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9018226 Antipsychotic agents and standardized antipsychotic fractions from Rauwolfia tetraphylla and process of their isolation  
The present invention relates to bioactive extracts its fractions and isolation of compound from Rauwolfia tetraphylla. The extracts and fractions are useful for the treatment of psychosis based...
9012468 One pot process for producing 6-hydroxyl nal-opiate  
The present invention provides processes for preparing nal-opiates without the isolation of intermediates. In general, the process provides for alkylation and reduction in the same pot to give the...
8993587 Combination of syrosingopine and mitochondrial inhibitors for the treatment of cancer and immunosuppression  
The invention relates to a combination of syrosingopine and a mitochondrial inhibitor, e.g. metformin or oligomycin, and the use of the combination of syrosingopine and a mitochondrial inhibitor...
8987223 Treatment of pulmonary and pleural fibrosis using HSP27 inhibitors  
Reduction of HSP27 expression is in beneficial in the treatment of pleural and pulmonary fibrosis and in particular subpleural fibrosis and IPF. Pharmaceutical compositions for this purpose...
8940338 Formulations for the treatment of mucositis induced by antitumor or immunosuppressive therapy  
Formulations containing sanguinarine or chelerythrine or the salts thereof or extracts containing them in admixture with suitable carriers and/or excipients for the treatment and/or prevention of...
8933092 Methods and compositions comprising sequential administration opioid receptor agonists  
Methods and compositions for the alleviation of pain in a patient. The methods and compositions sequentially administer a therapeutically effective amount of first compound having opioid receptor...
8901139 Tricyclic indole derivatives and methods of use thereof  
The present invention relates to Tricyclic Indole Derivatives, compositions comprising at least one Tricyclic Indole Derivatives, and methods of using the Tricyclic Indole Derivatives for treating...
8883847 Compositions and methods of treatment using modulators of motoneuron diseases  
The invention disclosed herein describes a novel therapeutic target for motoneuron diseases (altered dynamics of microtubules in neurons); a method for measuring the state of activity of this...
8877715 Cytotoxic conjugates having neuropeptide Y receptor binding compound  
There is provided a series of novel neuropeptide Y-cytotoxic conjugates, compositions comprising the same, and methods relating to their therapeutic use for the treatment of disease or condition...
8841317 Noscapine and analogs and methods related thereto  
The invention relates to the innate immune pathway and anti-inflammatory molecules with therapeutic properties. In some embodiments, the invention relates to compounds and pharmaceutical...
8822491 Methods and compositions for treating β-thalassemia and sickle cell disease  
The present invention provides compounds (such as compounds of formula I-a) that induce γ globin expression and pharmaceutical compositions thereof. Such compounds may have beneficial therapeutic...
8815306 Methods and compositions for promoting bone and joint health  
Methods and compositions that can be used to promote bone and joint health through amelioration, stabilization and repair of damage associated with various pathophysiological conditions are disclosed.
8741917 Benzo [C] phenanthridines as antimicrobial agents  
The present invention provides compounds of formula I: formula (I) wherein X1-X4 and R1-R12 have any of the values defined in the specification, as well as salts and prodrugs thereof, which...
8710071 Compounds, compositions and methods for reducing lipid levels  
The present technology relates to compounds of Formulas (V) and methods of making and using such compounds. Methods of use include prevention and treatment of hyperlipidemia, hypercholesterolemia,...
8697743 Antioxidant camptothecin derivatives and antioxidant antineoplastic nanospheres thereof  
The present invention is directed to antioxidant derivatives of camptothecin and antioxidant derivatives of camptothecin analogs and the preparation of nanometer-sized camptothecin prodrugs....
8653095 Small molecules with antimalarial activity  
The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria.
8648090 Indole alkaloid derivatives having opioid receptor agonistic effect, and therapeutic compositions and methods relating to same  
Indole alkaloid derivatives having an opioid receptor agonistic effect, their synthesis, and therapeutic compositions containing these derivatives, and methods of treating conditions with these...
8618123 Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors  
Disclosed are novel gamma secretase inhibitors of the formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, wherein L1, n, X, Ar, Y, Z, Q, and Q1 are as defined herein....
8569327 Phenanthroindolizidine derivative and NFκB inhibitor containing same as active ingredient  
A novel compound having an excellent NFκB inhibitory effect is provided. Specifically disclosed is a compound represented by the following formula (1) or a salt thereof: wherein, R1 represents a...
8524214 Polyal drug conjugates comprising variable rate-releasing linkers  
Polyal-Drug conjugates comprising a variable rate-releasing linker are described along with methods of making such conjugates. Uses for such Polyal-Drug conjugates is also described.
8518961 Pharmaceutical compositions comprising a camptothecin derivate  
The present invention relates to novel pharmaceutical compositions in which the active agent is a topoisomerase I inhibitor, in particular a camptothecin derivative, that is useful for the...
8507477 3- and 6-quinolines with N-attached heterocyclic CGRP receptor antagonists  
Compounds of Formula (I): (where variables R1A, R1B, R2, R3, R4, A, and Z are as defined herein) which are useful as antagonists of CGRP receptors, and useful in the treatment or prevention of...
8501167 Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer  
Provided herein are compositions and methods for targeted ablation of mutational escape in the face of cancer therapeutic agents. Compositions comprising the yeast-based vehicles are used in...
8486957 Chemotherapeutic for inducing an MSH2-dependent apoptotic pathway  
A method of treating cancer in a subject in need thereof comprises administering said subject reserpine, yohimbine, an analog thereof, or a pharmaceutically acceptable salt or prodrug thereof, in...
8481558 Compounds to inhibit or augment an inflammatory response  
Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided.
8440685 Method for treatment of neurologic dysfunction  
A method for treatment of the symptoms of neurologic dysfunctions, including major depression, an autism spectrum disorder (ASD), and schizophrenia. The patient is administered an amount of a...
8435963 Weight loss compositions and uses thereof  
This invention provides unique and advantageous formulations and methods for weight loss.
8431153 Bioactive composition for the treatment of the HIV/AIDS, method for manufacturing and using the same  
The present invention is about a bioactive composition for the treatment of HIV, particularly by the removal of the most prominent HIV antigen glycoproteins. The present invention further relates...
8415348 Nitrogenated derivatives of pancratistatin  
The present invention concerns nitrogenated derivatives of narciclasine and pancratistatin of the following general formula (I) as well their pharmaceutically acceptable salts. The present...
8372852 Purines as reverse transcriptase inhibitors  
Described herein are novel enzyme inhibitors. In some embodiments, the enzyme inhibitors are reverse transcriptase inhibitors, particularly HIV reverse transcriptase inhibitors. Also described...
8362028 Pseudobase benzo[c]phenanthridines with improved efficacy, stability and safety  
Pseudobase benzo[c]phenanthridines and the pharmaceutically acceptable salts thereof of Formula I are provided herein. The variables R, R1, R2, R3, and R4 are defined herein. Certain pseudobase...
8299088 Compositions and methods for treating cancer  
Hypoxia-activated prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.
8258149 Isoquinoline derivatives  
The invention provides novel compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R7 are as described herein, compositions including the compounds and methods of...
8226994 Formulations with sanguinarine, chelerythrine or chelidonine for the treatment of warts, verrucas and psoriatic plaques  
The invention provides formulations containing sanguinarine, chelerythrine or chelidonine or their salts or extracts containing them, mixed with suitable vehicles and/or excipients, for the...
8188109 Benzoquinolizinium salt derivatives as anticancer agents  
13-substituted 5,6-dihydrodibenzo[a,g]quinolizinium salt compounds of the general formula (I): processes for the preparation of said compounds, pharmaceutical compositions containing said...
8158645 Compound, corresponding compositions, preparation and/or treatment methods  
Disclosed is a novel crystalline form of topotecan monohydrochloride pentahydrate, which is a pentahydrate of...
8093247 Heteroaryl sulfonamides and CCR2  
Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The...
8067401 Compounds and compositions for treating infection  
Compounds from 14 Kenyan plants, including from the root of Dovyalis abyssinica and Clutia robusta have been characterized and isolated, and their uses are disclosed.
8048891 Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin  
The present invention relates to methods of treatment of non-Hodgkin's lymphomas. The present invention includes administering polymeric prodrugs of 7-ethyl-10-hydroxycamptothecin to patients in...
8022080 Small molecules with antiprotozoal activity  
The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria.
7989466 Methods to inhibit or augment an inflammatory response  
Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided.
7915276 Berberrubine derivatives having antifungal activities  
The present invention relates to a berberrubine derivative having superior antifungal activity, more particularly to a berberrubine derivative having activity against chitin synthase, which...
7897559 Dermatological composition and kit containing avermectin compound for treating dermatological conditions  
A dermatological composition and a kit containing the composition for treating dermatological conditions including transient acantholytic dermatitis, acne miliaris necrotica, acne varioliformis,...
7888368 Treatment of drug-resistant tumors  
A subclass of camptothecin derivatives is disclosed to be useful for the preparation of a medicament for the treatment of drug-resistant tumors and/or for the administration to patients who show...
7867979 Drug composition for treating 2 type diabetes and diabetic chronicity complications  
A drug composition for treating type 2 diabetes and diabetic chronicity complications is disclosed. The composition is composed of mangiferin and berberine in a certain ratio. The composition has...
7858627 Topoisomerase-targeting agents  
The invention provides compounds of formula I or formula II: wherein: the bond represented by is a single bond or a double bond, and R1—R5, X, and Y have any of the meanings defined in the...
7781445 Synthesis of indenoisoquinoliniums and methods of use  
Substituted indenoisoquinolinium compounds, and pharmaceutical formulations of substituted indenoisoquinolinium compounds are described. Also described are processes for preparing substituted...
7732458 Methods for preparing dehydrocavidine, dehydroapocavidine or their composition, their use and medicinal composition containing them  
A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium...
7723351 Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers  
A four arm-polyethylene glycol-7-ethyl-10-hydroxycamptothecin conjugate, such as, is disclosed. Methods of making the conjugates and methods of treating mammals using the same are also disclosed.
7700613 Use of 7-t-butoxyiminomethylcamptothecin for the preparation of a medicament for the treatment of uterine neoplasms  
The use of 7-ter-butoxyiminomethylcamptothecin is described in the preparation of a medicament useful for the treatment of uterine neoplasms, particularly cancer of the endometrium and of the neck...

Matches 1 - 50 out of 252 1 2 3 4 5 6 >