Match Document Document Title
9040550 2,4-pyrimidinediamine compounds and their uses  
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods...
9040558 Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors  
The invention is directed to novel substituted benzylamino quinolines, compounds comprising substituted benzylamino quinolines, methods of making substituted benzylamino quinolines, the use of...
9034311 Pyridin-2(1 H)-one derivatives as JAK inhibitors  
New pyridin-2(1H)-one derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in...
9034881 Treatment for vitiligo  
Compounds I and II, as well as prodrugs, hydrates, solvates, N-oxides, salts and pharmaceutical compositions containing them, are useful for treating vitiligo. In certain embodiments, the...
9034889 Compositions for oral administration of zoledronic acid or related compounds for treating low back pain  
Oral dosage forms of bisphosphonate compounds, such as zoledronic acid, can be used to treat or alleviate pain or related conditions. The oral bioavailabilty of zoledronic acid can be enhanced by...
9028876 Rate-controlled particles  
Rate-controlled particles, comprising compounds of the formula as a solid dispersion.
9029379 Application of 5-HT6 receptor antagonists for the alleviation of cognitive deficits of down syndrome  
Methods for treating Down syndrome and improving cognitive function of a patient with an intellectual disability are disclosed. 5-hydroxytryptamine sub-receptor six (5-HT6) receptor antagonists...
9029377 Platelet-activating factor receptor antagonists  
Cyclohexyl sulfonamide compounds which are platelet-activating factor (PAF) receptor antagonists. Said compounds may be useful, for example, for the treatment of atherosclerosis or other...
9023841 Compositions and methods for the treatment of asthma and associated disorders  
This disclosure provides methods for treating asthma or an associated disorder in a patient in need thereof, by administering to the patient an effective amount of an autophagy inducing agent,...
9018223 Certain amino-pyrimidines, compositions thereof, and methods for their use  
Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically...
9018133 Active compound combinations  
The present invention relates to compositions, in particular within a fungicide composition, which comprises (A) a dithiino-tetracarboximide of formula (I) and a further fungicidally active...
9018224 Substituted cyclopropyl compounds useful as GPR119 agonists  
Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The...
9018205 Substituted pyrimidinyl-amines as protein kinase inhibitors  
The present invention provides novel substituted pyrimidinyl-amines that are useful as inhibitors of protein kinases, especially c-Jun N-terminal kinases (JNK) and pharmaceutical compositions...
9012456 Compounds, pharmaceutical compositions and uses thereof  
The present invention relates to compounds of general formula I, wherein the groups R1, R2, and A are as defined in the application, which have valuable pharmacological properties, and in...
9012462 Phosphorous derivatives as kinase inhibitors  
The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
9006228 Substituted cyclopropyl compounds, compositions containing such compounds, and methods of treatment  
Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The...
9006243 HIV inhibiting 6-substituted pyrimidines  
HIV replication inhibitors of formula R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyl; C1-6alkyloxycarbonyl;R2, R3, R6 and R7 are hydrogen; hydroxy; halo; C3-7cycloalkyl; C1-6alkyloxy;...
9000003 Anti-folate antimalarials with dual-binding modes and their preparation  
The present invention is anti-folate antimalarials with dual-binding modes of the general formula (I) [refer to structure in the abstract] wherein R1 and R2 which may be the same or different are...
8993585 Cyclic amine substituted pyrimidinediamines as PKC inhibitors  
The invention encompasses compounds having formula I or II and the compositions and methods using these compounds in the treatment of conditions in which inhibition of PKC and PKD is...
8993619 Cyclic bridgehead ether DGAT1 inhibitors  
The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also...
8993554 Tetrahydroquinoline derivatives useful as bromodomain inhibitors  
Tetrahydroquinoline compounds, pharmaceutical compositions containing such compounds and their use in therapy.
8987288 Heterocyclic aminoberbamine derivatives, the preparation process and use thereof  
The present invention relates to a novel berbamine derivative of formula I or a pharmaceutically acceptable salt thereof, a process for preparation of the same, a pharmaceutical composition...
8987275 Indazole compounds and their uses  
The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease...
8986664 Use of monoamine oxidase inhibitors to improve epithelial biology  
The invention provides a method for improving hair biology, e.g., hair growth. The method comprises administering to a subject a monoamine oxidase inhibitor and a vasodilator, a zinc salt of a...
8969397 Systems and methods to treat pain locally  
Disclosed herein are systems and methods for contributing to the local treatment of pain. More specifically, the disclosed systems and methods contribute to the local treatment pain by inhibiting...
8969335 Benzonitrile derivatives as kinase inhibitors  
Compounds of the formula I, in which R1, R2, X and Y have the meanings indicated in Claim 1, are inhibitors of TBK1 and IKKε and can be employed, inter alia, for the treatment of cancer and...
8969366 Substituted pyrimidinylpyrrolopyridinone derivatives, process for their preparation and their use as kinase inhibitors  
Pyrimidinylpyrrolopyridinone derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical...
8962641 Pyrimidine-substituted pyrrolidine derivatives, pharmaceutical compositions and uses thereof  
The invention relates to new pyrrolidine derivatives of the formula wherein R1 to R3, Ar, L T and n are as defined in the description and claims, to their use as medicaments, to methods for their...
8962643 Compositions and methods for inhibition of the JAK pathway  
The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of...
8962632 Certain amino-pyrimidines, compositions thereof, and methods for their use  
Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically...
8962622 Benzotriazole kinase modulators  
Compounds of formula I modulate jnk and cdk: or a pharmaceutically acceptable salt thereof, where R, R1, R2, R3, and m are defined herein.
8962642 5-cyano-4- (pyrrolo [2,3B] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors  
The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of...
8962644 Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor  
Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including...
8962609 Pyrimidine compounds as inhibitors of protein kinases IKK epsilon and/or TBK-1, processes for their preparation, and pharmaceutical compositions containing them  
C Compounds of the general formula (I) and salts thereof are useful in the treatment of diseases associated with aberrant activity of the protein kinases IKKε and/or TBK-1: in which: R1 represents...
8957068 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH  
The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a...
8956541 Composition and method for retention of solvated compounds and ions  
Storage stable polyhydroxylated aromatic ether adducts of polyalkylene oxide are described. Reactive compositions are formed by combining an ether adduct with an aldehyde, optionally further...
8957083 Spiro-amino-imidazolone and spiro-amino-dihydro-pyrimidinone compounds as beta-secretase modulators and methods of use  
The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A1, A3, A4,...
8952001 Amino-heteroaryl derivatives as HCN blockers  
The invention relates to amino-heteroaryl derivatives having the general Formula I or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to...
8952028 Methods of treating chemoresistance and relapse in cancer cells  
Methods of treating or preventing chemoresistance or relapse growth of cancer cells are provided. Methods of treating or preventing resistance to tyrosine kinase based chemotherapeutic treatment...
8952029 Method of administration of gamma hydroxybutyrate with monocarboxylate transporters  
One embodiment of the present invention is to improve the safety and efficacy of the administration of GHB or a salt thereof to a patient. It has been discovered that the concomitant...
8946205 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors  
The present invention relates to novel triazolo[4,3-a]pyridine derivatives of Formula (I) wherein all radicals are as defined in the claims. The compounds according to the invention are positive...
8946248 HIV inhibiting 5-substituted pyrimidines  
HIV replication inhibitors of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein A is —CH2—CH2—, —CH═CH—,...
8940724 Quinoline derivitives and their uses  
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders,...
8940730 Methods and compositions of treating a Flaviviridae family viral infection  
Briefly described, embodiments of this disclosure include compounds, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods...
8937081 Statin bioavailability enhancement delivery composition  
A composition for increasing the bioavailability of a statin active pharmaceutical ingredient (“API”) in humans and animals, wherein that composition includes a statin API selected from the group...
8937082 Nilotinib salts and crystalline forms thereof  
Nilotinib salts and crystalline forms thereof have been prepared and characterized.
8933090 1-aza-bicyclo[3.3.1]nonanes  
The present invention relates to 1-aza-bicycloalkyl derivatives of Formula (I); wherein the substituents are as defined in the specification, to processes for their production, their use as...
8933037 Methods involving PDGFRBETA inhibitors  
The invention refers to PDGFRbeta inhibitor for use in the antiproliferative treatment of T-cell lymphoma, in particular NHL, ALCL and PTCL.
8933082 Materials and methods for suppressing and/or treating neurofibroma and related tumors  
Germline mutations in the NF1 tumor suppressor gene cause Von Recklinghausen's neurofibromatosis type 1 (NF1), a common genetic disorder of the nervous system characterized by plexiform...
8927547 Pyrimidine derivatives  
The invention provides novel pyrimidine derivatives of formula I, to methods of preparing such compounds, to pharmaceutical compositions containing such compounds, and to methods for using such...