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7381744 |
Method of treating osteoporosis comprising vacuolar-type (H+)-ATPase-inhibiting compounds
The present invention provides vacuolar-type (H+)-ATPase-inhibiting compounds, compositions thereof, and methods of using them to treat or prevent a condition treatable by the inhibition of a...
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7358233 |
Tetronic acid derivative
The present inventors intended to search for substances that can regulate the expression of a molecular chaperone, GRP78, using the expression of GRP78 as an indicator. As a result, a novel...
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7358232 |
Method for the antibiotic coating of bodies with interconnecting microcavities as well as coated bodies and their usage
The invention relates to a method for the antibiotic coating of bodies with interconnecting microcavities as well as bodies coated this way and their usage. The invented method is characterized in...
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7335753 |
Bifunctional heterocyclic compounds and methods of making and using same
The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7312200 |
9-ketospinosyn derivatives
The present invention relates to derivatives of 9-keto spinosyns, which are substituted by a āNā(O, NH or NR x )āR y moiety in the C-9 position, to methods for their manufacture, and to...
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7256178 |
Physiologically active substances
Compounds represented by the following general formula (I), pharmacologically acceptable salts thereof or hydrates of the same: (I) wherein W represents
and R 3 , R 7 , R 16 , R 17 , R 20 , R...
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7214759 |
Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same
Polymers containing polyesters and, optionally, agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable...
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7205001 |
Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
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7195773 |
Pesticidal composition
A pesticidal composition comprising a pesticidally effective amount of at least one of a pyridic compound of the formula (I) or it salt and at least one of other pesticides: wherein Y is a...
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7179493 |
Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
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7163703 |
Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
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7160867 |
Rapamycin carbohydrate derivatives
This invention provides modified rapamycins that have specific monosaccharide(s), oligosaccharide(s), pseudosugar(s) or derivatives thereof attached through a linker to create rapamycin...
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7153877 |
Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and...
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7141582 |
Method for enhancing mutant enzyme activities in Gaucher disease
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
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7129221 |
6,11-bicyclic erythromycin derivatives
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which exhibit antibacterial properties. The present invention further...
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7119246 |
Method of treating acne
This invention relates to a method for the treatment of acne that comprises applying a fluid comprising a polyalkylene carbonate over the area affected by acne and penetrating pores within the...
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7119124 |
Pharmaceutical compositions containing plasma protein
The invention is related to water-soluble products and pharmaceutical formulations in solid or liquid form mainly for parenteral use. They consist of or comprise a therapeutically active substance...
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7119110 |
Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7094397 |
Methods and reagents for the treatment of multiple sclerosis
The invention features methods and reagents for the diagnosis, monitoring, and treatment of multiple sclerosis. The invention is based in part on the discovery that Chlamydia is present in...
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7071233 |
Antimicrobial prevention and treatment of human immunedeficience virus and other infectious diseases
An improved medical treatment and medicine is provided to quickly and safely resolve HIV and other microbial infections. The inexpensive medicine can be self administered and maintained for the...
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7037523 |
Controlled release compositions for macrolide antimicrobial agents
The present invention provides a controlled release pharmaceutical composition of an acid labile, poorly soluble drug having pH dependent solubility profile in aqueous environment. In a preferred...
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7030095 |
Pediculicidal and ovacidal treatment compositions and methods for killing head lice and their eggs
The present invention relates to composition and methods for administering compositions in solutions for killing adult lice and the ova comprising water, PVM/MA Decadiene crosspolymers, propylene...
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7030093 |
Antibiotic coating for porous bodies and method for its production as well as its use
The invention describes an antibiotic coating for porous bodies and its use. Into the porous system of non-metallic porous bodies and of metallic porous bodies, a coating made of at least one...
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7015203 |
Macrolides
The invention relates to novel erythromycin analogs and azalides, particularly ones with novel C-13 substituents, and to pharmaceutically acceptable salts thereof. The compounds of this invention...
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6982252 |
Inhibition of vacuolar proton ATPase activity and/or the modulation of acidic organelle function sensitizes cells to radiation, chemotherapy and biological agents
The present invention relates to methods and compositions for inhibiting cell survival and/or promoting cell death following exposure to cytotoxic agents and stress such as radiation or...
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6946490 |
Antimicrobial treatment for herpes simplex virus and other infectious diseases
An improved medical treatment and medicine is provided to quickly and safely resolve herpes and other microbial infections. The inexpensive user-friendly medicine can be applied and maintained on...
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6927210 |
Ectoparasiticidal aqueous suspension formulations of spinosyns
The invention provides a stable ectoparasiticidal aqueous suspension formulation of a spinosyn, comprising the spinosyn, or a physiologically acceptable derivative or salt thereof, milled to an...
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6919317 |
Pharmaceutical composition comprising squalene epoxidase inhibitor and macrolide immunomodulator
Synergistic combinations of a squalene epoxidase inhibitor such as terbinafine and a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro, 33-desoxyascomycin are provided,...
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6919090 |
Active substance combinations with insecticidal and acaricidal properties
The invention relates to novel active combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties.
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6916829 |
Method for enhancing mutant enzyme activity in gaucher disease
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
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6914051 |
Penetrating antibiotic gel for soft tissue diseases
A penetrating antibiotic gel for treating pain, inflammation and other pathological conditions affecting musculoskeletal tissues and other soft tissues of the body. The composition includes an...
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6903052 |
Nematicidal compositions and methods
The invention concerns the use of certain compounds related to fatty acids to control nematodes that infest plants or the situs of plants. Nematodes that parasitize animals can also be controlled...
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6890526 |
Methods and reagents for the treatment of multiple sclerosis
The invention features methods and reagents for the diagnosis, monitoring, and treatment of multiple sclerosis. The invention is based in part on the discovery that Chlamydia is present in...
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6875451 |
Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
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6833362 |
Method and composition for the accelerated in vivo removal of ethanol
A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or...
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6821526 |
Compositions and devices using a spinosyn compound for control of insects
The subject invention pertains to compositions and devices for controlling insects and, in particular, houseflies. Insecticidal compositions of the present invention comprise spinosad and,...
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6800614 |
Pesticidal macrolides
Macrolide compounds produced by culturing Saccharopolyspora species LW107129 (NRRL 30141) have insecticidal and acaricidal activity and are useful intermediates for preparing spinosyn analogs.
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6797701 |
Antiparasitic formulations
A long-acting antiparasitic formulation suitable for topical application including: (a) 0.1-50% w/v an avermectin or milbemycin having activity against endo- and/or ectoparasites; (b) 1-50% v/v a...
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6747011 |
Antitumor drugs and methods
Derivatives of apoptolidin, including skeletal homologues, are potent and selective apoptosis-inducing agents which, unlike apoptolidin, do not undergo isomerization under physiological conditions....
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6746677 |
Stable vaccine compositions for parenteral administration, a method for their use, and a process for their preparation
The invention relates to certain stable vaccine compositions comprising a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof; at least one antigen; a...
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6727228 |
Pediculicidal and ovacidal treatment compositions and methods for killing head lice and their eggs
The present invention relates to compositions and methods for administering compositions in solutions for killing adult lice and the ova comprising water, PVM/MA Decadiene crosspolymers, propylene...
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6680055 |
Mycolactone and related compounds, compositions and methods of use
The present invention provides, inter alia, polyketide macrolides including a polyketide macrolide of the structure wherein R 1 -R 5 are the same or different and each is independently selected...
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6676978 |
Method and compositions for producing berry derived products
A method for isolating a mixture of anthocyanins, bioflavonoids and phenolics from an edible berry using adsorbent resins which are regenerable for reuse is described. The mixture with a consumable...
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6664237 |
Oral treatment of companion animals with ectoparasiticidal spinosyns
The invention provides single-dose oral formulations for controlling an ectoparasite infestation on a companion animal for a prolonged time, said formulations comprising a spinosyn component, or a...
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6660767 |
Coumarin compounds as microtubule stabilizing agents and therapeutic uses thereof
Compounds and compositions for stabilizing microtubules are disclosed. Also disclosed are methods of inhibiting, preventing, regulating, modulating, attenuating, stabilizing, or affecting...
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6656914 |
Method for treating tumors caused by APC gene mutation with anthocyanins and cyanidin
A method for inhibiting a tumor in a mammal using a composition comprising an anthocyanin or cyanidin from a berry is described. The method involves using the composition in an amount and for a...
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6653288 |
Injectable anthelmintic compositions and methods for using same
Injectable compositions containing a liquid solvent free of solid polymers, anthelmintic agent(s)and hormonal growth promoter(s), where the anthelmintic agent(s) and the hormonal growth promoter(s)...
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6649630 |
Methods and compositions controlling pests
The present invention provides compositions and methods which can provide a pesticidal effect. The compositions typically comprise 4-phenoxyphenyl 2-(2-pyridyloxy)propyl ether and an ether compound...
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