Matches 51 - 100 out of 230 < 1 2 3 4 5 >
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6878737 Reversal of multidrug resistance in human colon carcinoma cells  
The present invention describes the use of fumitremorgin A, B and C and a series of diketopiperazines of Formula (I) to resensitize multidrug resistant (MDR) cancer cells to the cytotoxic effects...
6875439 Formulation containing amphipathic weak base and/or amphipathic cation and multiple drug resistance inhibitor  
Methods are provided relating to the enhanced cytoplasmic accumulation of amphipathic weakly basic or amphipathic cationic molecules in prokaryotes and eukaryotes under conditions of high...
6844353 Fungicidal properties of sampangine and its analogs to agriculturally important fungal plant pathogens  
It has been found that sampangine and related analogs such as benzo[4,5]sampangine, 4-bromosampangine and 4-methoxysampangine may be used as effective fungicidal agents for plants. Fungicidal plant...
6828327 Macroheterocylic compounds useful as kinase inhibitors  
This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or...
6825206 Camptothecin compounds with a thioether group  
Camptothecin compounds which are effective anti-tumor compounds are disclosed. These conjugates inhibit the enzyme topoisomerase I and enhance the stability of the topoisomerase I-DNA cleavable...
6815438 Heteroaryl-diazabicycloalkanes  
The present invention relates to novel heteroaryl-diazabicycloalkanes which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the...
6806291 Analgesic compounds, their synthesis and pharmaceutical compositions containing them  
New analgesic compounds, which are prepared by the hydrolysis of N-acylated 4-hydroxyphenylamine derivatives, their synthesis and pharmaceutical compositions containing them are disclosed. These...
6790847 Topical application of cetirizine and loratadine  
The present invention relates to a drug composition containing the non-sedating H 1 antihistamines cetirizine, loratadine, mixtures or pharmaceutically acceptable salts thereof for topical...
6784186 Therapeutic compounds  
This invention relates to novel structural analogues and derivatives of compounds with general analgesic or related pharmacological activity. In particular the invention relates to derivatives of...
6770654 Indole derivatives and use thereof in medicines  
This invention relates to: an indole derivative or a pharmaceutically acceptable salt thereof represented by formula (I): wherein R 1 is, for example, hydrogen or C 1-5 alkyl; R 2 is, for...
6767888 Neuroprotective methods and reagents  
One aspect of the present application relates to a method for limiting damage to neuronal cells by ischemic or epoxic conditions, e.g., such as may be manifest by a reduction in brain infarct...
6703398 Orally administered analgesic compositions containing nalbuphine  
The present invention provides orally administered pharmaceutical compositions which contains an effective amount of free base or pharmaceutcially acceptable salts of nalbuphine and/or nalbuphine...
6696480 Upregulation of type III endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization  
A use for agents that disrupt actin cytoskeletal organization is provided. In the instant invention, agents that disrupt actin cytoskeletal organization are found to upregulate endothelial cell...
6689788 Method and composition for treatment of inflammatory bowel disease  
A composition in unit dosage form for the inhibition, prevention or treatment of inflammatory bowel disease comprising an effective amount of a compound having the formula: and a...
6642248 Benzo&lsqb b&rsqb pyrano&lsqb 3,2-h&rsqb acridin-7-one compounds  
A compound selected from those of formula (I): wherein: X and Y represent group selected from hydrogen, halogen, mercapto, cyano, nitro, alkyl, trihaloalkyl, trihaloalkylcarbonylamino, —ORa,...
6638941 Conformationallly constrained peptidomimetics as β-turn templates and modulators of SH3 domains  
Spirolactam compounds useful as inhibitors of protein-protein interactions modulated by SH3 domains are disclosed. Compounds of the invention are also useful as β-turn mimetics. Also disclosed are...
6613313 Aniline compound-containing hair dye composition and method of dyeing hair  
A hair dye composition containing at least one of the following compounds: or analogues thereof; and a method for dyeing hair which comprises a step of applying to the hair the hair dye...
6608073 Intranasal codeine for the rapid suppression of cough and rapid relief of pain  
This invention provides a method of rapidly and reliably delivering codeine, alone or in combination with other compounds, to the systemic circulation by administration via the nasal route to...
6602896 p38MAPK inhibitor and uses thereof  
The present invention demonstrates that p38 MAPK inhibitor induces low density lipoprotein receptor expression 6-8 fold, and further provides the application of such inhibitor in the treatment of...
6534514 Kappa opioid receptor antagonists  
Compounds of the formula: are provided, which are selective kappa opioid receptor antagonists, wherein R 1 is (C 1 -C 5 )alkyl, C 3 -C 6 (cycloalkyl)alkyl, C 5 -C 7 (cycloalkenyl)alkyl, (C 6 -C...
6528518 Treatment of depression with kappa receptor antagonists  
The invention features the treatment of depression using kappa opioid receptor antagonists.
6528517 Synthesis of quinobenzoxazine analogues with topoisomerase II and quadruplex interactions for use as antineoplastic agents  
The present invention discloses a novel quinobenzoxazine self-assembly complex on DNA and on the topoisomerase II-DNA complex. The related model is used to design a new series of quinobenzoxazines,...
6503919 Compounds of 7-oxo-2,3,7,14-tetrahydro-1H-benzo&lsqb b&rsqb pyrano&lsqb 3,2-h&rsqb acridin carboxylate  
A compound selected from those of formula (I): wherein: X and Y represent hydrogen, halogen, hydroxy, mercapto, cyano, nitro, alkyl, alkoxy, trihaloalkyl, optionally substituted amino,...
6500824 Kappa (OP2) opioid receptor antagonists  
The invention provides kappa receptor antagonists of formula (I), wherein R 1 -R 6 X and Y have any of the meanings given in the specification, as well as compositions comprising them, and methods...
6465479 Pyridomorphinans and use thereof  
Compounds represented by the formula: wherein each of Y, X and R individually is H, OH, alkyl, alkoxy, aryl, halo, CF 3 and NO 2 , provided that at least one of Y, X and R is other than H; and...
6410041 Culturing cells in presence of amphipathic weak bases and/or cations and multiple drug resistance inhibitor containing reserpine  
Methods are provided relating to the enhanced cytoplasmic accumulation of amphipathic weakly basic or amphipathic cationic molecules in prokaryotes and eukaryotes under conditions of high...
6407089 Triazatrinaphthyrins and the use thereof  
A novel class of macrocycles, termed triazatrinaphthyrins, is disclosed having general Formula I: or a solvate, hydrate, ester or salt thereof; wherein R 1 , R 2 , R 3 , R a , R a′ , R a″ ,...
6407115 Hexa-cyclic compound  
Accordingly, an object of this invention is to provide a hexa-cyclic compound represented by the following general formula: wherein R 1 and R 2 individually represent a hydrogen atom, a...
6383528 Pharmaceutical composition comprising ticlopidine and Ginkgo biloba extract  
The invention herein relates to a pharmaceutical composition comprising ticlopidine and Ginkgo biloba extract. In detail, as an anti-thrombotic preparation, the pharmaceutical composition...
6365594 Heterocycle-condensed morphinoid derivatives (II)  
Heterocycle-condensed morphinoid derivatives of formula (I), or solvates or salts thereof, are potent and selective delta opioid agonists and antagonists and are useful as i.a. analgesics....
6323038 Diagnostic reagent for complications associated with diabetes or renal failure  
In view of the situation of the prior art, the present invention specifies the structure of a late-stage product of Mailard reaction in vivo having a close relation with various tissue disorders,...
6291470 Indole derivatives process for producing the same and medicinal uses of the same  
A novel compound which is a δ-opioid antagonist having high selectivity and activity, that exhibits immunosuppressive action, antiallergic action, anti-inflammatory action and brain...
6288074 Method of treating lymphoproliferative syndrome  
Lymphoproliferative syndrome, including such diseases as malignant lymphoma, chronic lymphocytic leukemia, Hodgkin's lymphoma, and non-Hodgkin's lymphoma, is treated in human patients by the...
6288072 Camptothecin β-alanine esters with topoisomerase I inhibition  
β-Alanine esters of camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated...
6288073 Acronycine derivatives, preparation method and pharmaceutical compositions  
A compound selected from those of formula (I): ##STR1## in which: X and Y represent hydrogen, halogen, hydroxy, mercapto, cyano, nitro, alkyl, alkoxy, trihaloalkyl, optionally substituted amino,...
6284769 Nonpeptide kappa opioid receptor antagonists  
The compounds of structural formulae (I) and (II) ##STR1## and use of the compounds and salts and hydrates thereof, as therapeutic agents, is disclosed. A compound of formula (I) or (II) is an...
6277829 Process for preparing of aqueous formulation for opthalmic use  
The present invention describes a process for the preparation of aqueous formulations containing azithromycin for ophthalmic use, as well any formulations obtained by this process and their topical...
6271264 Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants  
The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises administering a therapeutically effective...
6268375 10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition  
Camptothecin compounds having a C 10 11 O--(CF 2 ) n O group where n is 1 or 2 are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the...
6268377 Method for treating androgen-related conditions  
The present invention provides for the combined use of 5α-reductase inhibitors together with calcium channel blockers for the treatment of benign prostatic hyperplasia (BPH), prostate cancer,...
6265413 Camptothecin compounds and a method of preparation thereof  
Camptothecin derivatives and pharmaceutically acceptable salts thereof, its manufacturing method and an antineoplastic agent containing it. The camptothecin derivatives are modified in B-ring and...
6258856 Method for preventing or controlling cataract  
A method for preventing or treating pathological changes which occur in association with cataract formation in the mammalian eye by protecting lens cells against the cataractogenic effects of...
6218398 Nocathiacin antibiotics  
Novel thiazolyl peptide antibiotic compounds, including nocathiacin I, II and III, are disclosed. Also, novel microorganism ATCC-202099 is disclosed.
6214835 Dihalopropene compounds insecticides containing them as active ingredients, and intermediates for their production  
The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R 1 is C 1 -C 10 alkyl or the like; L is C(O)NH or the like; R 2 , R 3 and R 4 are...
6194422 Anthracycline derivatives  
The present invention provides imino aza-anthracyclinones and a method of treating amyloidoses using the same.
6187783 Phenanthridinium derivatives  
A novel phenanthridinium derivative represented by general formula (A): ##STR1## wherein R 1 is a substituted or unsubstituted lower aliphatic hydrocarbon group; R is an aliphatic hydrocarbon...
6187782 Morphinane derivatives and medicinal use thereof  
Novel morphinan derivatives and pharmaceutically acceptable acid addition salts thereof as compounds having abilities to bind to opioid ε-receptor, which have agonist or antagonist activities, are...
6172078 Quinolinomorphinane derivatives and medicinal use thereof  
The present invention provides a quinolinomorphinan derivative or a pharmacologically acceptable acid addition salt thereof, and an agent for curing or preventing cerebral disorders composed of the...
6156762 Indolomorphinan derivative and agent for curing and preventing cerebral disorder  
The present invention provides an indolomorphinan derivative or a pharmacologically acceptable acid addition salt thereof, and an agent for curing and preventing cerebral disorders composed of the...
6156754 Glycoconjugates of modified camptothecin derivatives (A-or B-ring linkage)  
The present invention relates to glycoconjugates of camptothecin derivatives in which at least one carbohydrate component is linked via suitable spacers with the A or B ring of a camptothecin...
Matches 51 - 100 out of 230 < 1 2 3 4 5 >