R substituents and atoms X and Y are as defined in specification. The present invention also provides pharmaceutical...
6469019 Therapeutic application of nicergoline  
The invention concerns the use of nicergoline for preventing and/or treating motor neuron diseases.
6448255 Imidazo-isoquinolin-5-one derivatives, pyrimido-isoquinolin-6-one derivatives and imidazo-naphthyridin-5-one derivatives  
Antiatherosclerotic compounds are provided which have the following structure: wherein: R is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, heteroaryl, or aryl or heteroaryl substituted with one...
6440988 Use of agonists or antagonists of the 5-HT7 receptor to treat disorders of the bladder  
The present invention provides a method of treating urinary incontinence in a subject which comprises administering to the subject a therapeutically effective amount of a 5-HT 7 receptor...
6436971 Use of PDE 4-specific inhibitors to reduce the severity of a bacterial infection after a respiratory viral infection  
This invention relates to a method for the prophylaxis of or reducing the severity of post-viral bacterial infection by administering a PDE 4-specific inhibitor prior to or during the course of a...
Matches 1 - 50 out of 189 1 2 3 4 >