Patents in Class 514/280

Matches 51 - 100 out of 201

< 1 2 3 4 5 >

Match	Document	Document Title
51	6509344	Indenoisoquinolines as antineoplastic agents A number of indenoisoquinolines were prepared and evaluated for cytotoxicity in human cancer cell cultures and for activity versus topoisomerase I. The two most cytotoxic indenoisoquinolines proved...
52	6503919	Compounds of 7-oxo-2,3,7,14-tetrahydro-1H-benzo&lsqb b&rsqb pyrano&lsqb 3,2-h&rsqb acridin carboxylate A compound selected from those of formula (I): wherein: X and Y represent hydrogen, halogen, hydroxy, mercapto, cyano, nitro, alkyl, alkoxy, trihaloalkyl, optionally substituted amino,...
53	6500837	Fused ring system containing indole as M4 selective aza-anthracene muscarinic receptor antagonists Disclosed are compounds of the Formula I and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, wherein R 1 is hydrogen, lower alkyl, COOR 7 , (un)substituted aryl,...
54	6492332	Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation This invention relates to a method of inhibiting tumor cell adhesion, pain, and inflammation at a wound during a surgical procedure by delivering an irrigation solution containing a tumor cell...
55	6486167	Heterocyclic cytotoxic agents The present invention provides compounds of formula I: wherein the R substituents and atoms X and Y are as defined in specification. The present invention also provides pharmaceutical...
56	6476043	Use of camptothecin derivatives, with reduced gastrointestinal toxicity Use of sodium chloride for preparing an agent intended to reduce or eliminate the gastrointestinal side effects induced by the administration of camptothecin derivatives, characterized in that the...
57	6426351	Chelerythrine-based therapies for cancer Chelerythrine is an effective inhibitor of solid tumor growth and is extremely cytotoxic in combination with chemotherapeutic agents that directly damage DNA.
58	6420377	Covalent conjugates of topoisomerase I and topoisomerase II inhibitors The present invention provides covalent conjugates of topoisomerase I and topoisomerase II inhibitors. Such compounds have a structure according to formula I: T I —L—T II (I) wherein: T I ...
59	6410041	Culturing cells in presence of amphipathic weak bases and/or cations and multiple drug resistance inhibitor containing reserpine Methods are provided relating to the enhanced cytoplasmic accumulation of amphipathic weakly basic or amphipathic cationic molecules in prokaryotes and eukaryotes under conditions of high...
60	6383528	Pharmaceutical composition comprising ticlopidine and Ginkgo biloba extract The invention herein relates to a pharmaceutical composition comprising ticlopidine and Ginkgo biloba extract. In detail, as an anti-thrombotic preparation, the pharmaceutical composition...
61	6342487	Compositions containing at least one farnesyl transferase inhibitor and at least one topoisomerase inhibitor and compositions containing at least one farnesyl transferase inhibitor and at least one taxoid Combinations containing at least one farnesyl transferase inhibitor and at least one topoisomerase inhibitor. Combinations containing at least one taxoid and at least one farnesyl transferase...
62	6323211	Compositions and methods for treating sexual dysfunctions The present invention describes methods for preventing and treating sexual dysfunctions in patients by orally administering at least one α-adrenergic receptor antagonist and at least one compound...
63	6294517	Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use The present invention describes novel compositions and kits comprising alpha-adrenergic receptor antagonists and compounds that donate, transfer or release nitric oxide, elevate endogenous levels...
64	6288074	Method of treating lymphoproliferative syndrome Lymphoproliferative syndrome, including such diseases as malignant lymphoma, chronic lymphocytic leukemia, Hodgkin's lymphoma, and non-Hodgkin's lymphoma, is treated in human patients by the...
65	6288073	Acronycine derivatives, preparation method and pharmaceutical compositions A compound selected from those of formula (I): ##STR1## in which: X and Y represent hydrogen, halogen, hydroxy, mercapto, cyano, nitro, alkyl, alkoxy, trihaloalkyl, optionally substituted amino,...
66	6280768	Berberine alkaloids as a treatment for chronic protozoally induced diarrhea A method for the treatment or prevention of chronic diarrhea caused by protozoa, especially microsporidia and cryptosporidia, in a patient is disclosed which method comprises administering to the...
67	6255317	Cholesterol biosynthesis inhibitors The present invention provides a cholesterol biosynthesis inhibitor which specifically inhibits the sterol 14-reductase which is involved in the distal pathway of cholesterol biosynthesis, a...
68	6239139	13,13A-Didehydroberbine derivatives The present invention provides a cholesterol biosynthesis inhibitor which specifically inhibits the sterol 14-reductase which is involved in the distal pathway of cholesterol biosynthesis, a...
69	6194423	Fused isoquinolines as dopamine receptor ligands The present invention is directed to a novel dopamine receptor ligands of the formula: ##STR1## pharmaceutical formulations of such compounds, and a method using such compounds for treating a...
70	6187783	Phenanthridinium derivatives A novel phenanthridinium derivative represented by general formula (A): ##STR1## wherein R 1 is a substituted or unsubstituted lower aliphatic hydrocarbon group; R is an aliphatic hydrocarbon...
71	6184228	Anti-sickling agents: selection methods and effective compounds The present invention is directed to a method for selecting compounds for use in treating sickle cell disease in a patient. The method comprises the steps of selecting a first set of HbS ligands...
72	6177438	Morphinan derivatives and pharmaceutical use thereof A morphinan derivative or its pharmaceutically acceptable acid addition salt represented with, for example, ##STR1## and an analgesic, diuretic, antitussive and brain cell protector having its...
73	6166032	Method for controlling tobacco use and alleviating withdrawal symptoms due to cessation of tobacco use A method for controlling tobacco use and alleviating withdrawal symptoms due to the cessation of tobacco use comprising administering to a human desiring to control tobacco use and/or suffering...
74	6162455	Method for increasing lean meat, improving the lean meat to fat ratio and improving amino acid utilization in warm-blooded animals There is provided a method for increasing lean meat, improving the lean meat to fat ratio and improving amino acid utilization in warm-blooded animals by administering an effective amount of an...
75	6156723	Compositions comprising inhibitors of estrogen response The present invention provides novel assay methods for identifying compounds that may have both estrogen agonist and antagonist properties. In particular, the assay use cells comprising promoters...
76	6121275	*WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST* Coralyne analogs as topoisomerase inhibitors The present invention provides protoberberine alkaloid derivatives useful as anticancer agents, and methods of use thereof. The invention also provides protoberberine derivatives useful as...
77	6086884	Composition for treating impotence in men containing dried roe and yohimbine A composition for treating impotence in human males contains a synergistic mixture of dried sturgeon roe and yohimbine hydrochloride wherein the weight percent ratio of said dried sturgeon...
78	6030978	Antifungal formulation comprising protoberberine derivatives and salts thereof The antifungal formulation comprising the novel compounds of the following chemical formulae (I) and (II) exhibit in vitro antifungal activity against fungi including cutaneous filamentous fungus,...
79	6030979	Pharmaceutical composition comprising 5,6-dihydrodibenzo[A,G] Quinolizinium derivatives and the salts thereof The present invention provides a pharmaceutical composition comprising 5,6-dihydrodibenzo[a,g]quinolizinium derivative and the salts thereof of formula (I) which specifically inhibits the sterol...
80	6025365	Chelerythrine and radiation combined tumor therapy Combination of low doses of irradiation and chelerythrine results in increased apoptosis in tumor cells. The doses of either irradiation or chelerythrine alone are such that increased apoptosis or...
81	6020341	Enediyne quinone imines and methods of preparation and use thereof A quinone imine enediyne possessing cytotoxic activity towards cancer cells having general structure (I) wherein R 1 , R 2 and R 3 are independently the same or different and are H, Br, Cl, F, NH...
82	5989576	Method of lightening skin A method and composition for the topical application of a yohimbine or derivative or stereoisomer thereof or effective α 2 -antagonists, to the skin for inhibiting melanogenesis in the skin...
83	5981541	Substituted heterocycles as anti-tumor agents The present invention provides compounds of formula (I): ##STR1## wherein R 1 -R 7 , W, X, Y, and Z have any of the values defined in the specification, and pharmaceutically acceptable salt...
84	5981542	Camptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues A camptothecin analog characterized in that the hydroxy lactone of the camptothecin is a β-hydroxy lactone or the corresponding β-hydroxyacid, resulting from the opening of said lactone, or a...
85	5955466	Tamoxifen as a therapy to reduce irinotecan hydrochloride-induced diarrhea The present invention provides a method for preventing or decreasing diarrhea associated with irinotecan administration comprising the administration of tamoxifen at least two cell cycles prior to...
86	5900418	Method for treatment of obesity A method is provided for the control of obesity comprising administering to a mammal including humans suffering from obesity an acetylcholine esterase reactivator or prodrug derivative thereof...
87	5886004	Tetrahydrobetacarboline compounds The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. The invention provides formulations and methods for using the novel...
88	5886003	Methods of treating or ameliorating the symptoms of venomous bites and stings This invention provides a method for the treatment or amelioration of the symptoms of venomous bites or stings which comprises administering to a mammal in need thereof one or more 5-HT 2 ...
89	5876984	Sequiterpene derivatives having antiviral activity A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt, or a hydrate thereof, a process for preparing said compound, and a pharmaceutical composition having antiviral...
90	5861411	4-Acylaminopyridine derivative A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for...
91	5854255	Therapeutic package for the long term reduction of body fat stores insulin resistance hyperinsulinemia and hyperglycemia in vertebrates A therapeutic package for dispensing to, or for use in dispensing to, a vertebrate being treated for a metabolic condition selected from the group consisting of obesity, insulin resistance,...
92	5849750	Dynemicin analogs Non-naturally occuring dynemicin analogs are provided, which are useful as DNA cleaving agents, cytotoxic agents, and/or anti-tumor compounds. Methods of making dynemicin analogs are also provided.
93	5807882	Anthracene compounds useful in treating certain cancers A compound of formula (I): ##STR1## in which R 1 , R 2 , X and Y are as defined in the description, the isomers thereof and the addition salts thereof with a pharmaceutically acceptable acid or...
94	5786362	Method of treating Hormone independent cancer Activation of the c-fos promoter and the serum response element (SRE) in androgen independent cancer cells has been demonstrated. In androgen dependent cells, direct activation of protein kinase C...
95	5767130	Use of kainic acid antagonists to prevent toxic side effects of NMDA antagonists This invention discloses that kainic acid receptor antagonists (KA antagonists) can act as "safener" agents to reduce or prevent adverse side effects caused by NMDA antagonists. NMDA antagonists...
96	5747502	Process for preparing benzo c!phenanthridinium derivatives, novel compounds prepared by said process, and antitumor agents The present invention relates to benzo c!phenanthridinium derivative of the general formula A: ##STR1## wherein M and N individually represent a hydroxyl or lower alkoxy group, or M and N...
97	5672597	Acetamide derivative An acetamide derivative having the general formula (I): ##STR1## or a pharmacologically acceptable salt thereof; a synthetic intermediate of the above-mentioned acetamide derivative; a treating...
98	5663167	Antipsychotic composition and method of treatment A method for treating a serious psychotic mental illness includes the step of administering to a patient in need of such treatment a combination of (i) an α 2 -adrenergic receptor antagonist and...
99	5635506	1, 2-dihydro-3H-dibenzisoquinoline-1,3-dione anticancer agents This invention relates to a compound useful for the treatment of tumors having the formula: ##STR1##
100	5629307	Use of ibogaine in reducing excitotoxic brain damage This invention discloses that ibogaine, a plant derivative, can be used as a safe NMDA antagonist at relatively high dosages (including dosages high enough to cause hallucinations), to reduce or...

Matches 51 - 100 out of 201

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