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8258147 Compositions and methods for treating and preventing dermatoses  
The invention encompasses protectant agents including uracil or a metabolite thereof that effectively prevent and/or treat the cutaneous toxicities and dermatological side-effects associated with...
8252773 Combination therapy with organic arsenicals  
The invention provides a combination therapy wherein one or more other therapeutic agents are administered with an organic arsenical, preferably SGLU-1 or a pharmaceutically acceptable salt...
8252807 Methods of inhibiting the interaction between S100 and the receptor for advanced glycation end-products  
A method of inhibiting an interaction between a S100 protein and the receptor for advanced glycation end-products is provided comprising administering to a subject a therapeutically effective...
8242129 6-phenylpyrimidinones as PIM modulators  
A compound having Formula I or II (Formula I) or (Formula II), or a pharmaceutically acceptable salt thereof, wherein X, Z, R1, R2, R11 and R12 are as defined in the specification; pharmaceutical...
8236814 Composition and method for treatment of warts  
Provided is a composition comprising 5-FU and salicylic acid. This composition is useful as a treatment for warts. As opposed to conventional compositions and methods, this composition need only...
8232275 2,2-bis-(hydroxymethyl)cyclopropylidenemethyl-purines and -pyrimidines as antiviral agents  
Compounds which are active against viruses have the following formulas: wherein B is a purine or pyrimidine heterocyclic ring or base. In a preferred embodiment, the purine include 6-aminopurine...
8222266 Azabicyclo [3.1.0] hexyl derivatives as modulators of dopamine D3 receptors  
The present invention relates to certain azabicyclo compounds of formula (I)′: wherein the various groups are defined herein and that are modulators of dopamine D3 receptors, e.g. to treat drug...
8222257 Phosphono-pent-2-en-1-yl nucleosides and analogs  
Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections and/or cell proliferation. The compounds...
8217063 Lactam-substituted dicarboxylic acids and use thereof  
The present application relates to novel lactam-substituted dicarboxylic acid derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their...
8207142 Inhibitor of DNA methylation  
Zebularine has hypomethylating activity, and can be used to inhibit, reverse, and/or reduce DNA methylation in vivo and in vitro. Methods are provided for treating methylation-linked conditions...
8207182 Substituted cyclic urea derivatives and the use thereof as vanilloid receptor 1 modulators  
The present invention relates to substituted cyclic urea derivatives corresponding to formula I, to processes for the preparation thereof, to medicinal drugs containing such compounds, to the use...
8198273 Compounds and methods for kinase modulation, and indications therefor  
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described...
8193183 2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin D2 receptor antagonists  
The present invention is directed to a compound of Formula (I) wherein Cy1, Cy2, L1, L2, and R1 are as defined herein, a pharmaceutical composition comprising a pharmaceutically effective amount...
8188104 Anti-infective agents and uses thereof  
This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such...
8188105 Therapeutic agent for inflammatory bowel disease comprising uracil derivative as active ingredient  
A therapeutic agent for inflammatory bowel disease contains, as an active ingredient, a uracil derivative or a pharmaceutically acceptable salt thereof, represented by formula (1) where the R1 and...
8178131 Pyrrolopyridines as kinase inhibitors  
Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in...
8178549 Azabicyclo [3. 1. O] hexyl derivatives as modulators of dopamine D3 receptors  
The present invention relates to novel compounds of formula (I) or a salt thereof: wherein R1 is a 5-membered heteroaryl group, optionally fused with a 6-membered hetero or carbocycle; such 5 or...
8178548 Anti-infective agents and uses thereof  
This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such...
8173664 Modified pyrimidine glucocorticoid receptor modulators  
The present invention provides a class of modified pyrimidine compounds, compositions and methods of using the compounds as glucocorticoid receptor modulators.
8173663 Dipeptidyl peptidase inhibitors  
Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently...
8173665 I-pheny 1-3,4-dihydropyrimidin-2(1H)-one derivatives and their use  
The invention relates to 4-cyanophenyl, 2-sulfanyl, 1-phenyl pyrimidine derivatives, processes for their preparation, and pharmaceutical compositions of the same. Compounds and compositions of the...
8153644 Diacylglycerol acyltransferase inhibitors  
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
8153630 Kinase inhibitors  
Disclosed are protein kinase inhibitors of Formula Ia and Ib, compositions comprising such inhibitors, and methods of use, thereof. More particularly, these compounds and compositions are...
8148380 Antibacterial amide and sulfonamide substituted heterocyclic urea compounds  
The present invention provides novel amide and sulfonamide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and...
8148390 Monocyclic anilide spirolactam CGRP receptor antagonists  
The present invention is directed to compounds of Formula I: (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful...
8148389 Pharmaceutical comprising PPAR agonist  
An object of the present invention is to provide an agent for promoting proliferation of a meibomian gland epithelial cell and a corneal epithelial cell, as well as provide an agent for treating...
8129358 Substituted pyrazole and triazole compounds as KSP inhibitors  
Disclosed are new substituted pyrazole and triazole compounds of Formula (I) and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with...
8129399 Aminopyrimidines useful as kinase inhibitors  
The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of...
8124628 Diaryl substituted alkanes  
The instant invention provides compounds of Formula II which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula II are useful as anti-atherosclerotic, anti-asthmatic,...
8119635 Diazabicyclic central nervous system active agents  
Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
8106064 Pyrimidine-2,4-dione HIV reverse transcriptase inhibitors  
The invention is related to pyrimidine-2,4-dione HIV reverse transcriptase inhibitors of Formula (I), (II), or (III): or a pharmaceutically acceptable salt, thereof, compositions containing such...
8101625 Pyrimidinones as Casein Kinase II (CK2) modulators  
A compound having Formula (I) or a pharmaceutically acceptable salt thereof, wherein X, R1 and R2 are defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.
8101615 1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors  
The invention relates to novel heterocyclic derivatives of the general formula (I), processes for their preparation, and their use in medicaments, especially for the treatment of chronic...
8101626 GPR119 receptor agonists in methods of increasing bone mass and of treating osteoporosis and other conditions characterized by low bone mass, and combination therapy relating thereto  
The present invention relates to the use of GPR119 receptor agonists for treating or preventing a condition characterized by low bone mass, such as osteoporosis, and for increasing bone mass in an...
8093246 O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer  
O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described. Particular compounds of the invention are of formula I:
8093245 4-amino-1H-pyrimidin-2-one based compounds, compositions comprising them and methods of their use  
4-Amino-1H-pyrimidin-2-one-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of various diseases and disorders are disclosed....
8088783 MAPK/ERK kinase inhibitors  
Compounds of the substituted 1,3-dialkyl-2,4-dioxo-6-(pyrimidinylamino)-1,2,3,4-tetrahydr opyrimidine-5-hydroxamic acids, show below: wherein the variables are as defined herein, and...
8084458 Synthesis of locked nucleic acid derivatives  
Methods are described for the synthesis of Locked Nucleic Acid (LNA) derivatives using certain nitrogen-containing nucleophiles.
8076324 Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them  
The present invention relates to di(hetero)arylcyclohexane derivatives of the formula I, in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula I are...
RE43029 Process for preparing a creatine heterocyclic acid salt and method of use  
This invention relates to a process for the synthesis and method of use of an effective amount of a creatine heterocyclic acid salt for the regulation athletic function in humans.
8076302 Pyrimidine nucleoside derivatives and salts thereof  
A novel pyrimidine nucleoside derivative represented by the following formula (1) and a salt thereof, as well as a pharmaceutical composition comprising the same as an active ingredient have...
8076347 Compounds and methods for the treatment of cancer  
(−)-(2S,4S)-1-(2-Hydroxymethyl-1,3-dioxolan-4-yl)cytosine (also referred to as (−)-OddC) or its derivative and its use to treat cancer in animals, including humans.
8048888 Anti-proliferative combination therapy using certain platinum-based chemotherapeutic agents and EGFR inhibitors or pyrimidine analogues  
The present invention describes a method or uses of prevention and/or treatment of a cancer or a tumor, and in particular to a combination therapy, methods, compositions and pharmaceutical...
8044040 N-heterocyclic inhibitors of TNF-alpha expression  
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I): Methods of...
8034823 Method of increasing drug oral bioavailability and compositions of less toxic orotate salts  
The present invention relates generally to the method of increasing the oral bioavailability, reducing chemotherapy induced toxicity and side effects, and improving the effectiveness of...
8034824 Iontophoretic preparation for treatment of breast cancer and/or mastitis  
The present invention is to provide means to treat breast cancer and/or mastitis by topically administering a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent and allowing...
8030322 Spirocompounds useful as modulators for dopamine D3 receptors  
The present invention relates to compounds of formula (I) or salts thereof wherein A, X, R2, R4 and n are defined herein, processes for their preparation, intermediates used in these processes,...
8025899 Solid pharmaceutical dosage form  
A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one...
7994170 1,3-dihydro-imidazo[4,5-C]quinolin-2-ones as lipid kinase inhibitors  
The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use...
7994183 Solid preparation comprising 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile  
The present invention provides a solid preparation containing 2[[6-[(3R)-3-amino-1 -piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidin yl]methyl]-4-fluorobenzonitrile (compound (A)) or a...