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6649631 |
Compositions and methods for treating bone deficit conditions
Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or “linker” defined as including a covalent bond per se so as to space the aromatic...
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6645965 |
Nitrate salts of antihypertensive medicines
Nitric acid salts with medicines having an antihypertensive activity.
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6645968 |
Potassium channel openers
Compounds of formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of...
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6645991 |
αvβ3 integrin inhibitors
The invention describes novel compounds of the formula I which are biologically active as ligands of integrin α v β 3 X—Y—Z—R 1 —CH 2 —R 2 (R 4 )—CH 2 —CO—R 5 in which X, Y, Z,...
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6610695 |
Aryloxy substituted pyrimidine imidazole compounds
Novel 2,4,5-triaryl substituted imidazole compounds and compositions for use in therapy of CSBP/RK/p38 mediated diseases.
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6610698 |
Substituted pyrimidine compounds and methods of use
Selected novel substituted pyrimidine compounds are effective for prophylaxis and treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain...
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6608072 |
Thiazole compounds and their pharmaceutical use
Compounds of formula (I) and pharmaceutically-acceptable and -cleavable esters thereof and acid addition salts thereof, wherein the symbols are as defined are MAP kinase inhibitors, useful...
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6602878 |
Acylquanidine derivatives, method for preparing same, application as medicines and pharmaceutical compositions containing them
Acylquanidines of the formula wherein the substituents are defined as in the specification which are antagonists of the vitronectin receptor and inhibitors of cell adhesion and bone resorption...
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6599906 |
Method of local anesthesia and analgesia
The present invention provides a method of producing local analgesia and anesthesia in a mammal experiencing pain in a nerve tissue region. The method includes topically administrating to the...
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6599911 |
Arylsulfonic acid salts of pyrimidine-based antiviral agents
Salts of pyrimidine derivatives are provided having the formula: wherein R represents hydrogen, methyl or ethyl; Z represents a substituted or unsubstituted 1-piperidinyl, a substituted or...
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6593326 |
2,4-diamino pyrimidine compounds having anti-cell proliferative activity
A pyrimidine derivative of formula (I): wherein: R 1 is an optional substituent as defined within; R x is selected from halo, hydroxy, nitro, amino, cyano, mercapto, carboxy, sulphamoyl,...
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6589959 |
Crystalline bis&lsqb (e)-7-&lsqb 4-(4-fluorophenyl)-6-isopropyl-2-&lsqb methyl(methylsulfonyl)amino&rsqb pyrimidin-5-yl&rsqb (3R,5S)-3,5-dihydroxyhept-6-enoic acid&rsqb calcium salt
The present invention relates to a crystalline form of the compound bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsu
lfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoi
c...
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6586442 |
Benzofurane derivatives, their preparation process, their use as medicaments and the pharmaceutical compositions containing them
A compound of the formula wherein the substituents are as defined in the specification and its pharmaceutically acceptable salts and it prodrug useful for treating osteoporosis.
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6586441 |
Adenosine receptor ligands and their use in the treatment of disease
The invention relates to cyclic heteroaromatic compounds, containing at least one nitrogen atom, and to their use in the manufacture of medicaments for the treatment of diseases, related to...
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6586433 |
Substituted N-heteroaryl-N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6579874 |
Substituted azoles
Compounds of formula I wherein the symbols have meaning as defined herein, are p38 MAP kinase inhibitors, and are useful pharmaceutically for treating TNFα and IL-1 mediated diseases, such as...
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6579899 |
Composition for treatment of stress
A method of treating stress in a patient showing stress related symptoms is disclosed, where the method comprises administering to the patient an effective amount of a serotoninergic drug or...
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6576643 |
Vitronectin receptor antagonists
Compounds of the formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis: or a pharmaceutically acceptable salt thereof.
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6576637 |
β-alanine derivatives
The invention relates to β-alanine derivatives of formula (I), wherein Q 1 , Q 2 , Q 3 , Q 4 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and n have the meaning as disclosed in the disclosure, and to...
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6572848 |
Use of a substance agonist of a receptor associated with a chlorine or potassium canal for treating sensitive skins
Agonists of chlorine/potassium channel receptor, for example taurine, gamma-aminobutyric acid (GABA), isoguvacin, isonipecotic acid, 4,5,6,7-tetrahydroisoxazolo-(5,4-c)pyrid-3(2H)-one, a...
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6566357 |
Spirocyclic-6,7-dihydro-5H-pyrazolo&lsqb 1,2-a&rsqb pyrazol-1-ones which control inflammatory cytokines
The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms...
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6562833 |
Use of 2-(n-phenylamino)pyrimidines as fungicides, and novel 2-(n-phenylamino) pyrimidines
2-(N-phenylamino)pyrimidines of the formula I, where: R 1 , R 3 independently of one another are cyano, C 1 -C 8 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, where the radicals alkyl, alkenyl...
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6559156 |
Suspension concentrate formulation containing pyrimethanil
The invention provides an aqueous SC formulation comprising: a) 50 to 80% w/v pyrimethanil; b) 0.2 to 5% w/v of a polyoxyethylene-polyoxypropylene block copolymer surfactant; and c) 0.2 to 5% w/v...
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6555546 |
Use of 5HT3 antagonists for promoting intestinal lavage
The present invention is concerned with the use of 5HT 3 antagonists for promoting intestinal lavage, especially in combination with an osmotic agent.
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6552029 |
2-pyrimidineamine derivatives and processes for their preparation
Compounds of general formula (1) are described wherein: Ar is an optionally substituted aromatic group; R 2 is a hydrogen or halogen atom or a group —X 1 —R 2a where X 1 is a direct bond...
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6552030 |
Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
This invention is directed to poly-hydroxylated monocyclic N-heterocyclic derivatives selected from the following formulae: wherein Z 1 , Z 2 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are...
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6548513 |
Pharmaceutical compositions
The present invention relates to pharmaceutical compositions and more particularly to a pharmaceutical composition containing (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl...
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6548512 |
Nitrogen containing heteroaromatics as factor Xa inhibitors
The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and...
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6548507 |
Medical use
The present invention relates to the use of sodium channel antagonists in the treatment of diseases mediated by, or exacerbated by, neuronal apoptosis, in particular sensory neuronal apoptosis.
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6545008 |
Pyrimidine derivatives and processes for the preparation thereof
The present invention relates to novel pyrimidine derivatives and pharmaceutically acceptable non-toxic salts thereof which possess an excellent inhibitory activity against gastric acid secretion,...
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6544997 |
4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, —R 1 —R 2 —...
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6541480 |
1-aryl-1,8-naphthylidin-4-one derivative as type IV phosphodiesterase inhibitor
A 1-aryl-1,8-naphthylidin-4-one derivative having the formula (I): wherein R 1 indicates a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group, R 2 , R 3...
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6541505 |
Substituted (aminoiminomethyl or aminomethyl) benzoheteroaryl compounds
This invention is directed to an (aminoiminomethyl or aminomethyl)benzoheteroaryl compound of formula I which is useful for inhibiting the activity of Factor Xa by combining said compound with a...
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6531478 |
Amino pyrazole derivatives useful for the treatment of obesity and other disorders
Amino pyrazole derivatives of the formula: which are ligands for the neuropeptide Y, subtype 5 receptor and pharmaceutical compositions containing an amino pyrazole derivative as the active...
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6521646 |
Dibenzoazulene derivatives for treating thrombosis, osteoporosis, arteriosclerosis
Compounds of the formula (I) and their physiologically acceptable salts and solvates are useful as integrin-inhibiting substances. They are especially useful in the prophylaxis and treatment of...
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6521632 |
Method for the treatment or prevention of a disease mediated by the alpha-2B-adrenoceptor
A method for the treatment or prevention of a disease mediated by the alpha-2B-adrenoceptor in a mammal. The method includes administering to the mammal an effective amount of a selective...
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6506754 |
Non-covalent thrombin inhibitors
The present invention provides compounds which have a pyrazinone or pyridinone ring at P3 and which feature a six member heterocyclic ring having two ring nitrogen atoms and the remainder of the...
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6498165 |
Src kinase inhibitor compounds
Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same,...
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6492356 |
Acylguanidine derivatives as inhibitors of bone resorption and as vitronectin receptor antagonists
The present invention relates to acylguanidine derivatives of formula (I) in which R 1 , R 2 , R 4 , R 5 , R 6 , A, m and n have the meanings indicated in the patent claims, their physiologically...
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6489333 |
Integrin antagonists
This invention relates to novel heterocycles which are useful as antagonists of the α v β 3 integrin, the α 2b β 3 integrin, and related cell surface adhesive protein receptors, to...
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6479550 |
α-sulfenimino acid derivatives
α-Sulfenimino acid derivatives of formula I including the optical isomers thereof and mixtures of such isomers, wherein A is cycloalkyl, cycloalkenyl, aryl or heteroaryl, each optionally...
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6479498 |
Sodium channel drugs and uses
The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Na + channel, thereby modulating the...
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6469059 |
Fungicidal composition and method for disease control of paddy-rice plants
A fungicidal composition for paddy-rice plants has as active ingredients N-(1-cyano-1,2-dimethylpropyl)-2-(2,4-dichlorophenoxy)propan
amide in combination with one or more compounds selected from...
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6465514 |
Methods and compositions for the promotion of hair growth
Compositions, medicaments, and methods for the promotion of hair growth are disclosed. These compositions and medicaments are comprised of either local anesthetics of the secondary or tertiary...
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6465460 |
Compositions and methods for prevention and treatment of protozoal disease
A composition is provided that has been specially adapted for parenteral administration, e.g., intranasal, intramuscular, subcutaneous, transdernal or intraveneous administration, wherein the...
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6462024 |
Use of inhibitors of the sodium-hydrogen exchanger for the production of a medicament for decreasing undesired effects of substrates of the heart
Inhibitors of the sodium-hydrogen exchanger are used for the production of a medicament for decreasing the undesired effects in human and in veterinary medicine which originate from substances...
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6462047 |
Carboline derivatives as cGMP phosphodiesterase inhibitors
Compounds of general structural formula (I) wherein A represents a 5- or 6-membered heteroaryl group containing at least one heteroatom selected from the group consisting of oxygen, nitrogen, and...
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6462052 |
Synergistic fungicide and/or bactericide composition
The invention concerns a synergistic fungicide and/or bactericide composition comprising dodine and a derivative of the anilino-pyrimidine family. The invention also concerns a preventive or...
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6458801 |
Benzofurane derivatives, preparation method, use as medicines and pharmaceutical compositions containing same
A compound of the formula wherein the substituents are as defined in the specification and its pharmaceutically acceptable salts and its prodrug useful for treating osteoporosis.
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6448259 |
Substituted cycloalkyl-4-oxonicotinic carboxamides; GABA brain receptor ligands
Disclosed are compounds of the Formula: or the pharmaceutically acceptable non-toxic salts thereof wherein: the C ring is a(n) (un)substituted carbocycle; X is hydrogen, hydroxyl or lower alkyl;...
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