Matches 1 - 50 out of 55 1 2 >
Match Document Document Title
7622485 Method of enhancing lysosomal α-galactosidase A  
A method of enhancing the activity of lysosomal α-Galactosidase A (α-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related...
7598279 Neurotherapeutic azole compounds  
Azole compounds containing carbamoyl group and pharmaceutically useful salts thereof are described. The compounds are effective anticonvulsants which are used in the treatment of disorders of the...
7501433 Opioid and opioid-like compounds and uses thereof  
The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations thereof, and use thereof for prevention and treatment of disorders such as septic shock and organ...
7407939 Protein kinase inhibitors comprising ATP mimetics conjugated to peptides or peptidomimetics  
The present invention provides small molecules having high affinity to the ATP binding site of protein kinases, which are conjugated to apeptide or peptidomimetic moiety which mimics the substrate...
7271173 Mixed kappa/mu opioids and uses thereof  
This invention features opioid compounds having activity at kappa and mu receptors, methods for preparing the mu/kappa opioids, and methods for the treatment of pain or a dopamine dysregulation...
7141582 Method for enhancing mutant enzyme activities in Gaucher disease  
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
6972287 Method of inhibiting amyloid protein aggregation and imaging amyloid deposits  
The present invention provides a method of treating Alzheimer's disease using a compound of Formula (I). Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound...
6916829 Method for enhancing mutant enzyme activity in gaucher disease  
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
6774135 Method of enhancing lysosomal α-galactosidase A  
A method of enhancing the activity of lysosomal α-Galactosidase A (α-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related...
6740641 Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain  
Glucoside and glucuronide derivatives of hydromorphone, dihydromorphine, and dihydroisomorphine and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising a glucoside or...
6602881 Anti-inflammatory uses of manzamines  
The subject invention pertains to compounds which are useful as anti-inflammatory agents and to compositions containing such compounds as active ingredients. The novel uses of the compounds relate...
6569866 Sustained-release nalmefene preparations and method  
A nalmefene transdermal delivery system useful for the treatment of human patients suffering from opioid addiction.
6528519 Use of tetrandrine and its derivatives to treat malaria  
The specification discloses the treatment of malaria through the use of tetrandrine and its derivatives.
6482837 Antimuscarinic compounds and methods for treatment of bladder diseases  
Compositions comprising antimuscarinic compounds that have been modified to render them substantially irreversible, such as by quaternization of the heterocyclic ring nitrogen, have improved...
6365594 Heterocycle-condensed morphinoid derivatives (II)  
Heterocycle-condensed morphinoid derivatives of formula (I), or solvates or salts thereof, are potent and selective delta opioid agonists and antagonists and are useful as i.a. analgesics....
6288074 Method of treating lymphoproliferative syndrome  
Lymphoproliferative syndrome, including such diseases as malignant lymphoma, chronic lymphocytic leukemia, Hodgkin's lymphoma, and non-Hodgkin's lymphoma, is treated in human patients by the...
6271240 Methods for improved regulation of endogenous dopamine in prolonged treatment of opioid addicted individuals  
Methods for optimally regulating dopamine homeostasis in persons addicted to, then chemically detoxified from, opioid agonist analgesics, which generally include prolonged controlled administration...
6174891 Antipruritic agent  
6143756 Antimalarial activity of β-carboline alkaloids  
Manzamines, administered either intraperitoneally or orally, have been found to prolong survival and inhibit parasitemia in erythrocytic stage malaria. Thus, manzamines can be used for both...
6124310 Enediyne compounds  
The present invention provides compounds of formulae (I) and (II), where X in formula (I) represents a group cleavable by a nitroreductase or carboxypeptidase enzyme. Enzymatic activation of the...
6030980 Agent for the treatment of infections  
The present invention relates an agent for the treatment of infections, which comprises as the active ingredient at least one member selected from the group consisting of aconite-alkaloids, aconite...
5985887 Aza-anthracyclinone derivatives  
Compounds of formula I ##STR1## wherein X 1 and X 2 are CO, CNH or CH 2 , X 3 is CH 2 , CO, CHOH, ##STR2## wherein n=2 or, 3 or CN(R 9 ) wherein R 9 is hydroxy or amino-aryl, and each...
5981540 Heterocycle-condensed morphinoid derivatives  
Compounds of formula (I), are selective delta opioid agonsist and antagonists, and are useful as analgesics and in treating general neurologic disorders. ##STR1##
5972993 Composition and method for treating rosacea and sensitive skin with free radical scavengers  
A method for treating skin conditions, such as rosacea and sensitive skin, that manifest as a tendency towards flushing and blushing is provided. Also provided herein, are compositions for the...
5783583 17-(cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol, hydrochloride salt for the purpose of rapid narcotic detoxification  
Methods whereby the narcotic antagonist 17-(cyclopropylmethyl)-4,5alpha-6-methylenemorphinan-3,14-di ol,hydrochlori de salt and other narcotic antagonists are used for chemically precipitating a...
5744476 Dopamine D.sub.1 agonists for the treatment of dementia  
This invention provides for a method of raising extracellular brain acetylcholine levels to improve cognition by the administration to a warm-blooded animal of a pharmaceutical composition...
5648359 Tumor necrosis factor production inhibitors  
There is provided a composition for inhibiting the production or secretion of tumor necrosis factor effective for the treatment of cachexia, septic shock, multiple organ failure, rheumatoid...
5631264 Substituted 6,11-ethano-6,11-dihydrobenzo[B]quinolizinium salts and compositions and methods of use thereof  
Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment or prevention of neurodegenerative disorders or...
5512577 Bicyclic hexahydroaporphine and 1-benzyloctahydroisoquinoline therapeutic compositions and processes for utilizing said compositions  
The invention relates to the method of synthesis of bicyclic hexahydroaporphine compounds which may provide improved therapy for diseases characterized by an increase in intraocular pressure. More...
5500432 Induction and inhibition of apoptosis  
A method for inducing apoptosis in target cells employs designed enediynes which are triggered to become chemically reactive when bound to target cells. Conversely, a method for inhibiting the...
5492925 Thienyl-and furylpyrrole insecticidal and acaricidal agents  
There are provided thienyl- and furylpyrrole compounds of formula I ##STR1## and their use for the control of insects and acarina. Further provided are compositions and methods comprising those...
5434159 6,11-cyclyl-1,2,3,4,5,6,11,11a-octahydrobenzo[b]quinolines and compositions and method of use thereof  
6,11'-Cyclyl-1,2,3,4,5,6,11,11a-octahydrobenzo[b]quinolizine derivatives, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or...
5430036 6,11-substituted-6,11-dihydrobenzo[b]quinolizinium salts and compositions and method of use thereof  
6,11-Substituted-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic...
5369110 Biphenylyl compounds  
Biphenylyl compounds of formula ##STR1## wherein the variables R 1 , R 2 , R 3 , p, q and X and the rings A and B are as defined in claim 1, in free form or in salt form, can be prepared in a...
5324734 Oxidization metabolites of 5-α-23-methyl-4-aza-21-nor-chol-1-ene-3, 20-dione  
The compounds of formula (I) ##STR1## wherein R is selected from the group hydroxymethyl and carboxy, have been identified as metabolites of 5α-23-methyl-4-aza-21-nor-chol-1-ene-3,20-dione and are...
5302589 Heterocyclic inhibitors of 5-α-testosterone reductase  
The present invention relates to certain substituted 17 β-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I): ##STR1## wherein R 1 and R 2 are i) independently hydrogen or lower...
5162331 Aspernomine, an antiinsectan metabolite  
A tetrahydroquinoline alkaloid compound named "aspernomine" has been isolated from the sclerotia of the fungus Aspergillus nomius. Aspernomine has the structure: ##STR1## and is effective for...
5100898 Antitussive liquid compositions containing dyclonine  
Novel antitussive and anesthetic liquid compositions of matter for oral use comprising an effective oral antitussive drug and dyclonine; and method of using same.
5055464 Benzolactam compounds and pharmaceutical uses thereof  
Benzolactam compounds of the general formula ##STR1## or isomers thereof as well as salts thereof inclusive of hydrates and/or solvates forms thereof, and benzolactam compounds of the general...
4895854 Antitumor alkaloids  
This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions...
4853221 Method for treating non-small cell lung cancer, head and neck cancers and breast cancer  
5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]-methyl]-2,4-quin azolinediamine (trimetrexate) has been shown to possess clinical activity against non-small cell lung cancer, head and neck squamous...
4628047 Agent for enhancing antitumor activity of antitumor agent  
An agent for enhancing antitumor activity of antitumor agents comprising as the active ingredient diltiazem or a pharmaceutically acceptable acid addition salt thereof, an antitumor composition...
4626538 [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines  
Novel [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines useful as anxiolytic, antiepileptic and sedative-hypnotic agents as well as skeletal muscle relaxants, methods of using these...
4619935 Stable oncolytic formulations  
Stable, sterile, ready-to-use formulations of oncolytic vincristine are provided.
4599341 Substituted and bridged pyridines useful as calcium channel blockers  
Novel substituted and bridged pyridine compounds useful as calcium channel blockers, pharmaceutical compositions thereof, and methods of treatment are disclosed.
4587253 Bridged pyridine compounds useful as calcium channel blockers and analgesics  
Novel substituted and bridged pyridine compounds useful as calcium channel blockers and analgesics, pharmaceutical compositions thereof, and methods of treatment are disclosed.
4587251 Indolo[2,3-a]quinolizine and indolo[2,3-g]cyclopent[a]indolizine derivatives, compositions and methods employing them for treating ulcers  
The invention relates to new indolo[2,3-g]cyclopent[a]indolizine derivatives of the formulae (II) ##STR1## and/or (III) ##STR2## wherein W is alkoxycarbonyl having from one to four carbon atoms in...
4558052 10-Bromosandwicine, 10-bromoisosandwicine, pharmaceutical compositions thereof, and methods of treating heart rhythm disorders with them  
10-bromosandwicine and 10-bromoisosandwicine and acid addition salts thereof are disclosed. There novel compounds possess valuable pharmacological properties e.g. heart rhythm regulatory...
4554274 N.sub.b Quaternary derivatives of ajmaline and isoajmaline, methods and intermediate products in the manufacture of their derivatives and method of using same and pharmaceutical compositions thereof  
New quaternary derivatives of 10-bromoajmaline and 10-bromoisoajmaline are disclosed which exhibit antiarrhythmic and adrenolytic properties and which have the formula I ##STR1## wherein R...
4552877 N.sub.b -Quaternary derivatives of sandwicine and isosandwicine methods and intermediate products in the manufacture of their derivatives and methods of using same and pharmaceutical compositions thereof  
New N b -quaternary 10-bromosandwicine and 10-bromoisosandwicine derivatives are disclosed which exhibit antiarrhythmic properties and adrenolytic properties and which have the formula I ##STR1##...
Matches 1 - 50 out of 55 1 2 >