Matches 51 - 100 out of 275 < 1 2 3 4 5 6 >
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6548515 Dihydrofuro&lsqb 3,4-b&rsqb quinolin-1-one compounds  
The invention relates to compound of formula (I): wherein: represents a single or double bond, R 0 represents hydrogen or hydroxy or alkoxy, R 1 and R 2 , which are identical or different,...
6545011 Substituted 4,9-dihydrocyclopenta&lsqb imn&rsqb phenanthridine-5-ones, derivatives thereof and their uses  
This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
6541483 Acridone-derived compounds useful as antineoplastic and antiretroviral agents  
The present invention relates to several novel acridone-derived compounds of of formula (I) or (II). These compounds are potent anti-viral agents, useful in the treatment of viral diseases, such as...
6528521 Treatment of anti-depression drug-induced sexual dysfunction with apomorphine  
A method for treating sexual dysfunction that is caused by anti-depressant medication in a patient in need of such treatment, comprising administering a therapeutically effective amount of...
6521634 Uses of dl-THP  
The present invention is concerned with new, previously unsuggested, therapeutic uses of dl-THP (dl-tetrahydropalmatine) including anxiety disorders, seizures, and status epilepticus.
6509344 Indenoisoquinolines as antineoplastic agents  
A number of indenoisoquinolines were prepared and evaluated for cytotoxicity in human cancer cell cultures and for activity versus topoisomerase I. The two most cytotoxic indenoisoquinolines proved...
6506765 Apomorphine derivatives and methods for their use  
Apomorphine derivative compounds; pharmaceutically active compositions of apomorphine derivative compounds; and the use of apomorphine derivative compounds in methods for treating sexual...
6486167 Heterocyclic cytotoxic agents  
The present invention provides compounds of formula I: wherein the R substituents and atoms X and Y are as defined in specification. The present invention also provides pharmaceutical...
6486204 Treatment or prevention of prostate cancer with a COX-2 selective inhibiting drug  
A COX-2 selective inhibiting drug is disclosed as useful in treating or preventing prostate cancer. The compound is used alone or in combination with other drugs.
6476021 Compounds having cGMP-PDE inhibitory effect  
Novel fused tetracyclic heterocyclic compounds having a potent and highly selective effect of inhibiting cyclic GMP phosphodiesterase (cGMP-PDE) and a high safety; a process for producing the same;...
6469019 Therapeutic application of nicergoline  
The invention concerns the use of nicergoline for preventing and/or treating motor neuron diseases.
6468996 Substituted hetero-polycyclic compounds as PPARα and PPAR&ggr activators  
The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the...
6444683 17-azolyl steroids useful as androgen synthesis inhibitors  
Androgen synthesis inhibitors, as well as methods for the use of the same to reduce plasma levels of testosterone and/or dyhydrotestosterone, and to treat prostate cancer and benign prostatic...
6432971 Method of prevention of prostatic carcinoma with 17β-N-monosubstituted-carbamoyl-4-aza-5α-androst-1-en-3-ones  
17β-N-monosubstituted-carbamoyl-4-aza-5α-androst-1-en-3-on es of the formula wherein R 1 is selected from hydrogen, methyl and ethyl and R 2 is a straight or branched chain alkyl,...
6403640 Method for treating chronic prostatitis or chronic pelvic pain syndrome  
The use of a COX-2 selective inhibitor for the treatment of chronic prostatitis or chronic pelvic pain syndrome is disclosed.
6403605 Methods for the normalization of sexual response and amelioration of long term genital tissue degradation  
The present invention provides, in one embodiment, a method of normalizing the timing of sexual response in a mammal comprising the administration of an amount of a central nervous system sexual...
6395744 Method and compositions for the treatment or amelioration of female sexual dysfunction  
The present invention provide a method of treating sexual dysfunction in a female, including the vasculogenic symptoms of delayed vaginal engorgement, diminished vaginal lubrication, pain or...
6365597 4-aza steroids  
The invention related to 4-aza-17β-(cyclopropoxy)-androst-5α-androstan-3-one, 4-aza-17β-(cyclopropylamino)-androst-4-en-3-one and related compounds and to compositions incorporating these...
6355649 Method of treating seborrhea with 5-α reductase inhibitors  
The instant invention involves a method of treating and/or reversing androgenic alopecia and promoting hair growth, and methods of treating acne vulgaris, seborrhea, and female hirsutism, by...
6352997 Method of improving in-vitro fertilization  
The present invention provides for a method of treating polycystic ovary syndrome in a subject in need of such treatment comprising the administration of a therapeutically effective amount of a...
6342246 Image forms and method for ameliorating male erectile dysfunction  
The use of a pharmaceutical composition for oral administration comprising a carrier and active ingredient selected from a dopamine agonist, testosterone and mixtures thereof, the composition being...
6313134 Uses of thaliporphine or its derivatives in treatment of cardiac diseases and preparation of same  
The present invention discloses thaliporphine and its derivatives for the treatment and/or prophylaxis of cardiac diseases, including cardiac arrhythmia, myocardial ischemia or myocardial...
6306437 Apomorphine-containing dosage forms for ameliorating male erectile dysfunction  
Psychogenic impotence can be ameliorated without substantial undesirable side effects by administration of apomorphine and an antiemetic agent in an amount sufficient to substantially reduce nausea...
6297286 Therapeutic use and formulation  
Substantially single-enantiomer(-)-tramadol, and its metabolites and structural and/or functional analogues, are useful for the prevention and/or treatment of one or more symptoms selected from...
6291471 Use of apomorphine for the treatment of organic erectile dysfunction in males  
A method of treating organic erectile dysfunction, particularly vasculogenic erectile dysfunction comprises administering to a male in need of such treatment a therapeutically effective amount of...
6284770 Medicaments for the treatment of non-constipated female irritable bowel syndrome  
This invention relates to the use of 5-HT3 receptor antagonists in the treatment of nonconstipated female IBS patients.
6277416 Pesticides comprising benzophenanthridine alkaloids  
The present invention relates to a chemical composition useful in the chemical management of plant disease. The pesticides of the present invention incorporate benzophenanthridine alkaloids into...
6271246 Pharmaceutical compositions for managing scalp conditions  
This application relates to a pharmaceutical composition for the prevention, treatment, and management of scalp conditions, such as dandruff, seborrheic dermatitis, psoriasis, folliculitis, and...
6268377 Method for treating androgen-related conditions  
The present invention provides for the combined use of 5α-reductase inhibitors together with calcium channel blockers for the treatment of benign prostatic hyperplasia (BPH), prostate cancer,...
6251915 Method for prevention of prostate cancer  
A method for treatment or prevention of prostate cancer by administering an effective amount of a compound of the formula (I) or a pharmaceutically acceptable salt or ester thereof. In formula (I)...
6239139 13,13A-Didehydroberbine derivatives  
The present invention provides a cholesterol biosynthesis inhibitor which specifically inhibits the sterol 14-reductase which is involved in the distal pathway of cholesterol biosynthesis, a...
6204273 16-substituted-4-aza-androstane 5-α-reductase isozyme 1 inhibitors  
Compounds of the Formula I ##STR1## are inhibitors of the 5α-reductase 1 isozyme, and are useful alone, or in combination with a 5α-reductase 2 inhibitor, for the treatment of androgenic...
6200983 Dosage forms containing apomorphine for ameliorating male erectile dysfunction  
Psychogenic impotence or erectile dysfunction can be identified in psychogenic male patients and can be ameliorated, without substantial undesirable side effects, by sublingual administration of...
6200965 17-Azolyl steroids useful as androgren synthesis inhibitors  
Androgen synthesis inhibitors, as well as methods for the use of the same to reduce plasma levels of testosterone and/or dyhydrotestosterone, and to treat prostate cancer and benign prostatic...
6197768 Pyridocarbazole derivatives having cgmp-pde inhibitory activity  
The invention relates to novel pyridocarbazole derivatives having highly selective action in inhibiting cyclic GMP-phosphodiesterase (hereinafter abbreviated as cGMP-PDE), processes for producing...
6194423 Fused isoquinolines as dopamine receptor ligands  
The present invention is directed to a novel dopamine receptor ligands of the formula: ##STR1## pharmaceutical formulations of such compounds, and a method using such compounds for treating a...
6184228 Anti-sickling agents: selection methods and effective compounds  
The present invention is directed to a method for selecting compounds for use in treating sickle cell disease in a patient. The method comprises the steps of selecting a first set of HbS ligands...
6174892 Method of treating acne with 5-α reductase inhibitors  
The instant invention involves a method of treating and/or reversing androgenic alopecia and promoting hair growth, and methods of treating acne vulgaris, seborrhea, and female hirsutism, by...
6143757 Chemical compounds  
Compounds of the general structural formula ##STR1## and use of the compounds and salts and solvates thereof, as therapeutic agents.
6133288 Pentacyclic compounds, intermediates, processes, compositions, and methods  
The present invention provides compounds of formula I and II: ##STR1## wherein X is --O--, --S--, or --NR 5 --; Y is --O--, --S--, --CH 2 --, --CH 2 CH 2 --, --CHCH--, or --NR 5 --; B...
6133280 Androgen synthesis inhibitors  
This invention relates to novel inhibitors of androgen synthesis that are useful in the treatment of prostate cancer and benign prostatic hypertrophy. The present invention also provides methods of...
6130228 Polycyclic compounds  
Compounds of Formula (I), methods for their preparation, pharmaceutical formulations and use thereof. ##STR1##
6127378 Phenanthridines substituted in the 6 position  
Compounds of the formula I in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel efficacious bronchial therapeutics.
6124282 Drug formulations  
Various compounds that can inhibit the enzyme CYP2D6 are disclosed. The compounds are useful in increasing the effectiveness and reducing the abuse potential of drugs that are metabolised by CYP2D6.
6121275 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Coralyne analogs as topoisomerase inhibitors  
The present invention provides protoberberine alkaloid derivatives useful as anticancer agents, and methods of use thereof. The invention also provides protoberberine derivatives useful as...
6121277 Camptothecin-skeleton compounds isolated from Mappia foetida and the use thereof as syntones for novel medicaments as well as therapeutical agents  
The present invention relates to camptothecin-skeleton alkaloids isolated from Mappia foetida or obtained by semi-synthesis from said alkaloids. Mappia foetida, a plant growing in the Indian...
6114345 Phenylsubstituted 4-azasteroid fluoroderivatives  
Compounds of formula (I), wherein: the symbol ---- represents a single or a double bond; R is a hydrogen atom or a C 1 -C 4 alkyl group; R f and R' f , each independently, are C 1 -C 4 alkyl...
6114326 Use of cabergoline in the treatment of restless legs syndrome  
The present invention provides for the use of cabergoline and other agents for the treatment of restless legs syndrome (RLS).
6093722 Method for treating prostate cancer  
A method for treatment or prevention of prostate cancer by administering an effective amount of a compound of the formula (I) or a pharmaceutically acceptable salt or ester thereof. In formula (I)...
6087362 Apomorphine and sildenafil composition  
The treatment of sexual dysfunction in human patients by an oral therapy regimen of administration of apomorphine and sildenafil is disclosed. This treatment optimizes the efficacy of each drug and...
Matches 51 - 100 out of 275 < 1 2 3 4 5 6 >