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7273872 |
Inhibition of inflammation using α 7 receptor-binding cholinergic agonists
Methods for inhibiting an inflammatory cytokine cascade in a patient are provided. The methods are directed to treating the patient with a cholinergic agonist in an amount sufficient to inhibit the...
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7265107 |
Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes
The current invention relates to a series of rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms, specifically, the 3,4-cyclo-rifamycin...
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7253178 |
Carboxylic acids
The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the...
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RE39754 |
Benzamide derivatives and pharmaceutical compositions containing same
The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore,...
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7250157 |
Dermatological compositions and methods
Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin...
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7247640 |
Medicament for treatment of bone marrow suppression, for treatment of infectious diseases and for increasing the number of leukocytes
A medicament for prophylaxis or treatment of bone marrow suppression, for treatment of infectious diseases and for increasing the number of leukocytes, which comprise as an active ingredient a...
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7238715 |
Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
A method of treating a patient suffering from pancreatitis comprising treating said patient with a therapeutically effective amount of a cholinergic agonist selective for an α7 nicotinic receptor...
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7230003 |
Aromatic prodrugs of propofol, compositions and uses thereof
Prodrugs of propofol, methods of making prodrugs of propofol, pharmaceutical compositions of prodrugs of propofol and methods of using prodrugs of propofol and pharmaceutical compositions thereof...
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7223744 |
Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising a hydrolysis-resistant P2Y receptor...
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7223760 |
Substituted triazole compounds
Novel substituted triazole compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
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7220752 |
Compounds active at the glucocorticoid receptor II
This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in therapy...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7195773 |
Pesticidal composition
A pesticidal composition comprising a pesticidally effective amount of at least one of a pyridic compound of the formula (I) or it salt and at least one of other pesticides: wherein Y is a...
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7183302 |
Iminothiazolidinones as inhibitors of HCV replication
Compounds having the structure of formula I are described
wherein R, R′, R 1 , R 2 , and R 3 are as defined in the specification. The compounds can inhibit hepatitis C virus (HCV)...
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7179817 |
Carboxylic acid derivatives and drugs containing the same as the active ingredient
Compounds represented by formula (I), prodrugs thereof and salts thereof, and pharmaceutical compositions comprising the same as an active ingredient (wherein each symbol has the meaning as defined...
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7173041 |
Polyglutamic acid-camptothecin conjugates and methods of preparation
The invention provides polyglutamic acid-therapeutic agent conjugates and methods for their preparation and use.
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7166621 |
Pyridyloxyalkanoic acid amide derivatives useful as fungicides
Fungicidal compounds of the general formula (I): wherein X and Y are independently H, halo, C 1-8 alkyl, C 3-6 cycloalkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-8 alkoxy, C 1-8 alkylthio, nitro,...
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7166593 |
Glucocorticoid receptor modulators
The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonist and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor....
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7153864 |
Polyglutamic acid-camptothecin conjugates and methods of preparation
The invention provides polyglutamic acid-therapeutic agent conjugates and methods for their preparation and use.
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7151107 |
Use of benzoylalkyl-1,2,3,6-tetrahydropyridines
The invention relates to the use of compounds of formula
for the preparation of medicines designed for the treatment of neuronal and cerebral disorders.
The invention also relates to the...
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7148238 |
Phenyl-piperazine derivatives as serotonin reuptake inhibitors
The invention provides compounds represented by the general formula I
wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective...
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7144884 |
Phenyl-piperazine derivatives as serotonin reuptake inhibitors
The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder,...
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7144898 |
Indole derivatives for the treatment of depression and anxiety
The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of...
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7141582 |
Method for enhancing mutant enzyme activities in Gaucher disease
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
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7138407 |
Phenyl-piperazine derivatives as serotonin reuptake inhibitors
The invention provides compounds represented by the general formula I
wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective...
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7138406 |
Modulators of the glucocorticoid receptor
The present invention provides compounds of the formula
wherein A is of the formula
and X, Y, n, R 1 –R 25 are as described in the specification which are modulators of the...
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7132410 |
Di(uridine 5′-)tetraphosphate and salts thereof
The present invention are directed to P 1 , P 4 -di(uridine 5′-)tetraphosphate, tetra-alkali metal salts such as tetrasodium, tetralithium, tetrapotassium, and mixed tetra-alkali metal cations...
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7129246 |
N-adamantlmethyl derivatives and intermediates as pharmaceutical compositions and processes for their preparation
The invention provides compounds of general formula (I) in which m, A, R 1 and Ar have the meanings defined in the specification; a process for, and intermediates used in, their preparation;...
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7129247 |
Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents
The present invention relates to novel heterocyclyl-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising...
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7125873 |
Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in...
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7122543 |
Substituted benzoic acid derivatives having NF-κB inhibiting action
A substituted benzoic acid derivative which is represented by the following formula (I) and has an NF-κB inhibiting action (in the formula, R 3 , R 4 and R 5 each independently represents a...
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7122539 |
Nitric esters and nitrate salts of specific drugs
Nitric acid salts with medicines active in the respiratory system pathology treatment.
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7115618 |
α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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7115632 |
Sulfonyl aryl or heteroaryl hydroxamic acid compounds
A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a...
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7101889 |
Lipase inhibiting composition
The invention relates to compositions for treating dandruff comprising compounds that are non-polymeric and/or have a weight average molecular weight of less than about 1000. These compounds, when...
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7101868 |
Substituted arylamine derivatives and methods of use
Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
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7087106 |
Materials and methods for inhibiting fouling of surfaces exposed to aquatic environments
The subject invention provides materials and methods for inhibiting the biofouling of surfaces exposed to aquatic environments. In one embodiment, the subject invention provides additives for...
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7084149 |
Naphthalene derivatives, their production and use
A composition containing a compound of the formula:
wherein A is a nitrogen-containing heterocyclic group which may be substituted, R 1 is a hydrogen atom, hydrocarbon group which may be...
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7078391 |
Method of treating edematous retinal disorders
The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising a hydrolysis-resistant P2Y receptor...
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7078431 |
1,3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat VCAM-1 mediated disorders
It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I) inhibit the expression of VCAM-1, and thus can be used to treat a patient with a...
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7078403 |
Antiviral agents
Disclosed herein are compounds of formula II:
wherein Alk, Z, X 1 , X 2 , R 1 , —R 10 and R 11 are defined herein, and their salts and pharmaceutically acceptable derivatives thereof, as...
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7071175 |
Pyridine mercapto carboxylic acids as carboxypeptidase U inhibitors
The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts,
which compounds inhibit carboxypeptidase U and...
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7071201 |
Quinoline derivatives
A novel compound of the formula:
wherein A, B, C, D, T, Y, and Z represent each methine or nitrogen; R 1, R 2 , R 3 , R 4 , and R 5 represent each a substituent; n represents 0 or an integer...
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7067501 |
Aryloxyphenyl and arylsulfanylphenyl derivatives
The invention provides compounds of the formula
wherein the substituents are as defined in the application. The compounds are valuable glycine transport inhibitors.
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7067524 |
Substituted phenyl naphthalenes as estrogenic agents
This invention provides estrogen receptor modulators of formula I, having the structure
wherein
R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 , are as defined in the...
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7064132 |
Composition and method for treatment of otitis external
A compound, process and method for increasing external auditory canal patency while simultaneously preventing the occurrence of otitis externa is disclosed wherein an aerosolized mixture of lipid...
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7060715 |
Substituted pyridines as selective cyclooxygenase-2 inhibitors
The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic...
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7053079 |
Dihydroxy (3-pyridyl) borane compounds
A dihydroxy(3-pyridyl)borane compound of the formula (1):
wherein R 1 represents a hydrogen atom, halogen atom or alkoxycarbonylamino group; R 2 represents a hydrogen atom, halogen atom,...
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7037914 |
Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient
A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I)
(wherein all symbols are as defined in the specification), a non-toxic acid...
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