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4659736 |
Benzoyl urea compounds as agents for repelling snails and slugs
A method of combating slugs and snails comprising applying to a plant or to an area from which it is desired to exclude such slugs and snails a repellent amount of at least one benzoyl urea of the...
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4657908 |
Carbonyl derivatives
The invention relates to carbonyl derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention where is provided a guanidine derivative of...
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4649142 |
3,4-dihydro-1,3-disubstituted-6-(substituted phenylimino)-2(1H)-pyrimidinone useful as cardiotonic agent and anti-allergic agent
The invention relates to novel pyrimidinone compounds of anti-allergic and cardiotonic activity of the formula: ##STR1## wherein R 1 and R 2 are each lower alkyl, lower...
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4649138 |
Pharmaceutical compositions
S-(Aminoalkyl)isothioureas which have immunosuppressant activity. Two specific compounds are 2-(3-dimethylaminopropylthio)-2-imidazoline and N,N'-dimethyl-S-(3-dimethylaminopropyl)isothiourea.
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4636508 |
5-pyrimidinecarboxyamides and treatment of leukemia therewith
Novel 5-pyrimidinecarboxamides useful for regressing or inhibiting the growth of leukemia and tumors. The compounds have the formula: ##STR1## wherein R 1 is hydrogen or an alkoxy group having...
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4636505 |
Amide derivatives
Acylanilides of the formula ##STR1## wherein R 1 and R 2 , the same or different, each is cyano, carbamoyl, nitro, halogeno, perfluoroalkyl or other defined substituents; R 3 is hydrogen or...
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4636509 |
Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor
Compounds of the general formula: ##STR1## (wherein X represents a halogen atom or a trifluoromethyl group; R 1 represents an optionally substituted C 6 -10 carbocyclic aromatic group; and R 2 ...
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4614742 |
Fluorinated isophthalonitrile compound and nonmedical fungicide containing the same
A fluorinated isophthalonitrile compound having the general formula ##STR1## wherein Y is --O, --S, or --N(R'), R and R' are independently hydrogen, an alkyl group, an alkyl group, an alkynyl...
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4613604 |
Hydroxymethyl derivatives of 5-benzylacyclouridine and 5-benzoyloxybenzylacyclouridine and their use as potentiators for 5-fluoro-2'-deoxyuridine
A compound of the Formula (I): ##STR1## where X is a benzyl group or a benzyloxybenzyl group and pharmaceutical preparations containing the same.
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4608383 |
Cardioactive pyrazole and imidazole aryloxypropanolamines
The present invention provides aryloxypropanolamines of the general formula: ##STR1## wherein R 1 , R 2 , R 3 and R 4 , which may be the same or different, are hydrogen or halogen atoms or lower...
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4605659 |
Purinyl or pyrimidinyl substituted hydroxycyclopentane compounds useful as antivirals
Novel 4-substituted-5-hydroxymethyl-1,2-cyclopentanediols or 1-cyclopentanol substituted at the 3-position by various heterocyclic groups are useful as antiviral agents.
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4582834 |
Substituted phenyl-2-(1H)-pyrimidinones useful for treating cardiac insufficiency in a warm-blooded organism
New substituted phenyl-2-(1H)-pyrimidinones of the general formula I ##STR1## in which R 1 denotes an alkyl group having 1 to 4 carbon atoms, and R 2 and R 3 , which can be identical or...
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4581360 |
Sparsomycin (S.sub.c -R.sub.s) derivative; pharmaceutical composition having anti-tumor activity
The invention concerns novel sparsomycin (S c -R s ) derivatives having superior cytostatic activity compared to sparsomycin itself. Said derivatives contain a lipophilic group R 2 , selected from...
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4578388 |
Unsymmetrical guanidino, thioureido, isothioureido and nitromethyleneamino derivatives
The compounds are C 2 -C 8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino). N-(N'-substituted...
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4576948 |
Composition and method for inhibiting terminal deoxyribonucleotidyl transferase activity
New uracil compounds having the formula: ##STR1## wherein X is C 1 -C 10 alkoxy or amino are provided. These compounds are useful in treating patients having leukemia, the cells of which express...
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4571398 |
Cytosine derivatives having histamine H.sub.2 -antagonist activity
This invention relates to cytosine derivatives which have histamine H 2 -antagonist activity. A specific compound of this invention is...
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4571406 |
Anti-hypertensive chromans and chromenes
Compounds of formula (I): ##STR1## wherein: either one of R 1 and R 2 is hydrogen and the other is selected from the class of C 1 -6 alkylcarbonyl, C 1 -6 alkoxycarbonyl, C 1 -6 alkylcarbonyloxy,...
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4567191 |
Amino-phenyl-thiadiazoledioxides as gastric secretion inhibitors
Novel amino-phenyl-thiadiazoledioxides and related compounds and processes for preparing such compounds are disclosed. The compounds are useful for suppressing gastric acid secretions in mammals.
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4564618 |
5-Halovinyl-2'-deoxyuridine derivatives
Compounds of general formula (I): ##STR1## wherein R is a chlorine, bromine or iodine atom and physiologically acceptable salts thereof with bases of use as antiviral agents.
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4552900 |
3-(Pyrimidin-5-yl-oxyphenyl)-1-benzoyl-(thio)-urea compounds useful as pesticides
3-(Pyrimidin-5-yl-oxy-phenyl)-1-benzoyl-(thio)-ureas of the formula ##STR1## in which R represents hydrogen, alkyl, cycloalkyl, halogenoalkyl or optionally substituted aryl, R 1 represents...
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4535083 |
Cleavage products of 4',6'-didesoxy-4'-thio-,6'-amino-hepturonic acid nucleosides
The invention relates to compounds of the formula ##STR1## said compounds being obtainable by cleavage of compounds of formula ##STR2## The compounds of the invention as well as compositions and...
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4524146 |
Certain -2-heterocycle substituted pyrazoloquinolines
Pyrazolo[4,3-c]quinolin-3-ones of the formula ##STR1## e.g. wherein R 1 is an aromatic heterocyclic radical selected from quinolyl, isoquinolyl, pyrimidyl and thiazolyl, or such said heterocyclic...
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4524147 |
Uracil derivatives, process for preparing same, and pharmaceutical compositions comprising same
Disclosed are uracil derivatives having the general formula ##STR1## where R represents a hydrogen atom or an alkyl radical having 1 to 4 carbon atoms. Also disclosed are a process for preparing...
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4521406 |
Antitumor agent
An antitumor agent comprising a combination of 5-fluorocytosine and cytosinedeaminase has been developed. As to the practical administration procedure of the agent, it is preferable to carry out in...
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4514403 |
Hydrouracil compounds
A hydrouracil compound of the formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein A represents --CHCH--CH 2 -- or --CH 2 CH 2 --, and R represents hydrogen...
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4497815 |
1-(N-Substituted carbamoyl)-5-fluorouracil derivatives and the carcinostatic agents containing same as active ingredients
A 1-(N-substituted carbamoyl)-5-fluorouracil derivative represented by the following general formula: ##STR1## R is a 4-alkoxycyclohexyl group-containing radical which is...
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4481203 |
Composition containing 1-(n-hexylcarbamoyl)-5-fluorouracil and uracil
A composition for delivering 5-fluorouracil to cancer tissues, of a cancer sensitive to 5-fluorouracil, in warm blooded animals, comprising effective amounts of 1-(n-hexylcarbamoyl)-5-fluorouracil...
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4478839 |
Substituted pyrimid-2-ones, the salts thereof, processes for their preparation and pharmaceutical compositions containing them
Compounds of general formula: ##STR1## (wherein X represents a halogen atom or a trifluoromethyl group; R 1 and R 2 , which may be the same or different, each represents a hydrogen atom, or a C 1...
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4478822 |
Drug delivery system utilizing thermosetting gels
This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a...
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4474751 |
Ophthalmic drug delivery system utilizing thermosetting gels
This invention describes the application of selected polymers as novel drug delivery systems which use the body temperature and pH to induce a liquid to gel transition of the polymer which contains...
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4460588 |
5-Substituted pyrimidine derivatives active against internal animal parasites
The invention concerns a process for killing internal parasites, especially trematodes or nematodes, affecting warm blooded animals such as cattle, sheep and goats by administering an effective...
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4454133 |
Antimicrobial compounds
Compounds formed by condensation reactions of glutaraldehyde with various nitrogen-containing compounds are disclosed. The compounds exhibit anti-microbial activity and are useful in a method of...
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4444762 |
Vehicle composition containing 1-substituted azacyclopentan-2-ones
Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound...
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4438117 |
2-Substituted thio-4,5-diarylpyrimidines
2-Substitutedthio-4,5-diarylpyrimidines, such as 2-(1,1,2,2-tetrafluoroethylthio)-4,5-bis(4-methoxy-phenyl)py
rimidine useful for treating arthritis and/or alleviating pain.
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4434167 |
Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia
Pyrimidyl thioureas of the formula ##STR1## wherein R 1 , R 2 , and R 3 individually represent hydrogen, halogen, a linear or branched alkoxy group, or a linear or branched alkyl group, said...
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4432978 |
Hexahydro-trans-pyridoindole
Derivatives of 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]-indole and of (+)enantiomeric, mixtures of (+) and (-)enantiomeric or (±)racemic 2,3,4,4a,5,9b-hexahydro-4a,9b-trans-1H-pyrido[4,3-b]indole,...
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4432979 |
Pyridone compounds
Cardiotonic 5-heteroaryl-substituted-2-pyridone compounds, pharmaceutical compositions, and a method for the treatment of congestive heart failure.
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4424213 |
Biologically active heterobicyclic hydroximidates and thiolhydroximidates and carbamate ester derivatives thereof
Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described. ##STR1##
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4423040 |
Vehicle composition containing 1-substituted azacyclohexan-2-ones
Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound...
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4423047 |
Pyrimidine-2-sulphides and their S-oxides for use in medicine and methods of use therefor, pharmaceutical compositions containing them, processes for their preparation and per se novel sulphides and S-oxides
Compounds of the formula ##STR1## (wherein X represents a halogen atom; n is 0, 1 or 2; R 1 and R 2 , which may be the same or different, each represents a hydrogen atom or a carboxyl, esterified...
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4419363 |
Alkanolamine derivatives
Novel 1-aryloxy-3-amidoamidoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart...
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4415563 |
Vehicle composition containing 1-substituted azacyclononan-2-ones
Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound...
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4415573 |
Novel uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same
Novel uracil derivatives of the formula ##STR1## (wherein R 1 , R 2 R 3 and X are defined in the description) and their pharmaceutically acceptable salts, process for preparing the same and...
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4414216 |
Tetrahydrofuran compounds and analogs thereof
There are disclosed tetrahydrofuran compounds and analogs thereof of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein X is oxygen or sulfur, R 1 and R 2 ...
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4411893 |
Topical medicament preparations
Topical therapeutic compositions are disclosed which contain from about 0.1 to 70 percent by weight of a water-soluble tertiary amine oxide and a therapeutic agent selected from the group...
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4410530 |
2-(3-Amino-2-hydroxy-propoxy)-mono-and diazines
Heterocyclic compounds of the formula ##STR1## wherein Het denotes optionally substituted pyridazinyl, pyrimidinyl, pyrazinyl or substituted pyridyl, R 1 is hydrogen or methyl and R 2 is lower...
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4407793 |
Composition for temporary substitution of bone tissue defects
The composition for a temporary substitution of bone tissue defects according to the present invention consists of α-cyanacrylic acid esters and a powder-like filler which is a calcium salt of an...
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4406902 |
Dipeptidase inhibitors
Novel chemical compounds are provided which selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical...
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4405610 |
Drug for curing inflammatory and/or degenerative and/or atrophic mucous-membrane diseases
The invention relates to a pharmacuetical agent for curing inflammatory and/or degenerative and/or atrophic mucous-membrane diseases, more particularly for local application, which are...
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4405621 |
Heterocyclic thioureas, isothioureas, guanidines and nitromethylene-amidines
The compounds are C 2 -C 8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted...
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