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8168597 |
Method for treating cystic fibrosis
The present invention is directed to a method for treating cystic fibrosis. The method comprises the steps of: identifying a patient suffering from cystic fibrosis, and administering to the patient...
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8133871 |
Dihydropseudoerythromycin derivatives
A compound represented by the formula [I] wherein each symbol is as defined in the specification or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing the...
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8088745 |
Methods for assaying alpha-L-iduronidase enzymatic activity
Methods for assaying α-L-iduronidase enzymatic activity and methods for screening newborns for Mucopolysaccharidosis Type-I.
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8044085 |
Active agent combinations with insecticidal and acaricidal properties
The invention relates to novel active compound combinations of certain having very good insecticidal and acaricidal properties and containing (a) cyclic ketoenols having the formula in which the...
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8003616 |
Composition for the treatment of ear infections and method
A composition for treating ear infections in animals includes an antifungal agent, an antibiotic agent, a steroidal anti-inflammatory agent, and an acid dissolved to form a liquid. The acid aids in...
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7964205 |
Insecticide and molluscicide composition and methods
Bait compositions of spinosyns in combination with metal complexones and other mollusicides are provided in an environmentally safe composition that is effective to a treat and/or control a wide...
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7960354 |
Synergistic pesticidal mixtures
Synergistic pesticidal mixtures are provided.
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7960353 |
Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
Novobiocin analogues and pharmaceutical composition containing such compounds useful for the treatment and/or prevention of neurodegenerative disorders and autoimmune disorders.
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7947309 |
Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants
Compositions are provided which include hyaluronic acid derivatives in combination with vaccine antigens, and optionally adjuvants, for mucosal delivery. Also provided are methods of making the...
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7943585 |
Extended release antibiotic composition
An extended-release antibiotic composition comprising at least one antibiotic, and greater than 50 weight percent, based on the total weight of the composition, of a polymer component, wherein said...
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7939565 |
Active substance combinations having insecticidal and acaricidal properties
The present invention relates to novel insecticidally and acaricidally active compound combinations of...
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7910558 |
Bridged macrocyclic compounds and processes for the preparation thereof
The present invention provides a method for preparing bridged macrocyclic compounds comprising the step of reacting a macrocyclic compound characterized by having at least two nucleophilic moieties...
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7906489 |
18-membered macrocycles and analogs thereof
The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B),...
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7887828 |
Dual action organic formulation to control two stages of insect pests
The present invention discloses systems and methods for controlling arthropod populations. The systems include a polymeric substrate, a semiochemical that is reactive upon an adult-stage arthropod,...
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7879809 |
Fish production
This invention is directed to the use of spinosyn or a physiologically acceptable derivative or salt thereof for improved production of fish; controlling ectoparasite infestations in aquaculture...
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7875593 |
Fungicidal agent combinations
The invention relates to novel fungicidally active compound combinations of 2′-cyano-3,4-dichloroisothiazole-5-carboxanilide of the formula and active compounds listed in the disclosure.
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7863249 |
Macrolide polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof
The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions...
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7811998 |
Novobiocin analogues as anticancer agents
Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present...
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7795231 |
Concentrated aqueous azalide formulations
The present invention relates to formulations of concentrated azalide antibiotics and methods for making and using them. Specifically, the invention relates to a method of treating an infection...
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7737122 |
Spinosyn fumigants
Methods of controlling arthropod pests by dispersing spinosyn compositions in the form of aerosols, fogs, smokes, or vapors are disclosed.
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7713940 |
Water-soluble isoflavone composition, process for producing the same, and use thereof
An isoflavone composition which contains an α-glucosyl isoflavone and isoflavone and optionally an isoflavone aglycone, wherein the ratio of the amount of aglycone in the isoflavone and the ...
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7678740 |
Avermectin and avermectin monosaccharide derivatives substituted in the 4″-or 4′-position having pesticidal properties
What is described are a compound of the formula (I) Wherein U is —N(R2)OR3 or —N+(O−)═C(RE)RZ); n is 0 or 1; X—Y is —CH═CH— or —CH2—CH2—; R1 is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; R2 and...
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7622451 |
Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
Novobiocin analogues and pharmaceutical composition containing such compounds useful for the treatment and/or prevention of neurodegenerative disorders and autoimmune disorders.
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7608594 |
Novobiocin analogues as anticancer agents
Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present...
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7608595 |
4″-deoxy-4″-(S)-amido avermectin derivatives
A compound of formula (I); that has the S-configuration at the 4″-position and wherein the bond between carbon atoms 22 and 23 is a single or a double bond; R1 is C1-C12alkyl, C3-C8cycloalkyl; or C...
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7588774 |
Molecules enhancing dermal delivery of influenza vaccines
The present invention relates to dermal vaccine formulations, designed for targeted delivery of an immunogenic composition to a dermal compartment of skin including the intradermal and epidermal...
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7381744 |
Method of treating osteoporosis comprising vacuolar-type (H+)-ATPase-inhibiting compounds
The present invention provides vacuolar-type (H+)-ATPase-inhibiting compounds, compositions thereof, and methods of using them to treat or prevent a condition treatable by the inhibition of a...
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7358232 |
Method for the antibiotic coating of bodies with interconnecting microcavities as well as coated bodies and their usage
The invention relates to a method for the antibiotic coating of bodies with interconnecting microcavities as well as bodies coated this way and their usage. The invented method is characterized in...
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7358233 |
Tetronic acid derivative
The present inventors intended to search for substances that can regulate the expression of a molecular chaperone, GRP78, using the expression of GRP78 as an indicator. As a result, a novel...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7312200 |
9-ketospinosyn derivatives
The present invention relates to derivatives of 9-keto spinosyns, which are substituted by a ═N—(O, NH or NRx)—Ry moiety in the C-9 position, to methods for their manufacture, and to their use f...
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7195773 |
Pesticidal composition
A pesticidal composition comprising a pesticidally effective amount of at least one of a pyridic compound of the formula (I) or it salt and at least one of other pesticides: wherein Y is a...
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7163703 |
Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
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7160867 |
Rapamycin carbohydrate derivatives
This invention provides modified rapamycins that have specific monosaccharide(s), oligosaccharide(s), pseudosugar(s) or derivatives thereof attached through a linker to create rapamycin...
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7153877 |
Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and...
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7141582 |
Method for enhancing mutant enzyme activities in Gaucher disease
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
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7129221 |
6,11-bicyclic erythromycin derivatives
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
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7119246 |
Method of treating acne
This invention relates to a method for the treatment of acne that comprises applying a fluid comprising a polyalkylene carbonate over the area affected by acne and penetrating pores within the...
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7094397 |
Methods and reagents for the treatment of multiple sclerosis
The invention features methods and reagents for the diagnosis, monitoring, and treatment of multiple sclerosis. The invention is based in part on the discovery that Chlamydia is present in patients...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7071233 |
Antimicrobial prevention and treatment of human immunedeficience virus and other infectious diseases
An improved medical treatment and medicine is provided to quickly and safely resolve HIV and other microbial infections. The inexpensive medicine can be self administered and maintained for the...
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7037523 |
Controlled release compositions for macrolide antimicrobial agents
The present invention provides a controlled release pharmaceutical composition of an acid labile, poorly soluble drug having pH dependent solubility profile in aqueous environment. In a preferred...
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7030093 |
Antibiotic coating for porous bodies and method for its production as well as its use
The invention describes an antibiotic coating for porous bodies and its use. Into the porous system of non-metallic porous bodies and of metallic porous bodies, a coating made of at least one...
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7015203 |
Macrolides
The invention relates to novel erythromycin analogs and azalides, particularly ones with novel C-13 substituents, and to pharmaceutically acceptable salts thereof. The compounds of this invention...
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6982252 |
Inhibition of vacuolar proton ATPase activity and/or the modulation of acidic organelle function sensitizes cells to radiation, chemotherapy and biological agents
The present invention relates to methods and compositions for inhibiting cell survival and/or promoting cell death following exposure to cytotoxic agents and stress such as radiation or...
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6946490 |
Antimicrobial treatment for herpes simplex virus and other infectious diseases
An improved medical treatment and medicine is provided to quickly and safely resolve herpes and other microbial infections. The inexpensive user-friendly medicine can be applied and maintained on...
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6927210 |
Ectoparasiticidal aqueous suspension formulations of spinosyns
The invention provides a stable ectoparasiticidal aqueous suspension formulation of a spinosyn, comprising the spinosyn, or a physiologically acceptable derivative or salt thereof, milled to an...
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6919317 |
Pharmaceutical composition comprising squalene epoxidase inhibitor and macrolide immunomodulator
Synergistic combinations of a squalene epoxidase inhibitor such as terbinafine and a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro, 33-desoxyascomycin are provided,...
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6916829 |
Method for enhancing mutant enzyme activity in gaucher disease
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
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6914051 |
Penetrating antibiotic gel for soft tissue diseases
A penetrating antibiotic gel for treating pain, inflammation and other pathological conditions affecting musculoskeletal tissues and other soft tissues of the body. The composition includes an...
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