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7622485 |
Method of enhancing lysosomal α-galactosidase A
A method of enhancing the activity of lysosomal α-Galactosidase A (α-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related...
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7622475 |
EP2 agonists
The invention provides EP2 agonists, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for lowering...
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7619086 |
HIV integrase inhibitors
Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication:
wherein Z, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are defined herein. The compounds...
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7618988 |
Use of substituted aminomethyl chromans
Compounds of formula I in which R has a meaning as indicated in claim 1 , or one of their optical isomers or pharmaceutically acceptable salts, used for the treatment of extrapyramidal movement...
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7618966 |
Abnormal Cannabidiols as agents for lowering intraocular pressure
The present invention provides a method of treating glaucoma or ocular hypertension which comprises applying to the eye of a person in need thereof an amount sufficient to treat glaucoma or ocular...
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7612101 |
Abnormal cannabidiols as agents for lowering intraocular pressure
The present invention provides a method of treating glaucoma or ocular hypertension which comprises applying to the eye of a person in need thereof an amount sufficient to treat glaucoma or ocular...
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7585874 |
Aryl-isoxazol-4-yl-imidazo[1,2-a]pyridine derivatives
The present invention is concerned with aryl-isoxazol-4-yl-imidazo[1,2-a]pyridine derivatives of formula I:
wherein
R 1 to R 5 are as defined in the specification and pharmaceutically...
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7572934 |
Substituted biphenyl GPR40 modulators
The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I:
where the definitions of the variables...
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7572816 |
Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
The present invention is directed to compounds having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic agents...
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7572461 |
Borer-resistant wood, wood products, and wooden structures and methods
The invention provides methods for suppressing the degradation of wood, wood products, and wooden structures due to infestation by wood-boring organisms, by use of a polyurea composition. The...
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7563774 |
Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
A combination therapy of at least one FBPase inhibitor and at least one other antidiabetic agent is disclosed.
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7550476 |
Condensed polycyclic compounds
The present invention provides a novel a condensed polycyclic compound useful as a phosphodiesterase 4 inhibitor, which is shown by the formula [I]:
or a pharmaceutically acceptable salt...
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7550474 |
Substituted phenyl acetamides and their use as protease inhibitors
Phenyl acetamide compounds are described, including compounds of Formula I:
or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R 3 -R 6 , R 11 , B, Y and W are set forth...
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7550461 |
Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases
Disclosed are amide compounds of formula (I):
wherein Ar 1 , Q, Y and R 3 -R 6 of formula (I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory...
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7531695 |
Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
The present invention is directed to compounds having the structure (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic...
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7514453 |
Method for enhancing mutant protein activity
Provided is a method for enhancing the activity of a protein, which protein when mutated, folds in an incorrect conformation in the endoplasmic reticulum, by contacting the protein with an...
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7511151 |
Substituted pyridyloxyalkylamides and their use as fungicides
Fungicidal compounds of the general formula (1), or the corresponding pyridine N-oxide, wherein X, Y, R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the description.
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7511034 |
Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses
Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical...
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7510726 |
Methods and compositions for deterring abuse of opioid containing dosage forms
This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.
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7498337 |
Acid secretion inhibitor
The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by...
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7495111 |
Compounds useful as serotonin inhibitors and 5-HT1A agonists and antagonists
3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Such compounds are useful for modulating activity of a 5-HT 1A receptor (agonizing or...
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7495001 |
Benzannelated derivatives, their manufacture and use as pharmaceutical agents
There are presented compounds of the formula
wherein R 6 and R 7 is
R 4 and R 5 or R 5 and R 6 together with the carbon atoms to which they are attached, form a ring as...
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7491732 |
Compositions and methods for inhibition of the JAK pathway
The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of...
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7482358 |
Imidazoline compounds
Compounds represented by the general formula (I):
wherein Ar 1 and Ar 2 are each aryl or heteroaryl; R 1 is lower cycloalkyl, —Ar 3 , or a group of the general formula (a), (b) or (c):
...
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7482357 |
17-acetamido-4-azasteroid derivatives as androgen receptor modulators
Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment...
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7470702 |
Benzimidazoles
Novel compounds of the formula I in which R 1 , R 1′ , L, E, G, M, Q, U, R 2 , m, p and q have the meanings indicated. Further, the compounds of formula I can be used as, for example, inhibitors...
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7468437 |
Phenyl pyrrolidine ether tachykinin receptor antagonists
The present invention is directed to certain phenyl pyrrolidine ether compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular...
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7459461 |
Phosphonic acid compounds as inhibitors of serine proteases
The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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7446098 |
Combination therapy for treating protein deficiencies
This application provides methods of improving gene therapy by combining gene therapy with active site-specific chaperones (ASSCs). The ASSC increases the stability and efficiency of the protein...
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7435729 |
Compounds and methods for modulation of estrogen receptors
Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective modulators for...
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7423012 |
Phosphinyloxy, oxime and carboxylic acid derivatives which are useful as carboxypeptidase U inhibitors
The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts,
which compounds inhibit carboxypeptidase U and...
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7414056 |
Pyrazole-amide compounds useful as kinase inhibitors
The present invention provides pyrazole derived compounds of formula (I)
useful for treating p38 kinase-associated conditions, where G, X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and m are as...
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7407939 |
Protein kinase inhibitors comprising ATP mimetics conjugated to peptides or peptidomimetics
The present invention provides small molecules having high affinity to the ATP binding site of protein kinases, which are conjugated to apeptide or peptidomimetic moiety which mimics the substrate...
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7399769 |
Aryl-isoxazol-4-yl-imidazo[1,5-a]pyridine derivatives
The present invention is concerned with aryl-isoxazol-4-yl-imidazo[1,5-a]pyridine derivatives of formula
wherein:
R 1 , R 2 , and R 3 are as defined herein and pharmaceutically acceptable...
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7393856 |
Anti-viral uses of borinic acid complexes
Compositions and methods of use of borinic acid complexes, especially hydroxyquinoline, imidazole and picolinic acid derivatives, as anti-viral agents as well as therapeutic agents for the...
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7381731 |
Pharmaceutical composition comprising citrulline
Embodiments of the present invention include compositions and pharmaceutical compositions comprising citrulline and Hmg-CoA reductase inhibitors. Further embodiments relate to the use of such...
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7378425 |
(1-Indanone)-(1,2,3,6-tetrahydropyridine) compounds
The present invention provides an excellent sigma receptor binding agent and/or acetylcholinesterase inhibitor containing an (1-indanone)-(1,2,3,6-tetrahydropyridine) compound. More specifically,...
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7371747 |
Cyanoalkylamino derivatives as protease inhibitors
The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K Pharmaceutical...
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7338961 |
Sphingosine kinase inhibitors
The invention relates to substituted adamantane compounds, pharmaceutical compositions thereof, processes for their preparation, and methods for inhibiting sphingosine kinase and for treating or...
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7338960 |
Phenylalkanoic acid and phenyloxyalkanoic acid derivatives as hPPAR activators
A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, wherein:
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7335664 |
Colon cleansing composition and method
A composition and method for cleansing a colon prior to endoscopic procedure. More particularly, a combination of bisacodyl, metoclopramide, sodium, and/or a phosphorus containing composition...
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7332152 |
Cosmetic composition
A cosmetic composition is provided comprising vitamin B 6 , vitamin B 3 and an organic acid. The components of the composition interact synergistically to enhance skin lightening.
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7326723 |
Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same
The present invention relates to compounds of formula (I):
in which
X represents N or CH; R 1 represents a hydrogen or halogen atom or a CF 3 group; n is an integer from 1 to 5; A...
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7320982 |
Use of 4-substituted tetrahydropyridines for the manufacture of medicaments acting upon TGF-β 1
The invention relates to the use of a compound of formula (I):
for the preparation of pharmaceutical compositions for increasing the circulating, cellular and extracellular levels of TGF-β1.
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7297702 |
Contraception method using competitive progesterone antagonists and novel compounds useful therein
Competitive progesterone antagonists, including two novel steroids, viz., 11β,19-[4-(cyanophenyl)-o-phenylene]-17β-hydroxy-17α-(3-h
ydroxyprop-1(Z)-enyl)-4-androsten-3-one and...
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7291625 |
Use of a vitamin combination for the treatment of pruritus and non-infective disorders involving itching and/or inflammation
Use of a combination of two vitamin compounds, i.e. riboflavin (also known as vitamin B 2 ) and nicotinic acid (also referred to as niacin) or, as an alternative thereto, the corresponding amide,...
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RE39916 |
Compounds that modulate PPAR activity and methods for their preparation
This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the...
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7276514 |
Pyrroloquinoline quinone drugs for treatment of cardiac injury and methods of use thereof
The invention includes composition comprising substantially purified pyrroloquinoline quinone, that are useful in methods for the treatment and prevention of cardiac injury caused by hypoxia or...
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7273872 |
Inhibition of inflammation using α 7 receptor-binding cholinergic agonists
Methods for inhibiting an inflammatory cytokine cascade in a patient are provided. The methods are directed to treating the patient with a cholinergic agonist in an amount sufficient to inhibit the...
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7265107 |
Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes
The current invention relates to a series of rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms, specifically, the 3,4-cyclo-rifamycin...
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