|
Match
|
Document |
Document Title |
|
|
7491732 |
Compositions and methods for inhibition of the JAK pathway
The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of...
|
|
|
7491730 |
Compositions useful as inhibitors of GSK-3
The present invention provides a compound of formula I:
or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3...
|
|
|
7488734 |
Methods of treating hormone-related conditions using thio-oxindole derivatives
The present invention provides methods of inducing contraception which includes delivering to a female a composition containing a compound of formula I, or tautomers thereof, in a regimen which...
|
|
|
7488727 |
Thiazole compounds useful as inhibitors of protein kinase
The present invention provides a compound of formula I:
or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3,...
|
|
|
7485638 |
Pyrimidine compounds
Compounds of the formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and p are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described...
|
|
|
7482356 |
Bicyclic pyrazolone cytokine inhibitors
The present invention relates to 6,7-dihydro-5H-pyrazolo[1,2α]pyrazol-1-ones which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or...
|
|
|
7479495 |
N-heterocyclic inhibitors of TNF-α expression
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I:
Methods of...
|
|
|
7473695 |
4-imidazolin-2-one compounds
The present invention relates to a compound of the formula [I]:
wherein G 1 is an alkyl which is substituted by a halogen atom or an alkoxy, or a group of the formula:
...
|
|
|
7473691 |
Pyrazole compounds useful as protein kinase inhibitors
This invention describes novel protein kinase inhibitors of formula VII:
wherein G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or...
|
|
|
7470700 |
Dipeptidyl peptidase inhibitors
Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I:
wherein the substituents are as described herein.
|
|
|
7470685 |
Pyrimidine compounds
This invention features pyrimidine compounds of formula (I):
R 1 is
in which one of R a and R b is H or alkyl, and the other is aryl or heteroaryl optionally substituted with R d and R...
|
|
|
7470783 |
Photocleavable protecting groups and methods for their use
Novel compounds are provided which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally...
|
|
|
7470701 |
Substituted 2,5-heterocyclic derivatives
The present invention relates to new substituted five-membered compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with...
|
|
|
7465736 |
Azole methylidene cyanide derivatives and their use as protein kinase modulators
An azole derivative of formula (I)
a medicament that contains the azole derivative of formula (I), a method of treating a disease with the azole derivative of formula (I), and a method of...
|
|
|
7465728 |
Derivatives of 4-(imidazol-5-yl)-2-(4-sulfoanilino)pyrimidine with CDK inhibitory activity
Compounds of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 and p are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described...
|
|
|
7462625 |
Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: ...
|
|
|
7462619 |
Pyridazine, pyrimidine and pyrazine ethyne compounds
In accordance with the present invention, there is provided a novel class of heterocyclic compounds. Compounds of the invention contain a substituted or unsubstituted six membered heterocyclic ring...
|
|
|
7459460 |
Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators
Trisubstituted heteroaromatic compounds having the structure
are provided, wherein
X is C or N; A and B are each independently CH or N, with the proviso that A and B cannot both be CH; R...
|
|
|
7459455 |
Pyrimidine compounds
Pyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as...
|
|
|
7456190 |
Compositions useful as protein kinase inhibitors
The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of...
|
|
|
7456191 |
N-Aryl-sulfoximine-substituted pyrimidines as CDK-and/or VEGF inhibitors, their production and use as pharmaceutical agents
This invention relates to pyrimidine derivatives of general formula (I)
in which Q, R1, R2, R3, R4, R5, X, and m have the meanings that are contained in the description, as inhibitors of...
|
|
|
7449474 |
Tri-substituted ureas as cytokine inhibitors
The present invention relates to 1,1,3-tri-substituted ureas which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian...
|
|
|
7449471 |
5-phenylpyrimidines, their preparation, compositions comprising them and their use
5-Phenylpyrimidines of the formula I
in which the substituents and the index are as defined below:
R 1 ,R 2 are hydrogen, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, haloalkenyl,...
|
|
|
7449456 |
Diaminopyrimidinecarboxamide derivative
A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is...
|
|
|
7449462 |
Triazole derivatives which inhibit vasopressin antagonistic activity
Compounds of formula (I),
or pharmaceutically acceptable derivatives thereof, wherein:
Het represents 2-pyridinyl or 2-pyrimidinyl; R 1 represents H, C 1-3 alkyl or a...
|
|
|
7446109 |
Carbonylamino-derivatives as novel inhibitors of histone deacetylase
This invention comprises the novel compounds of formula (I) wherein n, m, t, R 1 , R 2 , R 3 , R 4 , R 5 , L, Q, X, Y and have defined meanings, having histone deacetylase inhibiting enzymatic...
|
|
|
7442699 |
Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
Compounds having activity as inhibitors of IKK are disclosed, particularly IKK-2. The compounds of this invention are anilinopyrimidine derivatives having the following structure:
wherein R 1 ...
|
|
|
7442705 |
HIV replication inhibiting pyrimidines and triazines
This invention concerns HIV replication inhibitors of formula (I), The N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms...
|
|
|
7442701 |
Amino-heterocycles as VR-1 antagonists for treating pain
The present invention provides a compound of formula (I): wherein V represents NR 5 , O, S, SO or S(O) 2 ; W and X each independently represent CH or N; Y represents N, CH or C—Ar 2 , with the...
|
|
|
7442698 |
Substituted heterocyclic compounds and methods of use
The present invention relates to pyrimidine or pyridine carbamate compounds having the general Formula I:
and pharmaceutically acceptable salts or derivatives thereof. Also included are methods...
|
|
|
7442697 |
4-imidazolyl substituted pyrimidine derivatives with CDK inhibitory activity
Compounds of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 and p are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described...
|
|
|
7439268 |
Compositions containing prodrugs of florfenicol and methods of use
The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one...
|
|
|
7432260 |
Pyrimidine compounds
The present invention relates to substituted pyrimidines of formula I, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs)...
|
|
|
7429599 |
Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
This invention generally relates to methods for treating or preventing a condition responsive to JNK inhibition, such as a metabolic condition, comprising administering to a patient in need thereof...
|
|
|
7427627 |
N-(4-(4-methylthiazol-5-yl) pyrimidin-2-yl)-N-phenylamines as antiproliferative compounds
The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases...
|
|
|
7427626 |
2-Anilino-4-(imidazol-5-yl)-pyrimidine derivatives and their use as cdk (cdk2) inhibitors
Compounds of the formula (I), and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Also described are processes for their preparation and their use as...
|
|
|
7423148 |
Small molecule PI 3-kinase inhibitors and methods of their use
Compounds having formula I are provided where the variables have the values described herein.
Pharmaceutical formulations include the compounds or pharmaceutically acceptable salts thereof and a...
|
|
|
7419984 |
Pyrimidines and uses thereof
The invention relates to pyrimidines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor-cells.
|
|
|
7417048 |
Aryl-substituted derivatives of cycloalkyl and branched chain alkyl carboxylic acids useful as antinociceptive drugs for peripheral targets
Novel peripheral antinociceptive compounds are disclosed having a pharmacophore unit that target small-diameter nerve fibers that transmit signals of pain and discomfort from the soma and viscera....
|
|
|
7407965 |
Phosphonate analogs for treating metabolic diseases
The invention is related to phosphorus substituted compounds with activity for treating metabolic diseases and/or disorders, e.g., diabetes and hypercholesterolemia, compositions containing such...
|
|
|
7405221 |
Substituted pyrimidines
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases...
|
|
|
7396836 |
Pyrimidine compound and medicinal composition thereof
A compound having excellent adenosine receptor (A 1 , A 2A , A 2B receptor) antagonistic action, of the following formula, a salt thereof or a solvate of them:
wherein, R 1 and R 2 , same or...
|
|
|
RE40332 |
Fungicidal trifluoromethylalkylamino-triazolopyrimidines
The novel compounds of formula I:
wherein (R 1 , R 2 , Hal and L 1 through L 5 are defined in the specification) show selective fungicidal activity. The new compounds may be processed with...
|
|
|
7371759 |
HMG-CoA reductase inhibitors and method
Compounds are provided having the following structure which are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example,...
|
|
|
7368455 |
6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
The present invention relates to 2-(4-fluorophenyl)-3-(2-phenoxy-pyrimidin-4-yl)-6,7-dihydro-
5H-pyrazolo-[1,2-a]pyrazol-1-one, including all enantiomeric and diasteriomeric forms and...
|
|
|
7361665 |
Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
The present invention provides compounds of formula I:
or a pharmaceutically acceptable derivative thereof, wherein R 1 , R 2 , A, G, and W are as described in the specification. These...
|
|
|
RE40245 |
Gyrase inhibitors and uses thereof
The present invention relates to compounds of the formula I:
or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase...
|
|
|
7358258 |
Prodrugs of an ERK protein kinase inhibitor
The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of...
|
|
|
7351733 |
Tetrahydrocarbazole derivatives and their pharmaceutical use
The present invention relates to novel compounds that are useful in the treatment of human papillomaviruses, and also to the methods for the making and use of such compounds.
|
|
|
7351711 |
Tricyclic indanyls as integrin inhibitors
The present invention is directed to substituted indanyl compounds of Formula (I):
Useful for treating integrin-mediated disorders such as, but not limited to unstable angina, thromboemboic...
|