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4683233 |
Salts of 2-keto-2H, 3H-1,2-benzisothiazole 1,1-dioxide as microbicides
A method of combating fungi and bacteria which comprises applying to such fungi, bacteria or a habitat thereof, a fungicidally or bactericidally effective amount of at least one salt of 3-keto-2-,...
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4673680 |
α.sub.2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
Selective α 2 -adrenergic receptor antagonists are effective in modifying gastrointestinal motility in a manner useful in the treatment of colonic spasm, irritable bowel syndrome and constipation.
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4672065 |
N-substituted phenoxyacetamide fungicides
The N-substituted phenoxyacetamides of this invention are effective fungicides. In particular, these compounds are particularly effective against Tomato Late Blight.
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4663327 |
1-heteroaryl-4-aryl-pyrazolin-5-ones
Microbicidally active novel 1-heteroaryl-4-aryl-pyrazolin-5-ones of the formula ##STR1## in which R represents hydrogen or alkyl, R 1 represents halogen, hydroxyl, optionally substituted alkyl,...
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4663341 |
Insecticidal n-aryl-3-aryl-4,5-dihydro-1h-pyrazole-1-carboxamides
This invention relates to N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds which are useful as pesticides, compositions containing those compounds, methods of controlling pests and...
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4661495 |
Arphamenine-related compounds useful for potentiating the immune response in a living animal
New arphamenine-related compounds are now provided, which are represented by the formula ##STR1## wherein R 1 denots a hydrogen atom or an amino-protecting group, R 2 denotes a...
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4661478 |
Process for potentiating effects of barbituate anesthesia to a warm-blooded animal
There is disclosed a process for treating a warm-blooded animal subjected to barbituate anesthesia to potentiate effects thereof wherein there is administered to the warm-blooded animal a...
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4661485 |
2-pyrimidylaminoalkoxymethyl-6-methyl-3,5-bis (alkoxycarbony-1)-1,4-dihydropyridine antihypertensive agents
Dihydropyridine Anti-ischaemic agents of the formula ##STR1## and their salts where R is aryl, R 1 and R 2 are each C 1 -C 4 alkyl or 2-methoxyethyl, Y is --(CH 2 ) n -- where n is 2, 3 or 4...
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4659363 |
N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof
The invention discloses novel N-(2-nitrophenyl)-2-aminopyrimidine derivatives of the general formula I ##STR1## wherein R 1 and R 2 are each independently NO 2 or CF 3 , with the proviso that...
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4659366 |
2-(alkoximinoalkoxycarbonyl)-phenylsulphonylurea herbicides and fungicides
Herbicidally and fungicidally active novel 2-(alkoximiminoalkoxycarbonyl)-phenylsulphonylureas of the formula ##STR1## in which R 1 represents hydrogen, halogen, alkyl, halogenoalkyl, alkoxy or...
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4657912 |
Granular bait compositions for the control of ants employing a pyrimidinone derivative in combination with ground pupa of silkworm
The invention is pesticidal granular bait compositions useful for the control of ants and a method of controlling ants using the composition.
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4657905 |
Novel hypotensive imidazothiadiazolealkanecarboxamides
Imidazothiadiazolealkenecarboxamides of the formula ##STR1## in which R 1 is hydrogen, aryl, substituted aryl or a cyclic or aliphatic hydrocarbon radical which is optionally interrupted by O, S,...
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4657908 |
Carbonyl derivatives
The invention relates to carbonyl derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention where is provided a guanidine derivative of...
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4638004 |
Substituted phenylsulphonylureas
Plant growth-regulating and fungicidally active novel substituted phenylsulphonylureas of the formula ##STR1## in which R is hydrogen, halogen, alkyl, alkoxy, halogenoalkyl or nitro, Y is oxygen...
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4636512 |
Anti-inflammatory 2-substituted-4-hydroxy-3-quinoline carboxamides
Novel racemates or optically active forms of 2-amino-4-hydroxy-3-quinoline carboxylic acid derivatives of the formula ##STR1## wherein X is in the 5-, 6-, 7- or 8-position and is selected from the...
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4632919 |
Process for prolonging recalcification, prothrombin and thrombin times of plasma
There is disclosed a process for prolonging recalcification, prothrombin and thrombin times of human plasma which comprises administering to a warm-blooded animal a composition selected from the...
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4629729 |
Endowed with anti-viral activity 2-alkylamino-4,6-dihalo pyrimidines
The invention relates to new pyrimidine derivatives endowed with anti-viral activity, to the method for the preparation thereof and to the pharmaceutical compositions containing them. Pyrimidine...
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4624952 |
Pyridazine and pyrimidine compounds active on the central nervous system as sedatives or anticonvulsants
The present invention relates to the compounds of formula ##STR1## in which X 1 represents N or ##STR2## X 2 represents N or ##STR3## provided that X 1 and X 2 are different from each other; R...
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4613603 |
Compounds with a nitrogen-containing heterocyclic nucleus, and drugs in which they are present
The invention relates to compounds with a nitrogen-containing heterocyclic nucleus, of the general formula: ##STR1## in which: Ar represents a group ##STR2## or a naphthyl group optionally...
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4613601 |
(1-benzodioxin-6-ylmethyl)-4-substituted piperazines having antipsychotic activity
Benzodioxine compounds of the formula: ##STR1## in which Het is a five- or six-membered heterocyclic radical containing from one to three hetero atoms, and from one to three double bonds,...
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4603136 |
Monoheteroring compounds and their use
Novel 2,4-diamino-5-(substituted naphthylmethyl)pyrimidines have been found to have superior antibacterial activity.
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4581453 |
Guanidinothiazole derivatives containing alkylene bridges, and their use for influencing lipid metabolism
The invention relates to guanidinothiazol derivatives of Formula (I) as defined herein, said compounds being useful for influencing lipid metabolism, as antithombotic agents and as antimycotic...
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4578388 |
Unsymmetrical guanidino, thioureido, isothioureido and nitromethyleneamino derivatives
The compounds are C 2 -C 8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino). N-(N'-substituted...
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4571406 |
Anti-hypertensive chromans and chromenes
Compounds of formula (I): ##STR1## wherein: either one of R 1 and R 2 is hydrogen and the other is selected from the class of C 1 -6 alkylcarbonyl, C 1 -6 alkoxycarbonyl, C 1 -6 alkylcarbonyloxy,...
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4563475 |
Guanidine derivatives for treating gastrointestinal motility dysfunction
A method for the treatment of a gastrointestinal motility dysfunction using a nitrogen containing heterocyclyl substituted acetylguanidine.
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4560491 |
Soft contact lens wetting solution and in-eye comfort solution containing preservative and method
Aqueous compositions for the wetting and rewetting of contact lenses and especially silicone, silicone copolymer (gas-permeable) and soft contact lenses are provided that include a preservative...
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4559345 |
Pyrimidine and s-triazine derivatives with antilipidemic activity
Pyrimidine and s-triazine derivatives of formula (I) ##STR1## in which X=CH or N; Y=for example halogen, alkoxy; W=for example --S--CH 2 --COOH, --O--CH 2 --COO alkyl, --NH--CH 2 --CONHCH 2 CH...
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4551461 |
Soft contact lens ambient temperature disinfectant and rinsing solution and method
Aqueous compositions for the ambient temperature or cold disinfection of soft contact lenses during non-wearing periods is provided. The composition includes water and a disinfectant composition...
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4533550 |
Heterocyclic derivatives of (4-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
Novel heterocyclic derivatives of (4-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles, useful as antifungal and antibacterial agents.
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4532246 |
2-(2-Pyridylaminoalkylamino)-4-pyrimidones
Pyridine derivatives are disclosed which are useful as histamine H 1 -antagonists.
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4532245 |
Pharmaceutical compositions
Pharmaceutical compositions of sulfonamide and sulfonamide-potentiator are disclosed. These compositions, which are suitable for injection administration, comprise an aldehyde in addition to the...
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4523945 |
2-Amino-6-(cyclopropylmethyl-amino)-pyrimidines useful as herbicides and microbicides
Compounds of the formula ##STR1## wherein R', R", R 1 , R 2 , X 1 , X 2 , Y 1 , Y 2 and Z are variable substituents of different types. The compounds are useful as herbicides and microbicides.
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4512993 |
4(Or 5)-(pyridinyl)-2-pyrimidinamines and cardiotonic use thereof
Shown are 2-(NB)-4-PY-5-Q-pyrimidines (I) and 2-(NB')-5-PY-4-Q'-pyrimidines (II) or salts thereof, where PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents, Q...
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4504482 |
[5(or 4)-(Pyridinyl)-2-pyrimidinyl]ureas and cardiotonic use thereof
N-R-N'-R'-N-[4(or 5)-PY-2-pyrimidinyl]ureas (I) or salts thereof, where PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents, R' is hydrogen or methyl and R is...
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4496564 |
Amide derivatives
The invention relates to amide derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of the...
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4492701 |
Isopropylamino pyrimidine derivative its preparation and therapeutic compositions containing the same
This invention relates to the 2-isopropylamino-pyrimidine-N-oxide of the formula: ##STR1## to a preparation process of the same consisting in submitting at 15° to 45° C., 2-isopropylamino...
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4486438 |
4-Hydroxy-3-quinoline-carboxylic acid derivatives
Novel 4-hydroxy-3-quinoline-carboxamides of the formula ##STR1## wherein X is in the 5,6,7 or 8-position and is selected from the group consisting of hydrogen, halogen, alkyl of 1 to 5 carbon...
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4478822 |
Drug delivery system utilizing thermosetting gels
This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a...
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4474751 |
Ophthalmic drug delivery system utilizing thermosetting gels
This invention describes the application of selected polymers as novel drug delivery systems which use the body temperature and pH to induce a liquid to gel transition of the polymer which contains...
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4468399 |
2-[2-(2-Aminoalkyl-4-thiazolylmethylthio)alkyl]-amino-5-substituted-4-pyr imidones
2-[2-(2-aminoalkyl-4-thiazolylmethylthio)-alkylene]amino-5-a
romatic-substit uted alkylene-4-pyrimidones and related compounds, H 2 receptor antagonists, useful in inhibiting gastric acid...
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4466966 |
N-aryl-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)ureas for intestinal disorders
N-(substituted phenyl)-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)ureas and pharmaceutically-acceptable salts thereof are disclosed to be useful in relieving the symptoms associated with irritable bowel...
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4451463 |
Alcohol derivatives
This invention relates to alcohol derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of...
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4443467 |
Antidiarrhoeal agents
Guanidines of formula ##STR1## and their pharmaceutically acceptable acid addition salts, (wherein R 1 and R 2 each represents lower alkyl or trifluoromethyl and R 3 and R 4 each represents...
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4438128 |
Cardioactive aryloxypropanolamines
The present invention provides aryloxypropanolamines of the general formula: ##STR1## wherein R 1 , R 2 , R 3 and R 4 , which may be the same or different, are hydrogen or halogen atoms or lower...
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4432979 |
Pyridone compounds
Cardiotonic 5-heteroaryl-substituted-2-pyridone compounds, pharmaceutical compositions, and a method for the treatment of congestive heart failure.
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4426385 |
Insecticidal bicyclooxyphenyl ureas
Novel bicyclooxyphenyl ureas, such as 1-(bicyclooxyphenyl)-benzoyl ureas, are provided which exhibit pesticidal activity. The compositions are conveniently prepared by reacting an isocyanate with...
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4415575 |
Suppression of gastric acid secretion using pyrimidylcarbamates
Heterocyclic carbamates are disclosed which have potent gastric secretion inhibitory properties. The heterocyclic substituent is a pyridyl group or a 6-membered heterocycle with two nitrogen...
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4415574 |
Soluble N.sub.2 substituted derivatives of 2,4-diamino 5-benzyl pyrimidine, process for their preparation and medicaments containing them
The present invention relates to novel soluble N 2 substituted derivatives of 2,4-diamino 5-benzyl pyrimidines. These derivatives correspond to the general formula III below: ##STR1## The novel...
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4410533 |
β-Lactam antibiotics, their preparation and use
The present invention provides a compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt or in-vivo hydrolyzable ester thereof wherein R 1 is a hydrogen atom, an...
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4405644 |
Medicaments for the treatment of disorders of lipometabolism and their use
The invention relates primarily to pharmaceutical compositions and medicaments containing a compound of Formula (I), infra as the active ingredient. Also included in the invention are methods for...
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