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6734193 |
(1,2,3,4-tetrahydroquinolin-8-yl)-heptatrienoic acid derivatives having serum glucose reducing activity
Compounds of the formula where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects...
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6727239 |
Derivatives of 2-aminopyridines, their use as medicaments and pharmaceutical compositions containing them
A compound of the formula wherein the substituents are defined as in the specification and their pharmaceutically acceptable salts having NOS and ROS activity.
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6716605 |
Indole derivatives having an antiviral activity
A compound of the formula: wherein R 1 is hydrogen, lower alkyl, or optionally substituted arylsulfonyl, or the like, R 2 is hydrogen, lower alkyl, or optionally substituted aralkyl, or the...
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6716457 |
Effects of bactericide (peracetic acid-hydrogen peroxide-water combination) to agricultural chemicals in bacteria control when they are in contact with one another
The present invention relates to a process for inhibiting or eliminating the growth of microorganisms in pesticide suspensions. More particularly, the process of the present invention includes the...
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6713467 |
Acid derivatives useful as serine protease inhibitors
Compounds of formula I and II, or pharmaceutically-acceptable salts thereof, are useful as inhibitors of Factor VIIa, Factor IXa, Factor Xa, Factor FXIa, tryptase, and urokinase, wherein ring B...
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6696440 |
Treatment of asthma with MEK inhibitors
This invention provides a method of preventing or treating asthma by administering to a patient in need of treatment an effective amount of a selective MEK inhibitor, especially a phenyl amine of...
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6689759 |
Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol...
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6689788 |
Method and composition for treatment of inflammatory bowel disease
A composition in unit dosage form for the inhibition, prevention or treatment of inflammatory bowel disease comprising an effective amount of a compound having the formula: and a...
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6689773 |
Uracil substituted phenyl sulfamoyl carboxamides
Novel uracil substituted phenyl sulfamoyl carboxamides I and salts thereof, where A=oxygen or sulfur; X 1 =H, halogen, C 1 -C 4 -alkyl; X 2 =H, CN, CS—NH 2 , halogen, C 1 -C 4 -alkyl, C 1 -C 4...
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6683108 |
Agonists of hedgehog signaling pathways and uses related thereto
The present invention makes available methods and reagents for inducing activation of a hedgehog pathway in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as a small...
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6683078 |
Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors
This invention is directed to a process for inhibiting aggrecanase activity. The process comprises administering a therapeutically effective amount of a sulfonyl aromatic or heteroaromatic...
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6677353 |
Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6667028 |
Hair growth promoter
The method for promoting hair growth and/or reducing hair loss includes providing a certain agent for reducing hair loss and/or promoting hair growth, applying an effective amount of the agent to...
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6667346 |
Method for protecting cells and tissues from ionizing radiation toxicity with α, β unsaturated aryl sulfones
Pre-treatment with α,β unsaturated aryl sulfones protects normal cells from the toxic side effects of ionizing radiation. Administration of a radioprotective α,β unsaturated aryl sulfone...
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6664248 |
2-nitromethylidene/2-cyanimino/2-nitro-imino-pyrrolidines and piperidines, intermediates, and their use as pesticides
Compounds of formula wherein A is an unsubstituted or substituted aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical wherein a ring nitrogen atom may have been replaced by a...
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6660728 |
Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists
The present invention relates to thienyl substituted acylguanidine derivatives, such as compounds of formula (I) in which R 1 , R 2 , R 4 , R 6 , A, B and D have the meanings indicated in the...
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6656957 |
Pyridine derivatives
A compound of formula I wherein X represents an optionally halo-substituted (C 2-4 )alkynylene group bonded via vicinal unsaturated carbon atoms.
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6653258 |
Hetero-aryl compounds having herbicidal, fungicidal and insecticidal activity
Fungicidal compounds of the formula (I): and stereoisomers thereof, wherein R 1 is optionally substituted aryl or optionally substituted heteroaryl; Y is oxygen, sulphur or NR 4 ; R 2 , R 3 ...
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6649658 |
(−)-Verbenone derivatives
A description is given here of novel solid and stable derivatives of (−)-verbenone having formula (I) wherein, when X=O Z=H, ═CHAr, ═C(OH)COOEt, ═NOR; Y=H, NH 2 , NH 3 +X 1 −, NHCOAr,...
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6649616 |
Substituted phenylcyclohexanecarboxamides and their use
The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in medicaments, in particular for the prevention...
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6642273 |
Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and in cosmetics
An unsaturated derivative at the 4-position of 6-tert-butyl-1,1-dimethylindane corresponding to the following formula: in which: X represents: a divalent radical of formula: and Y represents a...
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6638941 |
Conformationallly constrained peptidomimetics as β-turn templates and modulators of SH3 domains
Spirolactam compounds useful as inhibitors of protein-protein interactions modulated by SH3 domains are disclosed. Compounds of the invention are also useful as β-turn mimetics. Also disclosed are...
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6638940 |
Tetrahydropyridines as pesticides
Compounds of formula are described, wherein R 1 and R 2 are for example, independently of each other, halogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, halogen-C 1 -C 6 -alkyl, halogen-C 3 -C 6...
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6624173 |
Pharmaceutical compositions for treating and/or preventing CNS disorders
Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release...
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6613313 |
Aniline compound-containing hair dye composition and method of dyeing hair
A hair dye composition containing at least one of the following compounds: or analogues thereof; and a method for dyeing hair which comprises a step of applying to the hair the hair dye...
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6608061 |
Bisaryl compound and medicament for cancer treatment comprising the same
A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar 1 —S—R 1 —S—Ar 2 wherein R 1 ...
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6608073 |
Intranasal codeine for the rapid suppression of cough and rapid relief of pain
This invention provides a method of rapidly and reliably delivering codeine, alone or in combination with other compounds, to the systemic circulation by administration via the nasal route to...
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6605612 |
Cardioprotective phosohonates and malonates
The present invention provides for pyridoxine phosphonate analogues such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)alkylphosphon
ates, and and...
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6602896 |
p38MAPK inhibitor and uses thereof
The present invention demonstrates that p38 MAPK inhibitor induces low density lipoprotein receptor expression 6-8 fold, and further provides the application of such inhibitor in the treatment of...
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6602879 |
Pyrrole-type compounds, compositions, and methods for treating cancer or viral diseases
The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder...
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6579881 |
Indoles
A 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: wherein A, B, C, D, T, Y, and Z each represent a methine or a...
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6573271 |
Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists
Proliferation of retinal pigment epithelium following surgery or trauma or resulting in ocular diseases associated with choroidal neovascularization, such as age related macular degeneration and...
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6566396 |
Antitussive/antihistaminic compositions
Tannate compositions consisting essentially of carbetapentane tannate and chlorpheniramine tannate which are effective when administered orally for the symptomatic relief of coryza associated with...
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6566381 |
Hetero-substituted metalloprotease inhibitors
Heterocyclic substituted compounds having the general structure: which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these...
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6562824 |
Dihydropyridine soft drugs, and related compositions and methods
This invention relates to novel dihydropyridine soft drugs of the formula ΦOOR 1 , where Φ is a dihydropyridine moiety. These compounds are useful as calcium channel antagonists with...
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6559157 |
Dihydronaphthalene compounds
Dihydronaphthalene compounds have excellent 17α-hydroxylase/C 17-20 -lyase inhibiting activity, thromboxan A 2 synthesis inhibiting activity, and aromatase inhibiting activity and are thereby are...
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6551604 |
Skin care compositions
The present invention relates to topical compositions for effecting an immediate improvement in the appearance and feel of skin, in addition to providing chronic improvements in skin appearance....
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6548504 |
Compounds
The present invention therefore provides, in a first aspect, a compound of formula (I) or a salt thereof: in which the group D is selected from a group of formula (A), (B) or (C) below: in...
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6545009 |
Retinoid-related receptor function regulating agent
1,3-Azole derivatives, pharmaceutical compositions thereof and methods for regulating the function of retinoid-related receptors with 1,3-azole derivatives are disclosed. Such regulation may be...
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6541475 |
α, β-unsaturated sulfones for treating proliferative disorders
α, β-Unsaturated sulfones of the following formulae are provided, which are useful as antiproliferative agents, including, for example, anticancer agents:
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6538029 |
Methods for treatment of renal cell carcinoma
A method of treating renal cell carcinoma in a mammal with that disease comprising administering to the mammal a physiologically effective amount of an inhibitor of PDE10.
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6534513 |
Phenylalkanoic acid derivatives
Phenylalkanoic acid derivatives of formula (1) are described: wherein Ar 1 is an aromatic or heteroaromatic group; L 1 is a covalent bond or a linker atom or group; A is an optionally...
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6531480 |
Non-peptide bradykinin receptor antagonists for use in treating ophthalmic diseases and disorders
This invention relates to the topical ocular use of non-peptide bradykinin receptor antagonists for the treatment of human ocular pain, neovascularization, corneal haze, allergy and inflammatory...
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6528516 |
Methods for reducing intraocular pressure using A3 adenosine receptor antagonists
This invention relates to a method of decreasing intraocular pressure by administrating an A3 subtype adenosine receptor antagonist, a calmodulin antagonist or an antiestrogen such as tamoxifen.
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6524556 |
Aerosol compositions
The use of a medium-chain fatty acid triglyceride as the dispersant in the preparation of a medicinal aerosol composition comprising tricyclic compound (I) dispersed in a liquefied...
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6525065 |
Pharmaceutical compositions and methods for effecting dopamine release
Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release...
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6521633 |
Treating NIDDM with RXR agonists
This invention relates to methods and compositions for the treatment of non-insulin-dependent diabetes mellitus using an RXR agonist alone or in combination with a PPARγ agonist such as a...
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6521609 |
Use of CGRP antagonists and CGRP release inhibitors for combating menopausal hot flushes
A method for treating menopausal hot flushes using CGRP antagonists and/or CGRP release inhibitors and the corresponding pharmaceutical compositions containing as active substance one or more CGRP...
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6514996 |
Derivatives of benzofuran or benzodioxole
An oxygen-containing heterocyclic compound represented by following Formula (I): wherein R 1 and R 2 independently represent hydrogen, lower alkyl, cyano, —(CH 2 ) n —E 1 —CO—G 1 ...
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6515000 |
Fungicidal mixtures based on amide compounds
Fungicidal mixtures, comprising A) an amide compound of the formula I in which R 1 , R 2 are identical or different and are halogen, nitro, cyano, C 1 -C 8 -alkyl, C 2 -C 8 -alkenyl, C 2 -C 8...
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