Matches 101 - 150 out of 230 < 1 2 3 4 5 >
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6143757 Chemical compounds  
Compounds of the general structural formula ##STR1## and use of the compounds and salts and solvates thereof, as therapeutic agents.
6136817 Opioid receptor antagonist compounds  
New morphinane derivatives of the formula ##STR1## their pharmaceutically acceptable salts, a process for their preparation and their use in the manufacture of pharmaceutical preparations.
6127355 High molecular weight polymer-based prodrugs  
The present invention is directed compositions of the formula: ##STR1## wherein: D is a residue of a biologically active moiety; X is an electron withdrawing group; Y and Y' are independently...
6110933 Amino acid derivatives and their use as phospholipase A.sub.2 inhibitor  
6100273 Water soluble camptothecin derivatives  
The present invention relates to water soluble, camptothecin derivatives of formula (I). ##STR1## wherein A represents a moiety of the formula (IIA), (IIB) or (IIC): ##STR2## X is selected from the...
6096755 N-substituted azabicycloalkane derivatives, their preparation and use  
Compounds of the formula I ##STR1## where B, R 1 , R 2 , n, R 3 , A, X, Y and Z have the meanings stated in the description, and their preparation are described. The novel compounds are suitable...
6048867 Biologically active rupununines  
A method of therapy wherein there is administered to a person in need of such therapy a pharmacologically effective amount of a rupununine having the formula: ##STR1##
6046209 Water soluble camptothecin analogs  
The present invention provides water soluble camptothecin analogs of Formula I: ##STR1## which are particularly useful as antineoplastic agents; pharmaceutical compositions thereof; and a method of...
6030980 Agent for the treatment of infections  
The present invention relates an agent for the treatment of infections, which comprises as the active ingredient at least one member selected from the group consisting of aconite-alkaloids, aconite...
6008225 Derivatives of antibiotic GE2270 factors C.sub.2a, D.sub.2 and E  
Mono- or di-substituted derivatives of GE2270 factors C 2a , D 2 and E of general formula (I), wherein W represents a moiety of formula (a), (b) or (c), R 1 and R 2 representing a variety of...
6004977 N-(pyridinylamino) isoindolines and related compounds  
Novel N-(pyridinylamino)isoindolines and related compounds, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing...
6004969 Transdermal delivery of buprenorphine preparations  
Buprenorphine is a potent analgesic agent, it has been shown to be as effective as morphine. The main clinical application of buprenorphine is to relief postoperative pains or for patients in the...
5994327 Process for the preparation of morphinans  
A process for the preparation of 14-alkoxyindolomorphinans and 14-alkoxybenzofuranomorphinans is disclosed. The process facilitates the preparation of a large variety of 14-alkoxy substituted...
5990120 Hexacyclic camptothecin analogues, and process for preparing them  
The present invention relates to novel hexacyclic camptohecin analogues, having a five-membered aza-heterocycle fused to ring (A) of camptothecin at positions 9 and 10. Such compounds possess high...
5985877 Combination of tyrosine kinase inhibitor and chemical castration to treat prostate cancer  
A method of treating prostate cancer by co-administering a tyrosine kinase inhibitor such as an indolocarbazole and a chemical castration agent is disclosed. A composition containing a tyrosine...
5985887 Aza-anthracyclinone derivatives  
Compounds of formula I ##STR1## wherein X 1 and X 2 are CO, CNH or CH 2 , X 3 is CH 2 , CO, CHOH, ##STR2## wherein n=2 or, 3 or CN(R 9 ) wherein R 9 is hydroxy or amino-aryl, and each...
5981541 Substituted heterocycles as anti-tumor agents  
The present invention provides compounds of formula (I): ##STR1## wherein R 1 -R 7 , W, X, Y, and Z have any of the values defined in the specification, and pharmaceutically acceptable salt...
5981540 Heterocycle-condensed morphinoid derivatives  
Compounds of formula (I), are selective delta opioid agonsist and antagonists, and are useful as analgesics and in treating general neurologic disorders. ##STR1##
5977077 Xanthone analogs for the treatment of infectious diseases  
Therapeutic compositions for the treatment of infectious diseases are disclosed. These compositions comprise xanthones and xanthone derivatives, such as 2,3,4,5,6-pentahydroxyxanthone. Also...
5972952 Neuroprotective pharmaceutical composition containing stereoisomers of arylcyclohexylamines  
The invention relates to pharmaceutical compositions for neuroprotection containing the compound (1S,2R) 1-[1-(2-thienyl)-2-alkylcyclohexyl]piperidine or (1S,2R)...
5968824 Agents for inducing apoptosis and applications of said agents in therapy  
Agents which modulate pathways of apoptotic induction or repression in which products of opioid peptide precursors genes participate, useful as inducers of apoptosis in cells and in tumor cells in...
5932588 Camptothecin compounds with combined topoisomerase I inhibition and DNA alkylation properties  
Camptothecin compounds having a --CH 2 --L group are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and DNA of associated topoisomerase I-DNA complexes.
5908835 Anti-tumor compositions containing taxane derivatives  
Disclosed are antitumor compositions comprising taxol, taxotere or their derivatives in combination with an anthracycline antibiotic, the combination having a pharmacologic activity greater than...
5889013 Pyrimidine acyclonucleoside derivatives  
The present invention relates to novel pyrimidine acyclonucleoside derivatives represented by the following general formula (I), antiviral agents containing the derivatives as the active...
5886002 Use of rifaximin and of pharmaceutical compositions containing it in the treatment of the diarrhoea from cryptosporidiosis  
The use of therapeutically effective amounts of rifaxmin and of pharmaceutical compositions containing it in the treatment of the diarrhoeal symptomatology in case of cryptosporidiosis in patients...
5886001 Agonist compounds  
New morphinane derivatives of the formula (I) ##STR1## their pharmaceutically acceptable salts, a process for their preparation and their use in therapy. The variables in the above structure are as...
5861411 4-Acylaminopyridine derivative  
A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for...
5856333 Substituted camptothecin derivatives and process for their preparation  
The present invention relates to substituted camptothecin derivatives of formula (I) wherein the symbol - - - - represents a single or double bond; R 1 , R 2 and R 3 are as defined under (a) or...
5849731 Indole derivatives and medical application thereof  
The present invention relates to indole derivatives represented by the following compound 1 and the pharmacologically acceptable acid addition salt thereof. ##STR1## The compounds of the present...
5849750 Dynemicin analogs  
Non-naturally occuring dynemicin analogs are provided, which are useful as DNA cleaving agents, cytotoxic agents, and/or anti-tumor compounds. Methods of making dynemicin analogs are also provided.
5780479 Use of opioid antagonists to treat impulse-control disorders  
A method is provided for treating an individual afflicted with an impulse-control disorder by administering thereto an amount of one or more opioid receptor antagonists.
5776954 Substituted pyridyl pyrroles, compositions containing such compounds and methods of use  
The present invention addresses substituted pyridyl pyrroles, as well as compositions containing such compounds and methods of treatment. The compounds in the present invention are glucagon...
5776942 Bronchodilating pyrido 2,3-d!pyrimidine derivatives  
A rapid-acting remedy for asthma having a bronchodilating action contains at least one pyrido 2,3-d!pyrimidine derivative represented by the general formula (A) or pharmaceutically acceptable salts...
5770607 Aqueous liquid composition for external use  
This invention relates to an aqueous liquid composition for external use which contains a tricyclo compound of the chemical formula (I) presented here-under or a pharmaceutically acceptable salt...
5770605 Method for treating leukemia with a hexa-cyclic compound  
A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound by the...
5770604 Aconitine compound and an antipyretic/analgesic/anti-inflammatory agent  
This invention provides novel aconitine compounds of the formula (I) or salt thereof ##STR1## wherein, R 1 is a hydrogen atom or hydroxyl group; R 2 is an acetyloxy group; R 3 is an alkyl having...
5736156 Liposomal anf micellular stabilization of camptothecin drugs  
The present invention provides water soluble, stable, highly pharmacologically active camptothecin drugs by solubilizing the camptothecin drugs in liposomes composed of lipids or in micelles...
5728709 Alkyl and aralkyl-substituted pyrrolocarbazole derivatives that stimulate platelet production  
Described herein is a pyrrolocarbazole derivative and a pharmaceutically acceptable salt thereof having the following formula (I): ##STR1## wherein R 1 is lower alkyl or aralkyl; R 2 is hydrogen,...
5679671 Amino acid derivative  
The present invention relates to an amino acid derivative having an angiotensin I-converting enzyme inhibition activity, a vasopressin antagonism and an atrial natriuretic peptide hydrolase...
5672597 Acetamide derivative  
An acetamide derivative having the general formula (I): ##STR1## or a pharmacologically acceptable salt thereof; a synthetic intermediate of the above-mentioned acetamide derivative; a treating...
5658920 Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound  
A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound by the...
5654312 Treatment of inflammatory and/or autoimmune dermatoses with thalidomide alone or in combination with other agents  
Methods of treatment for inflammatory and autoimmune dermatoses which comprises topical and/or systemic administration of a therapeutically-effective amount of thalidomide alone or in combination...
5648359 Tumor necrosis factor production inhibitors  
There is provided a composition for inhibiting the production or secretion of tumor necrosis factor effective for the treatment of cachexia, septic shock, multiple organ failure, rheumatoid...
5643915 Treatment of ischemia/reperfusion injury with thalidomide alone or in combination with other therapies  
In accordance with the present invention, a method is provided for treating reperfusion injury, ischemia and runaway inflammatory conditions with thalidomide alone or in combination with other...
5641500 Use of purinergic receptor agonists as antineoplastic agents  
The instant invention is directed to the use of a pharmaceutical composition containing an effective amount of adenosine or an adenosine analog or derivative as an agent useful in the treatment of...
5639753 Insecticidal pteridines and 8-deazapteridines  
This invention relates to pteridine and 8-deazapteridine compounds and compositions containing the same which are useful for controlling insects in agricultural crops. These pteridines may be...
5631263 Use of delta opioid receptor antagonists to treat immunoregulatory disorders  
A therapeutic method is provided to elevate a depressed mammalian autologous mixed lymphocyte response and to alleviate the diseases associated therewith by the administration of an effective...
5631264 Substituted 6,11-ethano-6,11-dihydrobenzo[B]quinolizinium salts and compositions and methods of use thereof  
Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment or prevention of neurodegenerative disorders or...
5622957 Benzopyrrolizinoquinolizinones  
A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical ##STR2## and R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , R 8 , R 9 and Z are as defined in the...
5622723 Procedure for encapsulating chlorpheniramine  
An improvement in the process of coacervation of chlorpheniramine maleate is provided whereby a predetermined amount of chlorpheniramine maleate charged to the process is maintained in the...
Matches 101 - 150 out of 230 < 1 2 3 4 5 >