Patents in Class 514/275

Matches 101 - 150 out of 826

Match	Document	Document Title
101	7348335	Compositions useful as inhibitors of JAK and other protein kinases The present invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising the...
102	7348333	Cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists There are described cycloalkyl derivatives of the formula (I) R 1 —Y-A-B-D-E-F-G (I)
103	7338959	Diamino-pyrimidines and their use as angiogenesis inhibitors Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well...
104	7335672	Vanilloid receptor ligands and their use in treatments Substituted pyridines and pyrimidines and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache,...
105	7335663	Heteroaryl compounds which inhibit leukocyte adhesion mediated by α₄integrins Disclosed are compounds which bind α 4 integrins, where the α 4 integrin is preferably VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion...
106	7329670	Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas The compounds are aryl and heteroaryl substituted heterocyclic ureas of the formula A—NH—C(O)—NH—B where A is the aryl or hetaryl substituted heterocyclic group and B is an aryl or...
107	7329661	N-phenyl-3-pyrimidine-amine derivatives The invention relates to N-phenyl-2-pyrimidine-amine derivatives of formula I wherein the substituents are defined as indicated in the description, to processes for the preparation thereof, to...
108	7326717	Pyrimidine n-oxide compounds for stimulating the growth of keratin fibers and/or reducing loss thereof Novel pyrimidine N-oxide compounds and salts thereof, well suited for stimulating the growth of keratin fibers (e.g., the hair or the eyelashes) and/or limiting the loss thereof and/or increasing...
109	7326705	Heterocyclic sodium/proton exchange inhibitors and method Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 1 to 5; X is N or C—R 5 wherein R 5 is H, halo, alkenyl, alkynyl, alkoxy,...
110	7323464	Pyridine and pyrimidine derivatives Compounds of formula (1) are described in which R a and R b is each independently a hydrogen atom or a group R c , or R a and R b together form an oxo (═O) or thio (═S) group; X is a N atom...
111	7319104	hPPARs activators Compounds of formula (1) or a pharmaceutically acceptable salt, solvate, acid isostere, or hydrolyzable ester thereof, are disclosed. Methods of making and using the compounds are also disclosed....
112	7312216	N-phenyl-2-pyrimidine-amine derivatives The invention relates to N-phenyl-2-pyrimidine-amine derivatives of formula I wherein the substituents are defined as indicated in the description, to processes for the preparation thereof, to...
113	7312227	Compositions useful as inhibitors of JAK and other protein kinases The present invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising the...
114	7309704	Heteroaryl urea neuropeptide Y Y5 receptor antagonists The present invention relates to compounds represented by the structural Formula I: or a pharmaceutically acceptable salt thereof, which are useful for the treatment of metabolic and eating...
115	7304071	Protein kinase inhibitors and uses thereof Described herein are compounds that are useful as protein kinase inhibitors having the formulae I and V: or a pharmaceutically acceptable salt thereof, wherein Ring B, Z 1 , Z 2 , U, T, m, n,...
116	7304072	Spiro compounds Compounds represented by the general formula (I) wherein Ar 1 represents an aryl or heteroaryl which may be substituted; n represents 0 or 1; T, U, V and W each independently represent a...
117	7300933	Diazabicyclic biaryl derivatives This invention relates to novel diazabicyclic biaryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and...
118	7300940	Integrin α-v β-3 antagonists for use in imaging and therapy Integrin receptor antagonists whose molecular structure includes a tetrahydropyridimidinylaminoethyloxybenzoyl group on a sulfonylamino-β-alanine nucleus exhibit increased binding affinity for the...
119	7300941	Non-imidazole compounds Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I. Also disclosed are methods of treating various diseases or...
120	7294635	Substituted isoquinolinones Isoquinolinone compounds are provided that are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders.
121	7291624	CDK-inhibitory pyrimidines, their production and use as pharmaceutical agents This invention relates to pyrimidine derivatives of general formula I in which R 1 , R 2 , X, A and B have the meanings that are contained in the description, as inhibitors of the...
122	7288547	CDK-inhibitory 2-heteroaryl-pyrimidines, their production and use as pharmaceutical agents This invention relates to 2-heteroaryl-pyrimidine derivatives of general formula I or I f as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for...
123	7288544	Pyrimidine compounds useful as N-type calcium channel antagonists Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when...
124	7285560	Indole derivatives or benzimidazole derivatives for modulating IκB kinase The present invention relates to indole derivatives or benzimidazole derivatives, to processes for preparing such compounds, to pharmaceutical compositions comprising such compounds, and methods...
125	7285551	Fused-ring compounds and use thereof as drugs The present invention provides a fused ring compound of the following formula [I] wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a...
126	7282504	Kinase inhibitors The invention relates to inhibitors of kinases, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising...
127	7276510	HIV replication inhibitors This invention concerns HIV replication inhibitors of formula the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms...
128	7276502	Thiazoles useful as inhibitors of protein kinases The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of...
129	7273862	Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z...
130	7265115	Diazabicyclic CNS active agents Compounds of formula I: or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals.
131	7262203	Pyrimidineamines as angiogenesis modulators Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using...
132	7262202	Inhibitors of cyclin dependent kinases as anti-cancer agent The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases...
133	7256192	Aromatic diamide derivatives, chemicals for agricultural or horticultural use and usage thereof The present invention relates to an aromatic diamide derivative represented by the general formula (I): [A 1 is optionally substituted (C 1 -C 8 )alkylene group, (C 3 -C 8 )alkenylene...
134	7253174	N-heterocyclic inhibitors of TNF-α expression N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I): Methods...
135	7244740	Imidazo-pyridine derivatives for use in the treatment of herpes viral infection The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their...
136	7244735	Heterocyclic protein kinase inhibitors and uses thereof Described herein are compounds that are useful as protein kinase inhibitors of formula I: or a pharmaceutically acceptable salt thereof, wherein Ring B, Z 1 , Z 2 , U, p, Q, R 1 , R 2 , R 3 ,...
137	7241756	Combinations of dipeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diabetes mellitus A method for the treatment of diabetes mellitus, especially Type 2 diabetes and conditions associated with diabetes mellitus in a mammal such as a human, which method comprises administering an...
138	7241458	Antiviral compositions The present invention is concerned with pharmaceutical compositions of antiviral compounds which can be administered to a mammal, in particular a human, suffering from a viral infection. These...
139	7241769	Pyrimidines as PLK inhibitors The present invention comprises compounds of general formula (1) wherein A, X, Y, Z, R a , R b , R c , R 1 , R 2 and R 3 are defined as in claim 1 , which are suitable for the treatment of...
140	7238697	Pyridylpyrimidines for use as pesticides The present invention relates to novel pyridylpyrimidines of the formula in which R 1 , R 2 , X, n, Y, Z and R have the meanings given in the disclosure, to a plurality of processes for...
141	7235561	Compound and a composition including such a compound This invention relates to pyrimidine derivatives of general formula I in which R 1 , R 2 , X, A and B have the meanings that are contained in the description, as inhibitors of the...
142	7232825	Phenylaminopyrimidine derivatives and methods of use The present invention relates to phenylaminopyrimidine derivatives, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of...
143	7230002	Dipeptidyl peptidase IV inhibitors; processes for their preparation and compositions thereof The present invention relates to novel dipeptidyl peptidase IV (DPP-IV) inhibitors their analogs, isomers, pharmaceutical compositions, therapeutic uses and methods of making the same.
144	7226919	Compositions useful as inhibitors of protein kinases The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of...
145	7220736	Pyrimidine compounds A cyclic compound of the formula (I) or a pharmacologically acceptable salt thereof, wherein X is ═CH— or ═N—, Y is —NH—, —NR 4 —, —S—, —O—, —CH═N—,...
146	7217716	N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists Compounds represented by Formula (I): (I) or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain
147	7208499	Pyrimidine derivatives for the treatment of abnormal cell growth The present invention relates to a compound of the formula 1 wherein A and Ar are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such...
148	7205301	Microbiocidal N-phenyl-n-[4-(4-pyridyl)-2-pyrimidin-2-yl]-amine derivatives Fungicidal compounds of Formula (I) wherein m is 0, 1, 2 or 3; n and p are independently of each other 0 or 1; R 1 is halogen, optionally substituted alkyl, optionally substituted alkoxy,...
149	7205297	Substituted 5-alkynyl pyrimidines having neurotrophic activity The present invention relates to a series of novel substituted 5-alkynyl pyrimidines, pharmaceutical compositions which contain them, methods for their preparation, and their use in therapy,...
150	7205310	Pyrimidine hydantoin analogues which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are compounds which bind VLA-4 and/or LPAM-1. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4 and/or LPAM-1. Such...

Matches 101 - 150 out of 826

< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >