Patents in Class 514/274

Matches 1 - 50 out of 803

Match	Document	Document Title
1	7615569	Inhibitors of ion channels Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly,...
2	7615542	Dioxolane thymine and combinations for use against 3TC/AZT resistant strains of HIV The present invention relates to the use of a dioxolane thymine compound according to the chemical structure of Formula (I): where R 1 is H, an acyl group, a C 1 -C 20 alkyl or ether group, a...
3	7612093	Compositions of treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination therapy Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol...
4	7608618	Urea or thiourea substituted 1,4-pyrazine compounds useful as anti-cancer agents and for inhibiting Chk1 Compounds of the formula wherein: Y′ is O or S, W′ is optionally substituted, Z′ is selected from the group consisting of wherein Q′ is OR 7 and R 7 is C 1-3 alkyleneC 3-8...
5	7605137	Combination therapy comprising cloretazine This invention provides a method for treating tumor in a subject comprising administering to the subject an effective amount of: (1) VNP40101M, or its equivalent; and (2) a nucleoside, or a...
6	7601730	Carboxylic acid derivatives, their preparation and use Carboxylic acid derivatives where R—R 6 , X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling...
7	7592353	Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses Disclosed are compounds of formula (I): wherein R 1 and R 4 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are...
8	7582647	Carboxylic acid derivatives, their preparation and use Carboxylic acid derivatives where R—R 6 , X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling...
9	7569575	Synthesis of locked nucleic acid derivatives The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α- L -oxy-LNA, amino-LNA, α- L -amino-LNA, thio-LNA, α- L -thio-LNA, seleno-LNA and...
10	7566724	Glycine derivative and use thereof The compounds of the disclosure, for example, the compound represented by the formula: has excellent therapeutic and prophylactic effects against inflammatory bowel disease. Further, they are...
11	7563788	Substituted Imidazo[1,2-a]pyridines as Antibacterial Agents Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable...
12	7560483	Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
13	7560467	Indazolo-tetrahydropyrimidine-carboxamide derivative kinase inhibitors The present invention relates to indazolo-tetrahydropyrimidine-carboxamide derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such...
14	7557138	5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated Kv1.3 potassium channel Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects,...
15	7544692	Polymorphic and other crystalline forms of cis-FTC Solid phases of (−)-cis-FTC, which are designated herein as amorphous (−)-FTC and Forms II and III (−)-cis-FTC) are provided that can be distinguished from Form I (−)-cis-FTC by X-ray...
16	7531536	Pyrazole compounds useful as protein kinase inhibitors This invention describes novel pyrazole compounds of formula IIIa: wherein R 1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl,...
17	7528142	Aminopyrimidines useful as kinase inhibitors The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of...
18	7517889	2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin D2 receptor antagonists The present invention is directed to a compound of Formula (I) wherein Cy 1 , Cy 2 , L 1 , L 2 , and R 1 are as defined herein, a pharmaceutical composition comprising a pharmaceutically...
19	7511051	Cidofovir peptide conjugates as prodrugs Cidofovir-based compounds having an amino acid, dipeptide or tripeptide attached to a cidofovir or cyclic cidofovir framework. The compounds show enhanced oral bioavailability and increased binding...
20	7511027	Method of treating hepatitis delta virus infection A method for the treatment for hepatitis delta infection in a host, that includes administering an effective amount of a nucleoside or a nucleoside analog that suppresses the expression of the...
21	7495006	2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and...
22	7482439	Caprazene as novel compound and derivatives thereof, and caprazol as novel compound and derivatives thereof Caprazene and caprazol could be synthesized by hydrolysis of a caprazamycin. There could be synthesized a caprazene-1′″-amide derivative of the formula (II) and a caprazene-1′″-ester...
23	7482356	Bicyclic pyrazolone cytokine inhibitors The present invention relates to 6,7-dihydro-5H-pyrazolo[1,2α]pyrazol-1-ones which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or...
24	7482355	Pyrimidine derivatives as modulators of chemokine receptor activity Compounds of formula (1), pharmaceutically acceptable salts, solvates and in vivo hydrolysable esters thereof, have activity as pharmaceuticals, in particular as modulators of chemokine receptor...
25	7473695	4-imidazolin-2-one compounds The present invention relates to a compound of the formula [I]: wherein G 1 is an alkyl which is substituted by a halogen atom or an alkoxy, or a group of the formula: ...
26	7470686	Method of inhibiting the expression and/or the activity of JNK The present invention is related to benzazole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such benzazole derivatives. Said...
27	7470672	Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives This invention is in the field of chemical restructuring of pharmaceutical agents known to cause tissue toxicity as a side effect, by producing their orotate derivatives. More particularly, it...
28	7465736	Azole methylidene cyanide derivatives and their use as protein kinase modulators An azole derivative of formula (I) a medicament that contains the azole derivative of formula (I), a method of treating a disease with the azole derivative of formula (I), and a method of...
29	7465735	5-Phenypyrimidines their preparation compositions comprising them and their use 5-Phenylpyrimidines, their preparation, compositions comprising them and their use 5-Phenylpyrimidines of the formula I in which the substituents and the index are as defined below: R 1 ,R 2 ...
30	7452898	Phosphonate compounds The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and...
31	7452879	Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms...
32	7419983	Gonadotropin-releasing hormone receptor antagonists and methods related thereto GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: ...
33	7402588	Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane A method and composition for the treatment of HIV and HBV infections in humans is disclosed that includes administering an effective amount of...
34	7378446	Compound having anti-HCV activity and process for producing the same The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its...
35	7368456	Methods, compositions, and kits for organ protection during systemic anticancer therapy Methods, compositions, and kits are presented for local tissue protection during systemic administration of anticancer therapeutic agents.
36	7368455	6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines The present invention relates to 2-(4-fluorophenyl)-3-(2-phenoxy-pyrimidin-4-yl)-6,7-dihydro- 5H-pyrazolo-[1,2-a]pyrazol-1-one, including all enantiomeric and diasteriomeric forms and...
37	7364752	Solid dispersion pharamaceutical formulations A pharmaceutical composition is disclosed which comprises a solid dispersion of an HIV protease inhibitor in a water soluble carrier, such as PEG, having enhanced bioavailability and improved...
38	7361654	Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity...
39	7358239	Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z...
40	7354928	Small molecule inhibitors targeted at Bcl-2 The present invention relates to small molecule antagonists of Bcl-2 family proteins such as Bcl-2 and/or Bcl-X L . In particular, the present invention provides non-peptide cell permeable small...
41	7345046	Heteroaryl-fused pyrimidinyl compounds as anticancer agents Heteroaryl-fused pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the...
42	7345039	Enhancement of effectiveness of 5-fluorouracil in treatment of tumor metastases and cancer Tumor growth and metastases in cancer patients are inhibited by administration of a combination therapy including effective amounts of 5-Fluorouracil and a methylol transfer agent such as...
43	7335657	Cytokine inhibitors Disclosed are compounds of formula (I) Where Ar 1 , X, Y, Q, W, R 3 , R 4 , R 5 , R 6 and R y are defined herein. The compounds of the invention inhibit production of cytokines involved in...
44	7317014	Bio-active pyrimidine molecules The present invention relates to novel derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their...
45	7312209	Acridone inhibitors of IMPDH enzyme Compounds having the formula (I), wherein R 3 is selected from H, OH and NH 2 ; R 30 is selected from ═O and ═S; W is —C(═O)—, —S(═O)—, or —S(O) 2 —; or W may be —CH 2...
46	7294627	Chemical compounds Compounds of formula (I) in which R 1 , R 2 , R 3 and R 4 , have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.
47	7291642	Bradykinin-B1 antagonists, process for their preparation and their use as medicaments The present invention provides bradykinin-B1 antagonists of the formula in which A, Ar, G, Q, R 1 and R 4 are as defined in claim 1, their enantiomers, their diastereomers, their mixtures and...
48	7288544	Pyrimidine compounds useful as N-type calcium channel antagonists Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when...
49	7273862	Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z...
50	7265115	Diazabicyclic CNS active agents Compounds of formula I: or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals.

Matches 1 - 50 out of 803

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