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6514963 |
Methods for the inhibition of egg production in trematodes
The present invention comprises methods and compositions for use in inhibiting egg production by parasitic trematode worms comprising administering to an individual in need thereof an effective...
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6511985 |
Combination of cerivastatin and fibrates
The present invention relates to the combination of the 3-hydroxy-3-methylglutaryl-coenzyme A inhibitor (HMG-CoA inhibitor) cerivastatin with fibrates and its use in the prophylaxis and treatment...
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6506800 |
1,4 diaryl-2,3-difluoro-2-butene insecticidal and acaricidal agents
Pesticidal 1,4-diaryl-2,3-difluoro-2-butene compounds of formula I wherein Ar is phenyl, 1- or 2-naphthyl or a 5- or 6-membered heteroaromatic ring all of which aromatic systems may be...
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6503917 |
2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof
The present invention relates to novel substituted pyridine compounds of Formula (I) wherein the moiety Z, R 1 , R 2 and R 3 are as herein defined, having estrogenic activity, to processes for...
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6500849 |
1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino 1,3-propanediols and related compounds
Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and...
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6498150 |
Low molecular weight cell, bone marrow and immune stimulants
The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other...
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6492365 |
Microsomal triglyceride transfer protein
Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA...
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6489334 |
Method for the crystallization of a tetrahydropyridin derivative and resulting crystalline forms
The invention relates to a method of crystallizing a tetrahydropyridine derivative, to the novel crystalline forms thereby obtained and to the pharmaceutical compositions containing said...
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6472435 |
Anti-tumor agents
The invention concerns anti-tumor agents of formula (I), wherein each of R 1 , R 2 and R 3 has the meanings defined in the specification including hydrogen, (1-4C)alkyl, (3-4C)alkynyl and...
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6472400 |
Advanced gylcation end-product intermediaries and post-Amadori inhibition
The instant invention provides compositions and methods for modeling post-Amadori AGE formation and the identification and characterization of effective inhibitors of post-Amadori AGE formation,...
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6465493 |
Triarylimidazoles
Compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein R 1 , R 2 and R 3 are various substituent groups; and one of X 1 and X 2 is N or CR′, and the other is NR′...
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6465477 |
Stable pharmaceutical composition
Disclosed is a pharmaceutical composition comprising (E)-3,5-dihydroxy-7-[4′-4″-fluorophenyl-2′-cyclopropyl
-quinolin-3′-yl]-6-heptenoic acid, or its salt or ester, of which the aqueous...
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6461644 |
Anesthetizing plastics, drug delivery plastics, and related medical products, systems and methods
Anesthetizing plastic or other drug delivery polymer system including a hydrophobic polymer and a drug that has an aromatic ring.
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6458758 |
Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
Compositions and processes to alleviate free radical toxicity are disclosed based on the use of nitroxides in association with physiologically compatible macromolecules. In particular,...
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6458775 |
NAALADase inhibitors useful as pharmaceutical compounds and compositions
The present invention relates to N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) inhibitors enzyme activity, pharmaceutical compositions comprising such inhibitors, and methods of their use...
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6455574 |
Therapeutic combination
This invention relates to pharmaceutical combinations of amlodipine or a pharmaceutically acceptable acid addition salt thereof and atorvastatin or a pharmaceutically acceptable salt thereof, kits...
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6448243 |
1,4-substituted cyclic amine derivatives
A novel 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: (wherein A, B, C, D, T, Y and Z represent each methine or...
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6444688 |
Compounds and compositions with nitrogen-containing non-basic side chains
The instant invention provides compounds of formula I wherein R 1 is OH, O—C(O)—(C 1 -C 6 alkyl), O—C(O)—O(C 1 -C 6 alkyl), O—C(O)—Ar, or O—C(O)—O—Ar; R 2 is H, OH, O(C 1...
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6444230 |
Synergistic composition of peracetic acid and amine oxide
Composition in the form of an aqueous solution, useful for disinfecting hard surfaces comprises: a) from 0.0005% to 20% by weight of peracetic acid, b) from 0.001% to 45% by weight of acetic acid,...
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6444662 |
Stable hyperforin salts, method for producing same and their use in the treatment of alzheimer's disease
Described are salts of hyperforin and adhyperforin of formula I [A − ] m [B] p+ (I) wherein m is an integer from 1 to 3, p is equal to m and gives the total number of positive charges of the...
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6420375 |
Fused ring compounds, process for producing the same and use thereof
To provide a novel compound of the formula: [wherein A 1 ix a 5 or 6-membered ring which may be substituted by a group not containing a cyclic group, A 2 is an aromatic ring which may be...
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6410547 |
Phenylpyridine derivatives useful as phosphodiesterase inhibitors
(4-oxy-3-(aryl)phenyl)pyridine compounds, in free or acid addition salt form, are useful as pharmaceuticals for treatment and prophylaxis of inflammation, particularly inflammatory or obstructive...
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6395724 |
Multibinding inhibitors of cyclooxygenase-2
Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of...
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6391327 |
Pesticidal composition
A pesticidal composition comprising prallethrin and a neonicotinoid compound given in the following formula (1), (2) or (3), as an active ingredient wherein, A represents a 6-chloro-3-pyridyl,...
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6387934 |
2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives
2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives are suitable for the production of pharmaceuticals for the prophylaxis and therapy of diseases or disorders whose course involves increased...
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6387949 |
Substituted urea compounds useful in pain management
Compounds of general formula I are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel...
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6384058 |
2,4,6-trisubstituted pryridines with estrogenic activity and methods for the solid phase synthesis thereof
The present invention relates to novel substituted pyridine compounds of Formula (I) wherein the moiety Z, R 1 , R 2 and R 3 are as herein defined, having estrogenic activity, to processes for...
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6383528 |
Pharmaceutical composition comprising ticlopidine and Ginkgo biloba extract
The invention herein relates to a pharmaceutical composition comprising ticlopidine and Ginkgo biloba extract. In detail, as an anti-thrombotic preparation, the pharmaceutical composition...
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6384060 |
2,4,6-trisbstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof
The present invention relates to novel substituted pyridine compounds of Formula (I) wherein the moiety Z, R 1 , R 2 and R 3 are as herein defined, having estrogenic activity, to processes for...
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6369069 |
Biphenylsulfonyl cyanamides, method for the production thereof and their utilization as a medicament
The invention relates to compounds of the formula (I), in which the symbols have the following meaning: R(1) is 1. alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; 2. alkyl having 1, 2, 3, 4,...
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6361792 |
Lipid dispersions and methods of use
Methods for preventing or ameliorating the transient adverse physiological response to particulate dispersions (TAPR response) when these dispersions are administered parenterally to a patient. The...
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6362193 |
Cycloalkenyl substituted compounds
Novel pyridyl or pyrimidinyl substituted cycloalkenyl compounds and compositions for use in therapy.
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6355650 |
(3R,4R)-&Dgr 8-tetrahydrocannabinol-11-oic acids useful as antiinflammatory agents and analgesics
The present invention relates to non-psychoactive derivatives of tetrahydro-cannabinol, which exhibit anti-inflammatory, analgesic and leukocyte antiadhesion activities. The invention includes...
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6352994 |
Substituted 1H-pyridinyl-2-ones as GABAA alpha 2/3 ligands
Compounds according to Formula (I) or a salt thereof are selective ligands for GABA A receptors useful for treatment of disorders of the central nervous system:
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6344485 |
Method for treating glaucoma
Methods of using prostaglandin agonists for the reduction of intraocular pressure, and accordingly glaucoma.
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6344486 |
Benzamide and sulfonamide substituted aminoguanidines and alkoxyguanidines as protease inhibitors
The present invention is directed to aminoguanidine and alkoxyguanidine compounds, including compounds of Formula I: wherein X is O or NH, L is —O— or —SO 2 —, and R 1 -R 4 , R 9 -R 19 ,...
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6342505 |
Use of 4-substituted tetrahydropyridines for making medicines acting on TGF-β1
The invention relates to the use of a compound of formula (I): for the preparation of pharmaceutical compositions for increasing the circulating, cellular and extracellular levels of TGF-β1.
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6323038 |
Diagnostic reagent for complications associated with diabetes or renal failure
In view of the situation of the prior art, the present invention specifies the structure of a late-stage product of Mailard reaction in vivo having a close relation with various tissue disorders,...
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6316434 |
Assay for emetic activity
An assay for emetic activity among inhibitors of type 4 phosphodiesterase (PDE 4) is disclosed. The assay comprises: (A) administering to a test mammal an anesthetic compound in an amount...
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6313132 |
Therapeutically active diarylpropylamines; their pharmaceutically acceptable salts; a method for their preparation and method for their use
The invention relates to novel compounds of Formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and Ar are as defined in claim 1, their salts with physiologically acceptable acids and,...
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6313097 |
Antagonists of calcitonin gene-related peptide
Compounds of the formula (I) ##STR1## wherein A, R, R 1 , R 2 , X 1 , X 2 , X 3 , and Y are as defined herein, and the tautomers and the pharmaceutically acceptable salts thereof, including...
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6310059 |
Fused ring calcium channel blockers
Compounds of the formula ##STR1## or salts thereof, wherein the variable are as defined herein are useful as calcium channel blockers.
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6306870 |
N-cinnamoyl derivatives of beta-carboline
Carboline derivatives of formula (I), are potent and selective inhibitors of cyclic guanosine 3',5'-monophoshate specific phosphodiesterase (cGMP specific PDE) and have utility in a variety of...
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6306848 |
Method of modifying wrinkles using guanidine derivatives
The invention relates to wrinkling modifiers and anti-aging cosmetic compositions which each comprise a guanidine derivative represented by the following general formula (1): ##STR1## wherein...
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6303660 |
Enhanced anti-cancer agent delivery to solid tumors by primer compounds
Primer compositions for anti-cancer agent delivery to solid tumors in mammals, including man, are disclosed. The primer comprise a pharmaceutically acceptable agent which increases the...
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6300324 |
Composition for repelling ticks
A composition (10) for repelling ticks and other insects contains a combination of plant extracts (14) in a topical liquid carrier (12). The plant extracts (14) include lavender (26), rosemary...
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6300352 |
Pyridine derivatives and pharmaceutical compositions containing them
The invention relates to novel pyridyl derivatives, their use as medicaments, pharmaceutical formulations containing them and methods for their preparation.
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6297264 |
Trisubstituted phenyl derivatives and process for their preparation
Compounds of the general formula (1) ##STR1## are described wherein W is a N--, and Z and L are described in the specifications. These compounds are phosphodiesterase type IV inhibitors and are...
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6297290 |
Composition containing a nerve fiber reactivity modulating compound
The present invention relates to a novel aqueous composition based on a compound modulating the reactivity of nerve fibers. It relates more particularly to a pharmaceutical composition for topical...
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6294544 |
Peripheral circulation improvers for ophthalmic tissues containing dihydropyridines
The present invention provides a peripheral ocular circulation ameliorant which contains dihydropyridines represented by the general formula (I) or their medicinally acceptable salts as active...
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