Patents in Class 514/279

Matches 1 - 50 out of 274

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Match	Document	Document Title
1	8173678	Kappa opioid receptor ligands Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease...
2	8173689	6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of...
3	8163749	Six-membered heterocycles useful as serine protease inhibitors The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, R3 and R11 are as defined...
4	8158644	Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin Crystalline polymorphous forms of rifaximin (INN), referred to as rifaximin α and rifaximin β, and a poorly crystalline form referred to as rifaximin γ, useful in the production of medicaments co...
5	8153647	Aryl- and heteroaryl-ethyl-acylguanidine derivatives, their preparation and their application in therapeutics Disclosed are compounds according to formula (I): wherein A, Q, X, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are as defined herein. The disclosure also relates to pharmaceutical...
6	8153646	Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation The present invention provides methods of improving cognitive and motor deficits associated with central nervous system (CNS) disorder or condition in an animal. The methods comprise a general...
7	8138187	Substituted heteroaryl derivatives The invention relates to substituted heteroaryl derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of substituted heteroaryl derivatives for...
8	8128905	Stabilized uncoated particles of reversed liquid crystalline phase materials Uncoated particles of reversed cubic phase or reversed hexagonal phase material containing an active disposed within are provided. The uncoated particles have an ionic charge that is sufficient to...
9	8119653	Belactosin derivatives as therapeutic agents/biological probes and their synthesis Derivatives of belactosin and their synthesis are disclosed. In certain embodiments, compounds of the present invention exhibit anti-cancer, antiviral, antibiotic, and/or auto-immune therapeutic...
10	8110582	Prophylactic treatment of UV-induced epidermal neoplasia The present invention provides a method of protecting a subject against UV-induced epidermal neoplasia. Generally, the method includes administering to a subject an IRM compound in an amount...
11	8088786	Layered pharmaceutical formulations In one embodiment a layered pharmaceutical formulation includes two or more pharmaceutical layers and an intermediate layer disposed between at least two of the two or more pharmaceutical layers,...
12	8076351	Camptothecin derivatives with antitumor activity Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
13	8067429	Forms of rifaximin and uses thereof The present invention relates to Rifaximin polymorphic, salt, hydrate, and amorphous forms, to their use in medicinal preparations and to therapeutic methods using them.
14	8058268	Neuroprotective agents for the prevention and treatment of neurodegenerative diseases Disclosed herein are methods of treating neurodegenerative diseases comprising administering to the subject a compound having the structure: wherein α and R1-R8 are described herein, or a compound ...
15	8030323	Pyrazole carboxamide derivatives, pharmaceutical compositions and its preparation A compound of formula (I) or pharmaceutically acceptable salts and/or solvates or hydrates thereof. A process for preparing the compound, a pharmaceutical composition comprising the compound and an...
16	8030324	Pyridine derivatives for the treatment of metabolic disorders related to insulin resistance or hyperglycemia The present invention provides novel compounds represented by the general formula (I): their stereoisomers, pharmaceutically acceptable salts and their pharmaceutically acceptable solvates thereof,...
17	8022080	Small molecules with antiprotozoal activity The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria.
18	7964610	Buprenorphine derivatives and uses thereof Ester derivatives of the phenolic hydroxyl group of buprenorphine can be used in the treatment of opiate dependency and/or moderate to severe pain. The esters have an enhanced bioavailability, an...
19	7951817	Pyridomorphinans, pyridazinomorphinans and use thereof Compounds represented by the formula: wherein R is C1-6 alkyl; C4-6 cycloalkylalkyl; or C3-6 alkenyl; R′ is H or C1-6 alkyl; X is H or OH; Y is alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl or a...
20	7932263	Therapeutic treatment A combination comprising candesartan and rosuvastatin for the prevention or treatment of arteriosclerosis and for the prevention of cardiovascular events is described.
21	7928120	Cyanoisoquinoline compounds and methods of use thereof The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions. The cyanoisoquinoline...
22	7915275	Use of polymorphic forms of rifaximin for medical preparations The present invention relates to Rifaximin polymorphic forms α, β and γ, to their use in medicinal preparations for the oral or topical route and to therapeutic methods using them.
23	7910586	Compositions and methods for prevention and treatment of amyloid-β peptide-related disorders The present invention provides methods and compositions for modulating levels of amyloid-β peptide (Aβ) exhibited by cells or tissues. The invention also provides pharmaceutical compositions and m...
24	7902196	Synthesis of avrainvillamide, strephacidin B, and analogues thereof The syntheses of the natural products, avrainvillamide and stephacidin B, are provided. The α,β-unsaturated nitrone functionality of avrainvillamide and its 3-alkylidene-3H-indole 1-oxide core is s...
25	7902206	Polymorphic forms α, β and γ of rifaximin Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin α and rifaximin β, and a poorly crystalline form named rifaximin γ, useful in the production of medicinal pr...
26	7893080	Method of restoring the incretin effect The present invention relates to methods of treating metabolic syndrome, Type 2 diabetes mellitus, atherogenic dyslipidemia and/or obesity. The present invention also relates to methods of...
27	7888368	Treatment of drug-resistant tumors A subclass of camptothecin derivatives is disclosed to be useful for the preparation of a medicament for the treatment of drug-resistant tumors and/or for the administration to patients who show...
28	7879869	Drugs for ameliorating postcibal hyperglycemia It is mentioned to provide drugs for ameliorating postcibal hyperglycemia, drugs for inhibiting an increase in blood glucose level and pharmaceutical compositions for preventing or treating...
29	7872023	Kappa opioid receptor ligands Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease...
30	7872016	Method for treating skeletal disorders resulting from FGFR malfunction The invention provides materials, reagents, systems, and methods for identifying agents useful for treating diseases resulting from abnormal (e.g., excessive) FGF receptor signaling. The invention...
31	7868015	Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of...
32	7858637	Administration of TLR7 ligands and prodrugs thereof for treatment of infection by hepatitis C virus This invention relates to methods for treating or preventing hepatitis C virus infections in mammals using Toll-Like Receptor (TLR)7 ligands and prodrugs thereof. More particularly, this invention...
33	7858636	Hexarylene and pentarylene tetracarboxylic acid diimides Rylenetetracarboximides of the general formula I in which the variables are defined as follows: R are identical or different radicals: hydrogen; alkyl, cycloalkyl, aryl or hetaryl, each substituted...
34	7851439	EFTU inhibitors or aminothiazoles and their uses Organic compounds that are useful for the treatment, prevention and/or amelioration of diseases are described.
35	7838532	Aerosolized fluoroquinolones and uses thereof Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of...
36	7820143	Water soluble tetrapyrollic photosensitizers for photodynamic therapy A tetrapyrollic photosensitizer compound having at least one pendant —CH2CH2CON(CH2CON(CH2COOH)2)2 or —N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bac...
37	7799778	5-substituted 2-aminopyridine analogs for treating allergic and inflammatory diseases Methods for treating an allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition characterized by administering a composition which contains a therapeutically...
38	7781449	Trospium chloride treatment method A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum...
39	7781450	Substituted pyrroline kinase inhibitors The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
40	7781448	Once daily dosage forms of trospium A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum...
41	7781445	Synthesis of indenoisoquinoliniums and methods of use Substituted indenoisoquinolinium compounds, and pharmaceutical formulations of substituted indenoisoquinolinium compounds are described. Also described are processes for preparing substituted...
42	7763635	Once daily dosage forms of trospium A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum...
43	7759359	Method of treating bladder dysfunction with once-a-day trospium salt formulation A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum...
44	7736624	Methods and compositions for diagnostic and therapeutic targeting of COX-2 The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the...
45	7737158	Processes for regulating blood glucose in a mammal The present invention relates to processes for regulating the blood glucose concentration of a mammal.
46	7705015	Substituted pyrroline kinase inhibitors The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
47	7678807	Isoquinoline and benzo[H] isoquinoline derivatives, preparation and therapeutic use thereof as antagonists of the histamine H3 receptor The invention concerns a compound of formula (I): Wherein A, l, m, n, R1 and R2 are as defined herein. The compounds of this invention are useful as medicaments, particularly, in the treatment of...
48	7674797	2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity for the treatment of asthma and other inflammatory or immunological disorders The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the...
49	7671068	N-(alkoxyalkyl) carbamoyl-substituted 6-phenyl-benzonaphthyridine derivatives and their use as PDE ¾ inhibitors Compounds of the formula I in which the substitutents have the definitions provided in the specification, are novel, effective PDE 3/4 inhibitors.
50	7659281	HMG-CoA reductase inhibitors Compounds are provided of the following structure are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering...

Matches 1 - 50 out of 274

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