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5772990 |
Composition for slowing down the loss of hair based on pyrimidine N-oxides triaminosubstituted or their sulfoconjugated
Composition for slowing down the loss of hair and for inducing and stimulating its growth, comprising a compound of formula: ##STR1## in which: R 1 and R 2 denote H or an alkyl and do not...
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5773447 |
Compounds for treating disorders of lipid metabolism and their preparation
The present invention relates to tertiary 4-amino-2-ureidopyrimidine-5-carboxamides of formula I: ##STR1## in which R 1 is (C 1 -C 8 )-alkyl wherein one or more H are replaced by F; R 2 is...
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5773446 |
Diamino pyrimidines
Compounds of formula I ##STR1## wherein either R 1 signifies straight-chain C 5 -10 -alkyl, branched C 3 -5 -alkyl, C 3 -6 -cycloalkyl or C 3 -5 ω-carboxyalkyl and R 2 and R 3 signify C 1 -5...
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5763450 |
Substituted benzyl pyrimidines
Compounds of the formula: ##STR1## in which R 1 is lower alkoxy, R 2 is bromine or lower alkoxy, and R 3 is aryl, heteroaryl or a group --Q--R 30 , wherein Q is ethylene, vinylene or ethynylene...
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5763448 |
Pyrmidine derivatives
A class of substituted pyrimidine derivatives are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment of disorders of the dopamine system, in particular...
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5760037 |
Derivatives of N'N'-di(aralkyl)-N,N'-di(2-azaaralkyl)alkylene diamine and the use thereof in pharmaceutical and cosmetic compostions
These compounds correspond to the following general formula: ##STR1## where: n is 0, 1, or 2, m is are 1, 2, or 3, R, R 1 , R 2 , and R 3 , whether identical or different, represent an atom...
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5756532 |
Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives
The compounds of formula I: ##STR1## wherein R 1 and R 2 are, independently, hydrogen, alkyl, phenyl or benzyl; or R 1 and R 2 , taken together, are benzylidene optionally substituted with R 3 ...
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5747476 |
Treatment of equine protozoal myeloencephalitis
The present invention relates to compositions and methods for treating equines, such as horses, afflicted with equine protozoal myeloencephalitis or EPM. The therapeutic compositions comprise a...
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5739143 |
Imidazole compounds and compositions
Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
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5739142 |
4-aminobenzoylguanidine derivatives
4-Aminobenzoylguanidines of the formula I ##STR1## in which A, R 1 , R 2 and R 3 have the meanings given, and the physiologically unobjectionable salts thereof exhibit antiarrhythmic properties...
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5739134 |
N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2h-benzopyran, dihydrobenzodioxin, benzodioxole, dihydrobenzodioxepin, or tetrahydrobenzoxepin)carboxamide derivatives
N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives, their N-oxide forms and pharmaceutically acceptable salts having gastrointestinal...
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5728708 |
Pharmacologically active pyridine derivatives and processes for the preparation thereof
N-phenyl-2-pyrimidineamine derivatives of formula I ##STR1## wherein the substituents are as defined in claim 1 and the derivatives of formula I can be used, for example, in the treatment of tumour...
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5728687 |
Antitumour compositions containing taxane derivatives
Pharmaceutical compositions having therapeutic synergy comprising taxol or Taxotere or analogues thereof combined with at least one therapeutically useful substance for treating neoplastic diseases.
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5728696 |
Acaricidal, insecticidal and nematicidal substituted (hetero)arylalkyl ketone oxime O-ethers, processes for their preparation, agents containing them, and their use as pesticides
Acaricidal, insecticidal and nematicidal substituted (hetero)arylalkyl ketone oxime O-ethers, processes for their preparation, agents containing them, and their use as pesticides. The invention...
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5723469 |
Amino-acid amide derivatives, agricultural or horticultural fungicides, and method for producing the same
The present invention provides an agricultural or horticultural fungicide including an effective amount of an amino-acid derivative represented by the formula: ##STR1## wherein R 1 represents a...
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5719192 |
Use of terbinafine for the therapeutic treatment of pneumocystosis
A method of use comprising administering terbinafine for the primary and secondary prophylaxis and treatment of Pneumocystis carinii pneumonia, including oral administration of terbinafine at does...
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5710159 |
Integrin receptor antagonists
This invention relates to novel heterocycle compounds including but not limited to 3- 3- 3-(imidazolin-2-yl amino)propyloxy!isoxazol-5-ylcarbonylamino!-2-(benzyloxycarb
onylamino)-pro pionic acid,...
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5705502 |
Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof
Described are N-phenyl-2-pyrimidineamine derivatives of formula I ##STR1## wherein R 1 is a substituted cyclic radical, the cyclic radical being bonded at a ring carbon atom in each case and being...
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5698564 |
Diphenyl disulfide compounds
Diphenyl disulfide compounds having an inhibiting activity against the production of Interleukin-1β (IL-1β) or the release of Tumor Necrosis Factorα (TNFα), which are useful in the treatment or...
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5698562 |
Palatable trimethoprim oral solution
This invention is directed to an aqueous pharmaceutical composition with 1.25 mg to about 10 mg trimethoprim per mL (wt/vol) of solution and a compound of suitable acid strength to permit the...
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5698563 |
Bis- hydrazones!
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises bis(guanylhydrazone) of...
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5688798 |
Pyrimidine compounds
Compounds of the formula ##STR1## wherein R 1 and R 2 each individually are lower-alkyl or amino, A is ##STR2## B is hydrogen in A 4 , A 5 and A 6 ; ##STR3## in A 1 -A 6 ; lower-alkoxy in...
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5684005 |
Pharmacologically active CNS compounds
A class of substituted phenylpyrimidine compounds are disclosed which are potent inhibitors of the excitatory amino acid, glutamate. Such compounds are useful in the treatment or prevention of a...
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5674871 |
Iontophoretic delivery of an antimigraine drug
The present invention relates to the iontophoretic delivery to a patient, more in particular to a migraine patient, of a compound of formula (I) as shown hereinunder. The invention also relates to...
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5663176 |
Microbicides
Mixtures of certain triazole fungicides (component I) and 4,6-dimethyl-N-phenyl-2-pyrimidinamine (component II) achieve synergistically enhanced activity against fungus infestation. Components I...
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5637314 |
Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
A method for treating atopic dermatitis, hayfever, asthma and pruritis that includes topical or systemic application of an effective amount of buspirone or a buspirone derivative or its...
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5631017 |
Topical application of buspirone for treatment of pathological conditions associated with immune responses
A method for the treatment of a cutaneous, ocular, or mucosal pathological condition which is associated with an immune response in a human or other mammal, that includes topical application of an...
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5627188 |
Compositions and methods of combatting fungi employing triazoles and a pyrimidinamine derivative
Mixtures of certain triazole fungicides (component I) and 4-cyclopropyl-6-methyl-N-phenyl-2-pyrimidinamine (component II) have a synergistically increased activity against fungus infestation....
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5627189 |
Insecticidal 5-substituted-2,4-diaminopyrimidine derivatives
An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a compound of the formula: ##STR1## wherein R, R 1 , R 2 , R 3...
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5624929 |
Pyrroloquinoline and pyrrolophenothiazine carboxamides and related compounds
Compounds of the formula ##STR1## wherein the broken line represents an optional double bond; X is O, S, CH 2 or CH 2 CH 2 ; R 1 is selected from the group consisting of hydrogen, halogen, C 1 ...
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5622917 |
Substituted 1H--3-aryl-pyrrolidine-2,4-dione derivatives
The invention relates to new 1H-3-aryl-pyrrolidine-2,4-dione derivatives of the formula (I) ##STR1## in which A, B, X, Y and G have the meanings given in the description, to a plurality of...
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5622954 |
5[W(substituted aryl)alkenylene and alkynylene]-2,4-diaminopyrimidines as pesticides
5-Substituted-2,4-diaminopyrimidines, and agriculturally acceptable salts thereof, when present in insecticidally or acaricidally effective amounts, and with a suitable agricultural carrier, are...
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5618818 |
Muscarinic agonist compounds
A muscarinic agonist compound having the structure (I) or (II): ##STR1## where R is methyl or dimethylamino; or ##STR2## where R' is dimethylamino.
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5618831 |
Composition and method for treating cancer
A pharmaceutical composition for treatment of cancer in an animal comprising: (A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds...
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5612340 |
Pyrimidineamine derivatives and processes for the preparation thereof
N-phenyl-2-pyrimidineamine derivatives of formula (I) wherein the substituents are as defined in claim 1 are described. Those compounds can be used for example, in the treatment of tumour diseases....
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5604251 |
Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain and their use as angitensin II receptors
Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain, process for their preparation and their use Compounds of the formula (I) ##STR1## in which R 1 is, for...
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5597828 |
Certain 2,4-diamino-5-(2,3-dihalophenyl)-6-substituted pyrimidines which are pharmacologically active CNS compounds
A class of substituted phenylpyrimidine compounds are disclosed which are potent inhibitors of the excitatory amino acid, glutamate. Such compounds are useful in the treatment or prevention of a...
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5595994 |
1-Halopyrazin- and 1-halopyrimidin-4-amino-4-alkylpiperidines
The present invention relates to novel heteroarylpiperidines of formula (I): ##STR1## in which Hal is a halogen atom, Alk is a C 1 -4 alkyl group and one of X, Y and Z is a nitrogen atom while the...
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5591747 |
Fungicidal mixtures
A fungicidal synergistic mixture containing a) a compound of the formula I ##STR1## where the substituents have the following meanings: R 1 is a phenyl radical which can carry one to three of...
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5589492 |
Heterocyclic compounds and their use in the treatment of Type-II diabetes
A compound of the formula A 1 --X--(CH 2 ) n --O--A 2 --A 3 --CO.R 2 (I) or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof, and/or a pharmaceutically acceptable...
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5587380 |
Certain 2,4-diamino-5-(2,3,5-TRI-chlorophenyl)-6-substituted-pyrimidines which are pharmacologically active CNS compounds
A class of substituted phenylpyrimidine compounds are disclosed which are potent inhibitors of the excitatory amino acid, glutamate. Such compounds are useful in the treatment or prevention of a...
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5585381 |
Pyrimidine derivatives and pharmaceutical composition
A pyrimidine derivative of the formula (I): ##STR1## wherein R 1 is a hydrogen atom, alkyl of 1 to 6 carbon atoms, haloalkyl of 1 to 6 carbon atoms, or --NHR 11 group; R 2 is a hydrogen or...
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5578599 |
Stimulation of hair growth with minoxidil and a 5α-reductase inhibitor
An improved method and composition for promoting hair growth in mammals for treating various forms of alopecia or male pattern baldness comprising the concomitant administration of potassium...
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5576316 |
Method for inhibiting tumor growth rate using creatine or creatine analogs
A method for inhibiting tumor growth rate using creatine or creatine analogs is described. The creatine or creatine analogs are administered to subjects such that tumor growth rate is inhibited....
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5574040 |
Pyrimidine compounds and methods of use to derivatize neighboring lysine residues in proteins under physiologic conditions
A compound according to the formula: ##STR1## wherein A=CH 3 or CH 2 CH 3 and ##STR2## wherein X=NH 2 , CH 2 or CH 2 CH 3 ; X'=CH 3 or CH 2 CH 3 ; Y=NH 2 , NHCH 3 , N(CH 3 ) 2 ; and Z=H,...
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5571816 |
Pyrimidines
Compounds of the formula I ##STR1## in which R 1 to R 6 have the stated meanings, and the readily water-soluble salts of these compounds, and a process for the preparation thereof are described....
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5567705 |
Microbicides
Mixtures of certain triazole fungicides (component I) and 4-cyclopropyl-6-methyl-N-phenyl-2-pyrimidinamine (component II) have a synergistically increased activity against fungus infestation....
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5563159 |
Dithiocarbonimide derivatives useful as acaricidal, fungicidal, and insecticidal agents
There is disclosed a dithiocarbonimide derivative of the formula: ##STR1## wherein B is a C 1 -C 6 alkyl group; X is an NH group or an oxygen atom and Y is a nitrogen atom or a CH group, A is a...
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5561135 |
N,N,N',N'-tetrasubstituted-1,2-ethanediamine derivative compounds
The invention relates to new N,N,N'N'-tetra-substituted-1,2-ethanediamine compounds of the general formula (I): ##STR1## wherein X is a carbonyl (CO), hydroxymethylen (CHOH) or...
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5556859 |
N-(4-pyrimidinyl)amide pesticides
N-(4-Pyrimidinyl)amide pesticides of the formulas ##STR1## and N-oxides and salts thereof, wherein the variable groups are as defined in the specification, are active against nematodes, insects,...
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