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7557119 |
Large substituent, non-phenolic opioids
8-Substituted-2,6-methano-3-benzazocines of general structure
are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. One embodiment is...
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7550592 |
Hydromorphone polymorphs
Hydromorphone hydrochloride forms are disclosed which are useful as analgesic agents either in combination with or as replacements for hydromorphone hydrochloride.
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7538118 |
6-aminomorphinane derivatives, method for production and use thereof
This invention relates to compounds of the formula (I).
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7510726 |
Methods and compositions for deterring abuse of opioid containing dosage forms
This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.
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7501434 |
6-carboxy-normorphinan derivatives, synthesis and uses thereof
The present invention relates to compounds of formula I, synthesis thereof, and methods of using the same.
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7501433 |
Opioid and opioid-like compounds and uses thereof
The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations thereof, and use thereof for prevention and treatment of disorders such as septic shock and organ...
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7495098 |
Extraction of alkaloids from opium
A method for extracting at least one alkaloid from opium that includes dissolving opium in a solvent, heating the dissolved opium solution, cooling the dissolved opium solution, adjusting the pH of...
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7402591 |
Analgesic compositions containing buprenorphine
An analgesic composition in parenteral unit dosage form or in a unit dosage form suitable for delivery via the mucosa comprising an amount of buprenorphine which is less than the clinical dose...
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7375111 |
Compositions for affecting weight loss
Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is an opioid antagonist and the second compound causes increased...
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7354955 |
(2S)-amino(phenyl)acetic acid and derivatives as α2δ voltage-gated calcium channel ligands
The present invention relates to a method for treating pain, reflex sympathetic dystrophy, spasticity, and bipolar disorder using ligands of the α 2 δ voltage-gated calcium channel, wherein the...
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7320984 |
Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group
The invention provides a morphinan derivative of the Formula (I):
wherein R 1 is methyl, cyclopropylmethyl or the like; R 2 and R 3 are hydroxy, methoxy, acetoxy or the like; both Y and Z...
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7271173 |
Mixed kappa/mu opioids and uses thereof
This invention features opioid compounds having activity at kappa and mu receptors, methods for preparing the mu/kappa opioids, and methods for the treatment of pain or a dopamine dysregulation...
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7256200 |
Method and composition for potentiating an oplate analgesic
Composition and methods of treating pain and reducing, reversing, or preventing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and a calcium...
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7241741 |
Methods and compositions for the treatment of asthma and related disorders
The present invention provides methods for the treatment of respiratory tract mucositis in individuals in need of such treatment, the method comprising the systemic administration to the individual...
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7230005 |
Compounds and methods for lowering the abuse potential and extending the duration of action of a drug
The abuse potential of a bioavailable drug such as an opiate analgesic agent is reduced and its duration of action is extended by converting it to a poorly absorbed ester prodrug or other prodrug...
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7199129 |
Derivatives of morphine-like opioid compounds
The present disclosure concerns compounds of formula (I) and pharmaceutically acceptable salts, hydrates, solvates, pharmaceutically acceptable derivatives, pro-drugs, tautomers and/or isomers...
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7192966 |
Pharmaceutical composition
A pharmaceutical composition comprising an analgesic or analgesic combination and a stool softener is disclosed. The analgesic is selected from morphine, meperidine, fentanyl, hydromorphone,...
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7129248 |
Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
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7109161 |
Preserved pharmaceutical formulations
The present invention is directed to the use of benzethonium chloride, alone or in combination with phenoxyethanol or phenyl ethyl alcohol, to provide anti-microbial activity in pharmaceutical...
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RE39300 |
Inhibiting the development of tolerance to and/or dependence on an addictive substance
Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA-receptor...
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7101572 |
Taste masked aqueous liquid pharmaceutical composition
A substantially taste masked liquid pharmaceutical composition containing a pharmaceutically effective amount of an unpleasant tasting drug dissolved or dispersed in an aqueous excipient base, said...
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7074803 |
Opioid formulations
The present invention provides high-concentration formulations of opioids such as fentanyl or fentanyl congeners. The formulation of the invention comprises fentanyl or a fentanyl congener in...
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7060708 |
Active agent delivery systems and methods for protecting and administering active agents
The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active...
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7034036 |
Inhibitors of ABC drug transporters at the blood-brain barrier
The present invention relates to inhibitors of drug transporters of the ABC protein superfamily, particularly transporters present at the blood brain barrier. ABC transporter inhibitors identified...
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7030147 |
Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative
Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease.
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7008939 |
Use of weak opioids and mixed opioid agonists/antagonists for treatment of urinary incontinence
A pharmaceutical composition for the treatment of an increased urge to urinate or urinary incontinence, comprising an effective amount of at least a compound selected from the group consisting of...
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6979689 |
Compositions and methods for treating upper respiratory congestion
A composition of an antitussive, a decongestant, and diphenhydramine as an antihistamine to treat upper respiratory and oral pharyngeal congestion and related symptoms in a patient. In addition to...
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6972291 |
Method for reducing food intake
Provided is a method for curbing dietary cravings in a patient, typically a diabetic or obese patient, by administration of a low dose of naltrexone to the patient.
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6939876 |
Prevention of addiction in pain management
The present invention provides a composition for treating pain. The composition includes a pharmaceutically acceptable analgesic and a GABAergic agent, such as gamma vinyl GABA, effective in...
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6919350 |
Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
A method of reducing, treating or preventing drug-mediated respiratory depression, muscle rigidity, or nausea/vomiting in an animal, incident to the administration to said animal of a mixed...
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6919310 |
Method of treating the syndrome of coronary heart disease risk factors in humans
The invention provides an improved method of treating a human suffering from one or more conditions included within the Coronary Heart Disease Risk Factor (CHDRF) syndrome. The method includes...
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6846831 |
Method of treating the syndrome of lipodystrophy
Methods of treating a human suffering from the Syndrome of Lipodystrophy or one or more HIV-related abnormalities included therein are provided. One method may include administering, by a...
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6828328 |
Analgesic combination of muscarinic agonists
This invention relates to the combination of muscarinic agonists with narcotic analgesics, non-steroidal anti-inflammatory drugs or other analgesic drugs and to their use as antinociception (pain...
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6825205 |
N-substituted hydromorphones and the use thereof
This invention relates to N-substituted hydromorphones of Formula I: or a pharmaceutically acceptable salt thereof, wherein R is C 1-6 alkyl. These compounds act as μ opioid receptor agonists....
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6825203 |
Topical anesthetic/opioid formulations and uses thereof
Many chemical and pharmaceutical compositions are known to produce antinociceptive effects that are helpful in relieving pain and inflammation. Both opioids and local anesthetics serve an important...
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6806291 |
Analgesic compounds, their synthesis and pharmaceutical compositions containing them
New analgesic compounds, which are prepared by the hydrolysis of N-acylated 4-hydroxyphenylamine derivatives, their synthesis and pharmaceutical compositions containing them are disclosed. These...
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6787149 |
Topical application of opioid analgesic drugs such as morphine
The invention is directed to methods and pharmaceutical compositions for the topical administration of opioid analgesic drugs such as morphine. In particular, the invention relates to topical...
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6784187 |
8-carboxamido-2,6-methano-3-benzazocines
8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is —CH 2 —OH, —CH 2 NH 2 , —NHSO 2 CH 3 , and Y is O, S or NOH are useful as analgesics, anti-diarrheal agents,...
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6784186 |
Therapeutic compounds
This invention relates to novel structural analogues and derivatives of compounds with general analgesic or related pharmacological activity. In particular the invention relates to derivatives of...
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6784155 |
Inhibitor and stimulator of stem cell proliferation and uses thereof
Disclosed and claimed are methods for the isolation and use of stem cell modulating factors for regulating stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery....
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6780871 |
Methods and compositions for treating addiction disorders
A method for treating an addiction disorder (such as an addiction to or dependency on stimulants, nicotine, morphine, heroin, other opiates, amphetamines, cocaine, and/or alcohol) in a patient is...
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6780866 |
Analgesic composition and method
A pharmaceutical analgesic composition comprising an opioid analgesic agent and a compound that binds to the SS1 or SS2 subunit of a sodium channel, such as tetrodotoxin and saxitoxin, and analogs...
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6765010 |
Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects
The invention generally relates to compositions and methods with tramadol and an opioid antagonist to enhance analgesic potency and/or attenuate one or more adverse effects of tramadol, including...
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6750222 |
Substituted phenyl derivatives
The present invention relates to compounds of the formula (I) and/or salts thereof where R 1 , R 2 , A, B, X and Y are as defined in claim 1. The compounds according to the invention are...
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6740641 |
Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain
Glucoside and glucuronide derivatives of hydromorphone, dihydromorphine, and dihydroisomorphine and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising a glucoside or...
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6737400 |
Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists
This invention relates to a method for treating a subject with irritable bowel syndrome (“IBS”) which comprises long-term administration of an opioid receptor antagonist at an appropriately low...
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6734188 |
Composition for treatment of constipation and irritable bowel syndrome
Constipation and Irritable Bowel Syndrome are treated by a delayed and sustained release composition of an opioid antagonist which commences release of the opioid antagonist in the mid to distal...
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6713488 |
Neutral antagonists and use thereof in treating drug abuse
The invention relates to the use of naltrexone and naloxone analogs, which are neutral antagonists at the μ opioid receptor, for the treatment of drug dependency in a drug-dependent individual....
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6703398 |
Orally administered analgesic compositions containing nalbuphine
The present invention provides orally administered pharmaceutical compositions which contains an effective amount of free base or pharmaceutcially acceptable salts of nalbuphine and/or nalbuphine...
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6696457 |
Morphinoid compounds
Heterocycle condensed morphinoid derivatives of formula (I) have therapeutic utility as analgesics, in collagen disease, as anti-allergic and anti-inflammatory agents, brain cell protectants, in...
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