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7618978 |
Amides as BACE inhibitors
The present invention provides BACE inhibitors of Formula (I): methods for their use, and intermediates and methods for their preparation.
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7612056 |
Substituted diaza-spiro-[4.5]-decane derivatives and their use as neurokinin antagonists
This invention concerns substituted diaza-spiro-[4.5]-decane derivatives having neurokinin antagonistic activity, in particular NK 1 antagonistic activity, a combined NK 1 /NK 2 antagonistic...
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7605167 |
Use of cyclopamine in the treatment of psoriasis
This invention concerns the use of cyclopamine, a naturally occurring steroidal alkaloid known for over thirty years, for the treatment of psoriasis and achievement of rapid clearance of the...
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7598261 |
Spirocyclic heterocyclic derivatives and methods of their use
Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic...
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7589096 |
Azole derivatives
The present invention relates to a compound of the formula (I):
wherein Az is a group comprising a monocyclic azole or a bicyclic aromatic ring of the same or different fused azoles; T, U, V...
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7582649 |
Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
The present invention is directed to novel hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula
wherein all variables are as defined herein, useful in...
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7576207 |
Spirocyclic heterocyclic derivatives and methods of their use
Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic...
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7576094 |
Spiro derivatives as lipoxygenase inhibitors
The present invention is concerned with certain novel spiro substituted heterocylic ring derivatives. These compounds may be useful in the manufacture of pharmaceutical compositions for treating...
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7569604 |
Heterocyclic derivatives for modulation of calcium channels
Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
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7569579 |
Cyclopropyl compounds as ccr5 antagonists
The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in...
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7563802 |
Spirocyclic heterocyclic derivatives and methods of their use
Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic...
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7563801 |
Pharmaceutical formulations: salts of 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and treatment methods using the same
Pharmaceutical formulations containing salts of (5S,8S)-8-[{(1R)-1-(3,5-Bis-(trifluoromethyl)phenyl]-ethoxy}
-methyl]-8-phenyl-1,7-diazaspiro [4.5]decan-2-one, represented by Formula I, are...
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7560468 |
Substituted 1,4,8-triazaspiro[4,5]decan-2-one compounds
Novel 1,4,8-triazaspiro[4,5]decan-2-one compounds corresponding to formula I
processes for the preparation thereof, related methods of treatment and pharmaceutical formulations containing such...
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7557117 |
4-oxoimidazolidine-2-spiropiperidine derivatives
The invention relates to 4-oxoimidazolidine-2-spiropiperidine derivatives represented by a general formula [I]
[in which A 1 , A 2 , A 3 , A 4 and A 5 stand for optionally halogen-substituted...
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7553841 |
Amino cyclobutylamide modulators of chemokine receptor activity
The present invention is directed to compounds of the formulas I and II: wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 15 , R 16 , R 17 , R 18 , R 19 , R 25 , R 26 , Y, Z,...
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7547708 |
N-sulfamoyl-N′-benzopyranpiperidine compounds and uses thereof
N-sulfamoyl-N′-benzopyranpiperidine compounds of formula I and their physiologically acceptable acid addition salts, pharmaceutical compositions comprising them, processes for their preparation,...
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7547707 |
Spirocyclic cyclohexane compounds
Spirocyclic cyclohexane compounds corresponding to formula I
a method for producing them, pharmaceutical compositions containing them, and methods of using them.
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7547694 |
Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
The present invention relates to the CGRP antagonists of general formula
wherein A and R 1 to R 3 are defined as in claim 1 , the tautomers, the diastereomers, the enantiomers, the hydrates...
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7547660 |
Phenyl-substituted 4-hydroxy-tetrahydropyridones
The present invention relates to novel compounds of the formula (I)
in which W, X, Y, Z, G, A, B, Q 1 , Q 2 and D are each as defined in the disclosure,
to a plurality of processes for...
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7544695 |
Spirocyclic compounds
The present invention relates to a novel class of substituted spirocyclic compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal...
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7544694 |
Substituted diaza-spiro-[5.5]-undecane derivatives and their use as neurokinin antagonists
This invention concerns substituted diaza-spiro-[5.5]-undecane derivatives having neurokinin antagonistic activity, in particular NK 1 antagonistic activity, a combined NK 1 /NK 2 antagonistic...
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7544693 |
Spirofuropyridine aryl derivatives
Compounds of formula I:
wherein Ar is a moiety of formula II or III:
and pharmaceutically-acceptable salts thereof, wherein A, B, and R 1 are as defined in the specification, enantiomers,...
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7531549 |
Phenylalanine enamide derivatives
Phenylalanine enamide derivatives of formula (1) are described:
wherein
R 1 is a group Ar 1 L 2 Ar 2 Alk- in which: Ar 1 is an optionally substituted aromatic or heteroaromatic group; L 2 ...
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7528125 |
Water-soluble zinc ionophores, zinc chelators, and/or zinc complexes and use for treating cancer
Disclosed herein are novel zinc ionophores, zinc chelators and/or zinc complexes with enhanced aqueous solubility. Methods of treating cancer using at least one zinc ionophore and/or zinc chelator...
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7524856 |
Tricyclic spiroderivatives as modulators of chemokine receptor activity
The invention provides compounds of formula (I) wherein m, R 1 , n, R 2 , q, p, X, Y, R 3 , R 4 , t and, R 5 are as defined in the specification, processes for their preparation, pharmaceutical...
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7521458 |
Spiropiperidylrifamycins for the treatment of mycobacterial infections
The compounds of formula (1), their pharmaceutically acceptable salts and their solvates, wherein R 1 is a radical selected between hydrogen and alkyl; R 2 is selected from hydroxyalkyl, phenyl,...
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7507824 |
Spiro(2H-1benzopyran-2,4′-piperidine) derivates as glycine transport inhibitors
The present invention relates to spiro[2H-1-benzopyran-2,4′-piperidine] derivatives having general formula (I), or a pharmaceutically acceptable salt thereof. The invention also relates to...
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7507744 |
Spiroazabicyclic heterocyclic compounds
A pharmaceutical composition comprising a compound of formula
wherein n, m, p, X, Y, W, A, G and D are as defined in the specification, enantiomers thereof, or pharmaceutically acceptable salts...
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7504506 |
Therapeutic compounds and uses thereof
Compounds of formula (I) are described herein
The compounds can be used, for example, to modulate growth hormone secretagogue receptor (GHS-R). In some instances, the compounds can be used to...
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7501432 |
Spiro-piperidine derivatives
The present invention is concerned with novel spiro-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments....
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7501431 |
Physiologically active substances PF1270A, B and C substances
This invention provides novel PF1270A substance, PF1270B substance and PF1270C substance represented by the following formula (1) or pharmaceutically acceptable salts thereof, a method for...
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7501413 |
Dicarboxamide derivatives
The invention is concerned with novel dicarboxamide derivatives of formula (I)
wherein A, B, R c , D and E are as defined in the description and in the claims, as well as physiologically...
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7498339 |
Spiropiperidine glycinamide derivatives
In particular, the present invention is concerned with compounds of the general formula (I)
wherein X, Y and R 1 to R 10 are as described herein. The compounds are V1a receptor...
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7498338 |
Compounds
The invention provides compounds of formula (I) wherein m, R 1 , n, R 2 , q, X, Y, Z, t, R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined in the specification, processes for their preparation,...
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7498323 |
Spiro-piperidine compounds and medicinal use thereof
The present invention relates to a spiro-piperidine compound represented by formula (I):
wherein R 1 represents hydrogen, an aliphatic hydrocarbon group which may have a substituent(s) or a...
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7495007 |
Spiroindolinone derivatives
The present invention relates to spiroindolinone derivatives of the formula
and their enantiomers and pharmaceutically acceptable salts and esters thereof wherein R 1 , R 2 , R 3 , R 4 , R 5 ,...
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7479496 |
Substituted spiro azabicyclics as modulators of chemokine receptor activity
The present application describes modulators of CCR3 of formula (Ia) and (Ib):
or pharmaceutically acceptable salt forms thereof, wherein Z, R 1 , R 2 , R 3 , R 4 , R 5 , R 5 ′, R 6 , a, b,...
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7470783 |
Photocleavable protecting groups and methods for their use
Novel compounds are provided which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally...
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7465726 |
Substituted pyrrolo[2.3-B]pyridines
Compounds represented by Formula (I):
or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3,...
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7459462 |
Fredericamycin derivatives
The invention relates to novel fredericamycin derivatives, to medicaments containing these derivatives or salts thereof, and to the use of fredericamycin derivatives for treating diseases,...
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7452899 |
Gamma-secretase inhibitors
Compounds of Formula (I): inhibit the processing of APP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
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7449475 |
Tricyclic spiropiperidines or spiropyrrolidines
The invention provides compounds of formula (I)
wherein m R 1 , n, R 2 , q, X, Y, Z, R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , t, and R 9 are as defined in the specification, processes for their...
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7442706 |
Methods for treating sarcopenia with a growth hormone secretagogue
The present invention relates to methods for treating sarcopenia with a growth hormone secretagogue.
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7439251 |
Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor
There are provided methods for the treatment of diseases involving dysfunction of the peripheral and central nervous system comprising administering one or more spiro compounds. Also provided are...
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7429598 |
Spirocondensed quinazolinones and their use as phosphodiesterase inhibitors
The invention relates to compounds of formula (I)
wherein R 1 , R 2 and m are as defined in the description, their use as medicament, pharmaceutical compositions containing them and a process...
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7427621 |
Cyclic sulfamides for inhibition of gamma-secretase
Compounds of formula I:
inhibit the processing of AP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
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7417049 |
Furyl compounds
Compounds of formula I:
and pharmaceutically-acceptable salts thereof, wherein Ar and R are as defined in the specification, compositions containing such compounds and methods of using such...
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7414062 |
Triazaspiro compounds useful for treating or preventing pain
Triazaspiro Compounds, compositions comprising a Triazaspiro Compound, methods for treating or preventing pain in an animal comprising administering to an animal in need thereof an effective amount...
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7410978 |
Once daily dosage forms of trospium
A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum (C...
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7410976 |
Spirochromanone derivatives
The invention relates to a compound of a formula (I):
or a pharmaceutically acceptable salt or ester thereof, useful as a therapeutic agent for various ACC-related disorders.
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