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4876252 |
4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines
This disclosure describes novel 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines having antiasthmatic activity.
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4873249 |
Pharmaceutical composition
The invention relates to pharmaceutical compositions having analgesic and/or anti-inflammatory effect comprising as active ingredient 2,4-diamino-5-(3,4-dimethoxy-benzyl)-pyrimidine or a...
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4871722 |
Synergistic veterinary composition and/or fodder premix and process for preparing same
The invention relates to a synergistic veterinary composition and/or a fodder premix useful for preventing or curing bacterial, fungal and protozoic infection particularly occurring at poultry...
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4868181 |
1,4-dihydropyridine derivatives with calcium agonist and alpha.sub.1 -antagonist activity
1,4-Dihydropyridine derivatives which combine both calcium agonist and alpha 1 -antagonist activity are useful in treating congestive heart failure. These derivatives are compounds having the...
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4866067 |
6-piperidino-2,4-diaminopyrimidine-3-oxide salt of 3-carboxypyridine n-oxide and topical, related compositions
The 6-piperidino-2,4-diaminopyrimidine-3-oxide salt of 3-carboxypyridine N-oxide, according to formula (I) ##STR1## is described. The compound (I) is useful in cosmetic and pharmaceutical field for...
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4863947 |
N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamides and methods of their production
This invention relates to novel N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds which are useful as pesticides, compositions containing those compounds, methods of controlling pests...
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4859679 |
Antiulcer (alkyldithio) quinoline derivatives
Quaternary 8-(alkyldithio)-1-(2-pyrimidyl)-quinolinium salts, inhibitors of the H 30 /K + ATPase enzyme, are useful in the treatment of ulcers.
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4853387 |
Piperidine derivatives, and their application in therapy
A compound which is a piperidine derivative of formula (I) ##STR1## in which: n is 1, 2, 3 or 4, R is hydrogen or a halogen, R', which is identical to R, is hydrogen or a halogen, either R...
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4853389 |
Diuretic and antihypertensive substituted-5-pyrimidinesulfonylureas
This invention relates to substituted 5-pyrimidinesulfonamides, pharmaceutically acceptable salts thereof and to processes for synthesis thereof. Other aspects of the invention concern...
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4851406 |
Heterocyclic-substituted indoles and pharmaceutical compositions containing them
The present invention provides indole derivatives of the general formula: ##STR1## wherein R 1 is a hydrogen atom or an alkyl, alkenyl, cycloalkyl, cycloalkenyl, carboxyl, cyano, alkylcarbonyl,...
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4849424 |
Pyrimidine derivatives
The present invention relates to novel pyrimidine derivatives of the general formula ##STR1## wherein R 1 represents a pyrazolyl, imidazolyl, or triazolyl group, R 2 represents hydrogen atom or...
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4845106 |
Heterocyclic thiazole compounds
Novel insecticides of the formula ##STR1## in which n is 0 or 1, X is S, O, ##STR2## Y is N or ##STR3## Z is a 5- or 6-membered nitrogen-containing heterocyclic ring, and R to R 9 variously...
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4845103 |
Non-particulate, non-flowable, non-repellant insecticide-bait composition for the control of cockroaches
A solid, non-particulate, non-flowable, non-repellant insecticide bait composition for consumer household control of cockroaches, comprises a pentadienone hydrazone insecticide compound, a food...
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4839363 |
Ergolinyl heterocycles for the treatment of Parkinson's disease and dyskinetic symptoms
Ergoline derivatives of the formula I ##STR1## wherein R 1 represents a hydrogen atom or a methyl group; R 2 represents a hydrogen atom or a methoxy group; R 3 represents a hydrocarbon group...
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4833132 |
Process for treating a warm-blooded animal with an antineoplastic/antime-tastatic effective composition
There is disclosed a process for treating a warm-blooded animal wherein there is administered to the warm-blooded animal a therapeutically effective amount of composition selected from the group...
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4826853 |
6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta( 1,2-B)pyridines and compositions and methods of use
Derivatives of 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1
,2-b]pyridine, and pharmaceutically acceptable salts and solvates thereof are disclosed, which possess anti-allergic and...
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4826854 |
Certain cycloalka-(b)-pyrazolo(3,4-d)-pyridin-3-one derivatives
Certain 8 to 12 membered cycloalka-[b]-pyrazolo[3,4,-d]-pyridin-3- one compounds which are useful as benzodiazepine receptor modulators are disclosed.
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4826843 |
Cerebral function enhancing diazinylpiperidine derivatives
A series of diazinylpiperidine compounds of Formula I ##STR1## wherein X is an ethylene chain or a 1,2-benzo ring; Y is carbonyl or methylene; R 1 is hydrogen or lower alkyl; and Z is an R 2 , R 3...
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4820512 |
Composition in the form of a gel for inducing and stimulating hair growth and for decreasing their loss, based on piperidinopyrimidine derivatives
Composition in the form of a gel for inducing and stimulating hair growth and for reducing hair loss, characterized in that it contains at least one compound of formula (I): ##STR1## in which R 1 ...
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4820710 |
Benzimidazole derivatives and pharmaceutical compositions containing them
Benzimidazole derivatives corresponding to the formula (1) ##STR1## in which X is CH or N, R 1 is either a hydrogen atom, or a benzyl radical which can bear 1 to 3 substituents chosen from...
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4816457 |
Aralkylaminoethanol heterocyclic compounds
Heterocyclic aminoethanols of the formula: Het--CHOH--CH 2 --NH-aralkyl where Het is a 6-10 membered N-heterocycle are disclosed. The compounds are useful as pharmaceuticals.
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4814338 |
Pyrimidine derivative, process for preparing same and agricultural or horticultural fungicidal composition containing same
Disclosed are pyrimidine derivatives represented by general formula ##STR1## wherein Z 1 represents an alkynyl group, an alkenyl group, an alkoxy group, an alkenyloxy group, or an alkynyloxy group...
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4812309 |
Gel insecticidal compositions
An insecticidal gel composition comprising on a weight basis 14% to 22% of the gellant α-hydro-Ω-hydroxypoly(oxyethylene)poly(oxypropylene(poly(o
xyet hylene) block copolymer having an average...
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4810719 |
Anti-inflammator 1,n-diarylpyrazol-3-amines
There are described compounds of formula I, ##STR1## in which either R 2 represents hydrogen, alkyl or Ar 2 , and R 3 represents hydrogen, alkyl or alkyl substituted by Ar 3 ; or R 2 and...
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4798831 |
Substituted thieno[2,3-B]furan-2-sulfonamides as antiglaucoma agents
Thieno[2,3-b]furan-2-sulfonamides are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure and glaucoma.
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4792557 |
2,4-diamino-5[4-amino (or dimethylamino)-3,5-dimethoxybenzyl]pyrimidine and antibacterial composition thereof
2,4-Diamino-5-benzylpyrimidines of the formula ##STR1## wherein R 1 , R 2 , A, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful...
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4786644 |
1-aryl-3-quinolinecarboxamide
Novel 1-aryl-3-quinolinecarboxamides and 1-aryl-3-isoquinolinecarboxamides, processes for the preparation thereof, and methods for treating pain and inflammation utilizing compounds and...
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4783468 |
Insecticidal 5-pyrimidine carbonitriles
The invention relates to novel substituted 2,4-diamino-5-cyano-pyrimidines of formula ##STR1## wherein R 1 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl, R 2 is...
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4783459 |
Anilinopyrimidine fungicides
There are described new pyrimidine derivatives of the general formula I ##STR1## in which n is 0, 1 or 2; R 1 is (a) the group --CXR 5 , where X is oxygen or sulphur and R 5 is hydrogen, a...
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4782052 |
Octahydroindolo[2,3-a]quinolizin-1-yl-alkanecarboxylic acid amines and their therapeutically useful acid addition salts, pharmaceutical compositions containing them and process for preparing same
The invention relates to new 1,2,3,4,6,7,12,12b-octahydroindolo[2,3,-a]quinolizin-1-yl-al
kanecarboxylic acid amides of the formula (I), ##STR1## wherein R 1 and R 2 stand independently for a...
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4777182 |
6-Amidino-2-naphthyl 4-guanidinobenzoate derivatives and pharmaceutical composition containing them
Amidine compounds of formula (I) ##STR1## and the pharmaceutically acceptable acid addition salts thereof are novel and are of use as anti-trypsin, anti-plasmin, anti-kallikrein, anti-thrombin and...
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4774083 |
Novel pharmaceutical tablets
Novel tablets comprising (a) 80 to 98% by weight of a mixture of trimethoprim and/or an acid addition salt thereof and a sulfonamide and/or a salt thereof in a weight ratio of 1:20 to 20:1 and (b)...
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4774249 |
Pyrimidine derivatives for treating malaria
The pyrimidine derivatives of formula I ##STR1## wherein R 1 is naphthyl, substituted naphthyl or substituted phenyl; R 2 is hydrogen or lower alkoxy; and A is an optionally present ethylene or...
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4772609 |
Antiviral guanidine derivatives and compositions therefor
This invention relates to antiviral organic guanidine derivatives compositions; a process of producing the antiviral compositions; and a method for inhibiting viruses utilizing the compositions....
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4771061 |
Substituted piperazine-1,4-naphthalenediones useful for treating asthma, allergic diseases and/or inflammation
This disclosure describes certain substituted piperazine-1,4-naphthalenediones useful as anti-asthmatic agents.
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4769371 |
Dihydropyrimidine carboxylic acid esters
Pyridine compounds of the formula ##STR1## wherein R 4 is aryl or heterocyclo are disclosed. These compounds are useful as cardiovascular agents due to their calcium entry blocking vasodilator...
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4762834 |
3-alkoxy-2-(N-pyrrolidino)-N-pyrimidinyl- or -N-pyrazinolpropylamines useful for treatment of cardiovascular disorders
The present invention relates to new compounds of the general formula: ##STR1## in which Ar represents thienyl, furyl, pyridyl or an optionally substituted phenyl group, R represents a linear or...
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4749698 |
Antihypertensive derivatives
Compounds having the general structure ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are defined herein, which exhibit antihypertensive activity.
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4743442 |
Skin care composition
Skin care composition containing mineral salts releasing sodium, potassium, megnesium, calcium and zinc salts in defined concentration, and, optionally, compounds releasing copper, manganese,...
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4729995 |
Pyrimidine 2,4-dioxamate compounds and pharmaceutical compositions
Novel pyrimidine compounds of the formula: ##STR1## wherein R 1 and R 1 ' are each hydrogen atom, a lower alkyl, benzyl, an alkali metal, or ammonium; R 2 is hydrogen atom, a halogen atom, a...
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4711888 |
Hydroxy and alkoxy pyrimidines
2-Amino-4-substituted-5-(hydroxy or alkoxy)pyrimidines, which may be 6-substituted, and derivatives thereof are inhibitors of leukotriene synthesis and are therefore useful for the treatment of...
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4710501 |
Circulation active pyrimidinyl-dihydropyridines
Novel compounds of the formula ##STR1## in which R 2 is hydrogen or a substituent, and R 1 is optionally substituted alkyl or alkenyl, exhibit positive inotropic activity on the cardiac...
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4705792 |
4-amino-2-(imidazolidin-2-on-1-yl)-5-(3-trifluoromet hyl-phenyllaminocarbonyl)pyrimidines for antithrombotic prophylaxis and treatment
4-Amino-2-(imidazolidin-2-on-1-yl)-5-(3-trifluoromethylpheny
laminocarbonyl) pyrimidine of the formula I ##STR1## in which R 1 , R 2 , R 3 , R 4 and R 5 have the indicated meanings, and their...
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4704390 |
Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents
Novel phenyl and heterocyclic tetrahydropyridyl and piperazinyl alkoxy benzheterocyclic compounds are described which have valuable neuroleptic properties by virtue of their dopamine autoreceptor...
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4698344 |
1-Heteroaryl-4-aryl-pyrazolin-5-ones for use as medicaments
The invention relates to 1-heteroaryl-4-aryl-pyrazolin-5-ones, a preparation process and the use in combating diseases, in particular for use as lipoxygenase inhibitors.
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4696933 |
Guanidine compounds useful as histamine H2-antagonists
The invention relates to amide derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of the...
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4695571 |
Tricyclic oxindole antiinflammatory agents
Tricyclic oxindole carboxamides, prepared by (a) reaction of an isocyanate with the basic ring system or (b) ammonolysis of a corresponding alkyl ester, are non-steroidal antiinflammatory agents...
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4695567 |
Pyrrolobenzimidazoles, pharmaceutical compositions containing them and method of using them to treat certain heart and circulatory diseases
The present invention provided pyrrolobenzimidazoles or tautomer thereof, of the general formula: ##STR1## wherein R 1 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 3 -C 7 cycloalkyl; ...
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4689328 |
Process for controlling hyperlipidemia
A process for controlling hyperlipidemia in mammals is disclosed. In this process a mammal suffering from hyperlipidemia is treated with a hyperlipidemia controlling effective amount of a compound...
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4686224 |
Oxindole antiinflammatory agents
Ketone containing 1-substituted oxindole-3-carboxamides as antiinflammatory agents prepared by reaction of the 1-substituted oxindole with an isocyanate or by aminolysis of the corresponding alkyl...
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