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7199120 |
Pyrazolo-pyridine derivatives as antiherpes agents
The present invention provides compounds of formula (I):
wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their...
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7199124 |
JNK inhibitor
The present invention relates to a c-Jun N-terminal kinase inhibitor containing an azole compound (I) substituted by a nitrogen-containing aromatic group having substituent(s)(except a compound...
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7196095 |
(Pyrimidinyl) (phenyl) substituted fused heteroaryl p38 inhibiting and PKG kinase inhibiting compounds
Compounds of formula (I) and pharmaceutically acceptable salts thereof are useful in the treatment of cytokine mediated diseases such as arthritis and in the treatment and/or prevention of...
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7189717 |
Medicinal compositions promoting bowel movement
The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound...
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7189755 |
Pyrrolidine melanocortin-specific compounds
Melanocortin receptor-specific pyrrolidine compounds having the structure:
and stereoisomer and pharmaceutically acceptable salts thereof, where R 1 , R 2 , and R 3 are as described in the...
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7186714 |
Imidazo[1,2-α]pyridine derivatives for the prophylaxis and treatment of herpes viral infections
The present invention provides compounds of formula (I) wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use...
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7183288 |
Amide derivatives as glycogen synthase kinase 3-β inhibitors
This invention concerns a compound of formula
a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A represents...
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7179806 |
Δ1-pyrrolines used as pesticides
The invention relates to novel Δ 1 -pyrrolines of the formula (I)
in which R 1 , R 2 , R 3 , m, and Q have the meanings given in the disclosure, to a plurality of processes for preparing these...
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7176199 |
Aryl-substituted alicyclic compound and medical composition comprising the same
An aryl-substituted alicyclic compound of the formula (I):
wherein U is 1,4,5,6-tetrahydropyrimidin-2-yl, etc., A is phenylene, etc., B is piperidine-1,4-diyl, etc., Z is —CONH—, etc., R 3 ...
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7176212 |
2,4-diamino pyrimidine compounds having anti-cell proliferative activity
A pyrimidine derivative of formula (I) wherein, for example, R 1 is hydrogen, (1–6C)alkyl, (3–5C)alkenyl or (3–5C)alkynyl; Q 1 and Q 2 are independently selected from phenyl, naphthyl,...
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7173028 |
Pyrimidine derivatives
The present invention relates to trisubstituted pyrimidines of formula (I)
wherein
0R a to R e are defined as in claim 1, which are suitable for the treatment of illnesses characterised by...
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7169781 |
Imidazole derivatives and their use as pharmaceutical agents
Compounds of the general formula (I)
are presented which arevaluable therapeutics for the treatment of cancer and cancer related diseases.
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7169802 |
Fused pyrrolocarbazoles
The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also...
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7169791 |
Inhibitors of tyrosine kinases
The invention relates to compounds of formula
wherein the substituents R1, R2 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the...
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7166599 |
Trisubstituted pyrimidines
The present invention relates to trisubstituted pyrimidines of formula
wherein
R a to R e are defined as in claim 1, which are suitable for the treatment of illnesses in which β-amyloid...
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7166597 |
Fused pyrazole derivatives being protein kinase inhibitors
Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R 1 , R 2 , and R 4 are various substituent groups, are protein kinase...
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7163940 |
Pyrazolopyridinyl pyrimidine therapeutic compounds
The present invention provides compounds of formula (I):
wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their...
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7160876 |
Fused bicycloheterocycle substituted quinuclidine derivatives
Compounds of formula (I)
wherein n is 0, 1, or 2; X is O, S, —NH—, and —N-alkyl-; Ar 1 is a 6-membered aromatic ring; and Ar 2 is a fused bicycloheterocycle. The compounds are useful in...
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7157455 |
4-Aminopyrimidine-5-one derivatives
Novel 4-aminopyrimidine-5-one derivatives are disclosed. These compounds inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). These compounds and their pharmaceutically...
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7153863 |
Therapeutic compounds based on pyrazolopyridline derivatives
The present invention provides compounds of formula (I):
wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their...
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7153860 |
5-Phenylpyrimidines, methods and intermediate products for the production thereof and use of the same for controlling pathogenic fungi
The invention relates to 5-phenylpyrimidine of formula (I) wherein the substituents have the following designations: R 1 represents a five to ten-membered saturated, partially unsaturated or...
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7144889 |
Triarylimidazoles
Compounds of the general formula (I)
are presented and are valuable therapeutics for the treatment of cancer and cancer related diseases.
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7141569 |
Antiviral pyrazolopyridine compounds
The present invention provides compounds of formula (I):
pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
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7135477 |
Heterocyclic compounds which inhibit leukocyte adhesion mediated by α4 integrins
Disclosed are compounds which bind α 4 integrins, preferably VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by α 4 integrins,...
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7129238 |
Mandelic acid derivatives
The invention is concerned with novel mandelic acid derivatives of formula (I)
wherein R 1 to R 10 , X and Y are as defined in the description and in the claims, as well as pharmaceutically...
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7129245 |
Aromatic amides
This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa,...
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7125883 |
Integrin receptor ligands
The invention relates to novel compounds which bind to integrin receptors, to their preparation, to their use as integrin receptor ligands and for treating diseases, to pharmaceutical preparations...
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7122544 |
Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
Compounds having activity as inhibitors of IKK are disclosed, particularly IKK-2. The compounds of this invention are anilinopyrimidine derivatives having the following structure:
wherein R 1 ...
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7122552 |
Inhibitors of JAK and CDK2 protein kinases
The present invention provides a compound of formula I:
or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of JAK and CDK2...
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7119095 |
Pharmaceutically active compounds and methods of use thereof
The present invention relates to dihydrofolate reductase inhibitors having an aromatic group and a heteroaromatic group linked by a methylene group; and methods of treatment and pharmaceutical...
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7115617 |
Amino-substituted pyrimidinyl derivatives and methods of use
The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer.
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7109206 |
Methods and compositions for the rapid and enduring relief of inadequate myocardial function
Disclosed are methods and compositions for reducing coronary artery stenosis, restoring blood flow to infarcted myocardium, improving myocardial perfusion, reducing heart attacks or other adverse...
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7109197 |
N-phenyl-4-(4-pyridyl)-2-pyrimidineamine derivatives
The present invention relates to a method of protecting plants against attack or infestation by phytopathogenic organisms, such as nematodes or especially microorganisms, preferably fungi, bacteria...
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7109243 |
Inhibitors of cathepsin S
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at...
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7109204 |
Tyrosine kinase inhibitors
The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to...
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7105517 |
Thiazolyl substituted aminopyrimidines as plant protection agents
Compounds of formula (I), or a salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are specified organic redicals; and compositions containing them, processes for making them...
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7105530 |
Pyrimidineamines as angiogenesis modulators
Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also Includes methods of making such pyrimidine derivatives as well as methods of using...
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7101869 |
2,4-diaminopyrimidine compounds useful as immunosuppressants
Novel compounds according to the formula
and pharmaceutically acceptable salts, solvates, or hydrates thereof; wherein each occurrence of A is independently selected from CH or N; X is...
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7091202 |
4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators
The invention encompasses compounds of Formula I, which are blockers of KCNQ channels. Blockers of KCNQ channels are known to enchance cognition in laboratory animals. The invention includes,...
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7087616 |
Pyrazolyl pyrimidines
This invention relates to novel pyrazolylpyrimidines of the formula
in which R 1 , R 2 , X, n, Y, Z and R have the meanings given in the disclosure, to a plurality of processes for preparing...
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7087618 |
Pyrazolopyridinyl pyrimidine therapeutic compounds
The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their...
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7087617 |
Substituted pyrimidine derivatives
This invention relates to compounds of Formula I,
a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, or a pharmaceutically acceptable salt of a prodrug...
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7087614 |
Pyrimidine inhibitors of phosphodiesterase (PDE) 7
Pyrimidine phosphodiesterase 7 (PDE 7) inhibitors of the following formula
wherein R 1 , R 2 , Z, J and L are described herein, and analogs thereof are provided which are useful in treating...
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7084148 |
Substituted pyrimidines as selective cyclooxygenase-2 inhibitors
A compound of formula (I):
and pharmaceutically acceptable derivatives thereof, wherein R 1 is H or C 1-6 alkyl; R 2 is
wherein
defines the point of attachment of the ring; and R 3 ...
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7078060 |
Solutions and aerosols of metal-containing compounds
Solutions and aerosols of metal-containing compounds are disclosed. Methods of preparing and using the solutions and aerosols, particularly in the treatment of a subject having a condition, are...
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7074802 |
Pyrimidine derivatives as selective inhibitors of cox-2
The invention thus provides the compounds of formula (I)
and pharmaceutically acceptable salts thereof, in which:
R 1 and R 2 are independently selected from the group consisting of H, C 1-6...
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7074787 |
Microbiocidal N-phenyl-N-[4-(4-pyridyl-2-pyrimidin-2-yl]-amine derivatives
The invention relates to novel N-phenyl-4-(4-pyridyl)-2-pyrimidineamine derivatives of the general formula (I) wherein the sum of (m+p) together is 0, 1, 2 or 3; n and q are independently of each...
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7067514 |
Pyrimidine compounds
This invention features pyrimidine compounds of formula (I):
R 1 is
aryl, or heteroaryl; each of R 2 and R 4 , independently, is R c , halogen, nitro, cyano, isothionitro, SR c ,...
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7067522 |
2,4,DI (hetero-) arylamino (-oxy)-5-substituted pyrimidines as antineoplastic agents
Pyrimidine derivatives of formula (I) wherein Q 1 , Q 2 , G and R 1 are as defined within; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Processes...
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7060707 |
Isoquinoline derivatives
Isoquinoline derivatives of the general formula (I) in which X, Y, Z, R 1 , R 2 and n are as defined in Patent Claim ( 1 ), and physiologically acceptable salts or solvates thereof, are integrin...
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